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VincentVargas

NervousSystemLabReport

Thislabreportwillincludeactionpotentialalsoknownasimpulses,toxinseffectonaction
potentials,andcranialnerveandreflexactionpotential.Actionpotentialisinamultipolar
neuron.wherethefirstpartoftheaxonistriggeredbyastimulusandrespondsintransmitting
millivoltsacrossthecellmembrane,riseofconstantpace(allornothing)Depolarizationisthe
reductionofamembrane'srestingpotentialsothatthemembranebecomesless
negative.Repolarizationisthestateintheactionpotentialprocessthatreturnsmembraneback
toitsnegativevoltageafterthedepolarizationprocesshasoccurredbyselectivelyopeningand
closingofthepotassiumchannelsofthecellmembrane.Theperiodwhenaxonscanbe
stimulatedtogenerateanewactionpotentialiscalledtherefractoryperiodwhichlimits
impulsestoanaverageof100persecond.
Thefollowingfigureswilladdressnervous
systemactionpotentialstudies

Figure2.
Animaltoxinsthatcanaffectactionpotentials
Maculotoxin

BlocksSodiumchannels

Latrotoxin

Enhancesacetylcholinerelease

Bungarotoxin

Blocksacetylcholinereceptor

Tetrodotoxin

Blockssodiumchannels

Apamin

Blockspotassiumchannels

Charybdotoxin

Blockspotassiumreceptors

Conotoxin

oneblockscalciumchannelsoneblocks

sodiumoneblocksAChreceptors
Mutantgeneforavoltagegatedsodium
channelinnociceptiveneurons

Produceschannelsthatarenonfunctional,
blocksthesensorynervesforpain

Synthetictoxinthatdestroysmyelin
coveringofopticandmotornerves

Causeslossofmotorcontrol,messagescan't
getthrough,lossofmovement(paralysis)

Batrachotoxin

toxinbindstothesodiumchannelandkeeps
themembranepermeabletosodiumionsinan
allornonemanner

DendrotoxinK

Blocksvoltagegatedpotassiumchannelsand
canleadtoconvulsions

GeneralanestheticlikeSevoflurane

leadtotheactionpotentialtonotrepolarize
correctly,becomesunconscious

Potassium

Increasedpotassium,tomoreactionpotential
andmorefiringoftheneurons
:seizures/epilepsy

Sodiumchannelswithamutationthat
altersthevoltagesensitivity

Sodiumchannelsopenatamorepositive
membranepotentialandmakesneuronsless
excitable:seizuresbymembranedischarge

CranialNervesandtheirFunction

Nerve

Type

Function

Olfactory

sensory

Sensoryfibersconductimpulsesassociatedwithsenseofsmell

Optic

sensory

sensoryfibersconductimpulsesassociatedwithsenseof
vision

Oculomotor

primarilymotor

Motorfibersconductimpulsestomusclesthatraisetheeyelids
movetheeyesetc

Trochlear

primarilymotor

motorfibersconductimpulsestomusclesthatmovethe
eyes

Trigeminal

mixed

sensoryfibersconductimpulsesfromthesurfaceoftheeyes,tear
glands,scalp,anduppereyelids

Abducens

Mixed

Motorfibersconductimpulsestomusclesforeye
movement
Somesensoryfibersconductimpulseswithproprioceptors

Facial

mixed

controloffacialmuscles,salivation,taste,andcutaneous
sensation

Vestibulococh
lear

sensoryfibersconductimpulsesassociatedwiththesense
ofequilibriumandthesenseofhearing

Glossopharyn
geal

Sensoryfibersconductimpulsesfromthe
pharynx,tonsils,posteriortongue,andcarotidarteries

Vagus

mixed

Motorcontroltotheheartviscera,sensationfromthe
thorax,pharynxandabdominalviscera

Accessory

sensory

Motorimpulsestothepharynxandshoulder

Hypoglossal

mixed

Motorcontroloftonguesomeskeletalmusclessome
viscera,sensationfromtheskinandviscera

Figure.3

Followingfigureshowsthedifferentcranialnervesandtheirfunction.Thebraincontains
neuronswhicharepartoftheCNS.TheCNShasvariouscenterslocatedwithinit,thatcarryout
thesensory,motorandintegrationofdata.Thecranialnervesconnectwithactionpotentials
throughneuronsandmuscles.

ReflexData

ReflexTests

Left

Right

Bicep

StrongReflex

StrongReflex

Patellar

StrongReflex

WeakReflex

Figure4.

Inthefigureabovethetableshowsthelocationofwherewetestedthereflex.TheReflexarc
causethemusclestoreacttothereflexmallet.

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