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NervousSystemLabReport
Thislabreportwillincludeactionpotentialalsoknownasimpulses,toxinseffectonaction
potentials,andcranialnerveandreflexactionpotential.Actionpotentialisinamultipolar
neuron.wherethefirstpartoftheaxonistriggeredbyastimulusandrespondsintransmitting
millivoltsacrossthecellmembrane,riseofconstantpace(allornothing)Depolarizationisthe
reductionofamembrane'srestingpotentialsothatthemembranebecomesless
negative.Repolarizationisthestateintheactionpotentialprocessthatreturnsmembraneback
toitsnegativevoltageafterthedepolarizationprocesshasoccurredbyselectivelyopeningand
closingofthepotassiumchannelsofthecellmembrane.Theperiodwhenaxonscanbe
stimulatedtogenerateanewactionpotentialiscalledtherefractoryperiodwhichlimits
impulsestoanaverageof100persecond.
Thefollowingfigureswilladdressnervous
systemactionpotentialstudies
Figure2.
Animaltoxinsthatcanaffectactionpotentials
Maculotoxin
BlocksSodiumchannels
Latrotoxin
Enhancesacetylcholinerelease
Bungarotoxin
Blocksacetylcholinereceptor
Tetrodotoxin
Blockssodiumchannels
Apamin
Blockspotassiumchannels
Charybdotoxin
Blockspotassiumreceptors
Conotoxin
oneblockscalciumchannelsoneblocks
sodiumoneblocksAChreceptors
Mutantgeneforavoltagegatedsodium
channelinnociceptiveneurons
Produceschannelsthatarenonfunctional,
blocksthesensorynervesforpain
Synthetictoxinthatdestroysmyelin
coveringofopticandmotornerves
Causeslossofmotorcontrol,messagescan't
getthrough,lossofmovement(paralysis)
Batrachotoxin
toxinbindstothesodiumchannelandkeeps
themembranepermeabletosodiumionsinan
allornonemanner
DendrotoxinK
Blocksvoltagegatedpotassiumchannelsand
canleadtoconvulsions
GeneralanestheticlikeSevoflurane
leadtotheactionpotentialtonotrepolarize
correctly,becomesunconscious
Potassium
Increasedpotassium,tomoreactionpotential
andmorefiringoftheneurons
:seizures/epilepsy
Sodiumchannelswithamutationthat
altersthevoltagesensitivity
Sodiumchannelsopenatamorepositive
membranepotentialandmakesneuronsless
excitable:seizuresbymembranedischarge
CranialNervesandtheirFunction
Nerve
Type
Function
Olfactory
sensory
Sensoryfibersconductimpulsesassociatedwithsenseofsmell
Optic
sensory
sensoryfibersconductimpulsesassociatedwithsenseof
vision
Oculomotor
primarilymotor
Motorfibersconductimpulsestomusclesthatraisetheeyelids
movetheeyesetc
Trochlear
primarilymotor
motorfibersconductimpulsestomusclesthatmovethe
eyes
Trigeminal
mixed
sensoryfibersconductimpulsesfromthesurfaceoftheeyes,tear
glands,scalp,anduppereyelids
Abducens
Mixed
Motorfibersconductimpulsestomusclesforeye
movement
Somesensoryfibersconductimpulseswithproprioceptors
Facial
mixed
controloffacialmuscles,salivation,taste,andcutaneous
sensation
Vestibulococh
lear
sensoryfibersconductimpulsesassociatedwiththesense
ofequilibriumandthesenseofhearing
Glossopharyn
geal
Sensoryfibersconductimpulsesfromthe
pharynx,tonsils,posteriortongue,andcarotidarteries
Vagus
mixed
Motorcontroltotheheartviscera,sensationfromthe
thorax,pharynxandabdominalviscera
Accessory
sensory
Motorimpulsestothepharynxandshoulder
Hypoglossal
mixed
Motorcontroloftonguesomeskeletalmusclessome
viscera,sensationfromtheskinandviscera
Figure.3
Followingfigureshowsthedifferentcranialnervesandtheirfunction.Thebraincontains
neuronswhicharepartoftheCNS.TheCNShasvariouscenterslocatedwithinit,thatcarryout
thesensory,motorandintegrationofdata.Thecranialnervesconnectwithactionpotentials
throughneuronsandmuscles.
ReflexData
ReflexTests
Left
Right
Bicep
StrongReflex
StrongReflex
Patellar
StrongReflex
WeakReflex
Figure4.
Inthefigureabovethetableshowsthelocationofwherewetestedthereflex.TheReflexarc
causethemusclestoreacttothereflexmallet.