A Handbook

on the Management and

Reporting of Serious Adverse Events
following Mass Drug Administration
for Selected Neglected Tropical Diseases
Eric R. Salenga, RPh, MPH
NPO
World Health Organization

 Effective recognition and management of adverse events

following MDA (AEs-f-MDA) whether caused by the
medicines taken, or not should be an essential component
of preventive chemotherapy program planning and
implementation.

 As preventive chemotherapy programs scale up, more AEsf-MDA are almost certain to be reported along with
increases in the number of serious adverse events (SAEs) as
well.

 Proper management of AEs-f-MDA and effective reporting

and investigation of SAEs are essential and will enhance the
credibility of preventive chemotherapy programs.

 It is important to prepare all MDA facilitators as

well as community members to ensure that the
occurrence of adverse events will be minimized are
detected and handled appropriately.
Thus, the need for a readily available, easy-to-use
reference that will provide adequate information on
the detection, management, investigation and
reporting of AEs and SAEs.

 Chapter I. Introduction
Neglected Tropical Diseases
NTDs in the Philippines
Preventive Chemotherapy
Mass Drug Administration
Adverse Events

 Chapter II. MDA

Pre implementation of MDA
Implementation of MDA
Post-implementation of MDA

 Chapter III. Communication Skills

Essentials of Communication
Identifying stakeholders
How are messages accepted by the audience during AEs
Crisis Communication Lifecycle
Strategies for Presenting Information

 Train regional healthcare workers to identify adverse events

Establish relationships with shareholders and media
Constitute a Safety Surveillance Team (SST)
Primary objective of early detection and response and monitoring
and recording of adverse drug reactions
1. Quick response medical team
2. Active Surveillance Team
3. Crisis Management Team
4. Joint Information Cener