Nama : Much.

Hasyim Asyari
Kelas : FK B 2015
NPM : 1102015142

A. Skenario

Insomnia
Adi, 19 tahun baru saja lulus SMA dan ia selalu gagal diterima di FK Universitas Negeri
maupun Universitas FK swasta. Sudah sebulan terakhir ia mengalami susah tidur (insomnia),
gelisah dan sering merasa kesal kepada diri sendiri. Setelah Adi periksa di dua klinik, dokter
A menganjurkan Adi untuk mengonsumsi suplemen 5-Hydroxytrophan, dan dokter B
menganjurkan Adi untuk mengonsumsi suplemen L-Tryptophan.
B. Background Question
1. Apa efek samping 5-Hydroxytrophan?
2. Apa efek samping L-Tryptophan?
C. Foreground Question

Suplemen manakah yang lebih efektif untuk mengatasi insomnia, 5- Hydroxytrophan ataukah
L-Tryptophan?
D. PICO

P (patient)
I (indicator)
C (comparison)
O (outcome)

: Adi menderita insomnia.

: Mengonsumsi suplemen 5-Hydroxytrophan.
: Mengonsumsi suplemen L-Tryptophan?
: Menyembuhkan insomnia.

E. Type of Question : Therapy/Treatment

F. Type of Study
: Randomized Controlled Trial
G. Pencarian Bukti Ilmiah

Kata kunci
Sumber/database
Limitasi
Hasil pencarian

: Insomnia AND 5-Hydroxytrophan AND L-Tryptophan

: www.ebscohost.com
: 5 tahun terakhir (2010-2015), free article.
: 19 jurnal.

H. Judul-judul Jurnal
1. Sweet Dreams, Happy Days and Elevated 24-H Urine 5-Hydroxyindoleacetic Acid

Excretion.
2. Transcriptional Supression of Tryptamine 5-Hydroxylase, a Terminal Serotonin

Biosynthetic Gene, Induces Melatonin Biosynthesis in Oryza Sativa L.

3. Effects and Side Effects Associated with the Non-Nutritional Use of Tryptophan by
Humans.
4. Clinical Depression: an Evidence-Based Integrative Complementary Medicine
Treatment Model.

5. Neurotransmitter-Precursor-Supplement Intervention for Detoxified Heroin Addicts.

6. Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders.
7. Biological Phenotypes Underpin the Physio-Somatic Symptoms of Somatization,

Depression, and Chronic Fatigue Syndrome.

8. Tryptophan Kynurenine Metabolism as a Common Mediator of Genetic and

Environmental Impacts in Major Depressive Disorder.

9. Extrapineal Melatonin: Sources, Regulation, and Potential Functions.
10. Common Questions About the Pharmacologic Management of Depression in Adults.
11. Nutraceutical Preparation in Childhood Migraine Prophylaxis: Effects on Headache
12.
13.
14.
15.
16.
17.
18.
19.
I.

Outcomes Including Disability and Behaviour.

Protective Effects of Melatonin in Reducing Oxidative Stress and in Preserving the
Fluidity of Biological Membranes.
Emergance of Naturally Occuring Melatonin Isomers and Their Proposed
Nomenclature.
Streptozotocin-Induced Insulin Deficiency Leads to Development of Behavioral
Deficits on Rats.
Nutritional and Herbal Supplements for Anxiety and Anxiety-Related Disorders.
Pharmacological Treatment of Fibromyalgia Syndrome.
Pathophysiology of Premenstrual Syndrome and Syndrome Dysphoric Disorder.
Pharmacogenetic Aspects of the Effect of Cytochrome P450 Polymorphisms on
Serotonergic Drug Metabolism, Response, Interactions, and Adverse Effects.
Melatonin in Autism Spectrum Disorders: a Systematic Review and Meta-Analysis.

Jurnal yang Dipilih

1. Fernstorm, J. 2011. Effects and Side Effects Associated with the Non-Nutritional Use
of Tryptophan by Humans.
2. Sarris Jarome, 2011. Clinical Depression: an Evidence-Based Integrative
Complementary Medicine Treatment Model. Alternative Therapies Jul/Aug 2011. Vol.
17. No. 04.