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  • Phataphysiology: in Guillain - Barre Syndrome, The Myelin Qheath Surrounding The Axon Is Lost

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    sachin duduskar
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    Guillain-Barré syndrome is caused by demyelination of the nerves due to an immune response, commonly following an infection. There are different subtypes depending on whether the damage is to myelin sheaths or axons, and whether motor or sensory nerves are affected. The most common form is acute inflammatory demyelinating polyneuropathy where myelin sheaths are first damaged followed by axonal injury, typically affecting adults. Acute motor axonal neuropathy mainly impacts motor nerves through macrophage activation and is more common in children.

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    Guillain-Barré syndrome is caused by demyelination of the nerves due to an immune response, commonly following an infection. There are different subtypes depending on whether the damage is to myelin sheaths or axons, and whether motor or sensory nerves are affected. The most common form is acute inflammatory demyelinating polyneuropathy where myelin sheaths are first damaged followed by axonal injury, typically affecting adults. Acute motor axonal neuropathy mainly impacts motor nerves through macrophage activation and is more common in children.

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    18 vues1 page

    Phataphysiology: in Guillain - Barre Syndrome, The Myelin Qheath Surrounding The Axon Is Lost

    Transféré par

    sachin duduskar
    Guillain-Barré syndrome is caused by demyelination of the nerves due to an immune response, commonly following an infection. There are different subtypes depending on whether the damage is to myelin sheaths or axons, and whether motor or sensory nerves are affected. The most common form is acute inflammatory demyelinating polyneuropathy where myelin sheaths are first damaged followed by axonal injury, typically affecting adults. Acute motor axonal neuropathy mainly impacts motor nerves through macrophage activation and is more common in children.

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    sur 1

    PHATAPHYSIOLOGY:

    In Guillain Barre Syndrome, the myelin Qheath Surrounding the axon is lost.
    Demyelination is common response of heural tissue to many agent &
    conditions, including physical trauma, hupoxemia, toxic chemicals, vascular
    insufficience & immunological reactions.
    Loss of myelin sheath in Gaillian Barre Syndrome make never impulse
    transmission aborted.
    Probably a cell mediated immune response to preceding infection.

    Subtypes of Guillian Barre Syndrome


    Subtype

    Feature

    Electro
    diagnosis

    Acate
    inflammatory
    demuel in
    polyncuropathy
    (AIDP)
    Acute motor
    axonal
    neuropathy
    (AMAN)

    Adult affected
    more than
    children

    Demyelinating

    Children & young


    adult

    Axonal

    Acute motor
    Sensory axonal
    neuropathy
    (AMSAN)

    Adults & childrens


    uncomonon

    Axonal

    M.Fisher
    syndrome (MFS)

    Adults & childrens


    uncomonon

    Demyelinating

    Pathology
    1st attack on
    schwann all
    myelin damage
    2nd axonal
    damage.
    1st attack motor
    nerve,
    macrophage
    activation.
    Same as AMAN,
    but also affect
    sensory never &
    roots, axonal
    damage usually
    severe.
    Few case
    examined,
    resembles (AIDP)

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