Vous êtes sur la page 1sur 1

PHATAPHYSIOLOGY:

In Guillain Barre Syndrome, the myelin Qheath Surrounding the axon is lost.
Demyelination is common response of heural tissue to many agent &
conditions, including physical trauma, hupoxemia, toxic chemicals, vascular
insufficience & immunological reactions.
Loss of myelin sheath in Gaillian Barre Syndrome make never impulse
transmission aborted.
Probably a cell mediated immune response to preceding infection.

Subtypes of Guillian Barre Syndrome


Subtype

Feature

Electro
diagnosis

Acate
inflammatory
demuel in
polyncuropathy
(AIDP)
Acute motor
axonal
neuropathy
(AMAN)

Adult affected
more than
children

Demyelinating

Children & young


adult

Axonal

Acute motor
Sensory axonal
neuropathy
(AMSAN)

Adults & childrens


uncomonon

Axonal

M.Fisher
syndrome (MFS)

Adults & childrens


uncomonon

Demyelinating

Pathology
1st attack on
schwann all
myelin damage
2nd axonal
damage.
1st attack motor
nerve,
macrophage
activation.
Same as AMAN,
but also affect
sensory never &
roots, axonal
damage usually
severe.
Few case
examined,
resembles (AIDP)