19

, ,

(Expanded Programme
on Immunization: EPI)
.. 1974

adjuvant

potency
potency

(Adverse Events Following Immunization:
AEFI)
1-3

1-4

adjuvant

20

1.

2.

0 o.
potency

( 1)
3.

BCG, Measles, Rubella MMR

1.2



ice pack
1.3

1.4

1.5
1-7

1.

1.1

 3 21

2.
2.1
2.1.1

10
1
1) -15
o
-25 .
2) 2
8 o.
3) 2
2
4) ice pack

5)
3
6
6)

1:1

7)


8) 5
.
9)
10)
2.1.2 ( 2)
1)

2)

3)

4)

5) Lyophilized vaccines
2 - 8 o. 6 BCG
2 (HB, DTP, dT)
2 - 8 o. 8

22

2.2
2.2.1


3-4 ( 3)

1-1 ( 4)
2.2.2

1) ice pack
4
ice pack
2)
10-15
2 - 8 o.
3)

ice pack
4)
ice pack

5) ice pack
2 - 8 o.

2.3

2.3.1 Vaccine Vial Monitor (VVM)

VVM

( 5)
2.3.2 Freeze Watch (FW)




FW
0 o. 1

 3 23

5 Vaccine Vial Monitor (VVM)

6 Freeze Watch

HB, DTP-HB, DTP, dT

TT ( 6)
2.3.3 Data Logger

Sensor -40
+85 o.
//
/
( 7)
2.3.4 Vaccine Cold Chain Monitor (VCCM)
( 8)

(indicator)
A, B C
10 o. D
34 o. VCCM

1) A, B, C D

10 o.
2) A
B, C D 3
10 o.
1
3) A

24

7 Data Logger

8 Vaccine Cold Chain Monitor

B, C D 3

10 o. 3 OPV
VVM VVM 3

4) A
B
C D 2
10 o.
5 OPV VVM
VVM 3

5) A B

C
D 2
10 o. 8
OPV VVM
VVM M,
YF, MMR R 3

6) A B
C
D
10 o.
10 OPV VVM
VVM

 3 25

M, YF, MMR R
DTP BCG 3
dT TT
7) A, B C
D
10 o.
12 OPV VVM
VVM
M, YF, MMR R
DTP BCG 3
dT TT
8) A, B, C D

10 o. 14
34 o. 2 OPV
VVM VVM

3.

( 9)


4.1
breaker
4.2

4.3

4.

/
9

26

1. BCG

Live bacteria

2. HBV
Recombinant viral antigen
3. DTwP, DTap, DT, Td, Tdap, TT Toxoids and inactivated bacterial
component
4. OPV
Live virus
5. IPV
Inactivated virus
6. MMR, M, MMRV
Live-attenuated viruses
7. JE

Inactivated virus

8. JE
9. Hib
10. PCV
11. PS23
12. RV (ROTA)
13. Var

Live-attenuated virus
Polysaccharide-protein conjugate
Polysaccharide-protein conjugate
Polysaccharide
Live-attenuated virus
Live-attenuated viruses

14.
15.
16.
17.
18.
19.
20.

Inactivated viral antigen

Inactivated viral component
Recombinant viral antigens
Inactivated virus
Polysaccharide
Polysaccharide
Live-attenuated virus

HAV
Influenza
HPV
Rabies
Ty
MPSV
Yellow fever

2-8 o.
2
2-8 o.
2-8 o.
2-8 o.
2-8 o.
2-8 o.
6
2-8 o.
()
2-8 o.
2-8 o.
2-8 o.
2-8 o.
2-8 o.
2-8 o.
30
2-8 o.
2-8 o.
2-8 o.
2-8 o.
2-8 o.
2-8 o.
2-8 o.

: 1. 2-8 o.
2.

3. (-15 o. +20 o.)

2-8 o.
4.

 3 27

OPV
BCG
Measles
MMR
MR
Yellow fever
Hib lyophilized
Meningitis
JE
Hepatitis B
DTP-HB
DTP-HB-Hib
liquid
DTP
DT/TT/dT
Pneumococcal
Rotavirus

()

6-12
3
1-3
-15 o. -25 o.
OPV

lyophilized vaccines +2 o. +8 o.

-15 o. -25 o.

o
+2 . +8 o.

+2 o. +8 o.

+2 o. +8 o.

5.

(stability data)

( 10)
5.1

5.2 / , Lot
no.,
5.3 VVM

6. Shake Test ( 11)
Shake Test

HB, DTP, DTP-HB, dT TT



6.1 1

28

10

11 Shake Test

Lot no.
(control)
10 -10 o.

6.2

6.3
2 10-15
6.4 2

6.5 2

Thailand Chapter
of International Society of Tropical Pediatrics

1. Plotkin SA, Orestein WA, Offit PA, Editors.

Vaccines. 5th ed. China: Saunders Elsevier Inc.; 2008.

2.
.

 3 29

.. 2539.:
;
2539.
3.
.
.. 2547. :
; 2547.
4. Department of Immunization, Vaccines and
Other Biologicals, World Health Organization. Temperature monitors for vaccines and the cold chain. Geneva:
WHO; 1999.
5. Department of Immunization, Vaccines
and Other Biologicals, World Health Organization.
Cold chain, vaccines and safe-injection equipment
management. Geneva: WHO; 2008.
6. , ,
, ,
, .
2010-2011. :
; 2553.
7. . . :
, , . Leadership in Medicine 2010. :
; 2553. .184-90.