03 Biochemistry

Q world NEET PG TEST
SERIES

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TEST SERIES 03 BIOCHEMISTRY

A couple has three girls, the last of whom is affected with cystic fibrosis. The first-born daughter marries
her first cousin—that is, the son of her mother's sister—and they have a son with cystic fibrosis. The father
has a female cousin with cystic fibrosis on his mother's side. Which of the following pedigree diagrams best
represents this family history?’
1. Diagram E
2. Diagram F
3. Diagram G
4. Diagram H

A newborn girl is found to have marked swelling of the dorsal areas of her feet along with a broad (webbed) neck, a broad chest, and a heart murmur that is
due to coarctation of the aorta. Her physician suspects a chromosomal disorder and orders a karyotype. Which of the results pictured below is most likely?

Result A
Result C
See the following pictures..

Result B
Result D

1

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TEST SERIES 03 BIOCHEMISTRY

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TEST SERIES 03 BIOCHEMISTRY

3

First committed step of glycolysis is
catalysed by

2,3 DPG

Glucokinase

C

hexokinase

D

PFK

4

Oxaloacetate + Acetyl coA -> Citrate +
CoASH. This reaction is

reversible

irreversible

C

can be reversed by
catalase

D

competitive

5

In TCA cycle CO2 is released from

Thiokinase

Isocitrate
dehydrogenase

C

citrate
dehydrogenase

D

alpha ketoglutarate

6

Maximum redox potential is for

NADH/NAD

C

ubiquinone

D

Fe2+

7

Metabolites in HMP shunt are all except

glycerol 3
phosphate

succinyl co A
fumarate
Sedoheptulose 7
phosphate

C

glyceraldehyde 3
phosphate

D

xylose 5 phosphate

8

Enzyme common in gluconeognesis and
glycolysis is

PFK

Fructose 2,6
biphosphatase

C

hexokinase

D

Glucose 6 phosphatase

9

Fructokinase is necessary for

fructose 1
phosphate

Fructose 1,6
biphosphatase

C

fructose 6 phosphate

D

glyceraldehyde

10

enzyme for catabolism of fructose to
pyruvate in liver

Glyceraldehyde
3phosphate
dehydrogenase

phosphoglucomutase

C

LDH

D

glucokinase

11

Aldolase is an enzyme whose substrate is

Glucose 6
phosphate

Fructose 6
phosphate

C

fructose 6 phosphate

D

fructose 1,6 biphosphate

12

Constituent of Cytochrome C reductase

B1

B2

C

Biotin

D

Ascorbic acid

13

Not a component of transport system

receptor activation

selective gate

C

D

energy coupling system

14

Glucokinase is a

transferase

isomerase

C

non selective
channel
oxidoreductase

D

hydrolase

15

Completely dependent on glucose is

renal cortex

adrenal cortex

C

heart

D

retina

16

which does not occur in glycolysis ?

isomerisation

hydration

C

phosphoryl transfer

D

all of the above

17

End product of one stage fermentation is

Formic acid

pyruvate

C

lactate

D

Ethanol

18

Not a polymer of glucose

Glycogen

cellulose

C

amylose

D

inulin

3

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TEST SERIES 03 BIOCHEMISTRY

19

step in HMP pathway requiring TPP

G6PD

6 phosphoglucoate
dehydrogenase

C

transketolase

D

transaldolase

20

Allosteric inhibition with ATP affects

PFK

C

G6PD

D

pyruvate kinase

21

GTP is substrate for all except

Pyruvate
carboxykinase

Phosphoenol
pyruvate
succinate thiokinase

C

nucleoside
diphosphatase

D

none

22

During starvation non-protein RQ value
is close to

1

0.5

C

0.25

D

0.75

23

which is a fructosan ?

Pectin

chitin

C

inulin

D

glycogen

24

Reduction of glucose with calcium in
water produces

Glucuronic acid

Dulcitol

C

Sorbitol

D

Mannitol

25

In TCA cycle citrate is converted into
after loosing a molecule of H2O

isocitrate

cis-aconitate

C

oxaloacetate

D

glutarate

26

Which can not be metabolised in body ?

Galactose

Sucrose

C

fructose

D

dextrose

27

Major contribution towards
gluconeogenesis is by

lactate

glycerol

C

ketones

D

Alanine

28

Fluoroacetate inhibits

citrate synthetase

aconitase

C

Succinate
dehydrogenase

D

alpha keto glutarate
dehydrogenase

29

Which inhibitor in TCA cycle blocks
citrate ?

fluroacetate

arsenite

C

malonate

D

none

30

which FA does not belong to W6 series ?

linoleic acid

arachidonic acid

C

D

alpha linolenic acid

31

Apo B48 and Apo B100 are exposed as 2
different apo-proteins because of
difference in

RNA editing

RNA splicing

C

Gamma linolenic
acid
Chromosomal loci

D

Apo-B gene

32

Which helps in transport of chylomicrons
from intestine to liver ?

Apoprotein B

Apoprotein A

C

Apoprotein C

D

Apoprotein E

33

Highest amount of cholesterol is present
in

HDL

LDL

C

VLDL

D

IDL

34

Most important carrier of cholesteol in
plasma is ?

HDL

LDL

C

VLDL

D

IDL

35

In fatty acid synthesis CO2 loss occurs in
which step ?

hydration

dehydration

C

condensation

D

reduction

4

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TEST SERIES 03 BIOCHEMISTRY

36

Saturated aceyl enzyme formation causes

freeing of PANSH site

freeing of Cyst-SH
site

C

both

D

none

37

All participate in fatty acid synthesis
except

Hydratase

Reductase

C

Transacylase

D

Dehydrogenase

38

How many ATPs are formed in Stearic
acid beta oxidation ?

7

18

C

56

D

146

39

In well fed state , acetyl co-A obtained
from diet is least used in synthesis of

Palmityl CoA

Citrate

C

Acetoacetate

D

Oxalosuccinate

40

In starvation nitrogen is carried from
muscle to liver and kidney by

Alanine

Aspartic acid and
serine

C

Glycine

D

asparagine

41

Which is most essential fatty acid ?

Linolenic acid

linoleic acid

C

arachidonic acid

D

oleic acid

42

Ganglioside is composed of all except

Galactose

Phosphate

C

ceramide

D

sialic acid

43

HMG-CoA is formd in metabolism of all
except

Cholesterol

leucine

C

Ketone bodies

D

Bile acids

44

Cholesteol detection can be done with all
except

Libermanburchard reaction

Zimmerman reaction

C

Winslow test

D

Salkwski test

45

Fredrickson's type II hyperlipidemis is
due to excess amount of

VLDL remnants

VLDL

C

floating LDL

D

HDL

46

Unsaturated fatty acids are converted
into

Prostaglandins

cholesterol

C

Cell membrane lipid

D

Saturated fatty acids

47

Anionic gap is not present in

diabetic acidosis

uremic acidosis

C

respiratory acidosis

D

renal tubular acidosis

48

C17H29COOH is a formula of

linoleic acid

linolenic acid

C

arachidonic acid

D

Clupanodinic acid

49

Common metabolic process in humans
and bacteria

Purine synthesis

nitrogen fixation

C

mucolipid formation

D

non-oxidative
phosphorylation

50

DNA supercoiling is done by

DNA polymerase I

DNA polymerase II

C

DNA topoisomerase

D

DNA gyrase

51

Histone post-translational modification is
by all except

Acylation

Methylation

C

Phsphorylation

D

Glycosylation

52

Gene transmitted but not translated

t-RNA

C

Keratin

D

histone

53

Smallest fundamental unit coding for
DNA synthesis is

Glycosyl
transferase
Cistron

Operon

C

Replicon

D

Anticodone

5

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TEST SERIES 03 BIOCHEMISTRY

54

In cloning largest fragment can be
incorporated in

Plasmid

Bacteriphage

C

Cosmid

D

Retrovirus

55

Maximum damage to DNA is caused by

alpha rays

beta rays

C

gamma rays

D

delta rays and UV rays

56

Xeroderma pigmentosa is defect in

mismatch repair

base excision repair

C

D

SOS repair

57

Xeroderma pigmentosa is defect in

DNA polymerase I

DNA polymerase III

C

nuclotide excision
repair
DNA exonuclease

D

DNA ligase

58

RNA with highest percentage of modified
base is

mRNA

t-RNA

C

r-RNA

D

SnRNA

59

In a DNA coding region reads 5'-CGT-3'
. This would code in RNA as

5-CGU-3

5-AGA-3

C

5-ACG-3

D

5-UGC-3

60

Which is not a post-translational
modification of RNA ?

splicing

5'capping

C

3'polyadenylation

D

Glycosylation

61

In RNA , gene during processing
undergoes all except

Chemical
hydrolysis

Terminal addition

C

Nucleoside
modification

D

nucleoside clevage

62

hn RNA is seen in

Spinal muscular
atrophy

Sickle cell disease

C

Hutchison chorea

D

alpha thalssemia

63

RNA with abnormal purine bases

t-RNA

m-RNA

C

r-RNA

D

16S RNA

64

Molecular phenomenon in Ig genes
responsible for affinity maturation of
antibody response

Chain shuffling

junctional diversity

C

Somatic
hypermutation

D

Altered RNA splicing

65

All can detect mutation except

Single strand
conformational
polymorphism

LCR

C

PCR

D

DNA sequencing

66

DNA fragments formed by Restriction
endonucleases are separated by

Gel
electrophoresis

Agarose gel
electrophoresis

C

Paper
chromatogrpahy

D

HPLC

67

Total number of Human genes are

30000

50000

C

75000

D

100000

68

Inositic acid is a precursor of

uracil and thymine

purine and thymine

C

Adenylic acid and
guanylic acid

D

orotic acid and uridylic
acid

69

Photolyase helps in

DNA repair

DNA replication

C

Protein synthesis

D

None

70

percentage of bacterial chromosome
usually involved in transformation is

1

10

C

25

D

50-100

6

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TEST SERIES 03 BIOCHEMISTRY

71

SnNAP function is

initiation of
protein synthesis

activation of amino
acids

C

processing of RNA

D

Replication of DNA

72

Inhibitor of DNA synthesis is

Penicillin

Polymyxin

C

Cholramphenicol

D

Actinomycin

73

Random arrangement of molecule results
in

Crystallization

Precipitation

C

Denaturation

D

High solubility

74

3 dimensional shape of a protein is
mainatained mainly by

Strong covalent
interactions

interactive with
other proteins

C

multiple weak
interactions

D

interaction with prosthetic
groups

75

In centrifugal distribution , protein that
is precipitated first is

Fibrous

Globular

C

Completely
disorganized

D

none

76

Best method to differentiate proteins is
by

Gel
chromatography

Affinity
chromatography

C

Ion exchange
electrophoreiss

D

None

77

Molecualr weight of protein can be
determined by

Native PAGE

SDS h-PAGE

C

Isoelectric focusing

D

Ion exchange
chromatography

78

Sequence in a long chain of protein is
identified by

RFLP

Chromosome
walking

C

Leucine zipper

D

SSOP

79

Molecular size is assessed by

Sedimentation

Absorption mass
spectometry

C

Liophilzation

D

salting out

80

Ligand receptor complex dissociates in
endosome because

of its large size

vesicles looses its
clathrin coat

C

of acidic pH of
vesicle

D

of basic pH of vesicle

81

in Non-competitive antagonism

Km decreases ,
Vmax Normal

Km decreases ,
Vmax decreases

C

Km normal , Vmax
decreases

D

Km decreases , Vmax
increases

82

CK-1 increases in

Brain ischemia

C

kidney damage

D

electrical cardioversion

83

Serine protease not include

Myocardial
ischemia
Pepsin

trypsin

C

elastase

D

chymotrypsin

84

Which of the following is not a protein
misfolding disorder?

Tuberculosis

Creutzfeldt Jakob
disease

C

Alzheimer’s disease

D

Cystic fibrosis

85

Decreased energy production in thiamine
deficiency is due to?

It is a cofactor for
oxidative
reduction

It is required for
transamination
reactions

C

It is a coenzyme for
alpha ketoglutarate
dehydrogenase and
pyruvate
dehydrogenase in
citric acid cycle

D

It is a coenzyme for
transketolase in hexose
monophosphate shunt

7

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TEST SERIES 03 BIOCHEMISTRY

86

Which of the following enzymes is
responsible for the transfer of amino
groups from an amino acid to an alpha
keto acid?

Transaminase

Transketolase

C

Deaminase

D

Lyase

87

Process used in an expression vector to
increase yield of recombinant protein
synthesis ?

Translation
initiation

Promoter induction

C

Transcription
terminators

D

Multiple cloning sites

88

Site of urea cycle is?

Liver

Kidney

C

GIT

D

Lungs

89

Rothera’s test is utilised for detection of?

Glucose

Proteins

C

Urea

D

Ketone bodies

90

Sphingomyelinase deficiency is
characteristic of ?

Fabry disease

Krabbe’s disease

C

Tay Sachs disease

D

Niemann Pick disease

91

Xeroderma pigmentosum is produced as
a result of a defect in :

DNA polymerase
III

DNA polymerase I

C

DNA exonuclease

D

DNA ligase

92

A genetic disorder renders fructose 1,6
— biphosphatase in liver less sensitive to
regulation by fructose 2,6 — biphosphate. All of the following metabolic
changes are observed in this disorder
except:

Level of fructose
1,6—biphosphate
is higher than
normal

Level of fructose 1,6
— biphosphate is
lower than normal

C

Less pyruvate is
formed

D

Less ATP is generated

93

Alpha helix and Beta pleated sheet are
examples of:

Primary structure

Secondary structure

C

Tertiary structure

D

Quaternary structure

94

Cytochrome C of the bacteria has 50%
identity of amino acid sequence with that
of human. Which of the following is the
most conserved parameter in these two
proteins?

Quarternary
structure

Tertiary structure

C

Amino acid
sequence

D

Loop and turn segments

95

In which of the following conditions the
level of creatinine kinase 1 increases ?

Myocardial
ischemia

Brain Ischemia

C

Kidney damage

D

Electrical cardioversion

96

Which of the following elements is known
to influence the body’s ability to handle
oxidative stress ?

Calcium

Iron

C

Potassium

D

Selenium

8

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TEST SERIES 03 BIOCHEMISTRY

97

A small calcium binding protein that
modifies the activity of many enzymes
and other proteins in response to changes
of Ca2+ concentration, is known as:

Cycline

Calmodulin

C

Collagen

D

Kinesin

98

Which of the following substances acts to
increase the release of Ca2+ from
endoplasmic reticulum ?

Inositol
triphosphate

Parathyroid
hormone

C

1,25 dihydroxy
cholecalciferol

D

Diacylglycerol

99

Which of the following is a membrane
bound enzyme that catalyzes the
formation of cyclic AMP from ATP?

Tyrosine Kinase

Polymerase

C

ATP synthase

D

Adenylate cyclase

100

Proteins targeted for destruction in
eukaryotes are covalently linked to :

Clathrin

Pepsin

C

Laminin

D

Ubiquitin

101

Which of the following group of proteins
assist in the folding of other proteins?

Proteases

Proteosomes

C

Templates

D

Chaperones

102

The transmembrane region of protein is
likely to have

A stretch of
hydrophilic amino
acids

A stretch of
hydrophobic amino
acids

C

A disulphide loop

D

Alternating hydrophilic and
hydrophobic amino acids

103

Which of the following can be a
homologous substitution for valine in
hemoglobin?

Isoleucine

Glutamic acid

C

Phenylalanine

D

Lysine

104

An enzyme that makes a double stranded
DNA copy from a single stranded RNA
template molecule is known as:

DNA polymerase

RNA polymerase

C

Reverse transcriptase

D

Phosphokinase

105

A segment of a eukaryotic gene that is
not represented in the mature messenger
RNA is known as:

Intron

Exon

C

Plasmid

D

TATA box

106

RNA polymerase does not require :

Template (ds DN

Activated precursors
(ATP, GTP, UTP,
CTP)

C

Divalent metal ions
(Mn2+, Mg2+)

D

Primer

9

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TEST SERIES 03 BIOCHEMISTRY

107

Shine Dalgarno sequence in bacterial
mRNA is near:

AUG codon

UAA codon

C

UAG codon

D

UGA codon

108

Both Vitamin K and C are involved in:

The synthesis of
clotting factors

Post translational
modifications

C

Antioxidant
mechanisms

D

The microsomal
hydroxylation reactions

109

The predominant isozyme of LDH in
cardiac muscle is:

LD-1

LD-2

C

LD-3

D

LD-5

110

Fluoride, used in the collection of blood
samples for glucose estimation, inhibits
the enzyme:

Glucokinase

Hexokinase

C

Enolase

D

Glucose-6-phosphatase

111

Enzymes that move a molecular group
from one molecule to another are known
as:

Ligases

Oxido—reductases

C

Transferases

D

Dipeptidases

112

The amino acid residue having an imino
side chain is:

Lysine

Histidine

C

Tyrosine

D

Proline

113

All of the following enzymes are
regulated by calcium or calmodulin,
except:

Adenylate cyclase

Glycogen synthase

C

Guanylyl cyclase

D

Hexokinase

114

Vitamin B12 acts as co-enzyme to which
one of the following enzymes?

Isocitrate
dehydrogenase

Homocysteine
methyl transferase

C

Glycogen synthase

D

G-6-P dehydrogenase

115

The following methods can be used to
detect the point mutation in the beta (B)globin gene that causes sickle cell anemia,
except:

Polymerase chain
reaction with
allele-specific
oligonucleotide
hybridization

Southem blot
analysis

C

DNA sequencing

D

Northem blot analysis

116

Base substitution mutations can have the
following molecular consequence except:

Changes one
codon for an
amino acid into
another codon for
that same amino
acid

Codon for one
amino acid is
changed into a
codon of another
amino acid

C

Reading frame
changes downstream
to the mutant site

D

Codon for one amino acid
is changed into a
translation termination
codon

10

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TEST SERIES 03 BIOCHEMISTRY

117

All of the following cell types contain the
enzyme telomerase which protects the
length of telomeres at the end of
chromosomes, except:

Germinal

Somatic

C

Hemopoietic

D

Tumor

118

During replication of DNA, which one of
the following enzymes polymerizes the
Okazaki fragments?

DNA Polymerase
I

DNA Polymerase II

C

DNA Polymerase III

D

RNA Polymerase I

119

The sigma subunit of prokaryotic RNA
polymerase:

Is inhibited by txamanitin

C

ls part of the core enzyme

Mitochondrial DNA is:

Nicked circular

C

Specifically
recognizes the
promoter site
Linear

D

120

Binds the
antibiotic
rifampicin
Closed circular

D

Open circular

121

Microsatellite sequence is:

Small satellite

Extra chromosomal
DNA

C

Short sequence (2-5)
repeat DNA

D

Looped-DNA

122

Euchromatin is the region of DNA that is
relatively:

Uncondensed

Condensed

C

Overcondensed

D

Partially condensed

123

All of the following amino acids are
converted to succinyl-CoA, except:

Methionine

lsoleucine

C

Valine

D

Histidine

124

The structural proteins are involved in
maintaining the shape of a cell or in the
formation of matrices in the body. The
shape of these proteins is:

Globular

Fibrous

C

Stretch of beads

D

Planar

125

the most important factor to be
conserved in a protein for its function is
the:

Amino acid
sequence

Ligand binding
residues

C

Structure

D

Environment

126

A nucleic acid was analyzed and found to
contain 32% adenine, 18% guanine, 17%
cytosine and 33% thymine. The nucleic
acid must be:

Single-stranded
RNA

Single-stranded
DNA.

C

Double—stranded
RNA

D

Double stranded DNA

127

The electron flow in Cytochrome C
oxidase can be blocked by:

Rotenone

Antimycin—A

C

Cyanide

D

Actinomycin

11

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TEST SERIES 03 BIOCHEMISTRY

128

In a solution the concentration of
hydrogen ion (H+) is 1 x 10(-6)
moles/litre. The pH of the solution

Three

Six

C

Nine

D

Twelve

129

Which of the following estimates blood
creatinine level most accurately

Jaffe method

Kinetic jaffe method

C

Technicon method

D

Enzyme assay

130

The 40 nm gap in between the
tropocollagen molecule in collagen which
serve as the site of bone formation is
occupied by which of the following

Carbohydrate

Ligand moiety

C

Ca ion

D

Fe ion

131

Steroids act via nuclear receptors which
interact with DNA through

Helix turn helix

Zinc finger motif

C

Histidine

D

Leucine zipper

132

Chymotrypsinogen is a

Zymogen

Carboxypeptidase

C

Transaminase

D

Elastase

133

Cytosolic Cytochrome C mediates

Apoptosis

Electron transport

C

Krebs cycle

D

Glycolysis

134

Same aminoacid is coded by multiple
codons. This property is known as:

Degeneracy

Frame-shift
mutation

C

Transcription

D

Mutation

135

Agranular cytoplasmic reticulum is
involved in the synthesis of

Protein

Lipid

C

Vitamin

D

Carbohydrate

136

lncreased level of lipoprotein(a)
predisposes to

Liver cirrhosis

Atherosclerosis

C

Nephrotic syndrome

D

Pancreatitis

137

Vitamin which is excreted in urine is :

Vitamin A

Vitamin C

C

Vitamin D

D

Vitamin K

138

All take place in mitochondria except

EMP pathway

C

Citric acid cycle

Active form of vitamin D is

24, 25 (OH)2 vit-D

C

Electron transport
chain
1, 25 (OH)2 vit-D

D

139

Fatty acid
oxidation
Cholecalciferol

D

25-OH vit-D

140

Increased copper excretion in urine is
seen in all except

Primary sclerosing
cholangitis

Wilson’s disease

C

Primary biliary
cirrhosis

D

Hepatocellular carcinoma

141

All of the following are essential
aminoacids except

Methionine

Lysine

C

Alanine

D

Leucine

142

End product of purine metabolism in non
primate mammals is

Uric acid

Ammonia

C

Urea

D

Allantoin

143

Y chromosome is:

Metacentric

Sub-metacentric

C

Acrocentric

D

Longer than the X
chromosome

12

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TEST SERIES 03 BIOCHEMISTRY

144

Vitamin A intoxication causes injury to

Lysosomes

Mitochondria

C

145

SYBR Green Dye is used for:

HPLC

Immunofluorescence

C

146

Rapid method of chromosome
identilication in intersex is

FISH (Fluorescent
in situ
hybridization)

PCR (Polymerase
chain reaction)

C

147

Enzyme responsible for complete
oxidation of glucose to Carbon dioxide
and water is present in

Cytosol

Mitochondria

148

Hemoglobin electrophoresis is based on

molecular weight

149

The amino acid producing ammonia in
kidney is

Glutamine

150

Dinitrophenol causes:

151

Within the RBC, hypoxia stimulates
glycolysis by which of the following
regulating pathways?

152

Northern blot is used for the separation
of:

153

Endoplasmic
reticulum
PCR

D

cl) Microtubules

D

ELISA

D

Karyotyping

C

SSCP (Single
stranded
conformation
polymorphism)
Lysosomes

D

Endoplasmic reticulum

charge

C

solubility

D

calorirnetric properties

Alanine

C

Methionine

D

Glycine

Inhibition of ATP
synthase

Inhibition of
electron transport

C

D

Accumulation of ATP

Hypoxia inhibits
hexokinase

C

D

Activation of the
regulatory enzymes by
high PH

Hypoxia
Stimulates
pyruvate
dehydrogenase by
increased 2,3 DPG
mRNA

DNA

C

Uncoupling of
oxidation and
phosphorylation
Hypoxia stimulates
release of all
Glycolytic enzymes
from Band 3 on RBC
membrane
Protein

D

Protein DNA interaction

Study of multiplication of proteins in
disease process is called:

Proteomics

Genomics

C

Glycomics

D

Nucleomics

154

Regarding proteoglycans, false is:

They hold less
amount of water

C

They carry charge

Which of the following enzymes is stable
at acidic pH

Trypsin

C

They are made up of
sugar and
aminoacids
Chymotrypsin

D

155

Chondroitin
sulfate is a
Proteoglycan
Pepsin

D

Carboxypeptidase

156

Basement membrane degeneration is
mediated by?

Metalloproteinases

Oxidases

C

Elastases

D

Hydroxylases

157

Treatment of Multiple Carboxylase
Deficiency is:

Biotin

Pyridoxine

C

Thiamine

D

Folic acid

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TEST SERIES 03 BIOCHEMISTRY

158

All of the following are true regarding
oxygenases except :

Incorporate 2
atoms of oxygen

Incorporate 1 atom
of oxygen

C

159

CAP in Lac operon is an example of:

Positive regulator

Negative regulator

C

160

Splicing activity seen in

mRNA

snRNA

161

Acetyl coA can be directly converted to
all except

Glucose

162

After overnite fasing,levels of glucose
tranporters reduced in

Brain

163

Insulin stimulates A/E

164

Hepatomegaly is the essential feature for
all of the following except

165

D

Required for carboxylation
of drugs

D

Attenuation

C

Required for
hydroxylation of
steroids
Constitutive
expression
tRNA

D

rRNA

Fatty acids

C

Cholesterol

D

Ketone bodies

Muscle

C

Adipocytes

D

Hepatocyte

Glycolysis

Glycogenesis

C

Lipogenesis

D

Ketogenesis

Hepatic porphyria

Niemann Pick
disease

C

Von Gierke’s disease

D

Hurler syndrome

Urea is produced by the enzyme

Urease

Uricase

C

Arginase

D

Glutaminase

166

The major fuel for the brain after several
weeks of starvation

Glucose

Fatty acid

C

Beta hydroxy
butyrate

D

Glycerol

167

All amino acids are translated except

Hydoxyproline

Proline

C

Threonine

D

Tyrosine

168

Most active site of protein synthesis is the

Lysosome

Mitochondrion

C

Ribosme

D

Nucleus

169

Guanidoacetate is converted to

Choline

Hydroxyproline

C

Creatinine

D

Creatine phosphate

170

Guanido acetate is converted to

Creatinine

Creatine phosphate

C

Choline

D

Hydroxyproline

171

Which of the following is a dietary
essential

Glycine

Cholesterol

C

Glycerol

D

Linoleic acid

172

Which is a denaturing agent

Guanidine

Glutamate

C

Glycine

D

Guanosine

173

Retinol and Retinol binding protein is

Albumin

Alpha globulin

C

Prealbumin

D

Beeta globulin

174

In terms of chemical structure, which one
of the following is a tetrameric
glycoprotein

Insulin receptors

Leptins

C

Neuropeptide

D

Thyrotrophin

175

Tertiary Structure of proteins is
maintained by all except

H2 bond

Hydrophobic bond

C

Ionic bond

D

Disulphide bond

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TEST SERIES 03 BIOCHEMISTRY

176

Negative nitrogen balance is produced in
humans by elimination from the diet of
all of the following amino acids except

Leucine

Methionine

C

Lysine

D

Serine

177

Which of the following is a derived
protein

Prostamines

Peptones

C

Prolamines

D

Lactalbumin

178

Hair is rich in amino acid

Cystine

Lysine

C

Glycine

D

Leucine

179

Urea is formed in

Brain

Kidney

C

Liver

D

Intestine

180

Which of the following is not a part of
hemoglobin molecule

Pyrrole rings

Vinyl groups

C

Histidine

D

Ferric ions

181

People eating only maize as staple diet
develop niacin deficiency due to

Low niacin

Low tryptophan

C

High leucine

D

High isoleucine

182

Ammonia is destoxified in brain chiefly
as

Urea

Uric acid

C

Creatinine

D

Glutamine

183

Which of the following is a precursor of
proctoporphyrin

Alanine

Leucine

C

Histidine

D

Clycine

184

When the following amino acids are
separated by running them on agarose
gel, at pH 7, which one of them will
slowest to the anodic end

Glycine

Valine

C

Aspartic acid

D

Lysine

185

Choline, a most important lipotropic
factor is formed with the help of
following except

Methionine

Serine

C

Glycine

D

Histidine

186

Protien synthesis takes place in

Ribosome

Nucleus

C

Golgi bodies

D

Endoplasmic reticulum

187

Methlonine is important in

Disulphide bridge
formation

C

Fromation of choline

D

Transcarboxylation
reactions

188

Glycine is used in the synthesis of

Chain termination
in protein
synthesis
Heme

Glycocholic acid

C

Taurocholic acid

D

Purines

189

Transmethylation of guanido acetic acid
gives

Creatine

Creatinine

C

Choline

D

N-methyl nicotinamide

190

In mammals, protein synthesis takes
place chiefly in

Nucleolus

Smooth endoplasmic
reticulum

C

Nucleus

D

Rough endoplasmic
reticulum

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191

Chemical , oestrogens are characterized
by

Absence of O2 at
D-17

Aromatic character
at D-ring

C

Absence of methyl
group at C 10

D

A 21 - carbon steroid
skeleton

192

Skeletal muscle is deficient in

Glucose-6phosphatase

Hexokinase

C

Isomerase

D

Phosphofructokinase

193

The most important buffer pair RBCs
engaged in maintaining base equilibrium
of blood is

Bicarbonate

Protein

C

Phosphate

D

Haemoglobin

194

Which of the following belongs to
steroidal receptor super family

Vitamin D3

Encephalin

C

GH

D

Insulin

Medium-chain fatty acids are given because they:
A. Are more calorically dense than long-chain fatty acids.
B. Enter directly into the portal blood, and can be metabolized by the liver.
C. Are activators of lipoprotein lipase.
D. Are more efficiently packed into serum lipoproteins.
195

196. Which

one of the following is most often found in untreated patients with Type 1 and Type 2 diabetes?
A. Hyperglycemia.
B. Extremely low levels of insulin synthesis and secretion.
C. Synthesis of an insulin with an abnormal amino acid sequence.
D. A simple pattern of genetic inheritance.
197 Which

one of the following is the most important source of blood glucose during the last hours of a 48-hour fast?
A. Muscle glycogen.
B. Acetoacetate.
C. Liver glycogen.
D. Amino acids.
198 Which

one of the following is elevated in plasma during the absorptive period (compared with the postabsorptive state)?
A. Glucagon.
B. Acetoacetate.
C. Chylomicrons.
D. Free fatty acids.
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TEST SERIES 03 BIOCHEMISTRY

199 An

Ashkenazi Jewish couple brings their six-month-old son to you for evaluation of listlessness, poor head control, and a fixed gaze. You
determine that he has Tay-Sachs disease, an autosomal recessive disorder. The couple also has a daughter. The diagram below shows this
family's pedigree, along with Southern blots of an RFLP very closely linked to the hexosaminidase A gene, which is defective in Tay-Sachs.
Which of the statements below is most accurate with respect to the daughter?

A. She has a 25% chance of having Tay-Sachs disease.
B. She has Tay-Sachs disease.
C. She is a carrier for Tay-Sachs disease.
D. She is homozygous normal.
200 Which of the following is the basis for the intestine-specific expression of apoprotein B?
A. DNA rearrangement and loss
B. DNA transposition
C. RNA alternative splicing
D. RNA editing

17

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