2015.07.06 P&L Model v0.9 (GY)

MANUFACTURING PARAMETERS
50.0%
Minimal internal manufacturing
FINANCIAL PARAMETERS
10.0%
5.0%
2015
1.0%
36.0%
Discount factor for NPV

Depreciation (linear, starting after the last ye
Base year (for financial calculations)
Inflation rate
Income tax rate (to derive tax deduction effe
SCENARIO PARAMETERS
0.0%
Price crash
tarting after the last year with capital expenditures)

l calculations)
rive tax deduction effect = "tax shield")
DRUG MANUFACTORING MODEL: INPUT - MANUFACTURING OPTIONS
Architecture scenarios
A
x
x
x
B
x
x
x
C
x
x
x
Platform definition
D
x
x
x
x
x
x
PltOptID
01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
Plant option name

OSS BIO current (1 x 20kL SS)
WAG
OSS BIO upgraded (2 x 5kL SS)
OSS BIO upgraded (4 x 2kL SU)
Stainless steel (large)
Stainless steel (med)
Stainless steel (small)
Fed batch SU
Fed batch SU (hybrid)
Fed batch SU Intensified (hybrid)
Fed batch SU Intensified
Continuous SU
FoF_Greenfield
CMO: CHO - Current
CMO: CHO - Intensified fed batch
CMO: CHO - Continuous
CMO: Microbial - E.coli
CMO: Microbial - Yeast
Scenario input
Oss Bio current titer improvement

Oss titer
5.0
Unable to achieve intensified fed batch titer
Process
Fed batch
Fed batch
Fed batch
Fed batch
Fed batch
Fed batch
Fed batch
Fed batch
Fed batch
Fed batch
Fed batch
Continuous flow
Continuous flow
Fed batch
Fed batch
Continuous flow
Fed batch
Fed batch
Plant dedication
Plant capacity
Commercial
Technology
Current
Current
Current
Current
Stainless steel
Stainless steel
Stainless steel
Current
Hybrid
Hybrid
Intensified fed batch
Perfusion
Perfusion
Manufacturing type
CHO - Current
CHO - Current
CHO - Current
CHO - FotF
CHO - Current
CHO - FotF
CHO - FotF
CHO - FotF
CHO - FotF
CHO - FotF
CHO - FotF
CHO - FotF
CHO - FotF
CHO - CMO
CHO - CMO
CHO - CMO
CHO - CMO
CHO - CMO
DvTime
0.0 yrs
0.0 yrs
3.0 yrs
3.0 yrs
4.0 yrs
3.0 yrs
3.0 yrs
3.0 yrs
4.0 yrs
4.0 yrs
3.0 yrs
3.0 yrs
4.0 yrs
Investment
2015
2015
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
Launch
2015
2015
2019
2019
2020
2019
2019
2019
2020
2020
2019
2019
2020
2016
2016
2016
2016
2016
From
2015
2015
2018
2018
2020
2019
2019
2019
2020
2020
2019
2019
2020
2015
2015
2015
2015
2015
To
2035
2016
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
Rcts
1
2
2
4
3
4
2
6
6
6
6
1
6
2
2
2
6
6
* Available pr
acity
VolRct
20,000 L
2,000 L
5,000 L
2,000 L
6,000 L
15,000 L
15,000 L
2,000 L
2,000 L
2,000 L
2,000 L
500 L
2,000 L
6,000 L
6,000 L
1,000 L
2,000 L
2,000 L
VolTot
20,000 L
4,000 L
10,000 L
8,000 L
18,000 L
60,000 L
30,000 L
12,000 L
12,000 L
12,000 L
12,000 L
500 L
12,000 L
12,000 L
12,000 L
2,000 L
12,000 L
12,000 L
able processing volume in L
Avblty
80%
80%
80%
80%
80%
80%
80%
80%
80%
80%
80%
100%
100%
100%
100%
100%
100%
100%
VolPrc*
16,000 L
3,200 L
8,000 L
6,400 L
14,400 L
48,000 L
24,000 L
9,600 L
9,600 L
9,600 L
9,600 L
500 L
12,000 L
12,000 L
12,000 L
2,000 L
12,000 L
12,000 L
Fed batches
17 per year
20 per year
20 per year
20 per year
20 per year
20 per year
20 per year
20 per year
20 per year
20 per year
20 per year
Uptime**
300 days
300 days
20 per year
20 per year
300 days
10 per year
10 per year
Titer**
1.4
5.0
5.0
5.0
5.0
5.0
5.0
5.0
5.0
15.0
15.0
5.0
2.0
3.0
10.0
5.0
3.0
3.0
Yield
75.0%
75.0%
75.0%
75.0%
75.0%
75.0%
75.0%
75.0%
75.0%
75.0%
75.0%
80.0%
80.0%
80.0%
80.0%
80.0%
80.0%
80.0%
NO RAMP UP OF CAPACITY
Plant costs
Capital expenditure, total and relative to launch year
Batch size
16.8 kg/batch
12.0 kg/batch
30.0 kg/batch
24.0 kg/batch
54.0 kg/batch
180.0 kg/batch
90.0 kg/batch
36.0 kg/batch
36.0 kg/batch
108.0 kg/batch
108.0 kg/batch
200.0 kg/batch
1,920.0 kg/batch
20.2 kg/batch
67.2 kg/batch
20.2 kg/batch
20.2 kg/batch
Capacity
285.6 kg/year
240.0 kg/year
600.0 kg/year
480.0 kg/year
1,080.0 kg/year
3,600.0 kg/year
1,800.0 kg/year
720.0 kg/year
720.0 kg/year
2,160.0 kg/year
2,160.0 kg/year
600.0 kg/year
5,760.0 kg/year
403.2 kg/year
1,344.0 kg/year
1,680.0 kg/year
201.6 kg/year
201.6 kg/year
Total
0.0 m$
0.0 m$
40.0 m$
20.0 m$
180.0 m$
120.0 m$
100.0 m$
100.0 m$
100.0 m$
100.0 m$
100.0 m$
55.0 m$
50.0 m$
Lnch +0
100%
100%
20%
20%
20%
0%
0%
0%
0%
0%
0%
Lnch +1
60%
60%
60%
20%
20%
20%
20%
20%
20%
Lnch +2
15%
15%
15%
60%
60%
60%
60%
60%
60%
Lnch +3
5%
5%
5%
20%
20%
20%
20%
20%
20%
OpEx p.a.
11.0 m$
10.0 m$
5.0 m$
5.0 m$
30.0 m$
30.0 m$
30.0 m$
11.3 m$
11.3 m$
12.3 m$
12.3 m$
7.0 m$
7.0 m$
ONLY CMO PRODUCTION COSTS ARE INPUT
Production costs in $(2015)/g

2015
2016
2017
57.2
57.2
57.2
16.1
16.1
16.1
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
16.0
17.8
17.9
17.8
17.8
17.9
17.8
6.3
6.0
6.1
6.3
6.0
6.1
16.9
16.6
16.4
40.9
40.6
40.4
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
215.0
2018
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.0
6.0
16.4
40.4
215.0
215.0
215.0
215.0
215.0
2019
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.8
17.8
5.9
5.9
16.4
40.4
215.0
215.0
215.0
215.0
215.0
2020
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.4
40.4
215.0
215.0
215.0
215.0
215.0
2021
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.4
40.4
215.0
215.0
215.0
215.0
215.0
2022
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.0
6.0
16.5
40.5
215.0
215.0
215.0
215.0
215.0
2023
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.5
40.5
215.0
215.0
215.0
215.0
215.0
2024
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.6
40.6
215.0
215.0
215.0
215.0
215.0
2025
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.6
40.6
215.0
215.0
215.0
215.0
215.0
2026
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.6
40.6
215.0
215.0
215.0
215.0
215.0
DRUG MANUFACTORING MODEL: INPUT - DRUG PIPELINE

Product setup
Inventory management
Act
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
x
Priority
L1
DrgID
01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
Modality type
CHO - old
CHO - old
CHO - old
CHO - old
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - new
CHO - old subtotal
CHO - new subtotal
CHO - total
High volume CHO in existing technology
Baseline
High
CHO - old
CHO - old
Keytruda plateaus this year

01
01
L2
Campaign l
Scenario input
03
03
L1
Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
Keytruda baseline
Keytruda plateaus
CHO - old
CHO - old
Keytruda double its titer

01
Keytruda double titer
CHO - old
L1
New modality become predominant sooner than expected

05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
L2
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
High volume CHO in new technology

05
05
L0
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Consolidated pipeline to fewer high volume products

05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
L3
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug 5 - baseline
Drug 5 - high volume
CHO - new
CHO - new
Alternative pipeline demand profile

03
04
05
Drug 3
Drug 4
Drug 5
CHO - old
CHO - old
CHO - new
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
old
old
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
old
old
new
new
new
new
new
new
new
Ultra-high demand (pipeline)

03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Ultra-low demand (pipeline)

03
04
05
06
07
08
09
10
11
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
12
13
14
15
16
17
18
19
20
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
new
new
new
new
new
new
new
new
new
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
CHO
old
old
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
new
Low demand (pipeline)

03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
RUG PIPELINE
Commercial demand (kg/yr)

2015
90.0
40.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
130.0
0.0
130.0
2016
109.0
80.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
189.0
0.0
189.0
2017
128.0
198.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
326.0
0.0
326.0
2018
162.0
242.0
53.4
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
457.4
0.0
457.4
2019
200.0
308.0
88.3
20.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
616.4
0.0
616.4
2020
250.0
300.0
120.7
20.1
20.4
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
690.8
20.4
711.2
2021
300.0
300.0
153.1
20.3
20.0
19.6
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
773.4
39.6
813.1
53.4
96.2
88.3
171.4
120.7
249.7
153.1
314.5
90.0
90.0
109.0
90.0
128.0
90.0
162.0
90.0
200.0
90.0
250.0
90.0
300.0
90.0
45.0
54.5
64.0
81.0
100.0
125.0
150.0
0.0
0.0
0.0
0.0
20.4
20.0
19.6
20.4
40.1
0.0
0.0
0.0
0.0
0.0
0.0
20.4
96.2
20.0
171.4
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0

0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
94.6
167.1
49.1
239.5
49.3
50.3
325.9
50.5
50.3
49.3
9.7
9.4
9.5
9.4
9.6
9.4
21.1
20.2
20.3
20.6
20.6
20.8
2022
300.0
300.0
191.4
19.7
20.1
19.8
20.2
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
811.1
60.1
871.2
2023
300.0
300.0
218.4
20.1
20.3
20.3
19.8
20.2
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
838.5
80.6
919.1
2024
300.0
300.0
255.5
19.9
20.2
20.1
19.5
20.2
20.2
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
875.5
100.2
975.7
2025
300.0
300.0
286.1
20.1
20.4
19.5
19.5
20.3
20.0
20.4
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
906.2
120.1
1026.3
2026
300.0
300.0
324.3
20.3
20.0
20.2
20.3
20.1
19.9
19.9
19.7
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
944.5
140.0
1084.5
2027
300.0
300.0
353.9
19.8
19.7
20.3
19.7
20.1
20.3
19.7
19.7
19.7
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
973.8
159.4
1133.1
2028
300.0
300.0
385.3
20.3
20.0
20.3
20.0
19.6
20.1
20.0
19.5
20.0
20.4
0.0
0.0
0.0
0.0
0.0
0.0
0.0
1,005.6
179.9
1185.5
191.4
394.4
218.4
478.6
255.5
531.2
286.1
616.0
324.3
707.1
353.9
757.0
385.3
826.6
300.0
90.0
300.0
90.0
300.0
90.0
300.0
90.0
300.0
90.0
300.0
90.0
300.0
90.0
150.0
150.0
150.0
150.0
150.0
150.0
150.0
20.1
19.8
20.2
20.3
20.3
19.8
20.2
20.2
20.1
19.5
20.2
20.2
20.4
19.5
19.5
20.3
20.0
20.4
20.0
20.2
20.3
20.1
19.9
19.9
19.7
19.7
20.3
19.7
20.1
20.3
19.7
19.7
19.7
20.0
20.3
20.0
19.6
20.1
20.0
19.5
20.0
20.4
60.4
80.7
100.5
99.8
100.9
100.9
100.5
20.4
40.1
59.8
80.2
20.1
249.7
20.3
314.5
20.2
394.4
20.4
478.6
20.0
531.2
19.7
616.0
20.0
707.1
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
400.3
49.0
49.8
49.5
51.0
474.3
51.1
50.9
50.3
49.8
50.3
531.8
49.9
49.7
50.9
51.0
48.9
50.3
612.6
50.0
49.5
49.5
50.7
51.1
50.6
50.0
703.8
49.9
50.0
49.0
50.5
50.9
49.4
49.1
50.1
781.4
50.5
50.9
50.7
50.8
50.7
50.4
50.6
51.1
50.2
828.7
50.2
50.7
50.7
50.4
49.5
51.0
49.6
50.3
49.9
49.2
9.3
9.5
9.6
9.3
9.4
9.3
9.5
9.6
9.7
9.5
9.6
9.5
9.5
9.7
9.7
9.3
9.4
9.6
9.3
9.5
9.5
9.3
9.5
9.3
9.3
9.5
9.6
9.3
9.6
9.6
20.8
20.6
21.0
20.3
20.4
20.8
20.5
20.1
20.2
20.5
20.4
20.9
20.9
20.4
20.6
20.8
20.2
20.6
20.8
20.6
20.7
20.7
20.9
21.0
20.8
21.0
20.9
20.8
21.1
20.9
2029
200.0
300.0
429.8
19.6
20.1
20.3
20.2
19.5
20.3
19.8
20.3
20.4
19.9
19.5
0.0
0.0
0.0
0.0
0.0
0.0
949.4
200.1
1149.5
2030
125.0
300.0
471.1
19.7
20.1
20.2
19.6
19.9
20.1
19.9
19.6
20.0
19.6
20.0
19.9
0.0
0.0
0.0
0.0
0.0
915.8
218.9
1134.7
2031
80.0
300.0
477.1
20.0
19.8
19.4
20.3
20.1
19.6
19.6
20.1
19.8
20.0
19.9
19.8
19.8
0.0
0.0
0.0
0.0
877.1
238.2
1115.3
2032
75.0
300.0
477.1
19.9
19.7
20.0
19.9
19.6
19.5
20.2
19.5
19.9
19.5
19.8
19.5
20.1
19.6
0.0
0.0
0.0
872.0
256.7
1128.7
2033
60.0
300.0
477.1
20.1
20.3
20.0
19.9
19.8
20.2
20.2
19.8
19.7
19.8
19.7
20.3
20.2
20.3
20.3
0.0
0.0
857.2
280.5
1137.7
2034
55.0
300.0
477.1
19.6
19.6
20.1
20.0
19.5
19.5
20.2
19.6
19.5
19.7
19.6
19.7
20.3
20.0
20.1
19.7
0.0
851.8
297.1
1148.8
2035
55.0
300.0
477.1
19.6
19.6
20.1
20.0
19.5
19.5
20.2
19.6
19.5
19.7
19.6
19.7
20.3
20.0
20.1
19.7
19.3
851.8
316.3
1168.1
429.8
905.2
471.1
1008.3
477.1
1045.6
477.1
1139.7
477.1
1198.7
477.1
1212.3
477.1
1212.3
200.0
90.0
125.0
90.0
80.0
90.0
75.0
90.0
60.0
90.0
55.0
90.0
55.0
90.0
100.0
62.5
40.0
37.5
30.0
27.5
27.5
20.1
20.3
20.2
19.5
20.3
19.8
20.3
20.4
19.9
19.5
20.1
20.2
19.6
19.9
20.1
19.9
19.6
20.0
19.6
20.0
19.9
19.8
19.4
20.3
20.1
19.6
19.6
20.1
19.8
20.0
19.9
19.8
19.8
19.7
20.0
19.9
19.6
19.5
20.2
19.5
19.9
19.5
19.8
19.5
20.1
19.6
20.3
20.0
19.9
19.8
20.2
20.2
19.8
19.7
19.8
19.7
20.3
20.2
20.3
20.3
19.6
20.1
20.0
19.5
19.5
20.2
19.6
19.5
19.7
19.6
19.7
20.3
20.0
20.1
19.7
19.6
20.1
20.0
19.5
19.5
20.2
19.6
19.5
19.7
19.6
19.7
20.3
20.0
20.1
19.7
19.3
100.7
100.2
99.8
99.4
100.3
99.6
99.6
100.4
99.6
100.1
99.0
99.4
98.8
98.8
19.9
39.7
59.6
80.7
100.0
119.2
20.1
757.0
20.1
826.6
19.8
905.2
19.7
1008.3
20.3
1045.6
19.6
1139.7
19.6
1198.7
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
897.0
48.8
50.5
49.3
51.0
50.8
51.2
49.1
50.7
50.4
50.7
50.1
1014.3
49.2
50.5
49.9
50.8
49.8
50.5
50.4
49.6
48.9
48.8
49.1
49.9
1046.2
50.9
49.0
48.8
50.6
49.1
50.6
49.8
51.0
50.9
49.7
49.6
49.1
50.1
1169.5
50.9
49.0
51.2
49.9
49.0
50.1
49.7
50.7
48.8
51.0
50.6
50.8
49.1
50.3
1167.4
49.6
50.9
49.2
50.8
48.8
48.8
51.1
49.5
50.8
49.4
49.5
49.3
49.3
50.0
50.8
1167.4
51.0
50.9
50.4
51.0
50.6
49.1
50.5
50.2
49.4
51.0
49.5
50.9
51.1
49.8
49.6
50.3
1167.4
51.0
50.9
50.4
51.0
50.6
49.1
50.5
50.2
49.4
51.0
49.5
50.9
51.1
49.8
49.6
50.3
49.4
9.3
9.4
9.5
9.7
9.3
9.7
9.5
9.6
9.4
9.7
9.6
9.3
9.3
9.3
9.5
9.7
9.6
9.7
9.5
9.6
9.4
9.5
9.4
9.4
9.4
9.7
9.3
9.6
9.8
9.3
9.6
9.6
9.7
9.7
9.6
9.6
9.5
9.4
9.6
9.5
9.5
9.5
9.8
9.7
9.6
9.5
9.4
9.6
9.5
9.5
9.5
9.8
9.7
9.6
20.1
20.3
20.7
20.6
20.5
20.3
20.7
20.9
21.0
20.5
21.0
20.6
21.1
20.4
20.5
20.6
20.9
20.5
20.7
20.2
20.3
20.5
21.1
20.5
21.0
20.6
20.6
20.7
20.7
20.6
20.4
20.1
20.3
21.1
21.0
20.2
20.5
20.6
20.7
20.8
20.7
20.9
21.1
20.8
20.9
20.5
20.6
20.7
20.8
20.7
20.9
21.1
20.8
20.9
20.9
Unit price ($/g)

2015
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2016
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2017
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2018
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2019
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2020
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2021
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2022
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2023
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2024
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2025
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2026
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2027
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2028
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2029
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2030
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2031
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2032
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2033
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2034
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2035
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
Plant capacity
Scale out plant option name

Fed batch SU (small)
Intensified fed batch SU (small)
Continuous (small)
ARCHITECTURE A
Rcts
1
2
2
1
VolRct
5,000 L
2,000 L
2,000 L
500 L
2015
2016
2015
2016
2015
2016
2015
2016

Continuous (small)
ARCHITECTURE B
Continuous (small)
ARCHITECTURE C
Continuous (small)
ARCHITECTURE D
Continuous (small)
VolTot Avblty
5,000 L
80%
4,000 L
80%
4,000 L
80%
500 L 100%
VolPrc*
4,000 L
3,200 L
3,200 L
500 L
Fed batches
20 per year
20 per year
20 per year
Uptime**
300 days
Titer**
5.0
5.0
15.0
5.0
DSP Yield
75.0%
75.0%
75.0%
80.0%
2017
2018
2019
2020
2021
2022
2023
2017
2018
2019
2020
2021
2022
2023
2017
2018
2019
2020
2021
2022
2023
2017
2018
2019
2020
2021
2022
2023
Plant costs
Capacity
300.0 kg/year
240.0 kg/year
720.0 kg/year
600.0 kg/year
Total ($m)
Lnch +0
$
80
80.0%
$
30
80.0%
$
30
80.0%
$
25 100.0%
Lnch +1
20.0%
20.0%
20.0%
Lnch +2
2024
2025
2026
2027
2028
2029
2024
2025
2026
2027
2028
2029
2024
2025
2026
2027
2028
2029
2024
2025
2026
2027
2028
2029
Plant costs
o launch year
Lnch +3
Lnch +0 Lnch +1
$
64 $
16
$
24 $
6
$
24 $
6
$
25 $
-
2030
2031
2032
2033
2034
2035
2030
2031
2032
2033
2034
2035
2030
2031
2032
2033
2034
2035
2030
2031
2032
2033
2034
2035
Lnch +2 Lnch +3
$
$
$
$
$
$
$
$
-
aunch year
Demand Scenarios
Priority Level
L1
L1
Keytruda plateaus this year

L2
Keytruda double its titer
L1
New modality become predominant sooner than expected

L2
Consolidated pipeline to fewer high volume products

L3
L0
Alternative pipeline demand profile

Plant Scenarios
L1
5.0
L1
Oss Bio current titer improvement

Oss Bio improved titer
Unable to achieve intensified fed batch titer
Pricing Scenarios
L1
0.0%
Price crash
nt sooner than expected
h volume products
batch titer
ARCHITECTURE A
all values in $m
2015
Potential revenue
$
2,600 $
Lost revenue
$
$
Actual revenue
$ 2,600 $
Fixed manufacturing cost
$
(21) $
Variable manufacturing cost
$
(15) $
Total COGS
$
(36) $
Gross profit (EBIDTA)
$ 2,564 $
Gross margin (%)
99%
Depreciation
$
$
Operating profit (EBITA)
$ 2,564 $
Operating cost
$
(36) $
Operating margin (%)
99%
Taxes
$
(923) $
Net operating profit less adjusted taxes (NOPLAT) $ 1,641 $
Depreciation add-back
$
$
Operating cash flow
$ 1,641 $
Scale-out capital cost
$
$
Capital cost
$
$
Gross CapEx
$
$
Free Cash Flow
$ 1,641 $
NPV (2015)
$107,485
NPC (2015, operating cost)
$ (1,051)
2016
3,780
3,780
(21)
(22)
(43)
3,737
99%
3,737
(43)
99%
(1,345)
2,392
2,392
(40)
(40)
2,351
ARCHITECTURE B
all values in $m
2015
Potential revenue
$
2,600 $
Lost revenue
$
$
Actual revenue
$ 2,600 $
$
(21) $
$
(15) $
Total COGS
$
(36) $
$ 2,564 $
Gross margin (%)
99%
Depreciation
$
$
$ 2,564 $
Operating cost
$
(36) $
99%
Taxes
$
(923) $
$
$
Operating cash flow
$ 1,641 $
2016
3,780
3,780
(21)
(22)
(43)
3,737
99%
3,737
(43)
99%
(1,345)
2,392
2,392

Capital cost
Gross CapEx
Free Cash Flow
NPV (2015)
$
$
$
$ 1,641
$107,168
$ (1,346)
$
$
$
$
(77)
(77)
2,315
ARCHITECTURE C
all values in $m
2015
Potential revenue
$
2,600 $
Lost revenue
$
$
Actual revenue
$ 2,600 $
$
(21) $
$
(15) $
Total COGS
$
(36) $
$ 2,564 $
Gross margin (%)
99%
Depreciation
$
$
$ 2,564 $
Operating cost
$
(36) $
99%
Taxes
$
(923) $
$
$
Operating cash flow
$ 1,641 $
$
$
Capital cost
$
$
Gross CapEx
$
$
Free Cash Flow
$ 1,641 $
NPV (2015)
$107,397
$ (1,128)
ARCHITECTURE D
Potential revenue
Lost revenue
Actual revenue
Total COGS
Gross margin (%)
all values in $m
2015
$
2,600 $
$
$
$ 2,600 $
$
(21) $
$
(15) $
$
(36) $
$ 2,564 $
99%
2016
3,780
3,780
(21)
(22)
(43)
3,737
99%
3,737
(43)
99%
(1,345)
2,392
2,392
(40)
(40)
2,351
2016
3,780
3,780
(21)
(22)
(43)
3,737
99%
Depreciation
$
$ 2,564
Operating cost
$
(36)
99%
Taxes
$
(923)
Net operating profit less adjusted taxes (NOPLAT) $ 1,641
$
Operating cash flow
$ 1,641
$
Capital cost
$
Gross CapEx
$
Free Cash Flow
$ 1,641
NPV (2015)
$107,337
$ (1,188)
$
$
$
$
$
$
$
$
$
$
$
3,737
(43)
99%
(1,345)
2,392
2,392
(40)
(40)
2,351
Operating Cost Fixed manufaVariable

Architecture A $
18 $
Architecture B $
64 $
Architecture C $
31 $
Architecture D $
39 $
manu
98
96
96
96
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2017
6,520
6,520
(11)
(44)
(56)
6,464
99%
(2)
6,462
(58)
99%
(2,326)
4,136
2
4,138
4,138
2017
6,520
6,520
(11)
(44)
(56)
6,464
99%
(2)
6,462
(58)
99%
(2,326)
4,136
2
4,138
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2018
9,149
9,149
(11)
(53)
(64)
9,084
99%
(2)
9,082
(66)
99%
(3,270)
5,813
2
5,815
5,815
2018
9,149
9,149
(11)
(53)
(64)
9,084
99%
(2)
9,082
(66)
99%
(3,270)
5,813
2
5,815
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2019
12,327
12,327
(17)
(71)
(88)
12,239
99%
(2)
12,237
(90)
99%
(4,405)
7,832
2
7,834
7,834
2019
12,327
12,327
(17)
(71)
(88)
12,239
99%
(7)
12,232
(95)
99%
(4,404)
7,829
7
7,836
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2020
14,224
14,224
(17)
(84)
(101)
14,123
99%
(2)
14,121
(103)
99%
(5,084)
9,037
2
9,039
9,039
2020
14,224
14,224
(17)
(82)
(99)
14,125
99%
(16)
14,109
(115)
99%
(5,079)
9,030
16
9,046
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2021
16,261
16,261
(17)
(93)
(110)
16,151
99%
(2)
16,149
(112)
99%
(5,814)
10,335
2
10,337
10,337
2021
16,261
16,261
(17)
(93)
(110)
16,151
99%
(16)
16,135
(126)
99%
(5,809)
10,326
16
10,343
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2022
17,424
17,424
(17)
(94)
(111)
17,313
99%
(2)
17,311
(113)
99%
(6,232)
11,079
2
11,081
11,081
2022
17,424
17,424
(17)
(94)
(111)
17,313
99%
(16)
17,297
(127)
99%
(6,227)
11,070
16
11,086
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2023
18,382
18,382
(17)
(95)
(112)
18,269
99%
(2)
18,267
(114)
99%
(6,576)
11,691
2
11,693
11,693
2023
18,382
18,382
(31)
(95)
(125)
18,256
99%
(16)
18,240
(142)
99%
(6,566)
11,674
16
11,690
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
(131)
(131)
4,007
2017
6,520
6,520
(11)
(44)
(56)
6,464
99%
(2)
6,462
(58)
99%
(2,326)
4,136
2
4,138
(20)
(20)
4,118
2017
6,520
6,520
(11)
(44)
(56)
6,464
99%
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
(90)
(90)
5,725
2018
9,149
9,149
(11)
(53)
(64)
9,084
99%
(2)
9,082
(66)
99%
(3,270)
5,813
2
5,815
(62)
(62)
5,753
2018
9,149
9,149
(11)
(53)
(64)
9,084
99%
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
(30)
(30)
7,806
2019
12,327
12,327
(17)
(71)
(88)
12,239
99%
(7)
12,232
(95)
99%
(4,404)
7,829
7
7,836
(21)
(21)
7,815
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
9,046
2020
14,224
14,224
(17)
(82)
(99)
14,125
99%
(7)
14,118
(106)
99%
(5,082)
9,035
7
9,043
9,043
$
$
$
$ 10,343
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2021
16,261
16,261
(17)
(93)
(110)
16,151
99%
(7)
16,144
(117)
99%
(5,812)
10,332
7
10,339
10,339
$
$
$
$ 11,086
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2022
17,424
17,424
(30)
(94)
(124)
17,300
99%
(7)
17,293
(131)
99%
(6,225)
11,067
7
11,075
11,075
$
$
$
$ 11,690
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2023
18,382
18,382
(31)
(95)
(125)
18,256
99%
(7)
18,249
(132)
99%
(6,570)
11,679
7
11,687
11,687
2019
2020
2021
2022
2023
$ 12,327 $ 14,224 $ 16,261 $ 17,424 $ 18,382
$
$
$
$
$
$ 12,327 $ 14,224 $ 16,261 $ 17,424 $ 18,382
$
(17) $
(17) $
(17) $
(25) $
(38)
$
(71) $
(82) $
(93) $
(94) $
(95)
$
(88) $
(99) $
(110) $
(119) $
(133)
$ 12,239 $ 14,125 $ 16,151 $ 17,306 $ 18,249
99%
99%
99%
99%
99%
$
$
$
$
$
$
$
$
$
$
$
(2)
6,462
(58)
99%
(2,326)
4,136
2
4,138
(32)
(32)
4,106
Depreciation
$
2
$
16
$
7
$
10
$
$
$
$
$
$
$
$
$
$
$
(2)
9,082
(66)
99%
(3,270)
5,813
2
5,815
(96)
(96)
5,719
$
(10) $
(10) $
$ 12,229 $ 14,115 $
$
(98) $
(109) $
99%
99%
$
(4,403) $
(5,081) $
$ 7,827 $ 9,034 $
$
10 $
10 $
$ 7,837 $ 9,044 $
$
$
$
$
(32) $
$
$
(32) $
$
$ 7,805 $ 9,044 $
NPC
Architecture A
Architecture B
Architecture C
Architecture D
$
$
$
$
1,051
1,346
1,128
1,188
(10)
16,141
(120)
99%
(5,811)
10,330
10
10,340
10,340
$
(10) $
$ 17,296 $
$
(129) $
99%
$
(6,226) $
$ 11,069 $
$
10 $
$ 11,079 $
$
$
$
$
$
$
$ 11,079 $
(10)
18,239
(143)
99%
(6,566)
11,673
10
11,683
11,683
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2024
19,513
19,513
(17)
(96)
(113)
19,400
99%
(2)
19,398
(115)
99%
(6,983)
12,415
2
12,417
12,417
2024
19,513
19,513
(64)
(95)
(159)
19,354
99%
(16)
19,338
(175)
99%
(6,962)
12,376
16
12,393
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2025
20,526
20,526
(18)
(98)
(115)
20,410
99%
(2)
20,408
(117)
99%
(7,347)
13,061
2
13,063
13,063
2025
20,526
20,526
(64)
(96)
(160)
20,365
99%
(16)
20,349
(177)
99%
(7,326)
13,023
16
13,040
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2026
21,690
21,690
(18)
(101)
(119)
21,571
99%
(2)
21,569
(121)
99%
(7,765)
13,804
2
13,806
13,806
2026
21,690
21,690
(65)
(97)
(162)
21,528
99%
(16)
21,512
(178)
99%
(7,744)
13,768
16
13,784
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2027
22,663
22,663
(18)
(104)
(122)
22,541
99%
(2)
22,539
(124)
99%
(8,114)
14,425
2
14,427
14,427
2027
22,663
22,663
(66)
(98)
(163)
22,499
99%
(16)
22,483
(180)
99%
(8,094)
14,389
16
14,405
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2028
23,709
23,709
(18)
(107)
(125)
23,585
99%
(2)
23,583
(127)
99%
(8,490)
15,093
2
15,095
15,095
2028
23,709
23,709
(66)
(98)
(165)
23,545
99%
(16)
23,529
(181)
99%
(8,470)
15,058
16
15,075
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2029
22,989
22,989
(18)
(105)
(123)
22,866
99%
(2)
22,864
(125)
99%
(8,231)
14,633
2
14,635
14,635
2029
22,989
22,989
(67)
(98)
(165)
22,825
99%
(16)
22,808
(181)
99%
(8,211)
14,597
16
14,614
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2030
22,694
22,694
(19)
(104)
(122)
22,572
99%
(2)
22,570
(124)
99%
(8,125)
14,445
2
14,447
14,447
2030
22,694
22,694
(68)
(97)
(165)
22,529
99%
(16)
22,513
(181)
99%
(8,105)
14,408
16
14,424
$
$
$
$ 12,393
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2024
19,513
19,513
(31)
(95)
(126)
19,387
99%
(7)
19,380
(133)
99%
(6,977)
12,403
7
12,410
12,410
$
$
$
$ 13,040
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2025
20,526
20,526
(31)
(96)
(127)
20,398
99%
(7)
20,391
(135)
99%
(7,341)
13,050
7
13,058
13,058
$
$
$
$ 13,784
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2026
21,690
21,690
(32)
(97)
(128)
21,562
99%
(7)
21,555
(136)
99%
(7,760)
13,795
7
13,802
13,802
$
$
$
$ 14,405
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2027
22,663
22,663
(32)
(99)
(130)
22,532
99%
(7)
22,525
(138)
99%
(8,109)
14,416
7
14,423
14,423
$
$
$
$ 15,075
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2028
23,709
23,709
(32)
(101)
(133)
23,577
99%
(7)
23,570
(140)
99%
(8,485)
15,085
7
15,092
15,092
$
$
$
$ 14,614
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2029
22,989
22,989
(32)
(98)
(131)
22,859
99%
(7)
22,851
(138)
99%
(8,227)
14,625
7
14,632
14,632
$
$
$
$ 14,424
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2030
22,694
22,694
(33)
(97)
(130)
22,564
99%
(7)
22,557
(137)
99%
(8,120)
14,436
7
14,443
14,443
2024
2025
2026
2027
2028
2029
2030
$ 19,513 $ 20,526 $ 21,690 $ 22,663 $ 23,709 $ 22,989 $ 22,694
$
$
$
$
$
$
$
$ 19,513 $ 20,526 $ 21,690 $ 22,663 $ 23,709 $ 22,989 $ 22,694
$
(39) $
(39) $
(39) $
(40) $
(40) $
(41) $
(41)
$
(95) $
(96) $
(97) $
(99) $
(101) $
(98) $
(97)
$
(134) $
(135) $
(136) $
(138) $
(141) $
(139) $
(138)
$ 19,380 $ 20,391 $ 21,554 $ 22,524 $ 23,569 $ 22,851 $ 22,556
99%
99%
99%
99%
99%
99%
99%
$
(10) $
$ 19,370 $
$
(144) $
99%
$
(6,973) $
$ 12,396 $
$
10 $
$ 12,406 $
$
$
$
$
$
$
$ 12,406 $
(10)
20,381
(145)
99%
(7,337)
13,044
10
13,054
13,054
$
(10) $
$ 21,544 $
$
(146) $
99%
$
(7,756) $
$ 13,788 $
$
10 $
$ 13,798 $
$
$
$
$
$
$
$ 13,798 $
(10)
22,514
(148)
99%
(8,105)
14,409
10
14,419
14,419
$
(10) $
$ 23,559 $
$
(151) $
99%
$
(8,481) $
$ 15,078 $
$
10 $
$ 15,088 $
$
$
$
$
$
$
$ 15,088 $
(10)
22,841
(149)
99%
(8,223)
14,618
10
14,628
14,628
$
(10)
$ 22,546
$
(148)
99%
$
(8,116)
$ 14,429
$
10
$ 14,439
$
$
$
$ 14,439
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2031
22,307
22,307
(19)
(103)
(121)
22,185
99%
(2)
22,183
(124)
99%
(7,986)
14,197
2
14,199
14,199
2031
22,307
22,307
(68)
(97)
(165)
22,141
99%
(16)
22,125
(182)
99%
(7,965)
14,160
16
14,176
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2032
22,574
22,574
(19)
(103)
(122)
22,451
99%
(2)
22,449
(124)
99%
(8,082)
14,368
2
14,370
14,370
2032
22,574
22,574
(69)
(97)
(166)
22,408
99%
(16)
22,391
(182)
99%
(8,061)
14,330
16
14,347
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2033
22,755
22,755
(19)
(104)
(123)
22,632
99%
(2)
22,630
(125)
99%
(8,147)
14,483
2
14,485
14,485
2033
22,755
22,755
(70)
(97)
(167)
22,588
99%
(16)
22,572
(183)
99%
(8,126)
14,446
16
14,462
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2034
22,976
22,976
(19)
(105)
(124)
22,852
99%
(2)
22,850
(126)
99%
(8,226)
14,624
2
14,626
14,626
2034
22,976
22,976
(70)
(97)
(168)
22,809
99%
(16)
22,792
(184)
99%
(8,205)
14,587
16
14,603
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2035
23,361
23,361
(20)
(106)
(125)
23,236
99%
(2)
23,234
(127)
99%
(8,364)
14,870
2
14,872
14,872
2035
23,361
23,361
(71)
(97)
(168)
23,193
99%
(16)
23,177
(185)
99%
(8,344)
14,833
16
14,849
$
$
$
$ 14,176
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2031
22,307
22,307
(33)
(97)
(130)
22,176
99%
(7)
22,169
(137)
99%
(7,981)
14,188
7
14,196
14,196
$
$
$
$ 14,347
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2032
22,574
22,574
(33)
(97)
(131)
22,443
99%
(7)
22,436
(138)
99%
(8,077)
14,359
7
14,366
14,366
$
$
$
$ 14,462
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2033
22,755
22,755
(34)
(97)
(131)
22,624
99%
(7)
22,617
(138)
99%
(8,142)
14,475
7
14,482
14,482
$
$
$
$ 14,603
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2034
22,976
22,976
(34)
(97)
(131)
22,845
99%
(7)
22,838
(138)
99%
(8,222)
14,616
7
14,623
14,623
$
$
$
$ 14,849
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
$
2035
23,361
23,361
(34)
(97)
(132)
23,230
99%
(7)
23,222
(139)
99%
(8,360)
14,862
7
14,870
14,870
2031
2032
2033
2034
2035
$ 22,307 $ 22,574 $ 22,755 $ 22,976 $ 23,361
$
$
$
$
$
$ 22,307 $ 22,574 $ 22,755 $ 22,976 $ 23,361
$
(41) $
(42) $
(42) $
(43) $
(43)
$
(97) $
(97) $
(97) $
(97) $
(97)
$
(138) $
(139) $
(139) $
(140) $
(140)
$ 22,168 $ 22,435 $ 22,616 $ 22,837 $ 23,221
99%
99%
99%
99%
99%
$
(10) $
$ 22,158 $
$
(148) $
99%
$
(7,977) $
$ 14,181 $
$
10 $
$ 14,191 $
$
$
$
$
$
$
$ 14,191 $
(10)
22,425
(149)
99%
(8,073)
14,352
10
14,362
14,362
$
(10) $
$ 22,606 $
$
(149) $
99%
$
(8,138) $
$ 14,468 $
$
10 $
$ 14,478 $
$
$
$
$
$
$
$ 14,478 $
(10)
22,827
(150)
99%
(8,218)
14,609
10
14,619
14,619
$
(10)
$ 23,211
$
(150)
99%
$
(8,356)
$ 14,855
$
10
$ 14,865
$
$
$
$ 14,865
Operating Cost CAGR (

Terminal Value
$
0.8%
(1,398)
FCF CAGR (2025-2035)

Terminal Value
$
1.3%
173,273

Terminal Value
$
0.4%
(1,942)
FCF CAGR (2025-2035)

Terminal Value
$
1.3%
173,078

Terminal Value
$
0.3%
(1,443)
FCF CAGR (2025-2035)

Terminal Value
$
1.3%
173,309

Terminal Value
$
0.4%
(1,566)
FCF CAGR (2025-2035)

Terminal Value
$
1.3%
173,257
Scenarios
Real-time
Relative-NPC Real-time
Architecture
A
B
$ 107,485 $ 107,168
$
$
(317)
Baseline
93,141 $ 103,073
Price drop
10%
20%
30%
40%
50%
60%
70%
80%
90%
$
$
$
$
$
$
$
$
$
96,667
85,850
75,032
64,215
53,397
42,580
31,762
20,945
10,127

Keytruda plateaus
New modalities become predominant sooner than expected
Consolidation into high volume products
$ 115,640 $ 131,093
$
80,616 $
90,013
$
92,862 $
92,776
$
93,141 $ 103,126
$
93,382 $ 144,566
$
$
$
$
$
$
$
$
$
96,350
85,533
74,715
63,897
53,080
42,262
31,445
20,627
9,810
Architecture
C
D
$ 107,397 $ 107,337
$
(88) $
(148)
$
81,874 $
81,850
Winner
A
B
Price drop (du
$
$
$
$
$
$
$
$
$
96,580
85,762
74,945
64,127
53,310
42,492
31,675
20,857
10,040
$
82,619
$
78,048
$
72,380
$
81,923
$ 124,581
$
$
$
$
$
$
$
$
$
96,520
85,702
74,884
64,067
53,249
42,432
31,614
20,797
9,979
A
A
A
A
A
A
A
A
A
$
82,594
$
78,023
$
72,349
$
81,898
$ 124,584
B
B
A
B
B
Architecture A
Architecture B
Architecture C
Architecture D
$
$
$
$
10%
20%
30%
40%
50%
60%
70%
80%
90%
107,485
107,168
107,397
107,337
$
$
$
$
$
$
$
$
$
$
0% Price drop (du

0% Price
107,485
$ 107,168
96,667
10% $ 96,350
85,850
20% $ 85,533
75,032
30% $ 74,715
64,215
40% $ 63,897
53,397
50% $ 53,080
42,580
60% $ 42,262
31,762
70% $ 31,445
20,945
80% $ 20,627
10,127
90% $
9,810
drop
10%
20%
30%
40%
50%
60%
70%
80%
90%
$
$
$
$
$
$
$
$
$
$
0% Price
107,397
96,580
85,762
74,945
64,127
53,310
42,492
31,675
20,857
10,040
drop
10%
20%
30%
40%
50%
60%
70%
80%
90%
$
$
$
$
$
$
$
$
$
$
0%
107,337
96,520
85,702
74,884
64,067
53,249
42,432
31,614
20,797
9,979
Commercial demand (kg/yr)

2015
2016
2017
130
189
326
2018
457
2019
616
2020
711
2021
813
# of batches needed
2015
8.0
11.0
5.0
6.0
3.0
2.0
2.0
4.0
4.0
2.0
2.0
2.0
2.0
7.0
2.0
2016
12.0
16.0
7.0
8.0
4.0
2.0
3.0
6.0
6.0
2.0
2.0
2.0
2.0
10.0
3.0
2017
20.0
28.0
11.0
14.0
7.0
2.0
4.0
10.0
10.0
4.0
4.0
2.0
2.0
17.0
5.0
2018
28.0
39.0
16.0
20.0
9.0
3.0
6.0
13.0
13.0
5.0
5.0
3.0
3.0
23.0
7.0
2019
37.0
52.0
21.0
26.0
12.0
4.0
7.0
18.0
18.0
6.0
6.0
4.0
4.0
31.0
10.0
2020
43.0
60.0
24.0
30.0
14.0
5.0
8.0
20.0
20.0
7.0
7.0
5.0
5.0
36.0
11.0
2021
49.0
68.0
28.0
34.0
16.0
6.0
10.0
23.0
23.0
8.0
8.0
6.0
6.0
41.0
13.0
7.0
7.0
10.0
10.0
17.0
17.0
23.0
23.0
31.0
31.0
36.0
36.0
41.0
41.0
2018
326.7
91.5
91.5
91.5
91.5
91.5
91.5
91.5
91.5
30.5
30.5
91.5
228.7
152.5
45.7
91.5
152.5
2019
440.3
123.3
123.3
123.3
123.3
123.3
123.3
123.3
123.3
41.1
41.1
123.3
308.2
205.5
61.6
123.3
205.5
2020
508.0
142.2
142.2
142.2
142.2
142.2
142.2
142.2
142.2
47.4
47.4
142.2
355.6
237.1
71.1
142.2
237.1
2021
580.8
162.6
162.6
162.6
162.6
162.6
162.6
162.6
162.6
54.2
54.2
162.6
406.5
271.0
81.3
162.6
271.0
Volume of media needed (m3/yr)

2015
92.9
26.0
26.0
26.0
26.0
26.0
26.0
26.0
26.0
8.7
8.7
26.0
65.0
43.3
13.0
26.0
43.3
2016
135.0
37.8
37.8
37.8
37.8
37.8
37.8
37.8
37.8
12.6
12.6
37.8
94.5
63.0
18.9
37.8
63.0
2017
232.9
65.2
65.2
65.2
65.2
65.2
65.2
65.2
65.2
21.7
21.7
65.2
163.0
108.7
32.6
65.2
108.7
43.3
63.0
108.7
152.5
205.5
237.1
271.0
2022
871
2023
919
2024
976
2025
1,026
2026
1,085
2027
1,133
2028
1,185
2022
52.0
73.0
30.0
37.0
17.0
7.0
10.0
25.0
25.0
9.0
9.0
7.0
7.0
44.0
13.0
2023
55.0
77.0
31.0
39.0
18.0
8.0
11.0
26.0
26.0
9.0
9.0
8.0
8.0
46.0
14.0
2024
59.0
82.0
33.0
41.0
19.0
9.0
11.0
28.0
28.0
10.0
10.0
9.0
9.0
49.0
15.0
2025
62.0
86.0
35.0
43.0
20.0
10.0
12.0
29.0
29.0
10.0
10.0
10.0
10.0
51.0
16.0
2026
65.0
91.0
37.0
46.0
21.0
11.0
13.0
31.0
31.0
11.0
11.0
11.0
11.0
54.0
17.0
2027
68.0
95.0
38.0
48.0
21.0
12.0
13.0
32.0
32.0
12.0
12.0
12.0
12.0
57.0
17.0
2028
71.0
99.0
40.0
50.0
22.0
13.0
14.0
33.0
33.0
13.0
13.0
13.0
13.0
59.0
18.0
44.0
44.0
46.0
46.0
49.0
49.0
51.0
51.0
54.0
54.0
57.0
57.0
59.0
59.0
2022
622.3
174.2
174.2
174.2
174.2
174.2
174.2
174.2
174.2
58.1
58.1
174.2
435.6
290.4
87.1
174.2
290.4
2023
656.5
183.8
183.8
183.8
183.8
183.8
183.8
183.8
183.8
61.3
61.3
183.8
459.5
306.4
91.9
183.8
306.4
2024
696.9
195.1
195.1
195.1
195.1
195.1
195.1
195.1
195.1
65.0
65.0
195.1
487.8
325.2
97.6
195.1
325.2
2025
733.1
205.3
205.3
205.3
205.3
205.3
205.3
205.3
205.3
68.4
68.4
205.3
513.1
342.1
102.6
205.3
342.1
2026
774.6
216.9
216.9
216.9
216.9
216.9
216.9
216.9
216.9
72.3
72.3
216.9
542.3
361.5
108.5
216.9
361.5
2027
809.4
226.6
226.6
226.6
226.6
226.6
226.6
226.6
226.6
75.5
75.5
226.6
566.6
377.7
113.3
226.6
377.7
2028
846.8
237.1
237.1
237.1
237.1
237.1
237.1
237.1
237.1
79.0
79.0
237.1
592.7
395.2
118.5
237.1
395.2
290.4
306.4
325.2
342.1
361.5
377.7
395.2
2029
1,149
2030
1,135
2031
1,115
2032
1,129
2033
1,138
2034
1,149
2035
1,168
2029
69.0
96.0
39.0
48.0
22.0
14.0
14.0
32.0
32.0
14.0
14.0
14.0
14.0
58.0
18.0
2030
68.0
95.0
38.0
48.0
22.0
15.0
15.0
32.0
32.0
15.0
15.0
15.0
15.0
57.0
17.0
2031
67.0
93.0
38.0
47.0
21.0
16.0
16.0
31.0
31.0
16.0
16.0
16.0
16.0
56.0
17.0
2032
68.0
95.0
38.0
48.0
21.0
17.0
17.0
32.0
32.0
17.0
17.0
17.0
17.0
56.0
17.0
2033
68.0
95.0
38.0
48.0
22.0
18.0
18.0
32.0
32.0
18.0
18.0
18.0
18.0
57.0
18.0
2034
69.0
96.0
39.0
48.0
22.0
19.0
19.0
32.0
32.0
19.0
19.0
19.0
19.0
57.0
19.0
2035
70.0
98.0
39.0
49.0
22.0
20.0
20.0
33.0
33.0
20.0
20.0
20.0
20.0
58.0
20.0
58.0
58.0
57.0
57.0
56.0
56.0
56.0
56.0
57.0
57.0
57.0
57.0
58.0
58.0
2029
821.0
229.9
229.9
229.9
229.9
229.9
229.9
229.9
229.9
76.6
76.6
229.9
574.7
383.2
114.9
229.9
383.2
2030
810.5
226.9
226.9
226.9
226.9
226.9
226.9
226.9
226.9
75.6
75.6
226.9
567.4
378.2
113.5
226.9
378.2
2031
796.7
223.1
223.1
223.1
223.1
223.1
223.1
223.1
223.1
74.4
74.4
223.1
557.7
371.8
111.5
223.1
371.8
2032
806.2
225.7
225.7
225.7
225.7
225.7
225.7
225.7
225.7
75.2
75.2
225.7
564.3
376.2
112.9
225.7
376.2
2033
812.7
227.5
227.5
227.5
227.5
227.5
227.5
227.5
227.5
75.8
75.8
227.5
568.9
379.2
113.8
227.5
379.2
2034
820.6
229.8
229.8
229.8
229.8
229.8
229.8
229.8
229.8
76.6
76.6
229.8
574.4
382.9
114.9
229.8
382.9
2035
834.3
233.6
233.6
233.6
233.6
233.6
233.6
233.6
233.6
77.9
77.9
233.6
584.0
389.4
116.8
233.6
389.4
383.2
378.2
371.8
376.2
379.2
382.9
389.4
Cost of batches ($m/yr)

2015
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.2
0.2
0.1
0.1
0.1
0.1
0.0
0.0
2016
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.4
0.4
0.1
0.1
0.1
0.1
0.0
0.0
2017
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.6
0.6
0.2
0.2
0.1
0.1
0.0
0.0
2018
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.8
0.8
0.3
0.3
0.2
0.2
0.0
0.0
2019
0.0
0.1
0.0
0.0
0.0
0.0
0.0
1.1
1.1
0.4
0.4
0.2
0.2
0.0
0.0
2020
0.0
0.1
0.0
0.0
0.0
0.0
0.0
1.2
1.2
0.4
0.4
0.3
0.3
0.0
0.0
2021
0.0
0.1
0.0
0.0
0.0
0.0
0.0
1.4
1.4
0.5
0.5
0.4
0.4
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2018
26.1
7.3
7.3
7.3
7.3
7.3
7.3
7.3
7.3
2.4
2.4
7.3
18.3
0.0
0.0
0.0
0.0
2019
35.2
9.9
9.9
9.9
9.9
9.9
9.9
9.9
9.9
3.3
3.3
9.9
24.7
0.0
0.0
0.0
0.0
2020
40.6
11.4
11.4
11.4
11.4
11.4
11.4
11.4
11.4
3.8
3.8
11.4
28.4
0.0
0.0
0.0
0.0
2021
46.5
13.0
13.0
13.0
13.0
13.0
13.0
13.0
13.0
4.3
4.3
13.0
32.5
0.0
0.0
0.0
0.0
Cost of raw material ($m/yr)

2015
7.4
2.1
2.1
2.1
2.1
2.1
2.1
2.1
2.1
0.7
0.7
2.1
5.2
0.0
0.0
0.0
0.0
2016
10.8
3.0
3.0
3.0
3.0
3.0
3.0
3.0
3.0
1.0
1.0
3.0
7.6
0.0
0.0
0.0
0.0
2017
18.6
5.2
5.2
5.2
5.2
5.2
5.2
5.2
5.2
1.7
1.7
5.2
13.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2015
7.4
2.1
2.1
2.1
2.1
2.1
2.1
2.3
2.3
0.8
0.8
2.2
5.3
0.0
0.0
2016
10.8
3.0
3.0
3.0
3.0
3.0
3.0
3.4
3.4
1.1
1.1
3.1
7.7
0.0
0.0
2017
18.6
5.2
5.2
5.2
5.2
5.2
5.2
5.8
5.8
2.0
2.0
5.3
13.2
0.0
0.0
2018
26.2
7.4
7.3
7.3
7.3
7.3
7.3
8.1
8.1
2.7
2.7
7.5
18.5
0.0
0.0
2019
35.3
9.9
9.9
9.9
9.9
9.9
9.9
10.9
10.9
3.6
3.6
10.1
24.9
0.0
0.0
2020
40.7
11.4
11.4
11.4
11.4
11.4
11.4
12.6
12.6
4.2
4.2
11.7
28.7
0.0
0.0
2021
46.5
13.1
13.0
13.0
13.0
13.0
13.0
14.4
14.4
4.8
4.8
13.4
32.9
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2017
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.8
17.8
6.1
6.1
16.4
40.4
2018
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.0
6.0
16.4
40.4
2019
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.8
17.8
5.9
5.9
16.4
40.4
2020
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.4
40.4
2021
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.4
40.4
Total cost ($m)
Cost per gram ($/g)

Plant op
OSS BIO cur
WAG
OSS BIO up
OSS BIO up
Stainless st
Stainless s
Stainless st
Fed batch
Fed batch S
Fed batch S
Fed batch S
Continuous
FoF_Greenf
2015
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.8
17.8
6.3
6.3
16.9
40.9
2016
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.9
17.9
6.0
6.0
16.6
40.6
2022
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.5
1.5
0.5
0.5
0.4
0.4
0.0
0.0
2023
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.6
1.6
0.5
0.5
0.5
0.5
0.0
0.0
2024
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.7
1.7
0.6
0.6
0.5
0.5
0.0
0.0
2025
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.7
1.7
0.6
0.6
0.6
0.6
0.0
0.0
2026
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
0.7
0.7
0.7
0.7
0.0
0.0
2027
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
0.7
0.7
0.7
0.7
0.0
0.0
2028
0.1
0.1
0.0
0.1
0.0
0.0
0.0
2.0
2.0
0.8
0.8
0.8
0.8
0.0
0.0
2029
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
0.8
0.8
0.8
0.8
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2022
49.8
13.9
13.9
13.9
13.9
13.9
13.9
13.9
13.9
4.6
4.6
13.9
34.8
0.0
0.0
0.0
0.0
2023
52.5
14.7
14.7
14.7
14.7
14.7
14.7
14.7
14.7
4.9
4.9
14.7
36.8
0.0
0.0
0.0
0.0
2024
55.8
15.6
15.6
15.6
15.6
15.6
15.6
15.6
15.6
5.2
5.2
15.6
39.0
0.0
0.0
0.0
0.0
2025
58.6
16.4
16.4
16.4
16.4
16.4
16.4
16.4
16.4
5.5
5.5
16.4
41.1
0.0
0.0
0.0
0.0
2026
62.0
17.4
17.4
17.4
17.4
17.4
17.4
17.4
17.4
5.8
5.8
17.4
43.4
0.0
0.0
0.0
0.0
2027
64.8
18.1
18.1
18.1
18.1
18.1
18.1
18.1
18.1
6.0
6.0
18.1
45.3
0.0
0.0
0.0
0.0
2028
67.7
19.0
19.0
19.0
19.0
19.0
19.0
19.0
19.0
6.3
6.3
19.0
47.4
0.0
0.0
0.0
0.0
2029
65.7
18.4
18.4
18.4
18.4
18.4
18.4
18.4
18.4
6.1
6.1
18.4
46.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2022
49.8
14.0
14.0
14.0
14.0
13.9
13.9
15.4
15.4
5.2
5.2
14.4
35.3
0.0
0.0
2023
52.6
14.8
14.7
14.7
14.7
14.7
14.7
16.3
16.3
5.4
5.4
15.2
37.2
0.0
0.0
2024
55.8
15.7
15.6
15.7
15.6
15.6
15.6
17.3
17.3
5.8
5.8
16.2
39.6
0.0
0.0
2025
58.7
16.5
16.5
16.5
16.4
16.4
16.4
18.2
18.2
6.1
6.1
17.0
41.7
0.0
0.0
2026
62.0
17.4
17.4
17.4
17.4
17.4
17.4
19.2
19.2
6.4
6.4
18.0
44.0
0.0
0.0
2027
64.8
18.2
18.2
18.2
18.2
18.1
18.1
20.1
20.1
6.8
6.8
18.9
46.0
0.0
0.0
2028
67.8
19.1
19.0
19.0
19.0
19.0
19.0
20.9
20.9
7.1
7.1
19.7
48.2
0.0
0.0
2029
65.8
18.5
18.4
18.4
18.4
18.4
18.4
20.3
20.3
7.0
7.0
19.2
46.8
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2022
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.0
6.0
16.5
40.5
2023
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.5
40.5
2024
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.6
40.6
2025
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.6
40.6
2026
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
5.9
5.9
16.6
40.6
2027
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.0
6.0
16.6
40.6
2028
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.0
6.0
16.7
40.7
2029
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.1
6.1
16.7
40.7
2030
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
0.9
0.9
0.9
0.9
0.0
0.0
2031
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
1.0
1.0
1.0
1.0
0.0
0.0
2032
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
1.0
1.0
1.0
1.0
0.0
0.0
2033
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
1.1
1.1
1.1
1.1
0.0
0.0
2034
0.1
0.1
0.0
0.0
0.0
0.0
0.0
1.9
1.9
1.1
1.1
1.1
1.1
0.0
0.0
2035
0.1
0.1
0.0
0.0
0.0
0.0
0.0
2.0
2.0
1.2
1.2
1.2
1.2
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2030
64.8
18.2
18.2
18.2
18.2
18.2
18.2
18.2
18.2
6.1
6.1
18.2
45.4
0.0
0.0
0.0
0.0
2031
63.7
17.8
17.8
17.8
17.8
17.8
17.8
17.8
17.8
5.9
5.9
17.8
44.6
0.0
0.0
0.0
0.0
2032
64.5
18.1
18.1
18.1
18.1
18.1
18.1
18.1
18.1
6.0
6.0
18.1
45.1
0.0
0.0
0.0
0.0
2033
65.0
18.2
18.2
18.2
18.2
18.2
18.2
18.2
18.2
6.1
6.1
18.2
45.5
0.0
0.0
0.0
0.0
2034
65.6
18.4
18.4
18.4
18.4
18.4
18.4
18.4
18.4
6.1
6.1
18.4
46.0
0.0
0.0
0.0
0.0
2035
66.7
18.7
18.7
18.7
18.7
18.7
18.7
18.7
18.7
6.2
6.2
18.7
46.7
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2030
64.9
18.3
18.2
18.2
18.2
18.2
18.2
20.1
20.1
7.0
7.0
19.1
46.3
0.0
0.0
2031
63.8
17.9
17.9
17.9
17.9
17.9
17.9
19.7
19.7
6.9
6.9
18.8
45.6
0.0
0.0
2032
64.6
18.2
18.1
18.1
18.1
18.1
18.1
20.0
20.0
7.0
7.0
19.1
46.2
0.0
0.0
2033
65.1
18.3
18.2
18.3
18.2
18.2
18.2
20.1
20.1
7.1
7.1
19.3
46.6
0.0
0.0
2034
65.7
18.5
18.4
18.4
18.4
18.4
18.4
20.3
20.3
7.3
7.3
19.5
47.1
0.0
0.0
2035
66.8
18.8
18.7
18.7
18.7
18.7
18.7
20.7
20.7
7.4
7.4
19.9
47.9
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
2030
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.1
6.1
16.8
40.8
2031
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.2
6.2
16.9
40.9
2032
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.2
6.2
16.9
40.9
2033
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.3
6.3
16.9
40.9
2034
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.3
6.3
17.0
41.0
2035
57.2
16.1
16.0
16.0
16.0
16.0
16.0
17.7
17.7
6.4
6.4
17.0
41.0
Unit price ($/g)

2015
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2016
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2017
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2018
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2019
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2020
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2021
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2018
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2019
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2020
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2021
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
Calculated unit price ($/g)

2015
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2016
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2017
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2022
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2023
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2024
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2025
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2026
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2027
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2028
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2029
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2022
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2023
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2024
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2025
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2026
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2027
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2028
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2029
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2030
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2031
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2032
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2033
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2034
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2035
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2030
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2031
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2032
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2033
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2034
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
2035
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
20000.0
PltOptID
01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
Plant Option name

OSS BIO current (1 x 20kL SS)
WAG
OSS BIO upgraded (2 x 5kL SS)
OSS BIO upgraded (4 x 2kL SU)
Stainless steel (large)
Stainless steel (med)
Fed batch SU
Fed batch SU (hybrid)
Fed batch SU Intensified (hybrid)
Fed batch SU Intensified
Continuous SU
FoF_Greenfield
CMO: CHO - Current
CMO: CHO - Intensified fed batch
CMO: CHO - Continuous
CMO: Microbial - E.coli
CMO: Microbial - Yeast
From
2015
2015
2018
2018
2020
2019
2019
2019
2020
2020
2019
2019
2020
2015
2015
2015
2015
2015
To
2035
2016
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
2035
CapEx
0
0
40
20
180
120
100
100
100
100
100
55
50
0
0
0
0
0
Investment plan
OpEx p.a
11
10
5
5
30
30
30
11.25
11.25
12.25
12.25
7
7
0
0
0
0
0
Investment year
2015
2015
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
L +0
0%
0%
100%
100%
20%
20%
20%
0%
0%
0%
0%
0%
0%
0%
0%
0%
0%
0%
L +1
0%
0%
0%
0%
60%
60%
60%
20%
20%
20%
20%
20%
20%
0%
0%
0%
0%
0%
L +2
0%
0%
0%
0%
15%
15%
15%
60%
60%
60%
60%
60%
60%
0%
0%
0%
0%
0%
L +3
0%
0%
0%
0%
5%
5%
5%
20%
20%
20%
20%
20%
20%
0%
0%
0%
0%
0%
ARCHITECTURE A
ARCHITECTURE B
ARCHITECTURE C
ARCHITECTURE D
CapEx in m$
Development Time
1
1
4
4
4
3
3
3
3
3
3
-
2015
-
2016
40.4
20.2
36.4
24.2
20.2
141.4
2017
110.2
73.4
61.2
20.4
20.4
20.4
20.4
11.2
10.2
347.9
2018
27.8
18.5
15.5
61.8
61.8
61.8
61.8
34.0
30.9
374.0
2019
9.4
6.2
5.2
20.8
20.8
20.8
20.8
11.4
10.4
125.9
2016
40.4
-
2017
-
2018
-
2019
-
CapEx in m$
2015
-
40.4
CapEx in m$
2015
-
2016
40.4
36.4
76.8
2017
110.2
20.4
130.6
2018
27.8
61.8
89.6
2019
9.4
20.8
30.2
2016
40.4
-
2017
20.4
-
2018
61.8
-
2019
20.8
-
CapEx in m$
2015
-
40.4
20.4
61.8
20.8
2016
40.4
40.4
2017
20.4
11.2
31.6
2018
61.8
34.0
95.8
2019
20.8
11.4
32.3
CapEx in m$
2015
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
Depreciation in m$
Book value starting
2,015
2,015
40.4
2,017
20.2
2,017
183.7
2,020
122.5
2,020
102.1
2,020
103.0
2,019
103.0
2,019
103.0
2,019
103.0
2,019
56.7
2,019
51.5
2,019
2,016
2,016
2,016
2,016
2,016
2015
-
2016
-
2017
2.0
1.0
3.0
2018
2.0
1.0
3.0
2017
2.0
-
2018
2.0
-
Depreciation in m$
2015
-
2016
-
2.0
2.0
2017
2.0
2.0
2018
2.0
2.0
2017
2.0
-
2018
2.0
-
Depreciation in m$
2015
-
2016
-
Depreciation in m$
2015
-
2016
-
2.0
2.0
2017
2.0
2.0
2018
2.0
2.0
Depreciation in m$
2015
-
2016
-
2019
2.0
1.0
5.2
5.2
5.2
5.2
2.8
2.6
29.0
2020
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2021
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2022
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2023
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2024
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2025
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2026
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2019
2.0
-
2020
2.0
-
2021
2.0
-
2022
2.0
-
2023
2.0
-
2024
2.0
-
2025
2.0
-
2026
2.0
-
2.0
2.0
2.0
2.0
2.0
2.0
2.0
2.0
2019
2.0
5.2
7.2
2020
2.0
9.2
5.2
16.4
2021
2.0
9.2
5.2
16.4
2022
2.0
9.2
5.2
16.4
2023
2.0
9.2
5.2
16.4
2024
2.0
9.2
5.2
16.4
2025
2.0
9.2
5.2
16.4
2026
2.0
9.2
5.2
16.4
2019
2.0
5.2
-
2020
2.0
5.2
-
2021
2.0
5.2
-
2022
2.0
5.2
-
2023
2.0
5.2
-
2024
2.0
5.2
-
2025
2.0
5.2
-
2026
2.0
5.2
-
7.2
7.2
7.2
7.2
7.2
7.2
7.2
7.2
2019
2.0
5.2
2.8
10.0
2020
2.0
5.2
2.8
10.0
2021
2.0
5.2
2.8
10.0
2022
2.0
5.2
2.8
10.0
2023
2.0
5.2
2.8
10.0
2024
2.0
5.2
2.8
10.0
2025
2.0
5.2
2.8
10.0
2026
2.0
5.2
2.8
10.0
2027
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2028
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2029
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2030
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2031
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2032
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2033
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2034
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
2027
2.0
-
2028
2.0
-
2029
2.0
-
2030
2.0
-
2031
2.0
-
2032
2.0
-
2033
2.0
-
2034
2.0
-
2.0
2.0
2.0
2.0
2.0
2.0
2.0
2.0
2027
2.0
9.2
5.2
16.4
2028
2.0
9.2
5.2
16.4
2029
2.0
9.2
5.2
16.4
2030
2.0
9.2
5.2
16.4
2031
2.0
9.2
5.2
16.4
2032
2.0
9.2
5.2
16.4
2033
2.0
9.2
5.2
16.4
2034
2.0
9.2
5.2
16.4
2027
2.0
5.2
-
2028
2.0
5.2
-
2029
2.0
5.2
-
2030
2.0
5.2
-
2031
2.0
5.2
-
2032
2.0
5.2
-
2033
2.0
5.2
-
2034
2.0
5.2
-
7.2
7.2
7.2
7.2
7.2
7.2
7.2
7.2
2027
2.0
5.2
2.8
10.0
2028
2.0
5.2
2.8
10.0
2029
2.0
5.2
2.8
10.0
2030
2.0
5.2
2.8
10.0
2031
2.0
5.2
2.8
10.0
2032
2.0
5.2
2.8
10.0
2033
2.0
5.2
2.8
10.0
2034
2.0
5.2
2.8
10.0
(Fix) OpEx in $m
2035
2.0
1.0
9.2
6.1
5.1
5.2
5.2
5.2
5.2
2.8
2.6
49.5
TrmVal
2.0
1.0
36.7
24.5
20.4
15.5
15.5
15.5
15.5
8.5
7.7
162.7
2015
11.0
10.0
21.0
2016
11.1
10.1
21.2
2017
11.2
11.2
2018
11.3
11.3
2019
11.4
5.2
5.2
21.9
2017
11.2
-
2018
11.3
-
2019
11.4
5.2
-
(Fix) OpEx in $m
2035
2.0
-
TrmVal
2.0
-
2015
11.0
10.0
-
2016
11.1
10.1
-
2.0
2.0
21.0
21.2
11.2
11.3
16.6
2017
11.2
11.2
2018
11.3
11.3
2019
11.4
5.2
16.6
2017
11.2
-
2018
11.3
-
2019
11.4
5.2
-
(Fix) OpEx in $m
2035
2.0
9.2
5.2
16.4
TrmVal
2.0
36.7
15.5
54.2
2015
11.0
10.0
21.0
2016
11.1
10.1
21.2
(Fix) OpEx in $m
2035
2.0
5.2
-
TrmVal
2.0
15.5
-
2015
11.0
10.0
-
2016
11.1
10.1
-
7.2
17.5
21.0
21.2
11.2
11.3
16.6
2017
11.2
11.2
2018
11.3
11.3
2019
11.4
5.2
16.6
(Fix) OpEx in $m
2035
2.0
5.2
2.8
10.0
TrmVal
2.0
15.5
8.5
26.0
2015
11.0
10.0
21.0
2016
11.1
10.1
21.2
2020
11.6
5.3
5.3
22.1
2021
11.7
5.3
5.3
22.3
2022
11.8
5.4
5.4
12.1
13.1
7.5
55.2
2023
11.9
5.4
5.4
32.5
32.5
12.2
12.2
13.3
13.3
7.6
7.6
153.8
2024
12.0
5.5
5.5
32.8
32.8
32.8
12.3
12.3
13.4
13.4
7.7
7.7
188.1
2025
12.2
5.5
5.5
33.1
33.1
33.1
12.4
12.4
13.5
13.5
7.7
7.7
190.0
2026
12.3
5.6
5.6
33.5
33.5
33.5
12.6
12.6
13.7
13.7
7.8
7.8
191.9
2027
12.4
5.6
5.6
33.8
33.8
33.8
12.7
12.7
13.8
13.8
7.9
7.9
193.8
2020
11.6
5.3
-
2021
11.7
5.3
-
2022
11.8
5.4
-
2023
11.9
5.4
-
2024
12.0
5.5
-
2025
12.2
5.5
-
2026
12.3
5.6
-
2027
12.4
5.6
-
16.8
17.0
17.2
17.3
17.5
17.7
17.9
18.0
2020
11.6
5.3
16.8
2021
11.7
5.3
17.0
2022
11.8
5.4
17.2
2023
11.9
5.4
13.3
30.6
2024
12.0
5.5
32.8
13.4
63.7
2025
12.2
5.5
33.1
13.5
64.3
2026
12.3
5.6
33.5
13.7
65.0
2027
12.4
5.6
33.8
13.8
65.6
2020
11.6
5.3
-
2021
11.7
5.3
-
2022
11.8
5.4
13.1
-
2023
11.9
5.4
13.3
-
2024
12.0
5.5
13.4
-
2025
12.2
5.5
13.5
-
2026
12.3
5.6
13.7
-
2027
12.4
5.6
13.8
-
16.8
17.0
30.3
30.6
30.9
31.2
31.5
31.8
2020
11.6
5.3
16.8
2021
11.7
5.3
17.0
2022
11.8
5.4
7.5
24.7
2023
11.9
5.4
13.3
7.6
38.2
2024
12.0
5.5
13.4
7.7
38.6
2025
12.2
5.5
13.5
7.7
38.9
2026
12.3
5.6
13.7
7.8
39.3
2027
12.4
5.6
13.8
7.9
39.7
2028
12.5
5.7
5.7
34.1
34.1
34.1
12.8
12.8
13.9
13.9
8.0
8.0
195.8
2029
12.6
5.7
5.7
34.5
34.5
34.5
12.9
12.9
14.1
14.1
8.0
8.0
197.7
2030
12.8
5.8
5.8
34.8
34.8
34.8
13.1
13.1
14.2
14.2
8.1
8.1
199.7
2031
12.9
5.9
5.9
35.2
35.2
35.2
13.2
13.2
14.4
14.4
8.2
8.2
201.7
2032
13.0
5.9
5.9
35.5
35.5
35.5
13.3
13.3
14.5
14.5
8.3
8.3
203.7
2033
13.2
6.0
6.0
35.9
35.9
35.9
13.5
13.5
14.7
14.7
8.4
8.4
205.7
2034
13.3
6.0
6.0
36.2
36.2
36.2
13.6
13.6
14.8
14.8
8.5
8.5
207.8
2035
13.4
6.1
6.1
36.6
36.6
36.6
13.7
13.7
14.9
14.9
8.5
8.5
209.9
2028
12.5
5.7
-
2029
12.6
5.7
-
2030
12.8
5.8
-
2031
12.9
5.9
-
2032
13.0
5.9
-
2033
13.2
6.0
-
2034
13.3
6.0
-
2035
13.4
6.1
-
18.2
18.4
18.6
18.8
18.9
19.1
19.3
19.5
2028
12.5
5.7
34.1
13.9
66.3
2029
12.6
5.7
34.5
14.1
67.0
2030
12.8
5.8
34.8
14.2
67.6
2031
12.9
5.9
35.2
14.4
68.3
2032
13.0
5.9
35.5
14.5
69.0
2033
13.2
6.0
35.9
14.7
69.7
2034
13.3
6.0
36.2
14.8
70.4
2035
13.4
6.1
36.6
14.9
71.1
2028
12.5
5.7
13.9
-
2029
12.6
5.7
14.1
-
2030
12.8
5.8
14.2
-
2031
12.9
5.9
14.4
-
2032
13.0
5.9
14.5
-
2033
13.2
6.0
14.7
-
2034
13.3
6.0
14.8
-
2035
13.4
6.1
14.9
-
32.2
32.5
32.8
33.1
33.5
33.8
34.1
34.5
2028
12.5
5.7
13.9
8.0
40.1
2029
12.6
5.7
14.1
8.0
40.5
2030
12.8
5.8
14.2
8.1
40.9
2031
12.9
5.9
14.4
8.2
41.3
2032
13.0
5.9
14.5
8.3
41.7
2033
13.2
6.0
14.7
8.4
42.2
2034
13.3
6.0
14.8
8.5
42.6
2035
13.4
6.1
14.9
8.5
43.0
ARCHITECTURE A
Lnch +0
Lnch +1
Lnch +2
Lnch +3
Scale-out capital cost ($m)
2015
-

Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-

Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-
Continuous (small)
Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-
Total Scale-out capital cost ($M)
2016
-
2016
-
2016
-
2016
-
2017
2017
2017
2017
-
ARCHITECTURE B
Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-

Lnch +0
Lnch +1
Lnch +2
2015
-
2016
-
2016
-
2017
2017
-
Lnch +3

Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-
Continuous (small)
Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-
2016
-
2016
-
2017
2017
-
ARCHITECTURE C
Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-

Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-

Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-
Continuous (small)
Lnch +0
Lnch +1
2015
-
2016
-
2016
-
2016
-
2016
-
2017
2017
2017
2017
-
Lnch +2
Lnch +3
ARCHITECTURE D
Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-

Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-

Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-
Continuous (small)
Lnch +0
Lnch +1
Lnch +2
Lnch +3
2015
-
2016
-
2016
-
2016
-
2016
-
2017
2017
2017
2017
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
NPV
$0.00
2034
-
2035
-
NPV
$0.00
2034
-
2035
-
NPV
$0.00
2034
-
2035
-
NPV
$0.00
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
2034
-
2035
-
ARCHITECTURE A
Plant active
2015
1
1
1
-
2016
1
1
1
-
2017
1
1
-
2018
1
1
1
-
2019
1
1
1
-
CHO current capacity (kg/y

2015
286
240
526
CHO current cost ranking
2015
13
8
CHO current production ran

2015
2
1
CHO current production seq

Ranking
2015
1 WAG
2 OSS BIO curr
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Ranking
1
2
3
4
5
CHO current ranked produc

2015
240
286
-
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced (kg/y

Ranking
2015
1
65
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
65
CHO current backflow allow

Ranking
2015
1
175
2
286
3
4
5
6
7
8
9
-
10
11
12
13
14
15
16
17
18
461
CHO current max CMO swa

2015
65
CHO current unmet product

2015
65
-
CHO current CMO swapback

2015
-

2015
65
-
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced AFTE

2015
65
65
CHO current production AFT

Ranking
2015
1
65
2
3
4
5
6
7
-
8
9
10
11
12
13
14
15
16
17
18
65
Total CHO old demanded (k

2015
90
40
130
Internal CHO old demand (k

2015
45
20
-
65
Total CHO old demand build

2015
90
130
130
Internal CHO old demand b

2015
45
65
-
65
Minimal campaign count
2015
2
-
O current capacity (kg/yr)

2016
286
240
526
O current cost ranking

2016
13
8
2017
286
286
2018
286
600
886
2019
286
600
886
2020
286
600
886
2021
286
600
886
2022
286
600
886
2017
13
2018
13
2019
13
2020
13
2021
13
2022
13
2018
2019
2020
2021
2022
O current production ranking

2016
2017
2
1
O current production sequence

2016
2017
2018
2019
2020
2021
2022
WAG
OSS BIO curr OSS BIO upgrOSS BIO upgrOSS BIO upgrOSS BIO upOSS BIO up
OSS BIO curr
OSS BIO curr OSS BIO curr OSS BIO curr OSS BIO cuOSS BIO cu
O current ranked production (kg/yr)

2016
2017
240
286
286
-
2018
600
286
-
2019
600
286
-
2020
600
286
-
2021
600
286
-
2022
600
286
-
O current produced (kg/yr)

2016
95
95
2017
163
163
2018
229
229
2019
308
308
2020
345
345
2021
387
387
2022
406
406
O current backflow allowed (kg/yr)

2016
2017
146
123
286
-
2018
371
286
-
2019
292
286
-
2020
255
286
-
2021
213
286
-
2022
194
286
-
431
123
657
577
540
499
480
O current max CMO swapback allowed (kg/yr)

2016
2017
2018
95
123
229
2019
308
2020
345
2021
387
2022
406
O current unmet production before CMO swapback (kg/yr)

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
387
-
2022
406
-
O current CMO swapback (kg/yr)

2016
2017
-
2019
-
2020
-
2021
23
2022
62
O current unmet production AFTER CMO swapback (kg/yr)

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
410
-
2022
468
-
2018
-
O current produced AFTER CMO swapback (kg/yr)

2016
2017
2018
95
163
229
95
163
229
2019
308
308
2020
345
345
2021
410
410
2022
468
468
O current production AFTER CMO swapback buildup (kg/yr)

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
410
-
2022
468
-
95
163
229
308
345
410
468
al CHO old demanded (kg/yr)

2016
2017
109
128
80
198
189
326
2018
162
242
53
457
2019
200
308
88
20
616
2020
250
300
121
20
691
2021
300
300
153
20
773
2022
300
300
191
20
811
ernal CHO old demand (kg/yr)

2016
2017
55
64
40
99
-
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
95
163
229
308
345
387
406
al CHO old demand buildup (kg/yr)

2016
2017
109
128
189
326
189
326
2018
162
404
457
457
2019
200
508
596
616
616
2020
250
550
671
691
691
2021
300
600
753
773
773
2022
300
600
791
811
811
ernal CHO old demand buildup (kg/yr)

2016
2017
55
64
95
163
-
2018
81
202
229
2019
100
254
298
2020
125
275
335
2021
150
300
377
2022
150
300
396
95
163
229
308
308
345
345
387
387
406
406
imal campaign count

2016
2
-
2017
2
-
2018
3
-
2019
4
-
2020
4
-
2021
2
-
2022
2
-
2023
286
600
886
2024
286
600
886
2025
286
600
886
2026
286
600
886
2027
286
600
886
2028
286
600
886
2029
286
600
886
2030
286
600
886
2023
13
2024
13
2025
13
2026
13
2027
13
2028
13
2029
13
2030
13
2023
2024
2025
2026
2027
2028
2029
2030
2023
2024
2025
2026
2027
2028
2029
2030
OSS BIO upOSS BIO upOSS BIO upOSS BIO upOSS BIO upOSS BIO upOSS BIO upOSS BIO up
OSS BIO cuOSS BIO cuOSS BIO cuOSS BIO cuOSS BIO cuOSS BIO cuOSS BIO cuOSS BIO cu
2023
600
286
-
2024
600
286
-
2025
600
286
-
2026
600
286
-
2027
600
286
-
2028
600
286
-
2029
600
286
-
2030
600
286
-
2023
419
419
2024
438
438
2025
453
453
2026
472
472
2027
487
487
2028
503
503
2029
475
475
2030
458
458
2023
181
286
-
2024
162
286
-
2025
147
286
-
2026
128
286
-
2027
113
286
-
2028
97
286
-
2029
125
286
-
2030
142
286
-
466
448
433
413
399
383
411
428
2023
419
2024
438
2025
433
2026
413
2027
399
2028
383
2029
411
2030
428
2023
419
-
2024
438
-
2025
453
-
2026
472
-
2027
487
-
2028
503
-
2029
475
-
2030
458
-
2023
97
2024
135
2025
170
2026
209
2027
243
2028
279
2029
272
2030
274
2023
516
-
2024
572
-
2025
623
23
-
2026
681
81
-
2027
730
130
-
2028
782
182
-
2029
746
146
-
2030
732
132
-
2023
516
516
2024
572
572
2025
600
23
623
2026
600
81
681
2027
600
130
730
2028
600
182
782
2029
600
146
746
2030
600
132
732
2023
516
-
2024
572
-
2025
600
623
-
2026
600
681
-
2027
600
730
-
2028
600
782
-
2029
600
746
-
2030
600
732
-
516
572
623
681
730
782
746
732
2023
300
300
218
20
838
2024
300
300
256
20
875
2025
300
300
286
20
906
2026
300
300
324
20
945
2027
300
300
354
20
974
2028
300
300
385
20
1,006
2029
200
300
430
20
949
2030
125
300
471
20
916
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
2026
150
150
162
10
2027
150
150
177
10
2028
150
150
193
10
2029
100
150
215
10
2030
63
150
236
10
419
438
453
472
487
503
475
458
2023
300
600
818
838
838
2024
300
600
856
875
875
2025
300
600
886
906
906
2026
300
600
924
945
945
2027
300
600
954
974
974
2028
300
600
985
1,006
1,006
2029
200
500
930
949
949
2030
125
425
896
916
916
2023
150
300
409
2024
150
300
428
2025
150
300
443
2026
150
300
462
2027
150
300
477
2028
150
300
493
2029
100
250
465
2030
63
213
448
419
419
438
438
453
453
472
472
487
487
503
503
475
475
458
458
2023
2
-
2024
2
-
2025
2
1
-
2026
2
1
-
2027
2
1
-
2028
2
1
-
2029
3
-
2030
3
-
2031
286
600
886
2032
286
600
886
2033
286
600
886
2034
286
600
886
2035
286
600
886
2031
13
2032
13
2033
13
2034
13
2035
13
2031
2032
2033
2034
2035
CHO FotF capacity (kg/yr)

2015
2016
CHO FotF cost ranking
2015
2016
CHO FotF production ranking

2015
2016
2031
2032
2033
2034
2035
OSS BIO upOSS BIO upOSS BIO upOSS BIO upOSS BIO upgraded (2
OSS BIO cuOSS BIO cuOSS BIO cuOSS BIO cuOSS BIO current (1 x
2031
600
286
-
2032
600
286
-
2033
600
286
-
2034
600
286
-
2035
600
286
-
CHO FotF production sequence

2015
2016
CHO FotF ranked production (kg/yr)

2015
2016
-
2031
439
439
2031
161
286
-
2032
436
436
2032
164
286
-
2033
429
429
2033
171
286
-
2034
426
426
2034
174
286
-
2035
426
426
CHO FotF produced (kg/yr)

2015
2016
-
2035
174
286
-
CHO FotF backflow allowed (kg/yr)

2015
2016
-
447
450
457
460
460
2031
439
2032
436
2033
429
2034
426
2035
426
CHO FotF max CMO swapback allow

2015
2016
-
2031
439
-
2032
436
-
2033
429
-
2034
426
-
2035
426
-
CHO FotF unmet production before

2015
2016
-
2031
274
2032
289
2033
306
2034
320
2035
339
CHO FotF CMO swapback (kg/yr)

2015
2016
-
2035
765
165
-
CHO FotF unmet production AFTER C

2015
2016
-
2031
712
112
-
2032
725
125
-
2033
735
135
-
2034
746
146
-
2031
600
112
712
2031
600
712
-
2032
600
125
725
2032
600
725
-
2033
600
135
735
2033
600
735
-
2034
600
146
746
2034
600
746
-
2035
600
165
765
CHO FotF produced AFTER CMO swa

2015
2016
-
2035
600
765
-
CHO FotF production AFTER CMO sw

2015
2016
-
712
2031
80
300
477
20
877
2031
40
150
239
10
725
2032
75
300
477
20
872
2032
38
150
239
10
735
2033
60
300
477
20
857
2033
30
150
239
10
746
2034
55
300
477
20
852
2034
28
150
239
10
765
2035
55
300
477
20
852
Total CHO new demanded (kg/yr)

2015
2016
-
2035
28
150
239
10
Internal CHO new demanded (kg/yr)

2015
2016
-
439
2031
80
380
857
877
877
2031
40
190
429
436
2032
75
375
852
872
872
2032
38
188
426
429
2033
60
360
837
857
857
2033
30
180
419
426
2034
55
355
832
852
852
2034
28
178
416
426
2035
55
355
832
852
852
Total CHO new demand buildup (kg/

2015
2016
-
2035
28
178
416
Internal CHO new demand buildup (

2015
2016
-
439
439
436
436
429
429
426
426
426
426
2031
3
-
2032
3
-
2033
3
-
2034
3
-
2035
3
-

2015
2016
-
pacity (kg/yr)
2017
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
2017
2018
2019
2020
2021
2022
2023
2024
oduction ranking
2017
2018
2019
2020
2021
2022
2023
2024
st ranking
oduction sequence
2017
2018
2019
2020
2021
2022
2023
2024
nked production (kg/yr)

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
oduced (kg/yr)
2017
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
ckflow allowed (kg/yr)

2017
-
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
ax CMO swapback allowed (kg/yr)

2017
2018
-
2020
-
2021
-
2022
-
2023
-
2024
-
nmet production before CMO swapback (kg/yr)

2017
2018
2019
2020
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
2021
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
2022
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
2023
40
40
40
40
40
40
40
40
40
40
40
40
40
40
40
40
40
40
40
2024
50
50
50
50
50
50
50
50
50
50
50
50
50
50
50
50
50
50
50
MO swapback (kg/yr)
2017
-
2020
-
2021
-
2022
-
2023
-
2024
-
nmet production AFTER CMO swapback (kg/yr)

2017
2018
2019
2020
10
10
10
10
2021
20
20
20
20
2022
30
30
30
30
2023
40
40
40
40
2024
50
50
50
50
2018
-
2019
-
2019
-
10
10
10
10
10
10
10
10
10
10
10
10
10
10
20
20
20
20
20
20
20
20
20
20
20
20
20
20
30
30
30
30
30
30
30
30
30
30
30
30
30
30
40
40
40
40
40
40
40
40
40
40
40
40
40
40
50
50
50
50
50
50
50
50
50
50
50
50
50
50
2020
-
2021
-
2022
-
2023
-
2024
-
oduction AFTER CMO swapback buildup (kg/yr)

2017
2018
2019
2020
-
2021
-
2022
-
2023
-
2024
-
oduced AFTER CMO swapback (kg/yr)

2017
2018
2019
-
ew demanded (kg/yr)
2017
-
2018
-
2019
-
2020
20
20
2021
20
20
40
2022
20
20
20
60
2023
20
20
20
20
81
2024
20
20
20
20
20
100
O new demanded (kg/yr)

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50
ew demand buildup (kg/yr)

2017
2018
-
2019
-
2020
20
20
2021
20
40
40
2022
20
40
60
60
2023
20
41
60
81
81
2024
20
40
60
80
100
100
O new demand buildup (kg/yr)

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
20
20
10
20
30
30
10
20
30
40
40
10
20
30
40
50
50
2020
-
2021
-
2022
-
2023
-
2024
-
mpaign count
2017
-
2018
-
2019
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
60
60
60
60
60
60
60
60
60
60
60
60
60
60
60
60
60
60
60
2026
70
70
70
70
70
70
70
70
70
70
70
70
70
70
70
70
70
70
70
2027
80
80
80
80
80
80
80
80
80
80
80
80
80
80
80
80
80
80
80
2028
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
2029
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
2030
109
109
109
109
109
109
109
109
109
109
109
109
109
109
109
109
109
109
109
2031
119
119
119
119
119
119
119
119
119
119
119
119
119
119
119
119
119
119
119
2032
128
128
128
128
128
128
128
128
128
128
128
128
128
128
128
128
128
128
128
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
60
60
60
60
2026
70
70
70
70
2027
80
80
80
80
2028
90
90
90
90
2029
100
100
100
100
2030
109
109
109
109
2031
119
119
119
119
2032
128
128
128
128
60
60
60
60
60
60
60
60
60
60
60
60
60
60
70
70
70
70
70
70
70
70
70
70
70
70
70
70
80
80
80
80
80
80
80
80
80
80
80
80
80
80
90
90
90
90
90
90
90
90
90
90
90
90
90
90
100
100
100
100
100
100
100
100
100
100
100
100
100
100
109
109
109
109
109
109
109
109
109
109
109
109
109
109
119
119
119
119
119
119
119
119
119
119
119
119
119
119
128
128
128
128
128
128
128
128
128
128
128
128
128
128
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2025
20
20
20
20
20
20
120
2026
20
20
20
20
20
20
20
140
2027
20
20
20
20
20
20
20
20
159
2028
20
20
20
20
20
20
20
20
20
180
2029
20
20
20
19
20
20
20
20
20
19
200
2030
20
20
20
20
20
20
20
20
20
20
20
219
2031
20
19
20
20
20
20
20
20
20
20
20
20
238
2032
20
20
20
20
19
20
19
20
19
20
19
20
20
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
2025
20
40
59
80
100
120
120
2026
20
40
60
81
100
120
140
140
2027
20
40
60
80
100
120
140
159
159
2028
20
40
60
80
100
120
140
160
180
180
2029
20
40
61
80
100
120
140
161
181
200
200
2030
20
40
60
80
100
120
139
159
179
199
219
219
2031
20
39
60
80
99
119
139
159
179
199
218
238
238
2032
20
40
60
79
99
119
138
158
178
197
217
237
257
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
20
30
40
50
60
60
10
20
30
40
50
60
70
70
10
20
30
40
50
60
70
80
80
10
20
30
40
50
60
70
80
90
90
10
20
30
40
50
60
70
80
90
100
100
10
20
30
40
50
60
70
80
90
99
109
109
10
20
30
40
50
59
69
79
89
99
109
119
119
10
20
30
40
49
59
69
79
89
99
108
119
128
128
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
CHO CMO capacity (kg/yr)

2015
2016
2017
403
403
403
403
403
403
2033
2034
2035
CHO CMO cost ranking

2015
2016
14
2033
2034
2035
14
2017
14
CHO CMO production ranking

2015
2016
2017
CHO CMO production sequence

2033
2034
2035
CMO: CHO -CMO: CHO CMO: CHO
2033
-
2034
-
2035
-
CHO CMO ranked production (kg/yr)

2015
2016
2017
403
403
403
-
2033
-
2033
-
2034
-
2034
-
2035
-
CHO CMO produced (kg/yr)

2015
2016
2017
65
95
163
65
95
163
2035
-
CHO CMO backflow allowed (kg/yr)

2015
2016
2017
338
309
240
-
2033
-
2034
-
338
309
240
2035
-
CHO Combined max CMO swapback allowed (kg/yr)

2015
2016
2017
65
95
123
2033
140
140
140
140
140
140
140
140
140
140
140
140
140
140
140
140
140
140
140
2034
149
149
149
149
149
149
149
149
149
149
149
149
149
149
149
149
149
149
149
2035
158
158
158
158
158
158
158
158
158
158
158
158
158
158
158
158
158
158
158
CHO CMO unmet production before CMO swapback (

2015
2016
2017
65
95
163
-
2033
-
2034
-
2035
-

2015
2016
2017
-
2035
158
158
158
158
CHO CMO unmet production AFTER CMO swapback (

2015
2016
2017
65
95
163
-
2033
140
140
140
140
2034
149
149
149
149
140
140
140
140
140
140
140
140
140
140
140
140
140
140
149
149
149
149
149
149
149
149
149
149
149
149
149
149
158
158
158
158
158
158
158
158
158
158
158
158
158
158
2033
-
2034
-
2035
-
2033
-
2034
-
2035
-
CHO CMO produced AFTER CMO swapback (kg/yr)

2015
2016
2017
65
95
163
65
95
163
2033
20
20
20
20
20
20
20
20
20
20
20
20
20
20
281
2033
-
2034
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
297
2034
-
2035
- Total Demand
- Total Supplied
- Total Unmet
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
19
316
2035
-
Checksum
2015
2016
2017
130
189
326
130
189
326
OK
OK
OK
External CHO old demanded (kg/yr)

2015
2016
2017
45
55
64
20
40
99
-
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
2033
20
40
60
80
100
120
140
160
180
199
220
240
260
281
281
2034
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
297
2035
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
316
316
2033
-
2034
-
2035
-
65
95
163
10
20
30
40
50
60
70
80
90
100
110
120
130
140
140
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
149
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
158
158
2033
-
2034
-
2035
-
2018
403
403
2019
403
403
2020
403
403
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
2019
2020
2021
2022
2023
2024
2025
14
14
14
14
14
14
14
14
2018
2019
2020
2021
2022
2023
2024
2025
CMO: CHO CMO: CHO CMO: CHO CMO: CHO -CMO: CHO -CMO: CHO -CMO: CHO -CMO: CHO -
ction (kg/yr)
2018
403
-
2019
403
-
2020
403
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
229
229
2019
308
308
2020
366
366
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
174
-
2019
95
-
2020
37
-
2021
-
2022
-
2023
-
2024
-
2025
-
wed (kg/yr)
174
95
37
O swapback allowed (kg/yr)

2018
2019
229
308
2020
345
2021
387
2022
406
2023
419
2024
438
2025
433
ction before CMO swapback (kg/yr)

2018
2019
2020
229
308
366
-
2021
426
23
23
23
23
23
23
23
23
23
23
23
23
23
23
23
23
23
23
2022
466
62
62
62
62
62
62
62
62
62
62
62
62
62
62
62
62
62
62
2023
500
97
97
97
97
97
97
97
97
97
97
97
97
97
97
97
97
97
97
2024
538
135
135
135
135
135
135
135
135
135
135
135
135
135
135
135
135
135
135
2025
573
170
170
170
170
170
170
170
170
170
170
170
170
170
170
170
170
170
170
2020
-
2021
23
2022
62
2023
97
2024
135
2025
170
ction AFTER CMO swapback (kg/yr)

2018
2019
2020
229
308
366
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
-
2019
-
TER CMO swapback (kg/yr)

2018
2019
229
308
229
308
2020
366
366
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
457
457
OK
2019
616
616
OK
2020
711
711
OK
2021
813
813
OK
2022
871
871
OK
2023
919
919
OK
2024
976
976
OK
2025
1,026
1,026
OK
nded (kg/yr)
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
229
308
345
387
406
419
438
453
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
2027
2028
2029
2030
2031
2032
2033
14
14
14
14
14
14
14
14
2026
2027
2028
2029
2030
2031
2032
2033
CMO: CHO -CMO: CHO -CMO: CHO -CMO: CHO CMO:

CHO -CMO: CHO -CMO: CHO -CMO: CHO -
2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
413
2027
399
2028
383
2029
411
2030
428
2031
439
2032
436
2033
429
2026
612
209
209
209
209
209
209
209
209
209
209
209
209
209
209
209
209
209
209
2027
646
243
243
243
243
243
243
243
243
243
243
243
243
243
243
243
243
243
243
2028
683
279
279
279
279
279
279
279
279
279
279
279
279
279
279
279
279
279
279
2029
675
272
272
272
272
272
272
272
272
272
272
272
272
272
272
272
272
272
272
2030
677
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
2031
677
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
274
2032
693
289
289
289
289
289
289
289
289
289
289
289
289
289
289
289
289
289
289
2033
709
306
306
306
306
306
306
306
306
306
306
306
306
306
306
306
306
306
306
2026
209
2027
243
2028
279
2029
272
2030
274
2031
274
2032
289
2033
306
2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
1,085
1,085
OK
2027
1,133
1,133
OK
2026
150
150
162
10
2028
1,185
1,185
OK
2027
150
150
177
10
2029
1,149
1,149
OK
2028
150
150
193
10
2030
1,135
1,135
OK
2029
100
150
215
10
2031
1,115
1,115
OK
2030
63
150
236
10
2032
1,129
1,129
OK
2031
40
150
239
10
2033
1,138
1,138
OK
2032
38
150
239
10
2033
30
150
239
10
472
487
503
475
458
439
436
429
2034
403
403
2035
403
403
2034
2035
14
14
2034
2035
CMO: CHO -CMO: CHO - Current
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
-
2035
-
2034
426
2035
426
2034
723
320
320
320
320
320
320
320
320
320
320
320
320
320
320
320
320
320
320
2035
742
339
339
339
339
339
339
339
339
339
339
339
339
339
339
339
339
339
339
2034
320
2035
339
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
1,149
1,149
OK
2035
1,168
1,168
OK
2034
28
150
239
10
2035
28
150
239
10
External CHO new demanded (kg/yr)

2015
2016
2017
2018
-
2019
-
426
426
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
ARCHITECTURE B
Plant active
2015
1
1
1
-
2016
1
1
1
-
2017
1
1
-
2018
1
1
1
-
2019
1
1
1
-

2015
286
240
526
2015
13
8
CHO current production ran

2015
2
1
CHO current production seq

Ranking
2015
1 WAG
2 OSS BIO curr
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Ranking
1
2
3
4
5
CHO current ranked produc

2015
240
286
-
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced (kg/y

Ranking
2015
1
65
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
65
CHO current backflow allow

Ranking
2015
1
175
2
286
3
4
5
6
7
8
9
-
10
11
12
13
14
15
16
17
18
461
CHO current max CMO swa

2015
65

2015
65
-
CHO current CMO swapback

2015
-

2015
65
-
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced AFTE

2015
65
65
CHO current production AFT

Ranking
2015
1
65
2
3
4
5
6
7
-
8
9
10
11
12
13
14
15
16
17
18
65
Total CHO old demanded (k

2015
90
40
130
Internal CHO old demand (k

2015
45
20
-
65
Total CHO old demand build

2015
90
130
130
Internal CHO old demand b

2015
45
65
-
65
2015
2
-

2016
286
240
526

2016
13
8
2017
286
286
2018
286
600
886
2019
286
600
886
2020
286
600
1,080
1,966
2021
286
600
1,080
1,966
2022
286
600
1,080
1,966
2017
13
2018
13
2019
13
2020
13
2021
13
2022
13
2020
2021
2022

2016
2017
2018
2019
2
1

2016
2017
2018
2019
2020
2021
2022
WAG
OSS BIO curr OSS BIO upgrOSS BIO upgrStainless ste Stainless s Stainless s
OSS BIO curr
OSS BIO curr OSS BIO curr OSS BIO upgrOSS BIO upOSS BIO up
OSS BIO curr OSS BIO cuOSS BIO cu

2016
2017
240
286
286
-
2018
600
286
-
2019
600
286
-
2020
1,080
600
286
-
2021
1,080
600
286
-
2022
1,080
600
286
-

2016
95
95
2017
163
163
2018
229
229
2019
308
308
2020
345
345
2021
387
387
2022
406
406

2016
2017
146
123
286
-
2018
371
286
-
2019
292
286
-
2020
735
600
286
-
2021
693
600
286
-
2022
674
600
286
-
431
123
657
577
1,620
1,579
1,560

2016
2017
2018
95
123
229
2019
308
2020
345
2021
387
2022
406

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
387
-
2022
406
-

2016
2017
-
2019
-
2020
-
2021
3
2022
30

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
390
-
2022
436
-
2018
-

2016
2017
2018
95
163
229
95
163
229
2019
308
308
2020
345
345
2021
390
390
2022
436
436

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
390
-
2022
436
-
95
163
229
308
345
390
436

2016
2017
109
128
80
198
189
326
2018
162
242
53
457
2019
200
308
88
20
616
2020
250
300
121
20
691
2021
300
300
153
20
773
2022
300
300
191
20
811

2016
2017
55
64
40
99
-
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
95
163
229
308
345
387
406

2016
2017
109
128
189
326
189
326
2018
162
404
457
457
2019
200
508
596
616
616
2020
250
550
671
691
691
2021
300
600
753
773
773
2022
300
600
791
811
811

2016
2017
55
64
95
163
-
2018
81
202
229
2019
100
254
298
2020
125
275
335
2021
150
300
377
2022
150
300
396
95
163
229
308
308
345
345
387
387
406
406
imal campaign count

2016
2
-
2017
2
-
2018
3
-
2019
4
-
2020
4
-
2021
2
-
2022
2
-
2023
286
600
1,080
1,966
2024
286
600
1,080
1,966
2025
286
600
1,080
1,966
2026
286
600
1,080
1,966
2027
286
600
1,080
1,966
2028
286
600
1,080
1,966
2029
286
600
1,080
1,966
2030
286
600
1,080
1,966
2023
13
2024
13
2025
13
2026
13
2027
13
2028
13
2029
13
2030
13
2023
2024
2025
2026
2027
2028
2029
2030
2023
2024
2025
2026
2027
2028
2029
2030
Stainless s Stainless s Stainless s Stainless s Stainless s Stainless s Stainless s Stainless s
2023
1,080
600
286
-
2024
1,080
600
286
-
2025
1,080
600
286
-
2026
1,080
600
286
-
2027
1,080
600
286
-
2028
1,080
600
286
-
2029
1,080
600
286
-
2030
1,080
600
286
-
2023
419
419
2024
438
438
2025
453
453
2026
472
472
2027
487
487
2028
503
503
2029
475
475
2030
458
458
2023
661
600
286
-
2024
642
600
286
-
2025
627
600
286
-
2026
608
600
286
-
2027
593
600
286
-
2028
577
600
286
-
2029
605
600
286
-
2030
622
600
286
-
1,546
1,528
1,513
1,493
1,479
1,463
1,491
1,508
2023
419
2024
438
2025
453
2026
472
2027
487
2028
503
2029
475
2030
458
2023
419
-
2024
438
-
2025
453
-
2026
472
-
2027
487
-
2028
503
-
2029
475
-
2030
458
-
2023
51
2024
76
2025
97
2026
121
2027
140
2028
161
2029
142
2030
132
2023
471
-
2024
514
-
2025
550
-
2026
593
-
2027
627
-
2028
664
-
2029
616
-
2030
590
-
2023
471
471
2024
514
514
2025
550
550
2026
593
593
2027
627
627
2028
664
664
2029
616
616
2030
590
590
2023
471
-
2024
514
-
2025
550
-
2026
593
-
2027
627
-
2028
664
-
2029
616
-
2030
590
-
471
514
550
593
627
664
616
590
2023
300
300
218
20
838
2024
300
300
256
20
875
2025
300
300
286
20
906
2026
300
300
324
20
945
2027
300
300
354
20
974
2028
300
300
385
20
1,006
2029
200
300
430
20
949
2030
125
300
471
20
916
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
2026
150
150
162
10
2027
150
150
177
10
2028
150
150
193
10
2029
100
150
215
10
2030
63
150
236
10
419
438
453
472
487
503
475
458
2023
300
600
818
838
838
2024
300
600
856
875
875
2025
300
600
886
906
906
2026
300
600
924
945
945
2027
300
600
954
974
974
2028
300
600
985
1,006
1,006
2029
200
500
930
949
949
2030
125
425
896
916
916
2023
150
300
409
2024
150
300
428
2025
150
300
443
2026
150
300
462
2027
150
300
477
2028
150
300
493
2029
100
250
465
2030
63
213
448
419
419
438
438
453
453
472
472
487
487
503
503
475
475
458
458
2023
2
-
2024
2
-
2025
2
-
2026
2
-
2027
3
-
2028
3
-
2029
3
-
2030
3
-
2031
286
600
1,080
1,966
2032
286
600
1,080
1,966
2033
286
600
1,080
1,966
2034
286
600
1,080
1,966
2035
286
600
1,080
1,966
2031
13
2032
13
2033
13
2034
13
2035
13
2031
2032
2033
2034
2035

2015
2016
2015
2016

2015
2016

2031
2032
2033
2034
2035
2015
2016
Stainless s Stainless s Stainless s Stainless s Stainless steel (large)
2031
1,080
600
286
-
2032
1,080
600
286
-
2033
1,080
600
286
-
2034
1,080
600
286
-
2035
1,080
600
286
-

2015
2016
-
2031
439
439
2031
641
600
286
-
2032
436
436
2032
644
600
286
-
2033
429
429
2033
651
600
286
-
2034
426
426
2034
654
600
286
-
2035
426
426

2015
2016
-
2035
654
600
286
-

2015
2016
-
1,527
1,530
1,537
1,540
1,540
2031
439
2032
436
2033
429
2034
426
2035
426

2015
2016
-
2031
439
-
2032
436
-
2033
429
-
2034
426
-
2035
426
-

2015
2016
-
2031
121
2032
125
2033
125
2034
127
2035
132

2015
2016
-
2035
558
-

2015
2016
-
2031
560
-
2032
561
-
2033
553
-
2034
553
-
2031
560
560
2031
560
-
2032
561
561
2032
561
-
2033
553
553
2033
553
-
2034
553
553
2034
553
-
2035
558
558

2015
2016
-
2035
558
-

2015
2016
-
560
2031
80
300
477
20
877
2031
40
150
239
10
561
2032
75
300
477
20
872
2032
38
150
239
10
553
2033
60
300
477
20
857
2033
30
150
239
10
553
2034
55
300
477
20
852
2034
28
150
239
10
558
2035
55
300
477
20
852

2015
2016
-
2035
28
150
239
10

2015
2016
-
439
2031
80
380
857
877
877
2031
40
190
429
436
2032
75
375
852
872
872
2032
38
188
426
429
2033
60
360
837
857
857
2033
30
180
419
426
2034
55
355
832
852
852
2034
28
178
416
426
2035
55
355
832
852
852

2015
2016
-
2035
28
178
416

2015
2016
-
439
439
436
436
429
429
426
426
426
426
2031
3
-
2032
3
-
2033
3
-
2034
3
-
2035
3
-

2015
2016
-
pacity (kg/yr)
2017
-
2018
-
2019
-
2020
2,160
2,160
2021
2,160
2,160
2022
2,160
2,160
2023
2,160
2,160
2024
2,160
2,160
2017
2018
2019
2020
2021
2022
2023
2024
2020
2021
2022
2023
2024
st ranking
oduction ranking
2017
2018
2019
oduction sequence
2017
2018
2019

2017
2018
-
2019
-
2020
2021
2022
2023
2024
Fed batch Fed batch Fed batch Fed batch Fed batch
2020
2,160
-
2021
2,160
-
2022
2,160
-
2023
2,160
-
2024
2,160
-
oduced (kg/yr)
2017
-
2018
-
2019
-
2020
10
10
2021
20
20
2022
30
30
2023
40
40
2024
50
50

2017
-
2018
-
2019
-
2020
2,150
-
2021
2,140
-
2022
2,130
-
2023
2,120
-
2024
2,110
-
2,150
2,140
2,130
2,120
2,110
2020
10
2021
20
2022
30
2023
40
2024
50

2017
2018
2019
2020
10
-
2021
20
-
2022
30
-
2023
40
-
2024
50
-
MO swapback (kg/yr)
2017
-
2020
-
2021
0
2022
2
2023
5
2024
9

2017
2018
2019
2020
10
-
2021
20
-
2022
32
-
2023
45
-
2024
59
-

2017
2018
-
2018
-
2019
-
2019
-

2017
2018
2019
-
2020
10
10
2021
20
20
2022
32
32
2023
45
45
2024
59
59

2017
2018
2019
2020
10
-
2021
20
-
2022
32
-
2023
45
-
2024
59
-
ew demanded (kg/yr)
2017
-
10
20
32
45
59
2018
-
2019
-
2020
20
20
2021
20
20
40
2022
20
20
20
60
2023
20
20
20
20
81
2024
20
20
20
20
20
100

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50

2017
2018
-
2019
-
2020
20
20
2021
20
40
40
2022
20
40
60
60
2023
20
41
60
81
81
2024
20
40
60
80
100
100

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
20
20
10
20
30
30
10
20
30
40
40
10
20
30
40
50
50
2020
1
-
2021
1
-
2022
2
-
2023
3
-
2024
3
-
mpaign count
2017
-
2018
-
2019
-
2025
2,160
2,160
2026
2,160
2,160
2027
2,160
2,160
2028
2,160
2,160
2029
2,160
2,160
2030
2,160
2,160
2031
2,160
2,160
2032
2,160
2,160
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
Fed batch Fed batch Fed batch Fed batch Fed batch Fed batch Fed batch Fed batch
2025
2,160
-
2026
2,160
-
2027
2,160
-
2028
2,160
-
2029
2,160
-
2030
2,160
-
2031
2,160
-
2032
2,160
-
2025
60
60
2026
70
70
2027
80
80
2028
90
90
2029
100
100
2030
109
109
2031
119
119
2032
128
128
2025
2,100
-
2026
2,090
-
2027
2,080
-
2028
2,070
-
2029
2,060
-
2030
2,051
-
2031
2,041
-
2032
2,032
-
2,100
2,090
2,080
2,070
2,060
2,051
2,041
2,032
2025
60
2026
70
2027
80
2028
90
2029
100
2030
109
2031
119
2032
128
2025
60
-
2026
70
-
2027
80
-
2028
90
-
2029
100
-
2030
109
-
2031
119
-
2032
128
-
2025
13
2026
18
2027
23
2028
29
2029
30
2030
32
2031
33
2032
37
2025
73
-
2026
88
-
2027
103
-
2028
119
-
2029
130
-
2030
141
-
2031
152
-
2032
165
-
2025
73
73
2026
88
88
2027
103
103
2028
119
119
2029
130
130
2030
141
141
2031
152
152
2032
165
165
2025
73
-
2026
88
-
2027
103
-
2028
119
-
2029
130
-
2030
141
-
2031
152
-
2032
165
-
73
88
103
119
130
141
152
165
2025
20
20
20
20
20
20
120
2026
20
20
20
20
20
20
20
140
2027
20
20
20
20
20
20
20
20
159
2028
20
20
20
20
20
20
20
20
20
180
2029
20
20
20
19
20
20
20
20
20
19
200
2030
20
20
20
20
20
20
20
20
20
20
20
219
2031
20
19
20
20
20
20
20
20
20
20
20
20
238
2032
20
20
20
20
19
20
19
20
19
20
19
20
20
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
2025
20
40
59
80
100
120
120
2026
20
40
60
81
100
120
140
140
2027
20
40
60
80
100
120
140
159
159
2028
20
40
60
80
100
120
140
160
180
180
2029
20
40
61
80
100
120
140
161
181
200
200
2030
20
40
60
80
100
120
139
159
179
199
219
219
2031
20
39
60
80
99
119
139
159
179
199
218
238
238
2032
20
40
60
79
99
119
138
158
178
197
217
237
257
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
20
30
40
50
60
60
10
20
30
40
50
60
70
70
10
20
30
40
50
60
70
80
80
10
20
30
40
50
60
70
80
90
90
10
20
30
40
50
60
70
80
90
100
100
10
20
30
40
50
60
70
80
90
99
109
109
10
20
30
40
50
59
69
79
89
99
109
119
119
10
20
30
40
49
59
69
79
89
99
108
119
128
128
2025
4
-
2026
5
-
2027
6
-
2028
6
-
2029
7
-
2030
8
-
2031
8
-
2032
9
-
2033
2,160
2,160
2034
2,160
2,160
2035
2,160
2,160

2015
2016
2017
403
403
403
403
403
403
2033
2034
2035

2015
2016
14
2033
2034
2035
14
2017
14

2015
2016
2017

2033
2034
2035
Fed batch Fed batch Fed batch SU Intensified (h CMO: CHO -CMO: CHO CMO: CHO
2033
2,160
-
2034
2,160
-
2035
2,160
-

2015
2016
2017
403
403
403
-
2033
140
140
2033
2,020
-
2034
149
149
2034
2,011
-
2035
158
158

2015
2016
2017
65
95
163
65
95
163
2035
2,002
-

2015
2016
2017
338
309
240
-
2,020
2,011
2,002
338
309
240
2033
140
2034
149
2035
158

2015
2016
2017
65
95
123
2033
140
-
2034
149
-
2035
158
-

2015
2016
2017
65
95
163
-
2033
41
2034
44
2035
49

2015
2016
2017
-
2035
207
-

2015
2016
2017
65
95
163
-
2033
181
-
2034
193
-
2033
181
181
2034
193
193
2035
207
207
2033
181
-
2034
193
-
2035
207
-

2015
2016
2017
65
95
163
65
95
163
181
2033
20
20
20
20
20
20
20
20
20
20
20
20
20
20
281
2033
-
193
2034
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
297
2034
-
207
2035
- Total Demand
- Total Supplied
- Total Unmet
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
19
316
2035
-
Checksum
2015
2016
2017
130
189
326
130
189
326
OK
OK
OK

2015
2016
2017
45
55
64
20
40
99
-
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
2033
20
40
60
80
100
120
140
160
180
199
220
240
260
281
281
2034
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
297
2035
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
316
316
2033
-
2034
-
2035
-
65
95
163
10
20
30
40
50
60
70
80
90
100
110
120
130
140
140
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
149
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
158
158
2033
10
-
2034
10
-
2035
11
-
2018
403
403
2019
403
403
2020
403
403
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
2019
2020
2021
2022
2023
2024
2025
14
14
14
14
14
14
14
14
2018
2019
2020
2021
2022
2023
2024
2025
ction (kg/yr)
2018
403
-
2019
403
-
2020
403
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
229
229
2019
308
308
2020
356
356
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
174
-
2019
95
-
2020
48
-
2021
-
2022
-
2023
-
2024
-
2025
-
wed (kg/yr)
174
95
48

2018
2019
229
308
2020
356
2021
407
2022
436
2023
460
2024
488
2025
513

2018
2019
2020
229
308
356
-
2021
407
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2022
436
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
2023
460
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
2024
488
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
2025
513
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
2020
-
2021
3
2022
32
2023
56
2024
85
2025
110

2018
2019
2020
229
308
356
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
-
2019
-

2018
2019
229
308
229
308
2020
356
356
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
457
457
OK
2019
616
616
OK
2020
711
711
OK
2021
813
813
OK
2022
871
871
OK
2023
919
919
OK
2024
976
976
OK
2025
1,026
1,026
OK
nded (kg/yr)
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
229
308
345
387
406
419
438
453
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
2027
2028
2029
2030
2031
2032
2033
14
14
14
14
14
14
14
14
2026
2027
2028
2029
2030
2031
2032
2033

2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
542
2027
567
2028
593
2029
575
2030
567
2031
558
2032
564
2033
569
2026
542
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
2027
567
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
2028
593
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
2029
575
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
2030
567
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
2031
558
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
2032
564
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
2033
569
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
2026
139
2027
163
2028
190
2029
172
2030
164
2031
154
2032
161
2033
166
2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
1,085
1,085
OK
2027
1,133
1,133
OK
2026
150
150
162
10
2028
1,185
1,185
OK
2027
150
150
177
10
2029
1,149
1,149
OK
2028
150
150
193
10
2030
1,135
1,135
OK
2029
100
150
215
10
2031
1,115
1,115
OK
2030
63
150
236
10
2032
1,129
1,129
OK
2031
40
150
239
10
2033
1,138
1,138
OK
2032
38
150
239
10
2033
30
150
239
10
472
487
503
475
458
439
436
429
2034
403
403
2035
403
403
2034
2035
14
14
2034
2035
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
-
2035
-
2034
574
2035
584
2034
574
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
2035
584
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
2034
171
2035
181
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
1,149
1,149
OK
2035
1,168
1,168
OK
2034
28
150
239
10
2035
28
150
239
10

2015
2016
2017
2018
-
2019
-
426
426
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
ARCHITECTURE C
Plant active
2015
1
1
1
-
2016
1
1
1
-
2017
1
1
-
2018
1
1
1
-
2019
1
1
1
1
-
2020
1
1
1
1
-
2021
1
1
1
1
-
2022
1
1
1
1
-
2023
1
1
1
1
-
2024
1
1
1
1
-
2025
1
1
1
1
-
2026
1
1
1
1
-
2027
1
1
1
1
-
2028
1
1
1
1
-
2029
1
1
1
1
-
2030
1
1
1
1
-
2031
1
1
1
1
-
2032
1
1
1
1
-
2033
1
1
1
1
-
2034
1
1
1
1
-
2035
1
1
1
1
-

2015
286
240
526
2015
13
8
CHO current production ra

2015
2
1
CHO current production se

Ranking
2015
1 WAG
2 OSS BIO curr
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Ranking
1
2
3
4
5
CHO current ranked produ

2015
240
286
-
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced (kg

Ranking
2015
1
65
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
65
CHO current backflow allo

Ranking
2015
1
175
2
286
3
4
5
6
7
8
9
-
10
11
12
13
14
15
16
17
18
461
CHO current max CMO sw

2015
65
CHO current unmet produc

2015
65
-
CHO current CMO swapba

2015
-

2015
65
-
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced AFT

2015
65
65
CHO current production AF

Ranking
2015
1
65
2
3
4
5
6
7
-
8
9
10
11
12
13
14
15
16
17
18
65
Total CHO old demanded (

2015
90
40
130
Internal CHO old demand
2015
45
20
-
65
Total CHO old demand bui

2015
90
130
130
2015
45
65
-
65
2015
2
-

2016
286
240
526

2016
13
8
2017
286
286
2018
286
600
886
2019
286
600
886
2020
286
600
886
2021
286
600
886
2022
286
600
886
2017
13
2018
13
2019
13
2020
13
2021
13
2022
13
2018
2019
2020
2021
2022

2016
2017
2
1

2016
2017
2018
2019
2020
2021
2022
WAG
OSS BIO curr

2016
2017
240
286
286
-
2018
600
286
-
2019
600
286
-
2020
600
286
-
2021
600
286
-
2022
600
286
-

2016
95
95
2017
163
163
2018
229
229
2019
308
308
2020
345
345
2021
387
387
2022
406
406

2016
2017
146
123
286
-
2018
371
286
-
2019
292
286
-
2020
255
286
-
2021
213
286
-
2022
194
286
-
431
123
657
577
540
499
480

2016
2017
2018
95
123
229
2019
308
2020
345
2021
387
2022
406

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
387
-
2022
406
-

2016
2017
-
2019
-
2020
-
2021
3
2022
30

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
390
-
2022
436
-
2018
-

2016
2017
2018
95
163
229
95
163
229
2019
308
308
2020
345
345
2021
390
390
2022
436
436

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
390
-
2022
436
-
95
163
229
308
345
390
436

2016
2017
109
128
80
198
189
326
2018
162
242
53
457
2019
200
308
88
20
616
2020
250
300
121
20
691
2021
300
300
153
20
773
2022
300
300
191
20
811

2016
2017
55
64
40
99
-
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
95
163
229
308
345
387
406

2016
2017
109
128
189
326
189
326
2018
162
404
457
457
2019
200
508
596
616
616
2020
250
550
671
691
691
2021
300
600
753
773
773
2022
300
600
791
811
811

2016
2017
55
64
95
163
-
2018
81
202
229
2019
100
254
298
2020
125
275
335
2021
150
300
377
2022
150
300
396
95
163
229
308
308
345
345
387
387
406
406
imal campaign count

2016
2
-
2017
2
-
2018
3
-
2019
4
-
2020
4
-
2021
2
-
2022
2
-
2023
286
600
886
2024
286
600
886
2025
286
600
886
2026
286
600
886
2027
286
600
886
2028
286
600
886
2029
286
600
886
2030
286
600
886
2023
13
2024
13
2025
13
2026
13
2027
13
2028
13
2029
13
2030
13
2023
2024
2025
2026
2027
2028
2029
2030
2023
2024
2025
2026
2027
2028
2029
2030
2023
600
286
-
2024
600
286
-
2025
600
286
-
2026
600
286
-
2027
600
286
-
2028
600
286
-
2029
600
286
-
2030
600
286
-
2023
419
419
2024
438
438
2025
453
453
2026
472
472
2027
487
487
2028
503
503
2029
475
475
2030
458
458
2023
181
286
-
2024
162
286
-
2025
147
286
-
2026
128
286
-
2027
113
286
-
2028
97
286
-
2029
125
286
-
2030
142
286
-
466
448
433
413
399
383
411
428
2023
419
2024
438
2025
433
2026
413
2027
399
2028
383
2029
411
2030
428
2023
419
-
2024
438
-
2025
453
-
2026
472
-
2027
487
-
2028
503
-
2029
475
-
2030
458
-
2023
51
2024
76
2025
97
2026
119
2027
136
2028
153
2029
138
2030
131
2023
471
-
2024
514
-
2025
550
-
2026
591
-
2027
623
23
-
2028
656
56
-
2029
613
13
-
2030
589
-
2023
471
471
2024
514
514
2025
550
550
2026
591
591
2027
600
23
623
2028
600
56
656
2029
600
13
613
2030
589
589
2023
471
-
2024
514
-
2025
550
-
2026
591
-
2027
600
623
-
2028
600
656
-
2029
600
613
-
2030
589
-
471
514
550
591
623
656
613
589
2023
300
300
218
20
838
2024
300
300
256
20
875
2025
300
300
286
20
906
2026
300
300
324
20
945
2027
300
300
354
20
974
2028
300
300
385
20
1,006
2029
200
300
430
20
949
2030
125
300
471
20
916
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
2026
150
150
162
10
2027
150
150
177
10
2028
150
150
193
10
2029
100
150
215
10
2030
63
150
236
10
419
438
453
472
487
503
475
458
2023
300
600
818
838
838
2024
300
600
856
875
875
2025
300
600
886
906
906
2026
300
600
924
945
945
2027
300
600
954
974
974
2028
300
600
985
1,006
1,006
2029
200
500
930
949
949
2030
125
425
896
916
916
2023
150
300
409
2024
150
300
428
2025
150
300
443
2026
150
300
462
2027
150
300
477
2028
150
300
493
2029
100
250
465
2030
63
213
448
419
419
438
438
453
453
472
472
487
487
503
503
475
475
458
458
2023
2
-
2024
2
-
2025
2
-
2026
2
-
2027
2
1
-
2028
2
1
-
2029
3
-
2030
3
-
2031
286
600
886
2032
286
600
886
2033
286
600
886
2034
286
600
886
2035
286
600
886
2031
13
2032
13
2033
13
2034
13
2035
13
2031
2032
2033
2034
2035

2015
2016
2015
2016

2015
2016
2031
2032
2033
2034
2035
2031
600
286
-
2032
600
286
-
2033
600
286
-
2034
600
286
-
2035
600
286
-

2015
2016

2015
2016
-
2031
439
439
2031
161
286
-
2032
436
436
2032
164
286
-
2033
429
429
2033
171
286
-
2034
426
426
2034
174
286
-
2035
426
426

2015
2016
-
2035
174
286
-

2015
2016
-
447
450
457
460
460
2031
439
2032
436
2033
429
2034
426
2035
426

2015
2016
-
2031
439
-
2032
436
-
2033
429
-
2034
426
-
2035
426
-

2015
2016
-
2031
121
2032
125
2033
125
2034
127
2035
132

2015
2016
-
2035
558
-

2015
2016
-
2031
560
-
2032
561
-
2033
553
-
2034
553
-
2031
560
560
2031
560
-
2032
561
561
2032
561
-
2033
553
553
2033
553
-
2034
553
553
2034
553
-
2035
558
558

2015
2016
-
2035
558
-

2015
2016
-
560
2031
80
300
477
20
877
2031
40
150
239
10
561
2032
75
300
477
20
872
2032
38
150
239
10
553
2033
60
300
477
20
857
2033
30
150
239
10
553
2034
55
300
477
20
852
2034
28
150
239
10
558
2035
55
300
477
20
852

2015
2016
-
2035
28
150
239
10

2015
2016
-
439
2031
80
380
857
877
877
2031
40
190
429
436
2032
75
375
852
872
872
2032
38
188
426
429
2033
60
360
837
857
857
2033
30
180
419
426
2034
55
355
832
852
852
2034
28
178
416
426
2035
55
355
832
852
852

2015
2016
-
2035
28
178
416

2015
2016
-
439
439
436
436
429
429
426
426
426
426
2031
3
-
2032
3
-
2033
3
-
2034
3
-
2035
3
-

2015
2016
-
pacity (kg/yr)
2017
-
2018
-
2019
2,160
2,160
2020
2,160
2,160
2021
2,160
2,160
2022
2,160
2,160
2023
2,160
2,160
2024
2,160
2,160
2017
2018
2019
2020
2021
2022
2023
2024
2019
2020
2021
2022
2023
2024
st ranking
oduction ranking
2017
2018
oduction sequence
2017
2018

2017
2018
-
2019
2020
2021
2022
2023
2024
Fed batch Fed batch Fed batch Fed batch Fed batch Fed batch
2019
2,160
-
2020
2,160
-
2021
2,160
-
2022
2,160
-
2023
2,160
-
2024
2,160
-
oduced (kg/yr)
2017
-
2018
-
2019
-
2020
10
10
2021
20
20
2022
30
30
2023
40
40
2024
50
50

2017
-
2018
-
2019
2,160
-
2020
2,150
-
2021
2,140
-
2022
2,130
-
2023
2,120
-
2024
2,110
-
2,160
2,150
2,140
2,130
2,120
2,110
2019
-
2020
10
2021
20
2022
30
2023
40
2024
50

2017
2018
2019
2020
10
-
2021
20
-
2022
30
-
2023
40
-
2024
50
-
MO swapback (kg/yr)
2017
-
2020
-
2021
0
2022
2
2023
5
2024
9

2017
2018
2019
2020
10
-
2021
20
-
2022
32
-
2023
45
-
2024
59
-

2017
2018
-
2018
-
2019
-

2017
2018
2019
-
2020
10
10
2021
20
20
2022
32
32
2023
45
45
2024
59
59

2017
2018
2019
2020
10
-
2021
20
-
2022
32
-
2023
45
-
2024
59
-
ew demanded (kg/yr)
2017
-
10
20
32
45
59
2018
-
2019
-
2020
20
20
2021
20
20
40
2022
20
20
20
60
2023
20
20
20
20
81
2024
20
20
20
20
20
100

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50

2017
2018
-
2019
-
2020
20
20
2021
20
40
40
2022
20
40
60
60
2023
20
41
60
81
81
2024
20
40
60
80
100
100

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
20
20
10
20
30
30
10
20
30
40
40
10
20
30
40
50
50
2020
1
-
2021
1
-
2022
2
-
2023
3
-
2024
3
-
mpaign count
2017
-
2018
-
2019
-
2025
2,160
2,160
2026
2,160
2,160
2027
2,160
2,160
2028
2,160
2,160
2029
2,160
2,160
2030
2,160
2,160
2031
2,160
2,160
2032
2,160
2,160
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
2025
2,160
-
2026
2,160
-
2027
2,160
-
2028
2,160
-
2029
2,160
-
2030
2,160
-
2031
2,160
-
2032
2,160
-
2025
60
60
2026
70
70
2027
80
80
2028
90
90
2029
100
100
2030
109
109
2031
119
119
2032
128
128
2025
2,100
-
2026
2,090
-
2027
2,080
-
2028
2,070
-
2029
2,060
-
2030
2,051
-
2031
2,041
-
2032
2,032
-
2,100
2,090
2,080
2,070
2,060
2,051
2,041
2,032
2025
60
2026
70
2027
80
2028
90
2029
100
2030
109
2031
119
2032
128
2025
60
-
2026
70
-
2027
80
-
2028
90
-
2029
100
-
2030
109
-
2031
119
-
2032
128
-
2025
13
2026
20
2027
27
2028
36
2029
34
2030
33
2031
33
2032
37
2025
73
-
2026
90
-
2027
107
-
2028
126
-
2029
134
-
2030
143
-
2031
152
-
2032
165
-
2025
73
73
2026
90
90
2027
107
107
2028
126
126
2029
134
134
2030
143
143
2031
152
152
2032
165
165
2025
73
-
2026
90
-
2027
107
-
2028
126
-
2029
134
-
2030
143
-
2031
152
-
2032
165
-
73
90
107
126
134
143
152
165
2025
20
20
20
20
20
20
120
2026
20
20
20
20
20
20
20
140
2027
20
20
20
20
20
20
20
20
159
2028
20
20
20
20
20
20
20
20
20
180
2029
20
20
20
19
20
20
20
20
20
19
200
2030
20
20
20
20
20
20
20
20
20
20
20
219
2031
20
19
20
20
20
20
20
20
20
20
20
20
238
2032
20
20
20
20
19
20
19
20
19
20
19
20
20
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
2025
20
40
59
80
100
120
120
2026
20
40
60
81
100
120
140
140
2027
20
40
60
80
100
120
140
159
159
2028
20
40
60
80
100
120
140
160
180
180
2029
20
40
61
80
100
120
140
161
181
200
200
2030
20
40
60
80
100
120
139
159
179
199
219
219
2031
20
39
60
80
99
119
139
159
179
199
218
238
238
2032
20
40
60
79
99
119
138
158
178
197
217
237
257
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
20
30
40
50
60
60
10
20
30
40
50
60
70
70
10
20
30
40
50
60
70
80
80
10
20
30
40
50
60
70
80
90
90
10
20
30
40
50
60
70
80
90
100
100
10
20
30
40
50
60
70
80
90
99
109
109
10
20
30
40
50
59
69
79
89
99
109
119
119
10
20
30
40
49
59
69
79
89
99
108
119
128
128
2025
4
-
2026
5
-
2027
6
-
2028
7
-
2029
7
-
2030
8
-
2031
8
-
2032
9
-
2033
2,160
2,160
2034
2,160
2,160
2035
2,160
2,160

2015
2016
2017
403
403
403
403
403
403
2033
2034
2035

2015
2016
14
2033
2034
2035
14
2017
14

2015
2016
2017

2033
2034
2035
Fed batch Fed batch Fed batch SU Intensified
2033
2,160
-
2034
2,160
-
2035
2,160
-
CMO: CHO -CMO: CHO CMO: CHO

2015
2016
2017
403
403
403
-
2033
140
140
2033
2,020
-
2034
149
149
2034
2,011
-
2035
158
158

2015
2016
2017
65
95
163
65
95
163
2035
2,002
-

2015
2016
2017
338
309
240
-
2,020
2,011
2,002
338
309
240
2033
140
2034
149
2035
158

2015
2016
2017
65
95
123
2033
140
-
2034
149
-
2035
158
-

2015
2016
2017
65
95
163
-
2033
41
2034
44
2035
49

2015
2016
2017
-
2035
207
-

2015
2016
2017
65
95
163
-
2033
181
-
2034
193
-
2033
181
181
2034
193
193
2035
207
207
2033
181
-
2034
193
-
2035
207
-

2015
2016
2017
65
95
163
65
95
163
181
2033
20
20
20
20
20
20
20
20
20
20
20
20
20
20
281
2033
-
193
2034
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
297
2034
-
207
2035
- Total Demand
- Total Supplied
- Total Unmet
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
19
316
2035
-
Checksum
2015
2016
2017
130
189
326
130
189
326
OK
OK
OK

2015
2016
2017
45
55
64
20
40
99
-
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
2033
20
40
60
80
100
120
140
160
180
199
220
240
260
281
281
2034
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
297
2035
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
316
316
2033
-
2034
-
2035
-
65
95
163
10
20
30
40
50
60
70
80
90
100
110
120
130
140
140
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
149
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
158
158
2033
10
-
2034
10
-
2035
11
-
2018
403
403
2019
403
403
2020
403
403
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
2019
2020
2021
2022
2023
2024
2025
14
14
14
14
14
14
14
14
2018
2019
2020
2021
2022
2023
2024
2025
ction (kg/yr)
2018
403
-
2019
403
-
2020
403
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
229
229
2019
308
308
2020
356
356
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
174
-
2019
95
-
2020
48
-
2021
-
2022
-
2023
-
2024
-
2025
-
wed (kg/yr)
174
95
48

2018
2019
229
308
2020
356
2021
407
2022
436
2023
460
2024
488
2025
493

2018
2019
2020
229
308
356
-
2021
407
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2022
436
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
2023
460
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
2024
488
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
2025
513
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
2020
-
2021
3
2022
32
2023
56
2024
85
2025
110

2018
2019
2020
229
308
356
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
-
2019
-

2018
2019
229
308
229
308
2020
356
356
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
457
457
OK
2019
616
616
OK
2020
711
711
OK
2021
813
813
OK
2022
871
871
OK
2023
919
919
OK
2024
976
976
OK
2025
1,026
1,026
OK
nded (kg/yr)
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
229
308
345
387
406
419
438
453
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
2027
2028
2029
2030
2031
2032
2033
14
14
14
14
14
14
14
14
2026
2027
2028
2029
2030
2031
2032
2033

2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
483
2027
478
2028
473
2029
511
2030
537
2031
558
2032
564
2033
569
2026
542
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
2027
567
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
2028
593
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
2029
575
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
2030
567
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
2031
558
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
2032
564
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
2033
569
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
2026
139
2027
163
2028
190
2029
172
2030
164
2031
154
2032
161
2033
166
2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
1,085
1,085
OK
2027
1,133
1,133
OK
2026
150
150
162
10
2028
1,185
1,185
OK
2027
150
150
177
10
2029
1,149
1,149
OK
2028
150
150
193
10
2030
1,135
1,135
OK
2029
100
150
215
10
2031
1,115
1,115
OK
2030
63
150
236
10
2032
1,129
1,129
OK
2031
40
150
239
10
2033
1,138
1,138
OK
2032
38
150
239
10
2033
30
150
239
10
472
487
503
475
458
439
436
429
2034
403
403
2035
403
403
2034
2035
14
14
2034
2035
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
-
2035
-
2034
574
2035
584
2034
574
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
2035
584
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
2034
171
2035
181
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
1,149
1,149
OK
2035
1,168
1,168
OK
2034
28
150
239
10
2035
28
150
239
10

2015
2016
2017
2018
-
2019
-
426
426
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
ARCHITECTURE D
Plant active
2015
1
1
1
-
2016
1
1
1
-
2017
1
1
-
2018
1
1
1
-
2019
1
1
1
1
-
2020
1
1
1
1
1
-
2021
1
1
1
1
1
-
2022
1
1
1
1
1
-
2023
1
1
1
1
1
-
2024
1
1
1
1
1
-
2025
1
1
1
1
1
-
2026
1
1
1
1
1
-
2027
1
1
1
1
1
-
2028
1
1
1
1
1
-
2029
1
1
1
1
1
-
2030
1
1
1
1
1
-
2031
1
1
1
1
1
-
2032
1
1
1
1
1
-
2033
1
1
1
1
1
-
2034
1
1
1
1
1
-
2035
1
1
1
1
1
-

2015
286
240
526
2015
13
8
CHO current production ra

2015
2
1
CHO current production se

Ranking
2015
1 WAG
2 OSS BIO curr
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Ranking
1
2
3
4
5
CHO current ranked produ

2015
240
286
-
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced (kg

Ranking
2015
1
65
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
65
CHO current backflow allo

Ranking
2015
1
175
2
286
3
4
5
6
7
8
9
-
10
11
12
13
14
15
16
17
18
461
CHO current max CMO sw

2015
65

2015
65
-
CHO current CMO swapba

2015
-

2015
65
-
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current produced AFT

2015
65
65
CHO current production AF

Ranking
2015
1
65
2
3
4
5
6
7
-
8
9
10
11
12
13
14
15
16
17
18
65
Total CHO old demanded (

2015
90
40
130
2015
45
20
-
65
Total CHO old demand bui

2015
90
130
130
2015
45
65
-
65
2015
2
-

2016
286
240
526

2016
13
8
2017
286
286
2018
286
600
886
2019
286
600
886
2020
286
600
886
2021
286
600
886
2022
286
600
886
2017
13
2018
13
2019
13
2020
13
2021
13
2022
13
2018
2019
2020
2021
2022

2016
2017
2
1

2016
2017
2018
2019
2020
2021
2022
WAG
OSS BIO curr

2016
2017
240
286
286
-
2018
600
286
-
2019
600
286
-
2020
600
286
-
2021
600
286
-
2022
600
286
-

2016
95
95
2017
163
163
2018
229
229
2019
308
308
2020
345
345
2021
387
387
2022
406
406

2016
2017
146
123
286
-
2018
371
286
-
2019
292
286
-
2020
255
286
-
2021
213
286
-
2022
194
286
-
431
123
657
577
540
499
480

2016
2017
2018
95
123
229
2019
308
2020
345
2021
387
2022
406

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
387
-
2022
406
-

2016
2017
-
2019
-
2020
-
2021
3
2022
30

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
390
-
2022
436
-
2018
-

2016
2017
2018
95
163
229
95
163
229
2019
308
308
2020
345
345
2021
390
390
2022
436
436

2016
2017
2018
2019
95
163
229
308
-
2020
345
-
2021
390
-
2022
436
-
95
163
229
308
345
390
436

2016
2017
109
128
80
198
189
326
2018
162
242
53
457
2019
200
308
88
20
616
2020
250
300
121
20
691
2021
300
300
153
20
773
2022
300
300
191
20
811

2016
2017
55
64
40
99
-
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
95
163
229
308
345
387
406

2016
2017
109
128
189
326
189
326
2018
162
404
457
457
2019
200
508
596
616
616
2020
250
550
671
691
691
2021
300
600
753
773
773
2022
300
600
791
811
811

2016
2017
55
64
95
163
-
2018
81
202
229
2019
100
254
298
2020
125
275
335
2021
150
300
377
2022
150
300
396
95
163
229
308
308
345
345
387
387
406
406
imal campaign count

2016
2
-
2017
2
-
2018
3
-
2019
4
-
2020
4
-
2021
2
-
2022
2
-
2023
286
600
886
2024
286
600
886
2025
286
600
886
2026
286
600
886
2027
286
600
886
2028
286
600
886
2029
286
600
886
2030
286
600
886
2023
13
2024
13
2025
13
2026
13
2027
13
2028
13
2029
13
2030
13
2023
2024
2025
2026
2027
2028
2029
2030
2023
2024
2025
2026
2027
2028
2029
2030
2023
600
286
-
2024
600
286
-
2025
600
286
-
2026
600
286
-
2027
600
286
-
2028
600
286
-
2029
600
286
-
2030
600
286
-
2023
419
419
2024
438
438
2025
453
453
2026
472
472
2027
487
487
2028
503
503
2029
475
475
2030
458
458
2023
181
286
-
2024
162
286
-
2025
147
286
-
2026
128
286
-
2027
113
286
-
2028
97
286
-
2029
125
286
-
2030
142
286
-
466
448
433
413
399
383
411
428
2023
419
2024
438
2025
433
2026
413
2027
399
2028
383
2029
411
2030
428
2023
419
-
2024
438
-
2025
453
-
2026
472
-
2027
487
-
2028
503
-
2029
475
-
2030
458
-
2023
51
2024
76
2025
97
2026
119
2027
136
2028
153
2029
138
2030
131
2023
471
-
2024
514
-
2025
550
-
2026
591
-
2027
623
23
-
2028
656
56
-
2029
613
13
-
2030
589
-
2023
471
471
2024
514
514
2025
550
550
2026
591
591
2027
600
23
623
2028
600
56
656
2029
600
13
613
2030
589
589
2023
471
-
2024
514
-
2025
550
-
2026
591
-
2027
600
623
-
2028
600
656
-
2029
600
613
-
2030
589
-
471
514
550
591
623
656
613
589
2023
300
300
218
20
838
2024
300
300
256
20
875
2025
300
300
286
20
906
2026
300
300
324
20
945
2027
300
300
354
20
974
2028
300
300
385
20
1,006
2029
200
300
430
20
949
2030
125
300
471
20
916
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
2026
150
150
162
10
2027
150
150
177
10
2028
150
150
193
10
2029
100
150
215
10
2030
63
150
236
10
419
438
453
472
487
503
475
458
2023
300
600
818
838
838
2024
300
600
856
875
875
2025
300
600
886
906
906
2026
300
600
924
945
945
2027
300
600
954
974
974
2028
300
600
985
1,006
1,006
2029
200
500
930
949
949
2030
125
425
896
916
916
2023
150
300
409
2024
150
300
428
2025
150
300
443
2026
150
300
462
2027
150
300
477
2028
150
300
493
2029
100
250
465
2030
63
213
448
419
419
438
438
453
453
472
472
487
487
503
503
475
475
458
458
2023
2
-
2024
2
-
2025
2
-
2026
2
-
2027
2
1
-
2028
2
1
-
2029
3
-
2030
3
-
2031
286
600
886
2032
286
600
886
2033
286
600
886
2034
286
600
886
2035
286
600
886
2031
13
2032
13
2033
13
2034
13
2035
13
2031
2032
2033
2034
2035

2015
2016
2015
2016

2015
2016
2031
2032
2033
2034
2035
2031
600
286
-
2032
600
286
-
2033
600
286
-
2034
600
286
-
2035
600
286
-

2015
2016

2015
2016
-
2031
439
439
2031
161
286
-
2032
436
436
2032
164
286
-
2033
429
429
2033
171
286
-
2034
426
426
2034
174
286
-
2035
426
426

2015
2016
-
2035
174
286
-

2015
2016
-
447
450
457
460
460
2031
439
2032
436
2033
429
2034
426
2035
426

2015
2016
-
2031
439
-
2032
436
-
2033
429
-
2034
426
-
2035
426
-

2015
2016
-
2031
121
2032
125
2033
125
2034
127
2035
132

2015
2016
-
2035
558
-

2015
2016
-
2031
560
-
2032
561
-
2033
553
-
2034
553
-
2031
560
560
2031
560
-
2032
561
561
2032
561
-
2033
553
553
2033
553
-
2034
553
553
2034
553
-
2035
558
558

2015
2016
-
2035
558
-

2015
2016
-
560
2031
80
300
477
20
877
2031
40
150
239
10
561
2032
75
300
477
20
872
2032
38
150
239
10
553
2033
60
300
477
20
857
2033
30
150
239
10
553
2034
55
300
477
20
852
2034
28
150
239
10
558
2035
55
300
477
20
852

2015
2016
-
2035
28
150
239
10

2015
2016
-
439
2031
80
380
857
877
877
2031
40
190
429
436
2032
75
375
852
872
872
2032
38
188
426
429
2033
60
360
837
857
857
2033
30
180
419
426
2034
55
355
832
852
852
2034
28
178
416
426
2035
55
355
832
852
852

2015
2016
-
2035
28
178
416

2015
2016
-
439
439
436
436
429
429
426
426
426
426
2031
3
-
2032
3
-
2033
3
-
2034
3
-
2035
3
-

2015
2016
-
pacity (kg/yr)
2017
-
2018
-
2019
600
600
2020
2,160
600
2,760
2021
2,160
600
2,760
2022
2,160
600
2,760
2023
2,160
600
2,760
2024
2,160
600
2,760
2017
2018
2019
2020
2021
2022
2023
2024
2019
2020
2021
2022
2023
2024
st ranking
oduction ranking
2017
2018
oduction sequence
2017
2018

2017
2018
-
2019
2020
2021
2022
2023
2024
Continuou Fed batch Fed batch Fed batch Fed batch Fed batch
Continuou ContinuousContinuousContinuousContinuous
2019
600
-
2020
2,160
600
-
2021
2,160
600
-
2022
2,160
600
-
2023
2,160
600
-
2024
2,160
600
-
oduced (kg/yr)
2017
-
2018
-
2019
-
2020
10
10
2021
20
20
2022
30
30
2023
40
40
2024
50
50

2017
-
2018
-
2019
600
-
2020
2,150
600
-
2021
2,140
600
-
2022
2,130
600
-
2023
2,120
600
-
2024
2,110
600
-
600
2,750
2,740
2,730
2,720
2,710
2019
-
2020
10
2021
20
2022
30
2023
40
2024
50

2017
2018
2019
2020
10
-
2021
20
-
2022
30
-
2023
40
-
2024
50
-
MO swapback (kg/yr)
2017
-
2020
-
2021
0
2022
2
2023
5
2024
9

2017
2018
2019
2020
10
-
2021
20
-
2022
32
-
2023
45
-
2024
59
-

2017
2018
-
2018
-
2019
-

2017
2018
2019
-
2020
10
10
2021
20
20
2022
32
32
2023
45
45
2024
59
59

2017
2018
2019
2020
10
-
2021
20
-
2022
32
-
2023
45
-
2024
59
-
ew demanded (kg/yr)
2017
-
10
20
32
45
59
2018
-
2019
-
2020
20
20
2021
20
20
40
2022
20
20
20
60
2023
20
20
20
20
81
2024
20
20
20
20
20
100

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50

2017
2018
-
2019
-
2020
20
20
2021
20
40
40
2022
20
40
60
60
2023
20
41
60
81
81
2024
20
40
60
80
100
100

2017
2018
-
2019
-
2020
-
2021
-
2022
-
2023
-
2024
-
10
10
10
20
20
10
20
30
30
10
20
30
40
40
10
20
30
40
50
50
2020
1
-
2021
1
-
2022
2
-
2023
3
-
2024
3
-
mpaign count
2017
-
2018
-
2019
-
2025
2,160
600
2,760
2026
2,160
600
2,760
2027
2,160
600
2,760
2028
2,160
600
2,760
2029
2,160
600
2,760
2030
2,160
600
2,760
2031
2,160
600
2,760
2032
2,160
600
2,760
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
2025
2026
2027
2028
2029
2030
2031
2032
ContinuousContinuousContinuousContinuousContinuousContinuousContinuousContinuous
2025
2,160
600
-
2026
2,160
600
-
2027
2,160
600
-
2028
2,160
600
-
2029
2,160
600
-
2030
2,160
600
-
2031
2,160
600
-
2032
2,160
600
-
2025
60
60
2026
70
70
2027
80
80
2028
90
90
2029
100
100
2030
109
109
2031
119
119
2032
128
128
2025
2,100
600
-
2026
2,090
600
-
2027
2,080
600
-
2028
2,070
600
-
2029
2,060
600
-
2030
2,051
600
-
2031
2,041
600
-
2032
2,032
600
-
2,700
2,690
2,680
2,670
2,660
2,651
2,641
2,632
2025
60
2026
70
2027
80
2028
90
2029
100
2030
109
2031
119
2032
128
2025
60
-
2026
70
-
2027
80
-
2028
90
-
2029
100
-
2030
109
-
2031
119
-
2032
128
-
2025
13
2026
20
2027
27
2028
36
2029
34
2030
33
2031
33
2032
37
2025
73
-
2026
90
-
2027
107
-
2028
126
-
2029
134
-
2030
143
-
2031
152
-
2032
165
-
2025
73
73
2026
90
90
2027
107
107
2028
126
126
2029
134
134
2030
143
143
2031
152
152
2032
165
165
2025
73
-
2026
90
-
2027
107
-
2028
126
-
2029
134
-
2030
143
-
2031
152
-
2032
165
-
73
90
107
126
134
143
152
165
2025
20
20
20
20
20
20
120
2026
20
20
20
20
20
20
20
140
2027
20
20
20
20
20
20
20
20
159
2028
20
20
20
20
20
20
20
20
20
180
2029
20
20
20
19
20
20
20
20
20
19
200
2030
20
20
20
20
20
20
20
20
20
20
20
219
2031
20
19
20
20
20
20
20
20
20
20
20
20
238
2032
20
20
20
20
19
20
19
20
19
20
19
20
20
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
2025
20
40
59
80
100
120
120
2026
20
40
60
81
100
120
140
140
2027
20
40
60
80
100
120
140
159
159
2028
20
40
60
80
100
120
140
160
180
180
2029
20
40
61
80
100
120
140
161
181
200
200
2030
20
40
60
80
100
120
139
159
179
199
219
219
2031
20
39
60
80
99
119
139
159
179
199
218
238
238
2032
20
40
60
79
99
119
138
158
178
197
217
237
257
257
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
10
20
30
40
50
60
60
10
20
30
40
50
60
70
70
10
20
30
40
50
60
70
80
80
10
20
30
40
50
60
70
80
90
90
10
20
30
40
50
60
70
80
90
100
100
10
20
30
40
50
60
70
80
90
99
109
109
10
20
30
40
50
59
69
79
89
99
109
119
119
10
20
30
40
49
59
69
79
89
99
108
119
128
128
2025
4
-
2026
5
-
2027
6
-
2028
7
-
2029
7
-
2030
8
-
2031
8
-
2032
9
-
2033
2,160
600
2,760
2034
2,160
600
2,760
2035
2,160
600
2,760

2015
2016
2017
403
403
403
403
403
403
2033
2034
2035

2015
2016
9
14
2033
2034
2035
14
2017
14

2015
2016
2017
2
1

2033
2034
2035
Fed batch Fed batch Fed batch SU Intensified (h CMO: CHO -CMO: CHO CMO: CHO
ContinuousContinuousContinuous SU
2033
2,160
600
-
2034
2,160
600
-
2035
2,160
600
-

2015
2016
2017
403
403
403
-
2033
140
140
2033
2,020
600
-
2034
149
149
2034
2,011
600
-
2035
158
158

2015
2016
2017
65
95
163
65
95
163
2035
2,002
600
-

2015
2016
2017
338
309
240
-
2,620
2,611
2,602
338
309
240
2033
140
2034
149
2035
158

2015
2016
2017
65
95
123
2033
140
-
2034
149
-
2035
158
-

2015
2016
2017
65
95
163
-
2033
41
2034
44
2035
49

2015
2016
2017
-
2035
207
-

2015
2016
2017
65
95
163
-
2033
181
-
2034
193
-
2033
181
181
2034
193
193
2035
207
207
2033
181
-
2034
193
-
2035
207
-

2015
2016
2017
65
95
163
65
95
163
181
2033
20
20
20
20
20
20
20
20
20
20
20
20
20
20
281
2033
-
193
2034
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
297
2034
-
207
2035
- Total Demand
- Total Supplied
- Total Unmet
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
19
316
2035
-
Checksum
2015
2016
2017
130
189
326
130
189
326
OK
OK
OK

2015
2016
2017
45
55
64
20
40
99
-
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
2033
20
40
60
80
100
120
140
160
180
199
220
240
260
281
281
2034
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
297
2035
20
40
60
79
99
119
138
158
178
197
217
237
257
277
297
316
316
2033
-
2034
-
2035
-
65
95
163
10
20
30
40
50
60
70
80
90
100
110
120
130
140
140
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
149
10
20
30
40
49
59
69
79
89
99
109
119
129
139
149
158
158
2033
10
-
2034
10
-
2035
11
-
2018
403
403
2019
403
403
2020
403
403
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
2019
2020
2021
2022
2023
2024
2025
14
14
14
14
14
14
14
14
2018
2019
2020
2021
2022
2023
2024
2025
ction (kg/yr)
2018
403
-
2019
403
-
2020
403
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
229
229
2019
308
308
2020
356
356
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
174
-
2019
95
-
2020
48
-
2021
-
2022
-
2023
-
2024
-
2025
-
wed (kg/yr)
174
95
48

2018
2019
229
308
2020
356
2021
407
2022
436
2023
460
2024
488
2025
493

2018
2019
2020
229
308
356
-
2021
407
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2022
436
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
32
2023
460
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
56
2024
488
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
85
2025
513
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
110
2020
-
2021
3
2022
32
2023
56
2024
85
2025
110

2018
2019
2020
229
308
356
-
2021
403
-
2022
403
-
2023
403
-
2024
403
-
2025
403
-
2018
-
2019
-

2018
2019
229
308
229
308
2020
356
356
2021
403
403
2022
403
403
2023
403
403
2024
403
403
2025
403
403
2018
457
457
OK
2019
616
616
OK
2020
711
711
OK
2021
813
813
OK
2022
871
871
OK
2023
919
919
OK
2024
976
976
OK
2025
1,026
1,026
OK
nded (kg/yr)
2018
81
121
27
-
2019
100
154
44
10
2020
125
150
60
10
2021
150
150
77
10
2022
150
150
96
10
2023
150
150
109
10
2024
150
150
128
10
2025
150
150
143
10
229
308
345
387
406
419
438
453
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
2027
2028
2029
2030
2031
2032
2033
14
14
14
14
14
14
14
14
2026
2027
2028
2029
2030
2031
2032
2033

2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
-
2027
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2026
483
2027
478
2028
473
2029
511
2030
537
2031
558
2032
564
2033
569
2026
542
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
139
2027
567
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
163
2028
593
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
190
2029
575
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
172
2030
567
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
164
2031
558
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
154
2032
564
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
161
2033
569
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
166
2026
139
2027
163
2028
190
2029
172
2030
164
2031
154
2032
161
2033
166
2026
403
-
2027
403
-
2028
403
-
2029
403
-
2030
403
-
2031
403
-
2032
403
-
2033
403
-
2026
403
403
2027
403
403
2028
403
403
2029
403
403
2030
403
403
2031
403
403
2032
403
403
2033
403
403
2026
1,085
1,085
OK
2027
1,133
1,133
OK
2026
150
150
162
10
2028
1,185
1,185
OK
2027
150
150
177
10
2029
1,149
1,149
OK
2028
150
150
193
10
2030
1,135
1,135
OK
2029
100
150
215
10
2031
1,115
1,115
OK
2030
63
150
236
10
2032
1,129
1,129
OK
2031
40
150
239
10
2033
1,138
1,138
OK
2032
38
150
239
10
2033
30
150
239
10
472
487
503
475
458
439
436
429
2034
403
403
2035
403
403
2034
2035
14
14
2034
2035
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
-
2035
-
2034
574
2035
584
2034
574
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
171
2035
584
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
181
2034
171
2035
181
2034
403
-
2035
403
-
2034
403
403
2035
403
403
2034
1,149
1,149
OK
2035
1,168
1,168
OK
2034
28
150
239
10
2035
28
150
239
10

2015
2016
2017
2018
-
2019
-
426
426
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
10
10
10
10
20
10
10
10
30
10
10
10
10
40
10
10
10
10
10
50
10
10
10
10
10
10
60
10
10
10
10
10
10
10
70
10
10
10
10
10
10
10
10
80
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
10
10
10
10
10
10
10
10
10
90
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
10
109
10
10
10
10
10
10
10
10
10
10
10
10
119
10
10
10
10
10
10
10
10
10
10
10
10
10
128
10
10
10
10
10
10
10
10
10
10
10
10
10
10
140
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
149
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
158
ARCHITECTURE A
Total unmet production (kg/yr)
2015
2016
2017
2018
-
2019
-
Lost revenue ($m)

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
2015
-
2016
-
2017
-
2018
-
2019
-
2017
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2018
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2019
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2018
2019
Lost revenue sequence

Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
2015
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2016
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
Lost drug unit price ($/g)

2015
2016
2017
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
Drug commercial production required (kg/yr)

2015
90
40
-
2016
109
80
-
2017
128
198
-
2018
162
242
53
-
2019
200
308
88
20
-
Leftover unmet demand by drug (kg/yr)

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
2015
-
2016
-
2017
-
2018
-
2019
-
Drug 10
Unmet demand (kg/yr)

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
Checksum
2015
OK
2016
OK
2017
OK
2018
OK
2019
OK
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2021
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2022
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2023
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2024
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2025
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2026
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2027
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2020
2021
2022
2023
2024
2025
2026
2027
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2020
250
300
121
20
20
-
2021
300
300
153
20
20
20
-
2022
300
300
191
20
20
20
20
-
2023
300
300
218
20
20
20
20
20
-
2024
300
300
256
20
20
20
20
20
20
-
2025
300
300
286
20
20
20
20
20
20
20
-
2026
300
300
324
20
20
20
20
20
20
20
20
-
2027
300
300
354
20
20
20
20
20
20
20
20
20
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
OK
2021
OK
2022
OK
2023
OK
2024
OK
2025
OK
2026
OK
2027
OK
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2029
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2030
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2031
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2032
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2033
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2034
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2035
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Drug 11
Drug 12
Drug 13
Drug 14
Drug 15
Drug 16
Drug 17
Drug 18
Drug 19
Drug 20
2028
2029
2030
2031
2032
2033
2034
2035
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2028
300
300
385
20
20
20
20
20
20
20
20
20
20
-
2029
200
300
430
20
20
20
20
19
20
20
20
20
20
19
-
2030
125
300
471
20
20
20
20
20
20
20
20
20
20
20
20
-
2031
80
300
477
20
20
19
20
20
20
20
20
20
20
20
20
20
-
2032
75
300
477
20
20
20
20
20
19
20
19
20
19
20
19
20
20
-
2033
60
300
477
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
-
2034
55
300
477
20
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
-
2035
55
300
477
20
20
20
20
19
19
20
20
20
20
20
20
20
20
20
20
19
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
OK
2029
OK
2030
OK
2031
OK
2032
OK
2033
OK
2034
OK
2035
OK
MK-3415A
ARCHITECTURE B
2015
2016
2017
2018
-
2019
-
Lost revenue ($m)

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
2015
-
2016
-
2017
-
2018
-
2019
-
2017
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2018
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2019
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2018
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2019
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000

Ranking
1
2
3
4
5
6
7
8
9
10
2015
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2016
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10

2015
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2016
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2017
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000

2015
90
40
-
2016
109
80
-
2017
128
198
-
2018
162
242
53
-
2019
200
308
88
20
-

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2015
-
2016
-
2017
-
2018
-
2019
-
2017
-
2018
-
2019
-

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
Checksum
2015
OK
2016
OK
OK
OK
OK
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2021
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2022
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2023
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2024
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2025
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2026
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2027
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2020
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2021
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2022
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2023
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2024
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2025
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2026
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2027
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
OK
2020
250
300
121
20
20
-
2021
300
300
153
20
20
20
-
2022
300
300
191
20
20
20
20
-
2023
300
300
218
20
20
20
20
20
-
2024
300
300
256
20
20
20
20
20
20
-
2025
300
300
286
20
20
20
20
20
20
20
2026
300
300
324
20
20
20
20
20
20
20
2027
300
300
354
20
20
20
20
20
20
20
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
OK
OK
OK
OK
OK
OK
OK
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2029
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2030
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2031
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2032
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2033
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2034
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2035
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2028
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2029
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2030
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2031
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2032
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2033
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2034
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2035
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
OK
2028
300
300
385
20
20
20
20
20
20
20
2029
200
300
430
20
20
20
20
19
20
20
2030
125
300
471
20
20
20
20
20
20
20
2031
80
300
477
20
20
19
20
20
20
20
2032
75
300
477
20
20
20
20
20
19
20
2033
60
300
477
20
20
20
20
20
20
20
2034
55
300
477
20
20
20
20
19
19
20
2035
55
300
477
20
20
20
20
19
19
20
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
OK
OK
OK
OK
OK
OK
OK
MK-3415A
ARCHITECTURE C
2015
2016
2017
2018
-
2019
-
Lost revenue ($m)

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
2015
-
2016
-
2017
-
2018
-
2019
-
2017
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2018
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2019
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2018
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2019
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000

Ranking
1
2
3
4
5
6
7
8
9
10
2015
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2016
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10

2015
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2016
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2017
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000

2015
90
40
-
2016
109
80
-
2017
128
198
-
2018
162
242
53
-
2019
200
308
88
20
-

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2015
-
2016
-
2017
-
2018
-
2019
-
2017
-
2018
-
2019
-

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
Checksum
2015
OK
2016
OK
OK
OK
OK
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2021
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2022
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2023
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2024
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2025
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2026
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2027
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2020
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2021
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2022
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2023
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2024
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2025
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2026
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2027
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
OK
2020
250
300
121
20
20
-
2021
300
300
153
20
20
20
-
2022
300
300
191
20
20
20
20
-
2023
300
300
218
20
20
20
20
20
-
2024
300
300
256
20
20
20
20
20
20
-
2025
300
300
286
20
20
20
20
20
20
20
2026
300
300
324
20
20
20
20
20
20
20
2027
300
300
354
20
20
20
20
20
20
20
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
OK
OK
OK
OK
OK
OK
OK
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2029
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2030
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2031
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2032
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2033
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2034
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2035
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2028
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2029
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2030
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2031
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2032
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2033
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2034
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2035
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
OK
2028
300
300
385
20
20
20
20
20
20
20
2029
200
300
430
20
20
20
20
19
20
20
2030
125
300
471
20
20
20
20
20
20
20
2031
80
300
477
20
20
19
20
20
20
20
2032
75
300
477
20
20
20
20
20
19
20
2033
60
300
477
20
20
20
20
20
20
20
2034
55
300
477
20
20
20
20
19
19
20
2035
55
300
477
20
20
20
20
19
19
20
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
OK
OK
OK
OK
OK
OK
OK
MK-3415A
ARCHITECTURE D
2015
2016
2017
2018
-
2019
-
Lost revenue ($m)

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
2015
-
2016
-
2017
-
2018
-
2019
-
2017
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2018
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2019
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2018
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2019
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000

Ranking
1
2
3
4
5
6
7
8
9
10
2015
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2016
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10

2015
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2016
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2017
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000

2015
90
40
-
2016
109
80
-
2017
128
198
-
2018
162
242
53
-
2019
200
308
88
20
-

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2015
-
2016
-
2017
-
2018
-
2019
-
2017
-
2018
-
2019
-

Drug name
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
Total
Checksum
2015
OK
2016
OK
OK
OK
OK
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2021
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2022
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2023
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2024
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2025
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2026
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2027
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2020
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2021
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2022
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2023
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2024
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2025
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2026
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2027
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
OK
2020
250
300
121
20
20
-
2021
300
300
153
20
20
20
-
2022
300
300
191
20
20
20
20
-
2023
300
300
218
20
20
20
20
20
-
2024
300
300
256
20
20
20
20
20
20
-
2025
300
300
286
20
20
20
20
20
20
20
2026
300
300
324
20
20
20
20
20
20
20
2027
300
300
354
20
20
20
20
20
20
20
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
2020
-
2021
-
2022
-
2023
-
2024
-
2025
-
2026
-
2027
-
OK
OK
OK
OK
OK
OK
OK
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2029
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2030
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2031
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2032
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2033
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2034
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2035
Keytruda
MK-3415A
Drug 3
Drug 4
Drug 5
Drug 6
Drug 7
Drug 8
Drug 9
Drug 10
2028
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2029
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2030
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2031
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2032
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2033
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2034
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
2035
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
20,000
OK
2028
300
300
385
20
20
20
20
20
20
20
2029
200
300
430
20
20
20
20
19
20
20
2030
125
300
471
20
20
20
20
20
20
20
2031
80
300
477
20
20
19
20
20
20
20
2032
75
300
477
20
20
20
20
20
19
20
2033
60
300
477
20
20
20
20
20
20
20
2034
55
300
477
20
20
20
20
19
19
20
2035
55
300
477
20
20
20
20
19
19
20
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
2028
-
2029
-
2030
-
2031
-
2032
-
2033
-
2034
-
2035
-
OK
OK
OK
OK
OK
OK
OK
MK-3415A
ARCHITECTURE A
CHO current raw material cost ($/L)
Ranking
2015
2016
2017
2018
1
80
80
80
80
2
80
80
80
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2019
80
80
2020
80
80
2018
5
1
2019
5
1
2020
5
1
CHO current raw material COGS ($m)

Ranking
2015
2016
2017
2018
1
1
2
9
4
2019
5
2020
6
CHO current titer (g/L)

Ranking
2015
2016
1
5
5
2
1
1
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2017
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Total
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current batch cost ($/batch)

2015
2016
2017
1,000
1,000
1,000
1,000
1,000
CHO current # of batches needed

Ranking
2015
2016
2017
1
6
8
10
2
3
4
5
2018
1,000
1,000
2019
1,000
1,000
2020
1,000
1,000
2018
8
-
2019
11
-
2020
12
-
6
7
8
9
10
11
12
13
14
15
16
17
18
CHO current batch cost ($m)
Ranking
2015
2016
2017
1
0
0
0
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
0
0
0
CHO current total ($m)
CHO FotF total ($m)
CHO CMO total ($m)
CHO Grand total ($m
1
14
15
20
22
35
44
2018
0
-
2019
0
-
2020
0
-
4
49
53
66
71
79
84
2021
80
80
2022
80
80
2023
80
80
2024
80
80
2025
80
80
2026
80
80
2027
80
80
2028
80
80
2021
5
1
2022
5
1
2023
5
1
2024
5
1
2025
5
1
2026
5
1
2027
5
1
2028
5
1
2021
7
2022
7
2023
8
2024
9
2025
10
2026
10
2027
10
2028
10
2021
1,000
1,000
2021
14
-
1
11
5
14
7
17
10
20
2022
1,000
1,000
2023
1,000
1,000
2024
1,000
1,000
2025
1,000
1,000
2026
1,000
1,000
2027
1,000
1,000
2028
1,000
1,000
2022
16
-
2023
18
-
2024
20
-
2025
20
2
2026
20
5
2027
20
8
2028
20
11
2021
0
-
2022
0
-
2023
0
-
2024
0
-
2025
0
0
2026
0
0
2027
0
0
2028
0
0
8
87
94
87
95
87
96
11
87
98
14
87
101
17
87
104
20
87
107
87
93
2029
80
80
2030
80
80
2031
80
80
2032
80
80
2033
80
80
2034
80
80
2035
80
80
2029
5
1
2030
5
1
2031
5
1
2032
5
1
2033
5
1
2034
5
1
2035
5
1
2029
10
2030
10
2031
10
2032
10
2033
10
2034
10
2035
10
8
18
8
17
6
16
7
17
8
17
8
18
9
19
2029
1,000
1,000
2030
1,000
1,000
2031
1,000
1,000
2032
1,000
1,000
2033
1,000
1,000
2034
1,000
1,000
2035
1,000
1,000
2029
20
9
2030
20
8
2031
20
7
2032
20
8
2033
20
9
2034
20
9
2035
20
10
2029
0
0
2030
0
0
2031
0
0
2032
0
0
2033
0
0
2034
0
0
2035
0
0
18
87
105
17
87
104
16
87
103
17
87
103
17
87
104
18
87
105
19
87
106
CHO FotF raw material cost ($/g)

2015
2016
2017
2018
2019
2020
2021
2022
CHO FotF titer (g/L)

2015
2016
2018
2019
2020
2021
2022
2018
-
2019
-
2020
-
2021
-
2022
-
2017
CHO FotF raw material COGS ($m)

2015
2016
2017
-
CHO FotF batch cost ($/batch)

2015
2016
2017
2018
2019
2020
2021
2022
CHO FotF # of batches needed

2015
2016
2017
2018
2019
2020
2021
2022
CHO FotF batch cost ($m)

2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2023
2024
2025
2026
2027
2028
2029
2030
2023
-
2024
-
2025
-
2026
-
2027
-
2028
-
2029
-
2030
-
2023
2024
2025
2026
2027
2028
2029
2030
2023
2024
2025
2026
2027
2028
2029
2030
2023
2024
2025
2026
2027
2028
2029
2030
2031
2032
2033
2034
2035
2031
2032
2033
2034
2035
2031
-
2032
-
2033
-
2034
-
2035
-
CHO CMO production cost ($/g)

2015
2016
215
215
CHO CMO total COGS ($m)

2015
2016
14
20
2031
2032
2033
2034
2035
2031
2032
2033
2034
2035
14
20
2031
2032
2033
2034
2035
roduction cost ($/g)

2017
215
2018
215
2019
215
2020
215
2021
215
2022
215
2023
215
2024
215
tal COGS ($m)

2017
35
2018
49
2019
66
2020
79
2021
87
2022
87
2023
87
2024
87
35
49
66
79
87
87
87
87
2025
215
2026
215
2027
215
2028
215
2029
215
2030
215
2031
215
2032
215
2025
87
2026
87
2027
87
2028
87
2029
87
2030
87
2031
87
2032
87
87
87
87
87
87
87
87
87
2033
215
2034
215
2035
215
2033
87
2034
87
2035
87
87
87
87
ARCHITECTURE B
Ranking
2015
2016
2017
2018
1
80
80
80
80
2
80
80
80
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2019
80
80
2020
80
80
80
2018
5
1
2019
5
1
2020
5
5
1

Ranking
2015
2016
2017
2018
1
1
2
9
4
2019
5
2020
6

Ranking
2015
2016
1
5
5
2
1
1
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2017
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Total
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18

2015
2016
2017
1,000
1,000
1,000
1,000
1,000

Ranking
2015
2016
2017
1
6
8
10
2
3
4
5
2018
1,000
1,000
2019
1,000
1,000
2020
1,000
1,000
1,000
2018
8
-
2019
11
-
2020
7
-
6
7
8
9
10
11
12
13
14
15
16
17
18
Ranking
2015
2016
2017
1
0
0
0
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
0
0
0
CHO FotF total ($m)
CHO CMO total ($m)
CHO Grand total ($m
1
14
15
20
22
35
44
2018
0
-
2019
0
-
2020
0
-
4
49
53
6
0
76
82
66
71
2021
80
80
80
2022
80
80
80
2023
80
80
80
2024
80
80
80
2025
80
80
80
2026
80
80
80
2027
80
80
80
2028
80
80
80
2021
5
5
1
2022
5
5
1
2023
5
5
1
2024
5
5
1
2025
5
5
1
2026
5
5
1
2027
5
5
1
2028
5
5
1
2021
6
2022
7
2023
8
2024
8
2025
9
2026
9
2027
10
2028
11
2021
1,000
1,000
1,000
2021
8
-
10
11
2022
1,000
1,000
1,000
2023
1,000
1,000
1,000
2024
1,000
1,000
1,000
2025
1,000
1,000
1,000
2026
1,000
1,000
1,000
2027
1,000
1,000
1,000
2028
1,000
1,000
1,000
2022
9
-
2023
9
-
2024
10
-
2025
11
-
2026
11
-
2027
12
-
2028
13
-
2021
0
-
2022
0
-
2023
0
-
2024
0
-
2025
0
-
2026
0
-
2027
0
-
2028
0
-
6
0
87
93
7
0
87
94
8
0
87
95
8
0
87
95
9
1
87
96
10
1
87
97
10
1
87
98
11
1
87
98
2029
80
80
80
2030
80
80
80
2031
80
80
80
2032
80
80
80
2033
80
80
80
2034
80
80
80
2035
80
80
80
2029
5
5
1
2030
5
5
1
2031
5
5
1
2032
5
5
1
2033
5
5
1
2034
5
5
1
2035
5
5
1
2029
10
2030
9
2031
9
2032
9
2033
9
2034
9
2035
9
10
2029
1,000
1,000
1,000
2029
12
-
2030
1,000
1,000
1,000
2031
1,000
1,000
1,000
2032
1,000
1,000
1,000
2033
1,000
1,000
1,000
2034
1,000
1,000
1,000
2035
1,000
1,000
1,000
2030
11
-
2031
11
-
2032
11
-
2033
11
-
2034
11
-
2035
11
-
2029
0
-
2030
0
-
2031
0
-
2032
0
-
2033
0
-
2034
0
-
2035
0
-
10
1
87
98
9
1
87
97
9
1
87
97
9
1
87
97
9
2
87
97
9
2
87
97
9
2
87
97

2015
2016
2017
2018
2019
2020
80
2021
80
2022
80

2015
2016
2018
2019
2020
15
2021
15
2022
15
2018
-
2019
-
2020
0
2021
0
2022
0
2017

2015
2016
2017
-

2015
2016
2017
2018
2019
2020
60,000
2021
60,000
2022
60,000

2015
2016
2017
2018
2019
2020
1
2021
1
2022
2

2015
2016
2017
2018
2019
2020
0
2021
0
2022
0
2023
80
2024
80
2025
80
2026
80
2027
80
2028
80
2029
80
2030
80
2023
15
2024
15
2025
15
2026
15
2027
15
2028
15
2029
15
2030
15
2023
0
2024
0
2025
0
2026
0
2027
1
2028
1
2029
1
2030
1
2023
60,000
2023
3
2024
60,000
2025
60,000
2026
60,000
2027
60,000
2028
60,000
2029
60,000
2030
60,000
2024
3
2025
4
2026
5
2027
6
2028
6
2029
7
2030
8
2023
0
2024
0
2025
0
2026
0
2027
0
2028
0
2029
0
2030
0
2031
80
2032
80
2033
80
2034
80
2035
80
2031
15
2032
15
2033
15
2034
15
2035
15
2031
1
2032
1
2033
1
2034
1
2035
1

2015
2016
215
215

2015
2016
14
20
2031
60,000
2031
8
2032
60,000
2033
60,000
2034
60,000
2035
60,000
2032
9
2033
10
2034
10
2035
11
14
20
2031
0
2032
1
2033
1
2034
1
2035
1

2017
215
2018
215
2019
215
2020
215
2021
215
2022
215
2023
215
2024
215
tal COGS ($m)

2017
35
2018
49
2019
66
2020
76
2021
87
2022
87
2023
87
2024
87
35
49
66
76
87
87
87
87
2025
215
2026
215
2027
215
2028
215
2029
215
2030
215
2031
215
2032
215
2025
87
2026
87
2027
87
2028
87
2029
87
2030
87
2031
87
2032
87
87
87
87
87
87
87
87
87
2033
215
2034
215
2035
215
2033
87
2034
87
2035
87
87
87
87
ARCHITECTURE C
Ranking
2015
2016
2017
2018
1
80
80
80
80
2
80
80
80
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2019
80
80
2020
80
80
2018
5
1
2019
5
1
2020
5
1

Ranking
2015
2016
2017
2018
1
1
2
9
4
2019
5
2020
6

Ranking
2015
2016
1
5
5
2
1
1
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2017
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Total
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18

2015
2016
2017
1,000
1,000
1,000
1,000
1,000

Ranking
2015
2016
2017
1
6
8
10
2
3
4
5
2018
1,000
1,000
2019
1,000
1,000
2020
1,000
1,000
2018
8
-
2019
11
-
2020
12
-
6
7
8
9
10
11
12
13
14
15
16
17
18
Ranking
2015
2016
2017
1
0
0
0
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
0
0
0
CHO FotF total ($m)
CHO CMO total ($m)
CHO Grand total ($m
1
14
15
20
22
35
44
2018
0
-
2019
0
-
2020
0
-
4
49
53
6
0
76
82
66
71
2021
80
80
2022
80
80
2023
80
80
2024
80
80
2025
80
80
2026
80
80
2027
80
80
2028
80
80
2021
5
1
2022
5
1
2023
5
1
2024
5
1
2025
5
1
2026
5
1
2027
5
1
2028
5
1
2021
6
2022
7
2023
8
2024
8
2025
9
2026
9
2027
10
2028
10
2021
1,000
1,000
2021
13
-
1
11
3
13
2022
1,000
1,000
2023
1,000
1,000
2024
1,000
1,000
2025
1,000
1,000
2026
1,000
1,000
2027
1,000
1,000
2028
1,000
1,000
2022
15
-
2023
16
-
2024
18
-
2025
19
-
2026
20
-
2027
20
2
2028
20
4
2021
0
-
2022
0
-
2023
0
-
2024
0
-
2025
0
-
2026
0
-
2027
0
0
2028
0
0
6
0
87
93
7
0
87
94
8
0
87
95
8
0
87
95
9
1
87
96
9
1
87
97
11
1
87
99
13
1
87
101
2029
80
80
2030
80
80
2031
80
80
2032
80
80
2033
80
80
2034
80
80
2035
80
80
2029
5
1
2030
5
1
2031
5
1
2032
5
1
2033
5
1
2034
5
1
2035
5
1
2029
10
2030
9
2031
9
2032
9
2033
9
2034
9
2035
9
1
10
2029
1,000
1,000
2029
20
1
2030
1,000
1,000
2031
1,000
1,000
2032
1,000
1,000
2033
1,000
1,000
2034
1,000
1,000
2035
1,000
1,000
2030
20
-
2031
19
-
2032
19
-
2033
19
-
2034
19
-
2035
19
-
2029
0
0
2030
0
-
2031
0
-
2032
0
-
2033
0
-
2034
0
-
2035
0
-
10
1
87
98
9
1
87
97
9
1
87
97
9
1
87
97
9
2
87
97
9
2
87
97
9
2
87
97

2015
2016
2017
2018
2019
80
2020
80
2021
80
2022
80

2015
2016
2018
2019
15
2020
15
2021
15
2022
15
2018
-
2019
-
2020
0
2021
0
2022
0
2017

2015
2016
2017
-

2015
2016
2017
2018
2019
60,000
2020
60,000
2021
60,000
2022
60,000

2015
2016
2017
2018
2019
-
2020
1
2021
1
2022
2

2015
2016
2017
2018
2019
-
2020
0
2021
0
2022
0
2023
80
2024
80
2025
80
2026
80
2027
80
2028
80
2029
80
2030
80
2023
15
2024
15
2025
15
2026
15
2027
15
2028
15
2029
15
2030
15
2023
0
2024
0
2025
0
2026
0
2027
1
2028
1
2029
1
2030
1
2023
60,000
2023
3
2024
60,000
2025
60,000
2026
60,000
2027
60,000
2028
60,000
2029
60,000
2030
60,000
2024
3
2025
4
2026
5
2027
6
2028
7
2029
7
2030
8
2023
0
2024
0
2025
0
2026
0
2027
0
2028
0
2029
0
2030
0
2031
80
2032
80
2033
80
2034
80
2035
80
2031
15
2032
15
2033
15
2034
15
2035
15
2031
1
2032
1
2033
1
2034
1
2035
1

2015
2016
215
215

2015
2016
14
20
2031
60,000
2031
8
2032
60,000
2033
60,000
2034
60,000
2035
60,000
2032
9
2033
10
2034
10
2035
11
14
20
2031
0
2032
1
2033
1
2034
1
2035
1

2017
215
2018
215
2019
215
2020
215
2021
215
2022
215
2023
215
2024
215
tal COGS ($m)

2017
35
2018
49
2019
66
2020
76
2021
87
2022
87
2023
87
2024
87
35
49
66
76
87
87
87
87
2025
215
2026
215
2027
215
2028
215
2029
215
2030
215
2031
215
2032
215
2025
87
2026
87
2027
87
2028
87
2029
87
2030
87
2031
87
2032
87
87
87
87
87
87
87
87
87
2033
215
2034
215
2035
215
2033
87
2034
87
2035
87
87
87
87
ARCHITECTURE D
Ranking
2015
2016
2017
2018
1
80
80
80
80
2
80
80
80
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2019
80
80
2020
80
80
2018
5
1
2019
5
1
2020
5
1

Ranking
2015
2016
2017
2018
1
1
2
9
4
2019
5
2020
6

Ranking
2015
2016
1
5
5
2
1
1
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
2017
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Total
Ranking
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18

2015
2016
2017
1,000
1,000
1,000
1,000
1,000

Ranking
2015
2016
2017
1
6
8
10
2
3
4
2018
1,000
1,000
2019
1,000
1,000
2020
1,000
1,000
2018
8
-
2019
11
-
2020
12
-
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Ranking
2015
2016
2017
1
0
0
0
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
0
0
0
CHO FotF total ($m)
CHO CMO total ($m)
CHO Grand total ($m
1
14
15
2
20
22
9
35
44
2018
0
-
2019
0
-
2020
0
-
4
49
53
5
66
71
6
0
76
82
2021
80
80
2022
80
80
2023
80
80
2024
80
80
2025
80
80
2026
80
80
2027
80
80
2028
80
80
2021
5
1
2022
5
1
2023
5
1
2024
5
1
2025
5
1
2026
5
1
2027
5
1
2028
5
1
2021
6
2022
7
2023
8
2024
8
2025
9
2026
9
2027
10
2028
10
2021
1,000
1,000
2021
13
-
1
11
3
13
2022
1,000
1,000
2023
1,000
1,000
2024
1,000
1,000
2025
1,000
1,000
2026
1,000
1,000
2027
1,000
1,000
2028
1,000
1,000
2022
15
-
2023
16
-
2024
18
-
2025
19
-
2026
20
-
2027
20
2
2028
20
4
2021
0
-
2022
0
-
2023
0
-
2024
0
-
2025
0
-
2026
0
-
2027
0
0
2028
0
0
6
0
87
93
7
0
87
94
8
0
87
95
8
0
87
95
9
1
87
96
9
1
87
97
11
1
87
99
13
1
87
101
2029
80
80
2030
80
80
2031
80
80
2032
80
80
2033
80
80
2034
80
80
2035
80
80
2029
5
1
2030
5
1
2031
5
1
2032
5
1
2033
5
1
2034
5
1
2035
5
1
2029
10
2030
9
2031
9
2032
9
2033
9
2034
9
2035
9
1
10
2029
1,000
1,000
2029
20
1
2030
1,000
1,000
2031
1,000
1,000
2032
1,000
1,000
2033
1,000
1,000
2034
1,000
1,000
2035
1,000
1,000
2030
20
-
2031
19
-
2032
19
-
2033
19
-
2034
19
-
2035
19
-
2029
0
0
2030
0
-
2031
0
-
2032
0
-
2033
0
-
2034
0
-
2035
0
-
10
1
87
98
9
1
87
97
9
1
87
97
9
1
87
97
9
2
87
97
9
2
87
97
9
2
87
97

2015
2016
2017
2018
2019
80
2020
80
80
2021
80
80
2022
80
80

2015
2016
2018
2019
5
2020
15
5
2021
15
5
2022
15
5
2018
-
2019
-
2020
0
2021
0
2022
0
2017

2015
2016
2017
-

2015
2016
2017
2018
2019
60,000
2020
60,000
60,000
2021
60,000
60,000
2022
60,000
60,000

2015
2016
2017
2018
2019
-
2020
1
-
2021
1
-
2022
2
-

2015
2016
2017
2018
2019
-
2020
0
-
2021
0
-
2022
0
-
2023
80
80
2024
80
80
2025
80
80
2026
80
80
2027
80
80
2028
80
80
2029
80
80
2030
80
80
2023
15
5
2024
15
5
2025
15
5
2026
15
5
2027
15
5
2028
15
5
2029
15
5
2030
15
5
2023
0
2024
0
2025
0
2026
0
2027
1
2028
1
2029
1
2030
1
2023
60,000
60,000
2023
3
-
2024
60,000
60,000
2025
60,000
60,000
2026
60,000
60,000
2027
60,000
60,000
2028
60,000
60,000
2029
60,000
60,000
2030
60,000
60,000
2024
3
-
2025
4
-
2026
5
-
2027
6
-
2028
7
-
2029
7
-
2030
8
-
2023
0
-
2024
0
-
2025
0
-
2026
0
-
2027
0
-
2028
0
-
2029
0
-
2030
0
-
2031
80
80
2032
80
80
2033
80
80
2034
80
80
2035
80
80
2031
15
5
2032
15
5
2033
15
5
2034
15
5
2035
15
5
2031
1
2032
1
2033
1
2034
1
2035
1

2015
2016
215
215

2015
2016
14
20
2031
60,000
60,000
2031
8
-
2032
60,000
60,000
2033
60,000
60,000
2034
60,000
60,000
2035
60,000
60,000
2032
9
-
2033
10
-
2034
10
-
2035
11
-
14
20
2031
0
-
2032
1
-
2033
1
-
2034
1
-
2035
1
-

2017
215
2018
215
2019
215
2020
215
2021
215
2022
215
2023
215
2024
215
tal COGS ($m)

2017
35
2018
49
2019
66
2020
76
2021
87
2022
87
2023
87
2024
87
35
49
66
76
87
87
87
87
2025
215
2026
215
2027
215
2028
215
2029
215
2030
215
2031
215
2032
215
2025
87
2026
87
2027
87
2028
87
2029
87
2030
87
2031
87
2032
87
87
87
87
87
87
87
87
87
2033
215
2034
215
2035
215
2033
87
2034
87
2035
87
87
87
87

2015.07.06 P&L Model v0.9 (GY)

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2015.07.06 P&L Model v0.9 (GY)

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MANUFACTURING PARAMETERS

Minimal internal manufacturing

Discount factor for NPV

tarting after the last year with capital expenditures)

rive tax deduction effect = "tax shield")

DRUG MANUFACTORING MODEL: INPUT - MANUFACTURING OPTIONS

Plant option name

Oss Bio current titer improvement

Unable to achieve intensified fed batch titer

able processing volume in L

ONLY CMO PRODUCTION COSTS ARE INPUT

Production costs in $(2015)/g

DRUG MANUFACTORING MODEL: INPUT - DRUG PIPELINE

High volume CHO in existing technology

Keytruda plateaus this year

Keytruda double its titer

Keytruda double titer

New modality become predominant sooner than expected

High volume CHO in new technology

Consolidated pipeline to fewer high volume products

Alternative pipeline demand profile

Ultra-high demand (pipeline)

Ultra-low demand (pipeline)

Low demand (pipeline)

Commercial demand (kg/yr)

Ultra-high demand (pipeline)

Unit price ($/g)

Scale out plant option name

Stainless steel (small)

Capital expenditure, total and relative to launch year

High volume CHO in existing technology

Keytruda plateaus this year

Keytruda double its titer

New modality become predominant sooner than expected

Consolidated pipeline to fewer high volume products

High volume CHO in new technology

Alternative pipeline demand profile

Oss Bio current titer improvement

nt sooner than expected

Scale-out capital cost

Operating Cost Fixed manufaVariable

Operating Cost CAGR (

FCF CAGR (2025-2035)

Operating Cost CAGR (

FCF CAGR (2025-2035)

Operating Cost CAGR (

FCF CAGR (2025-2035)

Operating Cost CAGR (

FCF CAGR (2025-2035)

High volume CHO in existing technology

0% Price drop (du

Commercial demand (kg/yr)

Volume of media needed (m3/yr)

Cost of batches ($m/yr)

Cost of raw material ($m/yr)

Total cost ($m)

Cost per gram ($/g)

Unit price ($/g)

Calculated unit price ($/g)

Plant Option name

Fed batch SU (small)

Intensified fed batch SU (small)

Total Scale-out capital cost ($M)