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MULTIPLE CHOICE
1. Which would be considered a positive symptom of schizophrenia?
a. Blunted affect
c. Poverty of speech
b. Auditory hallucinations
d. Lack of social interaction
ANS: B
Positive symptoms frequently occur during a psychotic episode, when an individual loses
touch with reality and experiences something that should be absent (e.g., hallucinations). The
remaining options are classified as negative symptoms.
PTS: 1
A leading hypothesis for the cause of schizophrenia suggests that the illness results from
neurodevelopmental defects that occur in fetal life. Several early environmental factors have
been suggested to increase the risk of developing schizophrenia, including viral infection
during pregnancy, prenatal nutritional deficiencies, and perinatal complications, such as birth
defects and neonatal hypoxia. No current research supports the theory that any of the other
options are prenatal triggers of schizophrenia.
PTS: 1
In the dorsal prefrontal cortex of schizophrenic brains, glutamic acid decarboxylase, the major
enzyme in gamma-aminobutyric acid GABA biosynthesis, is diminished, which likely impairs
synaptic performance and cognitive and behavioral functions associated with this brain region.
The other neurotransmitters mentioned in the option choices are not related to the presentation
of schizophrenia.
PTS: 1
4. Alterations in which part of the brain are linked to hallucinations, delusions, and thought
c. Temporal lobe
d. Hypothalamus
Only temporal lobe alterations may be responsible for the production of positive
schizophrenic symptoms, such as hallucinations, delusions, thought disorders, and bizarre
behavior.
PTS: 1
6. What data confer the link between bipolar disorders and schizophrenia?
a. Individuals with bipolar disorder who exhibit psychotic behaviors have deficits in
Interestingly, loci on chromosomes 18 and 22 have been linked to bipolar disorder and
schizophrenia. Individuals with bipolar disorder, who may exhibit psychotic behavior, have
deficits in reelin expression linked to genetic loci located on chromosome 22, which confers
susceptibility to schizophrenia. The remaining options do not appropriately describe the link
between bipolar disorder and schizophrenia.
PTS: 1
individuals with:
a. Schizophrenia
b. Major depression
c. Mania
d. Panic disorder
ANS: B
Excessive activation of the HPA system resulting in elevated glucocorticoid secretion is found
in a large percentage (30% to 70%) of people with major depression, suggesting that
mechanisms responsible for HPA hormone alterations contribute to the pathophysiologic
condition of depression. HPA system abnormalities do not necessarily exit in individuals
represented by the remaining options.
PTS: 1
8. The common property among the three types of medications used to treat depression is that
they:
Increase neurotransmitter levels within the synapse.
Increase neurotransmitter levels in the presynapse.
Decrease neurotransmitter levels in the postsynapse.
Decrease neurotransmitter levels within the synapse.
a.
b.
c.
d.
ANS: A
All available antidepressants share the common property, albeit through different mechanisms,
that increasing monoamine neurotransmitter levels within the synapse is the basis for their
antidepressant effects. The processes by which antidepressants affect depression make the
remaining options untrue.
PTS: 1
9. The link between major depression and cortisol secretion is that individuals with depression:
a. Show suppression of plasma cortisol when given dexamethasone.
b. Have a decreased plasma cortisol level, despite the administration of exogenous
corticosteroids.
c. Show that persistently elevated plasma cortisol levels can result in inflammation
.
Persistent elevations in cortisol may also induce immunosuppression that compromises the
bodys immune systems to contain inflammation and infectious diseases. Increasing evidence
suggests that inflammation is another risk factor that triggers the onset of depression. The
options related to dexamethasone and exogenous corticosteroids are not true as they apply to
depression and cortisol secretion.
PTS: 1
10. A decrease in receptor binding for which neurotransmitter is found in individuals with
depression?
a. Norepinephrine
b. Serotonin
c. Dopamine
d. Acetylcholine
ANS: B
Postmortem and/or brain imaging studies of individuals with depression reveal a widespread
decrease in serotonin 5-HT1A-receptor subtype binding in frontal, temporal, and limbic cortex,
as well as serotonin-transporter binding in cerebral cortex and hippocampus. A decrease in
receptor binding is not observed in the other neurotransmitters.
PTS: 1
11. When treating individuals with depression, the result produced by electroconvulsive therapy
c. Norepinephrine
d. The limbic system
ANS: A
Although the mechanism of action of ECT is not clear, the procedure is known to produce
alterations in only the monoamine systems.
PTS: 1
Lithium toxicity can be a result of hyponatremia. Lithium is normally removed from the
kidneys; however, when the body is sodium depleted, the kidneys reabsorb sodium along with
lithium. Lithium toxicity does not result from any of the remaining options.
PTS: 1
Panic disorder also may involve the GABA-benzodiazepine (BZ) receptor system. The other
options are more related to depression.
PTS: 1
14. A criterion for a diagnosis of generalized anxiety disorder (GAD) is a period of excessive
a. 3
b. 6
ANS: B
GAD is diagnosed when an individual spends at least 6 months worrying excessively and
exhibits at least three of the six symptoms. Although 3 months is not sufficient time, the
remaining options are excessive.
PTS: 1
15. Individuals who eat aged cheese and avocado when taking monoamine oxidase inhibitors
c. Orthostatic hypotension
d. Weight gain
ANS: B
MAOIs also may induce acute and heightened elevations in blood pressure (e.g., hypertensive
crisis) after the intake of tyramine-rich foods, such as aged cheeses, sour cream, pods of broad
beans, pickled herring, liver, canned figs, raisins, and avocados. The ingestion of tyraminerich foods is not a trigger for the remaining options.
PTS: 1
ECT is used to treat depression when individuals fail to respond to antidepressants or when
they are severely depressed, pregnant, suicidal, or psychotic. The other options are not true
regarding the conditions of this treatment.
PTS: 1
Of the available options, the only notable complication of panic disorder is the development
of agoraphobia or phobic avoidance of places or situations where escape or help is not readily
available.
PTS: 1
.
In PTSD, the individual re-experiences the traumatic event as intrusive collections or
flashbacks during the day and during persistent nightmares. Nightmares replicate the
traumatic experiences and often prevent sleep. The remaining options are not typically
attributed to PTSD.
PTS: 1
19. Hallucinations, delusions, and thought disorders occur with alterations to which part of the
brain?
a. Temporal lobe
b. Parietal lobe
c. Hypothalamus
d. Cerebral cortex
ANS: A
Only temporal lobe alterations may be responsible for the production of positive
schizophrenic symptoms, such as hallucinations, delusions, and thought disorders.
PTS: 1
MULTIPLE RESPONSE
20. Significant numbers of individuals with depression have problems related to: (Select all that
apply.)
a.
b.
c.
d.
e.
Sleep cycles
Weight stabilization
Eating patterns
Thyroid function
Cognitive skills
ANS: A, B, C, D
Insomnia, loss of appetite and body weight, and reduced interest in pleasurable activities and
interpersonal relationships frequently accompany depression. Approximately 20% to 30% of
persons with unipolar depression have an altered hypothalamic-pituitary-thyroid (HPT)
system. Impaired cognitive skills are not necessarily associated with depression.
PTS: 1
21. Which neurotransmitter is inhibited in generalized anxiety disorder (GAD)? (Select all that
apply.)
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Epinephrine
a.
b.
c.
d.
e.
ANS: B, D
Abnormalities in the norepinephrine and serotonin systems were reported in GAD. The other
options are more related to depression.
PTS: 1
22. What are the most common side effects of selective serotonin reuptake inhibitors (SSRIs)?
a.
b.
c.
d.
e.
ANS: C, E
Common side effects of SSRIs include sleep disturbances (e.g., insomnia) and nausea. The
remaining options are not common side effects of SSRIs.
PTS: 1
MATCHING
23.
24.
25.
26.
27.
28.
23. ANS: D
PTS: 1
REF: Page 644
MSC: A hallucination is a perception experienced without external stimulation of the sense organs.
24. ANS: A
PTS: 1
REF: Page 646
MSC: A delusion is a persistent belief contrary to the educational and cultural background of the
individual.
25. ANS: B
PTS: 1
REF: Page 646
MSC: A common form of disorganized speech is formal thought disorder, which involves fluent
speech that is difficult to comprehend.
26. ANS: E
PTS: 1
REF: Page 646
MSC: Alogia is the absence of spontaneous speech production for the purpose of answering questions
or expressing oneself.
27. ANS: C
PTS: 1
REF: Page 646
MSC: In anhedonia, individuals are unable to experience emotions such as pleasure or pain; they
report a sense of detachment from the environment.
28. ANS: F
PTS: 1
REF: Page 646
MSC: Avolition is a deficit in spontaneous or goal-directed behavior in which an individual may sit
for prolonged periods and must be prodded into completing simple daily tasks.