Evidence of KA21

Antitumor beta glucan from the cultured fruit body of Agaricus blazei.
http://www.ncbi.nlm.nih.gov/pubmed/11456124

Antitumor activity

Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with

therapeutic antioxidant potential in streptozotocin-induced diabetic
rats.
http://www.ncbi.nlm.nih.gov/pubmed/21562638

Diabetes
Blood sugar

normal
control
Ipomoea batatas
Kingagaricus

Week

Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in

Human Volunteers.
http://www.ncbi.nlm.nih.gov/pubmed/18604247

Safety data

Table 3. Safety of A. brasiliensis KA21 in human volunteers

Biochemical
parameters

Before (mean SD) After (mean SD)

Statistics (P-value)

Total protein (g dl1)

7.50 0.16

7.41 0.25

0.31

BUN (mg dl1)

15.81 5.93

13.45 2.25

0.12

Creatinine (mg dl1)

0.92 0.21

0.90 0.20

0.19

GOT ( l1)

18.8 4.75

19.8 4.40

0.10

GPT ( l1)

15.7 6.90

16.3 4.90

0.52

-GTP ( l1)

35.4 29.6GTP

35.9 30.1

0.89

(N = 11).
Kingagaricus100 9g a day was administrated for 6 months to 11 subjects

Effect of A. brasiliensis on body weight

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

The normal dose was administrated to 12 subjects for 3 months

Copyright restrictions may apply.

Effect of A. brasiliensis on BMI

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

The normal dose was administrated to 12 subjects for 3 months

Copyright restrictions may apply.

Effect of A. brasiliensis on percentage body fat

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

The normal dose was administrated to 12 subjects for 3 months

Copyright restrictions may apply.

Effect of A. brasiliensis on percentage visceral fat

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

The normal dose was administrated to 12 subjects for 3 months

Copyright restrictions may apply.

Effect of A. brasiliensis on blood glucose level

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

The normal dose was administrated to 12 subjects for 3 months

Copyright restrictions may apply.

Effect of A. brasiliensis on blood cholesterol level from the viewpoint of Mibyou

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

Copyright restrictions may apply.

Effect of A. brasiliensis on neutral fat level from the viewpoint of Mibyou

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

Copyright restrictions may apply.

Comparison of NK cell activity before and after administration of A. brasiliensis

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

The normal dose or placebo was administrated to 8 subjects for 7 days (DBT)
Copyright restrictions may apply.

Comparison of NK cell activity before and after administration of placebo

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

The normal dose or placebo was administrated to 8 subjects for 7 days (DBT)
Copyright restrictions may apply.

Agaricus brasiliensis KA21 improves circulatory functions in

spontaneously hypertensive rats.
http://www.ncbi.nlm.nih.gov/pubmed/24433071

Improve Circulatory Function SHR)

Diet

Neutral Fat (Triglyceride)

Protect
Heart
Function
Centra Nerve system
Heart

Muscle

Differences in antioxidant activities of outdoor- and indoor-cultivated

Agaricus brasiliensis, and protective effects against carbon
tetrachloride-induced acute hepatic injury in mice.
http://www.ncbi.nlm.nih.gov/pubmed/25418207

Antioxidant activity

Kingagaricus

Green house

Liver Protection
Normal
Kingagaricus 3%
Green house agaricus 3%

10 days

Liver Protection
Normal
Kingagaricus 10%

24hours

Open-Label Study of the Influence of Food Containing the Royal Sun

Mushroom, Agaricus brasiliensis KA21 (Higher Basidiomycetes), on the
Quality of Life of Healthy Human Volunteers.
http://www.ncbi.nlm.nih.gov/pubmed/26756293

QOL
Fatigue

Grey Hair

Hair Loss

4.0

4.0

4.0

3.8

3.8

3.8

3.6

3.6

3.4

3.4

3.2

3.2

3.0

3.0

2.8

2.8

2.6

3.6
3.4
3.2
3.0
2.8
2.6

2.6

2.4
2.2
2.0

Pre-intake

6th week
L

12th week

900mg or 1500mg

2.4

2.4

2.2

2.2

2.0

2.0

Pre-intake
Pre-intake

6th week

12th week

6th week
L
H

12th week

QOL
Eye strain

Shoulder stiffness

coldness of extremities

4.0

4.0

4.0

3.8

3.8

3.8

3.6

3.6

3.4

3.4

3.2

3.2

3.0

3.0

2.8

2.8

2.6

2.6

2.4

2.4

2.2

2.2

2.0

2.0

3.6
3.4
3.2
3.0
2.8
2.6
2.4

Pre-intake

6th week

12th week

2.2
2.0

Pre-intake
Pre-intake

6th week

6th week

12th week
L

12th week

QOL
difficulty staying awake during the day

ease of getting out of bed

2.0

2.0

1.8

1.8

1.6

1.6

1.4

1.4

1.2

1.2

1.0

1.0

0.8

0.8

0.6

0.6

0.4

0.4

0.2

0.2

0.0

Pre-intake

6th week

12th week

0.0

Pre-intake

6th week

12th week

Not published data

IGF-1
Peak

IGF-1 level High

Aging

Low

Years old

IGF-1
Anti-Aging effects
Hair regrowth
Improve immunity
Better skin condition, less spots, wrinkles
Improve cognitive function
Improve metabolic syndrome
Generative function

IGF-1

This is not Kingagaricus data

Anti-Aging
* , p<0.01 vs. control

* , p<0.01 vs. control

150

100

50

* , p<0.01 vs. control

Hippocampus
IGF-I
(ng/g tissue)

250
200
150
100

50
0

* , p<0.01 vs. control

Reach to the goal (Seconds)

Hippocampus
CGRP
(pg/g tissue)

200

100
80

Control (n=5)

60
40
Agaricus (n=5)

250

Blood
IGF-I
(ng/ml)

200

20

150

100

50
0

Control
(n=5)

Agalicus blazei
(water extract)
(10 mg/kg/day,
po)
(n=5)

4
Kingagaricus data

*
5

IGF-1

2 months

Dog took Kingagaricus100 for 2 months

Reduce side effect from anti cancer drug

Number of Leucocyte
Control
cyclophosphamide; CPA
cyclophosphamide; CPA+agaricus hot
cyclophosphamide; CPA+agaricus cold