Aslistedinthe2016PhysiciansDeskReference(PDR)

Immunocal
NUTRACEUTICAL
Glutathioneprecursor(Bondedcysteinesupplement)
PowderSachets

DESCRIPTIONandCLINICALPHARMACOLOGY
IMMUNOCALisaspeciallyformulatedundenaturedwhey
proteinisolate.ItholdsseveralpatentsintheUSAand
worldwideandislistedbytheFDAinthecategoryofGRAS
(generallyrecognizedassafe).Itassiststhebodyinmaintaining
optimalconcentrationsofglutathione(GSH)bysupplyingthe
precursorsrequiredforintracellularglutathionesynthesis.Itis
clinicallyproventoraiseglutathionevalues.

GlutathioneisatripeptidemadeintracellularlyfromitsconstituentaminoacidsLglutamate,L
cysteineandglycine.Thesulfhydryl(thiol)group(SH)ofcysteineisresponsibleforthe
biologicalactivityofglutathione.Provisionofthisaminoacidistheratelimitingfactorin
glutathionesynthesisbythecellssincebioavailablecysteineisrelativelyrareinfoodstuffs.

Immunocalisabovinewheyproteinisolatespeciallypreparedsoastoprovidearichsourceof
bioavailablecysteine.Immunocalcanthusbeviewedasacysteinedeliverysystem.

The disulphide bond in cystine is pepsin and trypsin resistant but may be split by heat, low pH or
mechanical stress releasing free cysteine. When subject to heat or shearing forces (inherent in most
extractionprocesses),thefragiledisulfidebondswithinthepeptidesarebrokenandthebioavailability
ofcysteineisgreatlydiminished.

Glutathione is a tightly regulated intracellular constituent and is limited in its production by negative
feedbackinhibitionofitsownsynthesisthroughtheenzymegammaglutamylcysteinesynthetase,thus
greatlyminimizinganypossibilityofoverdosage.

Glutathionehasmultiplefunctions:
1. It is the major endogenous antioxidant produced by the cells, participating directly in the
neutralization of free radicals and reactive oxygen compounds, as well as maintaining
exogenousantioxidantssuchasvitaminsCandEintheirreduced(active)forms.
2. Through direct conjugation, it detoxifies many xenobiotics (foreign compounds) and
carcinogens,bothorganicandinorganic.
3. It is essential for the immune system to exert its full potential, e.g. (1) modulating antigen
presentation to lymphocytes, thereby influencing cytokine production and type of response
(cellular or humoral) that develops, (2) enhancing proliferation of lymphocytes thereby
increasingmagnitudeofresponse,(3)enhancingkillingactivityofcytotoxicTcellsandNKcells,
and(4)regulatingapoptosis,therebymaintainingcontroloftheimmuneresponse.
4. It plays a fundamental role in numerous metabolic and biochemical reactions such as DNA
synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport and
enzyme activation. Thus, most systems in the body can be affected by the state of the
glutathione system, especially the immune system, the nervous system, the gastrointestinal
systemandthelungs.

INDICATIONSANDUSAGE
IMMUNOCALisanaturalfoodsupplementandassuchislimitedfromstatingmedicalclaims
per se. Statements have not been evaluated by the FDA. As such, this product is thus not
intendedtodiagnose,cure,preventortreatanydisease.

Glutathione augmentation is a strategy developed to address states of glutathione deficiency, high

oxidative stress, immune deficiency, and xenobiotic overload in which glutathione plays a part in the
detoxificationofthexenobioticinquestion.Glutathionedeficiencystatesinclude,butarenotlimitedto:
HIV/AIDS, infectious hepatitis, certain types of cancers, cataracts, Alzheimers Disease, Parkinsons,
chronic obstructive pulmonary disease, asthma, radiation, poisoning by acetominophen and related
agents, malnutritive states, arduous physical stress, aging, and has been associated with suboptimal
immune response. Many clinical pathologies are associated with oxidative stress and are elaborated
uponinnumerousmedicalreferences.

Lowglutathioneisalsostronglyimplicatedinwastingandnegativenitrogenbalance,notablyasseenin
cancer, AIDS, sepsis, trauma, burns and even athletic overtraining. Cysteine supplementation can
opposethisprocessandinAIDS,forexample,resultinimprovedsurvivalrates.

CONTRAINDICATIONS
IMMUNOCALiscontraindicatedinindividualswhodeveloporhaveknownhypersensitivitytospecific
milkproteins.

PRECAUTIONS
EachsachetofIMMUNOCALcontainsninegramsofprotein.Patientsonaproteinrestricteddietneed
to take this into account when calculating their daily protein load. Although a bovine milk derivative,
IMMUNOCAL contains less than 1% lactose and therefore is generally well tolerated by lactose
intolerantindividuals.

WARNINGS
Patients undergoing immunosuppressive therapy should discuss the use of this product with
their health professional. Individuals with the autosomalrecessive metabolic disorder
cystinuria,areathigherriskofdevelopingcysteinenephrolithiasis(12%ofrenalcalculi).

ADVERSEREACTIONS
Gastrointestinalbloatingandcrampsifnotsufficientlyrehydrated.Transienturticariallikerash
inrareindividualsundergoingseveredetoxificationreaction.Rashabateswhenproductintake
stoppedorreduced.

OVERDOSAGE
OverdosingonIMMUNOCALhasnotbeenreported.

DOSAGEANDADMINISTRATION
For mild to moderate health challenges, 20 grams per day is recommended. Clinical trials in
patientswithAIDS,COPD,cancerandchronicfatiguesyndromehaveused3040gramsperday
withoutilleffect.IMMUNOCALisbestadministeredonanemptystomachorwithalightmeal.
Concomitantintakeofanotherhighproteinloadmayadverselyaffectabsorption.

RECONSTITUTION
IMMUNOCAL is a dehydrated powdered protein isolate. It must be appropriatelyrehydrated
beforeuse.Ideallyconsumedaftermixing.Ifitispremixedforlaterconsumption,itshouldbe
refrigeratedandconsumedshortlyaftermixing.DONOTheatoruseahotliquidtorehydrate
theproduct.DONOTuseahighspeedblenderforreconstitution.Thesemethodswilldecrease
theactivityoftheproduct.

Propermixingisimperative.Consultinstructionsincludedinpackaging.

HOWSUPPLIED
10gramsofbovinemilkproteinisolatepowderpersachet.
30sachetsperbox.

STORAGE
Storeinacooldryenvironment.Refrigerationisnotnecessary.

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ManufacturedbyImmunotecInc.
Tel:4504249992ext.4453
www.immunocal.com