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HarmeetSingh
APBiology
1stHour
23March2016
SamRhineAssignment
Therearethreeboxesintheworldofgenetics:Box1iscytogenetics,Box2Monogenic,
andboxthreeisMultifactorial,orwhatwecallitpolygenicgenes.Theseboxesholdahandfull
ofgeneticalinformationthatwillchangeourfutureforever.Indeep,Box1containmanyaspects
consideringwithDownSyndrome,PatauSyndrome,EdwardsSyndromeKlinefelterSyndrome,
andTurnerSyndrome.ThesearejustabunchofchromosomeSyndromesthatwerepadlocked
forcenturiesbutopenedin,1956.SamRhineexplainedthatinthefuturethereisgoingtobea
cureforalloftheseandmanymoregeneticissueinthefuture.FurthermoreSamRhinewenton
talkingaboutBoxTwo,howMonogenicTraitswasaanotherlockthatwasopenedbetween
1865to1903.InthisboxweremanydiseaseslikeSickleCellAnemia,CysticFibrosis,
TaySachs,Huntington'sDisease,Neurofibromatosis,MarfanSyndrome,FragileXSyndrome,
Hemophilia,DuchenneMuscularDystrophy,andRetinitisPigmentosa.Thebox3,Multifactorial
genes,wasaresultoftheHumanGenomeProjectwhichendedApril25,2003.Thethreeboxes
wasjustastarttowhatthegenomeprojectresultedfrom.
TheHumanGenomeProjectwasabigstarttounravelbigsecretsaboutthehumanDNA.
TheystartedbyunzippingDNA,makingandfindingitsstructuresandfunctionsthatitperforms.
Itwasaprojectwere20countriescametogether,ItwasmostlyUnitedStatesandUnited
Kingdomwhohelpedabunch.ItofficiallybeganOctober1,1990andendedSeptember30,
2005.Afterfewyearsintotheprojectscientistfiguredthat99.6%ofDNAofeveryhumanwas
identical.Theofthe0.4%aredifferentgenescontainsheight,color,weightandmanyother
functionsoftraits.AfterfiguringoutDNA,scientiststartedtoaskmorequestionsthatwere
carriedthroughinotherprojects.
SmaRhinetalkedaboutcommondiseaseandhowtheywerecontrolledbyQuantitative
traitsandpolygenictraits.Hesaidthesetraitscontrolledifpeoplewerenormalbelowthe
threshold.UsuallythepeoplewhofallbelowthethresholdhavealowIQoradifferenttypeof

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defect.HesaidwecangoinDNAandcutthecertainpartsofDNAthatmakesgivespeoplea
certaindefect,andthentheDNAwillselfrepairitself.Bydoingthisprocesswehavetheability
tocurejustaboutanything.Wehavethetechtogoandchangestemcellsorembryoniccellsor
somaticcells.TheevaluationofSNPsandCNPsisbecomingcheaperastimegoesby.Thereare
220differentwaystheacelltakes,andnow,sincethetechnologyhasinvolvedwewillbeableto
altercellsinwhichphasethebecome.
TherewasmanythingsthatSamRhinesaidwereimportant.ThemostinterestingthingI
foundwasthatcloningisaactualthing.IfIhadtheknowledgeofcloningIcoulddoalotwithit
thatwillhelptheworldandme.Ifounditprettyfunnythatthefirstthingthatscientistcloned
wasasheep.Afterasheepthewentoneandclonedotheranimalslikegoats.Thismeansifthe
scientistgettheapproval,wecanclonehumans.
Makingabrainfromjustaskincell,wow!Thewayheexplainedthatwehavetheability
totakeaskincellandputintoapetridishtomakeabrain.Theprocessincludesalotof
alterationstothecell'sDNA.Notjustbrains,scientistacancreateanyhumanorganandthen
transplantintoahumansbodyforgreatuse.Thistechnologycanhelpmanypeoplewhocould
beneed.
Themostinterestingthingwasthedisease,syndromes,andotherhorribledefectsthat
humansgothroughcanbecured.IwasamazedtohearthetechnologytochangeDNAisalready
outanditwascalledcrisper.Wecanmakepeoplesmarter,tallerormoreathleticifwewanted
to.ThisgoodnewsbecauseinthefutureIcouldprobablychoosewhatmychildrenwouldlook
like.Sofarscientistaren'tapprovethisyetbutonceitouteverythingisgoingbeabigblast.
Withthisadvantagewecouldhelpoutalltheendangeredspeciestobecomebacktoitsnormal
populations.
Myknowledgeofgeneticswasjustabagfull,butaftergoingtoJacksonCollege's
AuditoriumIwasdelighted.TheinformationofGeneticsthatwaspresentedbySamRhinewas
outstanding.Takingingeneticinformationlikethatishelpfulforthisclass,theAPtest,andour
future.IfIweretoneverattendthisIwouldvebeenleftbehindonsomuchimportant
informationongeneticdiscoveries.IfIweretosaysomethingbadaboutthisitwouldbethatit

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waskindacoldandthechairswereuncomfortable.Ireallythinkyoushouldcontinuethisevry
yearwithyourAPbiologystudents.

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