HISTORICAL BACKGROUND

1492, Leonardo da Vinci depicted the appendix in his anatomic drawings

1521, Berengario Da Capri and, in 1543, Andreas Vesalius published
drawings recognizing the appendix
Jean Fernel describing appendiceal disease in a paper published in
1544, case report of 7th years with diarrhea treated with quince an
apple like fruit.
pain and died. At autopsy, the quince was found to have
obstructed the lumen of the appendix, causing necrosis and perforation.
3 Lorenz Heister provided the first description of classic
appendicitis in