mechanisms of disease

Acute Lymphoblastic
Leukemia
Jornal review, The new England of journal of medicine, 20014

The rate of
success in the
treatment
of
acute
lymphoblastic
leukemia
(ALL)
has
increased
steadily since
the 1960s.
The best hope for
continued
progress lies in a
better
understanding of
the pathogenesis
of ALL and the
basis of
resistance to
chemotherapy.

The five-year
event-free
survival rate is
nearly 80 percent
for children with
ALL and
approximately
40percent for
adults
review current
and emerging
concepts of the
pathobiology of
ALL, emphasizing
results likely to
have the greatest
influence on
clinical
management
during the next
decade.

molecular genetic
alterations

primary abnormalities

chimeric transcription
factors

HOX
transcription
factors bind to DNA
and regulate genes
involved
in
the
differentiation
of
both the embryo and
the
hematopoietic
stem cell; they are
also important in the
self-renewal
and
proliferation
of
hematopoietic stem
cells.

cooperative mutations