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Genetics: An Introduction
What is Genetics?
Genetics is the
fraction of biology
that studies
heredity.
Genetics is the
center of all
biology because
gene
activity underlies
all biological
processes.
Classic Genetics
From Mendel to the
Central Dogma of
Genetics (1866-1941).
Mendels published
work, Experiments in
Plant Hybridization
(1865), languished with
no discernable impact
until in 1900 three other
investigators
independently
discovered the same
genetic principles.
Modern Genetics
From the Central
Dogma of Genetics
(1941 to todays
Genomics).
Beadle and Tatum (one
gene-one polypeptide),
Watson and Crick
(DNA structure), Paul
Berg (genetic
engineering) are
examples of rosetta
stones findings in
Modern Genetics.
Transmission Genetics
Sometimes called classic
genetics deals with how
genes are transmitted from
generation to generation
and how they recombine
Molecular Genetics
It deals with the
molecular structure
and function of genes.
Analyzing the
sequence of the
nitrogen bases in a
gene (and how it may
change its expression)
is an example of
molecular genetics.
Population Genetics
POPULATION
LACTOSE
INTOLERANT
ADULTS
U.S.
European
Americans
2-19 %
Latinos
(Hispanic
Americans)
52 %
African
Americans
70-77 %
Native
Americans
95 %
Asian
Americans
95-100 %
It studies heredity of
one or a few genes in a
large group of
individuals
(population). For
example the study of
the distribution and
inheritance of lactose
intolerance in different
ethnic american
groups.
Source: Robert D. McCracken, "Lactase Deficiency: An Example of Dietary Evolution," current Anthropology 12 (Oct.-Dec. 1971, pp. 479-517) and Norman Kretchner, "Lactose and
Lactase," Scientific American 277 (Oct. 1972, pp. 71-78)
Quantitative Genetics
It also studies heredity of
a trait in a large group of
individuals but the
individual trait is codified
by many genes
simultaneously. For
example the discontinous
distribution of shell color
(a polygenic trait) in the
snail Cepaea nemoralus
from a population in
England.
In eukaryotes,
the DNA is
located in the
nucleus forming
linear
chromosomes.
Each
chromosome
consists of a
single DNA
molecule
complexed
(associated)
with histone
proteins.
Scanning
micrograph of a
chromosome