 Actuality

 Disease spreading all over the world

 It can induce severe epidemic outbreak

 Life threatening illness -163 millions cases and 1 million death annually)

 History

 Definition

Shigellosis (bacillary dysentery) is acute infectious disease characterized by syndromes of intoxication

and terminal colitis

 Etiology-1

 Etiology-2

 Gram-negative bacilli

 Non-spore forming

 Facultative anaerobic bacilli

 Able to produce endotoxin (exotoxin)

 Pathogenesis

 Pathogenesis-1

 Pathogenesis-2

 Criteria of severity

Fever

 Mild – up to 38 C

 Moderate – up to 40 C

 Severe – above 40 C

Frequency of defecations

 Mild - till 10 times/day

 Moderate – till 15 times/day

 Severe – more than 15 times/day (sometimes – countless)

 Typical Form of Dysentery

 Colitis’ syndrome

 Gastrointestinal form of dysentery

 Obliterated form of dysentery

 Subclinical form of dysentery

 Bacteria carrying

 Complications of dysentery

 Toxic shock

 Intestinal bleeding

 Invagination of intestine

 Peritonitis

 Diagnosis

 Anamnesis

 Clinical inspection

 Investigation of excretion

 Lab. Studies

 Endoscopic inspection

 Treatment

 Dietary treatment

 Etiological treatment

 Pathogenically tr.

 Detoxication

 Antispastic