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  • Pa Tho Physiology

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    docjunet
    41 vues3 pages
    FIBROSARCOMA ( FIBROSARCOMA ) is a malignant tumor of fibroblasts. The tumor is found in the bones, head, neck, face,oral cavity and cheek. It can be treated with chemotherapy, immunotherapy, radiation therapy and biotherapy.

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    FIBROSARCOMA ( FIBROSARCOMA ) is a malignant tumor of fibroblasts. The tumor is found in the bones, head, neck, face,oral cavity and cheek. It can be treated with chemotherapy, immunotherapy, radiation therapy and biotherapy.

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    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOC, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    41 vues3 pages

    Pa Tho Physiology

    Transféré par

    docjunet
    FIBROSARCOMA ( FIBROSARCOMA ) is a malignant tumor of fibroblasts. The tumor is found in the bones, head, neck, face,oral cavity and cheek. It can be treated with chemotherapy, immunotherapy, radiation therapy and biotherapy.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOC, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 3

    PATHOPHYSIOLOGY

    FIBROSARCOMA

    PREDISPOSING FACTORS PRECIPITATING FACTORS

    - GENES - Ionizing Radiation

    - AGE - Chemical Substances

    - SEX - Physical Irritants

    - Viruses

    Normal Cell
    (fibroblasts)
    are mutated

    Tumor suppressor genes


    Proto-oncogenes inactivation DNA repair gene inactivation
    become oncogenes

    Stimulation or further mutation


    Inaccurate DNA
    Hyperactive growth of cells Cell looses control over DNA repairtoisthe
    hindered or
    Proto-oncogenes and
    replication
    cell cycle inhibited Tumor suppressor genes

    abnormal formation of vessels then grow


    Endothelial cells take
    Release of new blood vessels. MoreExcessive
    than 2mm
    towards
    growth
    the tumour
    up microvesicles of formation
    anomalous cells
    microvesicles armed Tumor
    with cancer protein (fibroblasts)
    Weight Loss
    Angiogenesis Supplies the tumor with
    nutrients
    Pain

    Mass Tumor or localize mass in the


    ( bones, head, neck, face,oral cavity
    Fatigue and cheek)-FIBROSARCOMA

    Anemia

    If treated: If Not treated:

    Treatment:
    Attachment of abnormal
    Surgery fibroblasts into the
    basement membrane
    Chemotherapy ( lymph node)

    Immunotherapy
    Abnormal fibroblasts
    Radiation Therapy
    adhere to cellular matrix
    Biotherapy by expressing surface
    Tumor adheres
    adhesion to the
    molecules
    adjacent extracellular matrix

    Once free of the confines of


    the local tissue(lymph node),
    the tumor travels to nearby
    structures

    Tumor release enzymes


    that destroy neighboring
    matrix
    Metastatic tumor
    Tumor appears/ Fibrosarcoma
    metastasize other (
    bones, head, lungs,neck,
    tissues (Shoc
    fibrous face,oral cavity
    Bad
    Deat

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