ON

RELATIONSHIP BETWEEN VITAMIN

& HORMONE INTERRELATION
CONTENTS

 INTRODUCTION
 VITAMIN D & HORMONES

 VITAMIN A & HORMONES

 VITAMIN B6 & HORMONES

 VITAMIN C, B6 & PROGESTERONE

 VITAMIN E & HORMONES

 CONCLUSION

 REFERENCES
WHAT ARE VITAMINS ?

 Organic compounds occurring in

small quantities in different natural
food and necessary for growth and
maintenance of good health in
human beings.

 Interrelationship between different

nutrients.

 Alterations in function of one

nutrient alters other’s function in the
body.
WHAT ARE HORMONES ?

 Organic compounds secreted in small

amounts by indegeneously located
endocrine glands in blood stream.

 These have specific excitatory and

inhibitory roles in the body.

 Also known as Chemical messengers.

 VITAMIN D & HORMONES
VITAMIN D AS HORMONE

 Vitamin is a group of fat soluble

vitamins.

 Two major physiological relevant

forms are Vit. D2 and Vit.D3.

 In liver Vit.D is converted into

prehormone Calcidiol.

 Calcitriol is biologically most

potent steroid hormone.
VITAMIN D & PROGESTERON
 Vit. D along with progesteron is applied to neurons
under stress.

 It increases the effectiveness of progesteron.

 Small amount of Vit.D with pgogesteron protect neurons

from excito toxicity – a principle cause of cell death.
VITAMIN D & PARATHYROID
HORMONE

 Collip’s Hormone – an active hormone secreted by

Parathyroid gland.

 It functions in following ways :

 Activates Vit. D and increases dietary Calcium
absorption.
 Mobilises Calcium from bones.

 Decreases Calcium excretion.

VITAMIN A & THYROID HORMONE

 Relationship between Vit.A and Thyroid

hormone is apparent in Liver chirrhosis.

 Due to cirrhosis increase in Estrdiol

disrupts thyroid function and Vit. A
metabolism.

 Cause reduction in total serum T3

concentration and T4 to T3 conversion.
VITAMIN A & GONADOTROPINS

 Absence of Vit.A causes cornification of Epithelial

tissue.

 Alters balanced secretion of Gonadotropins i.e

Luteinizing and Follicle stimulating hormone.

 Deficiency causes infertility.

ADRENAL BURNT OUT SYNDROME
 Low functioning of Adrenal gland , related to
Adrenal weakness or Adrenal exhaution.

 Mild form of Addison’s disease.

 Vit.B6 plays crucial role as it stimulates adrenal

function release of adrenal gland hormones.

 Pyridoxal phosphate dependent dopamine

decarboxylase is involved in the formation of
adrenaline and noradrenaline.

cont…
VITAMIN B6 & NEUROHORMONES

 Pyridoxal phosphate is required as a coenzyme .

 This is crucial in formation of Serotonin and alpha

Aminobutyric acid – neurohormones

 Deficiency cause Convulsive Seizures in brain.

 These are called Stress hormones i.e they help us to
cope with stress.

 They govern Fight and Flight response.

 Symptoms of Adrenal insufficiency :

 Fatigue , weakness , nervousness , sweet carvings and
allergy.

 Long term deficiency may result in Adrenal atrophy.

VITAMIN B6 & THYROID HORMONES

 Pyridoxal phosphate dependent thyroid hormone

transaminase , which deaminate thyroxine,
diiodothyronine.

 It can not function well in B6 deficiency.

 Deficiency also results in hyperglycemia and decresed

ability to utilize glucose.
VITAMIN B6 & ESTROGEN
DOMINANCE
 It is situation in which level of estrogen outweighs
progesteron levels in body.

 Affect both male and female fertility.

 Inhibit conception causing Endometriosis and Polycystic
ovary syndrome.

 Major cause of Breast, Uterine and Ovarian cancer and pre

menstrual syndrome.

cont…
 Complications include anxiety, severe headache,
depression, digestive problems, irregular menstruation,
water retention and weight gain.

 Low levels of vitamin B6 and C and poor diet like

processed food and foods high in fat and sugar increase
estrogen levels.

 Vitamin B6 neutralize estrogen levels.

LUTEAL PHASE DEFECT &
VITAMINS

 Deficiency of Progesteron cause Luteal phase defect.

 It is time of women’s women cycle between ovulation and

menstruation.

 Naturally it is 14 days long and anywhere between 10 to 17

days.

 If it lasts under 10 days ; called Luteal phase defect.

cont..
 Women do not produce normal levels of FSH leading to
inadequate follicle development.

 This results in poor corpus luteum quality; as a result

progesteron secretion from corpus luteum decreases
drastically.

 These cahanges can be due to oxidative stress, free

radicals that interfere with production of progesteron and
high levels of lipoperoxidase.

cont..
 Vitamin C along with Vitamin A and B6 act as strong
oxidizing agent to prevent stress problems.

 It is most effective to take progesteron dissolved in

Vitamin E .

 It increases absorption and its blood circulation.

CONCLUSION
 Vitamins are very important for normal and healthy
body functioning .

 Take 600mg. per day retinol or 2400ug. per day carotene

as a source of Vit.A. Lactating woman should include
950ug.per day retinol daily in diet.

 Include 2mg.per day and 1ug.per day Pyridoxin and

Vit.B12 in diet. Lactating woman should take 2.5mg.per
day and 1.5ug.per day Pyridoxin and Vit.B12
respectively.
 Increased intake of Biotin rich foods like poultry, dairy
products and fish decreases the risk of insulin resistance.

 Take Vit.B supplements to increase Adrenal gland output.

 Enhance body’s activity to process estrogen with Vit.B6,

Vit.B12, and Choline. They support liver’s ability to
excrete excess estrogen.

 Take 40mg. per day Ascorbic acid(Vit.C) . Lactating

woman should increase the intake to 80mg. per day.