- Aging (75 y.

o) - Lifestyle

-Family History >smoking

> Alcohol Drinking
( Diabetes Mellitus,
Hypertension) ( Hypertension,
Diabetes Milletis,
Recurrent infection)

Decreased renal blood

flow, Primary Kidney
disease, Damage from other
disease, and Urine outflow Treatmen
obstruction t of
underlyin
g cause

BUN Glomerular serum

serum
BUN
Filtration creatinin
creatinin
ee

Hypertrophy of
remaining nephron

Dehydr
Dehydr Inability to Loss of Na Hyper
Hyper
ation
ation concentrate Urine in urine --
natre
natre
mia
mia
Further loss of
nephron function
Dilute
Dilute
polyuri
polyuri
aa
libido
libido
Disturbance In
Loss of nonexcratory Reproduction
renal function Infertilit
Infertilit
yy

Failure to produce
erythropoietin Anem
Anem
ia
ia
Pallor
Pallor

Osteo-
Osteo-
dystroph
dystroph
Failure to produce
yy
inactive forms of Calcium
Dialysi Calcium Absorption
s
Hypo-
Hypo-
calcem
calcem
ia
ia

Loss of excretory
ranal function
 Na
Bicarbonat
e
Phosphorus Calcium Vitamin
binding Replacement
agent D
Hydrogen Metabol
Metabol
ic
ic
excretion Acidosi
Acidosi
ss

Phosphate Hyper-
Hyper- Calcium Hypo-
Hypo-
excretion phosphatemi
phosphatemi Absorption calcemi
calcemi
aa aa

Hyperparathyroidism

Potassiu
m
binding Potassium
agent Excretion

Potassium Hyper-
Hyper-
kalemia Potassiu
Excretion kalemia
m Potassiu
Potassiu
restriction m
m

Fluid Diuretic
Restrictio s
n Edem Hyper-
Hyper- Heart
Heart
a tensio
tensio Failur
Failur
nn ee

Sodium
Reabsorption Water
in tubule retention

Anti- Lotions
Peripher
Peripher onvulsant Bathing
al
al Nerve
Nerve
damage
damage
CNS
CNS
Creatinin
Creatinin chan
chan
BUN
BUN ee ges
ges

Excretion of
Nitrogenous
waste Uremia

Uric Proteinu
Proteinu Altere
Altere
Uric ria Pericardi
Pericardi Prurit
Prurit
acid ria dd
acid tis
tis us
us taste
taste
Legend:

Precipitating Factors:

Predisposing Factors:

Pathophysiology

Manifestation

Interventio

Interruption of the progress of the disease, through medical interventio