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MALIGNANT MELANOMA MALIGNANT MELANOMA


oClinical features oMicroscopy
. Asymptomatic . Radial growth pattern
. Changes in morphology of the lesion (ABCDE) " Superficial spreading, lentigo
" A=Ampettr malignmtl6ions tend to be more lopsided ad . Unable to metastasis
iregular.
. 6=gq4mrpmrlydefined as in thepictureabove.
. Vertical growth pattern
6 C=gdgE&.']&lQgr iregutar " Deeper slruciures
. D--U!!!glC!: g@ter " Metastasb
. E=EvolylCSllpld&: chdg6noticeablywilhin aperiod as shortN
' lncrease mitoses
. Lymphocytic cells intiltrates
.. Large & atypical nevus cells with
,. large nucleus and prominent
eosinophilic nucleolus

MALIGNANT MELANOMA
sAssessment of prognosis f| THE-ENn--I
--- '
. Tumourdepth (mm)
t

. No. of mitoses per square mm giiffi


' Presence of immune response to lhe superficial growth
(regression)
. Presence &degree oflymphocytes atthe base of ri trri' iir:,i-':

vertical growth
Gender
ns*d rl; ___'-
'
. Location - central / extremities 4$P'
Favourable indicators: depth <1.7mm, low mitoses,
presence of immune response, female & extremity skin
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