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Hypertension – JNC VII

Goal: <140/90
< 130/80 if diabetic or renal disease
Therapy:
120-139 or 80-89 140-159 or 90-99 >160 or >100
Lifestyle Thiazide-type 2-drug combination
Modifications diuretics for most. for most (usually
May consider thiazidetype diuretic
ACEI, ARB, BB, and ACEI, or ARB,
CCB, or or BB, or CCB).
combination.

Compelling indications:
• Heart failure: THIAZ, BB, ACEI, ARB, ALDO ANT
• Post myocardial infarction: BB, ACEI, ALDO ANT
• High CVD risk: THIAZ, BB, ACEI, CCB
• Diabetes: THIAZ, BB, ACEI, ARB, CCB
• Chronic kidney disease: ACEI, ARB
• Recurrent stroke prevention: THIAZ, ACEI

Identifiable causes of HTN:


• Sleep apnea • Cushing’s syndrome
• Drug induced/related • Steroid therapy
• Chronic kidney disease • Pheochromocytoma
• Primary aldosteronism • Coarctation of aorta
• Renovascular disease • Thyroid/parathyroid disease

CVD Risk factors:


• Hypertension • Physical inactivity
• Obesity (body mass index • Age (>55 for men, >65 for
>30 kg/m2) women)
• Dyslipidemia • Diabetes mellitus
• Microalbuminuria, est GFR • FH of early CVD (men age
<60 mL/min <55, women age <65)
• Cigarette smoking • Physical inactivity
Lifestyle Modifications:
Weight Maintain normal body 5–20 mmHg/10 kg
reduction weight (body mass index
18.5–24.9 kg/m2).
DASH eating Adopt a diet rich in 8–14 mmHg
plan fruits, vegetables, and
lowfat dairy products
with reduced content of
saturated and total fat.
Dietary sodium Reduce dietary sodium 2–8 mmHg
reduction intake to <100 mmol per
day (2.4 g sodium or 6 g
sodium chloride).
Aerobic Regular aerobic physical 4–9 mmHg
physical activity (e.g., brisk
activity walking) at least 30
minutes per day, most
days of the week.
Moderation of Men: limit to <2 drinks 2–4 mmHg
alcohol per day. Women and
consumption lighter weight persons:
limit to <1 drink per day.

Contraindications and Side Effects:


THIAZ gout, HypoNa, hypoK
BB Asthma, heart block, cocaine use, bradycardia
ACEI Pregnancy, angioedema, cough
CCB Edema, flushing
ARB Pregnancy, angioedema

2ndary benefits:
angina: nitrates
BPH: -blocker
Migraine: -blocker, calcium channel blocker

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