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  • Pa Tho

    Transféré par

    Jamine Joyce Ortega-Alvarez
    10 vues3 pages
    This document discusses the pathophysiology of pulmonary tuberculosis. It outlines predisposing factors like age and precipitating factors like repeated close contact with an infected person. When the tuberculosis bacteria is inhaled, it causes an inflammatory reaction and phagocytosis in the lungs, leading to the accumulation of exudates in the alveoli and formation of Ghon tubercles containing bacteria and macrophages. Without treatment, this process can progress to necrosis, cavitation, and reactivation of dormant bacteria which spreads through the lungs.

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    This document discusses the pathophysiology of pulmonary tuberculosis. It outlines predisposing factors like age and precipitating factors like repeated close contact with an infected person. When the tuberculosis bacteria is inhaled, it causes an inflammatory reaction and phagocytosis in the lungs, leading to the accumulation of exudates in the alveoli and formation of Ghon tubercles containing bacteria and macrophages. Without treatment, this process can progress to necrosis, cavitation, and reactivation of dormant bacteria which spreads through the lungs.

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    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOC, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    10 vues3 pages

    Pa Tho

    Transféré par

    Jamine Joyce Ortega-Alvarez
    This document discusses the pathophysiology of pulmonary tuberculosis. It outlines predisposing factors like age and precipitating factors like repeated close contact with an infected person. When the tuberculosis bacteria is inhaled, it causes an inflammatory reaction and phagocytosis in the lungs, leading to the accumulation of exudates in the alveoli and formation of Ghon tubercles containing bacteria and macrophages. Without treatment, this process can progress to necrosis, cavitation, and reactivation of dormant bacteria which spreads through the lungs.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOC, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 3

    PATHOPHYSIOLOGY Risk Factors

    PREDISPOSING FACTORS Age PRECIPITATING FACTORS Occupation Repeated close contact with infected person Recurrence of

    Immunosuppressi
    on Systemic Infection

    Leads to
    Inhalation/exposure of M. Tuberculosis

    through

    Airway to alveoli

    causing
    Inflammatory reaction & phagocytosis

    causing
    Accumulation of exudates in the Alveoli

    Ghon Tubercle (Bacteria & Macrophages)

    leads to
    Necrosis (forming a cheesy mass)

    Calcification/Liquifica tion

    Tubercle Bacilli Immunity develops (2-6 weeks after infection) DIAGNOSIS Sputum Culture Tuberculin Skin Test Chest X-ray

    causing
    Bacteria become dormant

    With Medical Intervention Early detection/diagnosis Multi-bacterial

    Without Medical

    Leads to
    Reactivation of the Tubercle Bacilli (due to repeated exposure to infected individual, immunosuppression)

    causing
    No recurrence recurrence Ghon Tubercle Ulcerates

    releasing
    MEDICATION Isoniazid Rifampicin Pyrazinamide Ethambutol Inflammation of lungs Cheesy material into bronchi (bacterial become airborne)

    PULMONARY TUBERCULOSIS

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