Allele Biotech-Introducing Cost Effectiveness to Research
I
n order to carry out large scale synthesis of RNA transcripts by way of
in vitro
transcription, adjustment of the RNA cap-ping element is suggested. To help researchers accomplish this, Allele offers ARCA (Anti-Reverse Cap Analog), which is
a modied cap analog in which the 3’ OH group is replaced with OCH
3
. This re-guration allows for RNA polymerase to
only initiate transcription with the remaining hydroxyl group, and forces ARCA incorporation in the forward orientation. This outcome leads to the transcripts synthesized with
ARCA at the 5’ end to become translatable causing a stimu
-latory effect on translation. This feature is not found in stan-dard cap analogs.
ARCA
,
5’(ppp)5’G
Anti-Reverse Cap Analog
Quality Assurance:
Each batch of reagents is vigorously tested for consist-
ency and stability, and certied 99% pure and free of en
-donucleases and modifying agents.
Box 1 | Content
Cat. No.
ABP-PP-NTPARCA
QuantityConcentration
50µl100mM
Description
Website: www.allelebiotech.comCall: 1-800-991-RNAi/858-587-6645
(Pacifc Time: 9:00AM~5:00PM)
Email: oligo@allelebiotech.com
For Technical Support:Email:oligo@allelebiotech.com
Box 2 | ARCA Structure
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