Hormonal Drugs

and

Contraceptive
Rezaur Rahman Siddiqui
Product Executive Orion Pharma Ltd

Hormone

A substance secreted by specialized cells, released in to the bloodstream Are chemical messengers Secreted into the blood by endocrine cells or neurons

Use of Hormonal Drug

Market Scenario

Systemic Corticosteroid + Thyroid Therapy

Market Scenario: SYSTEMIC CORTICOSTEROIDS

Rank Company SYSTEMIC CORTICOSTEROIDS 1 2 3 4 5 6 7 8 9 10 OPSONIN PHARMA NUVISTA PHARMA INCEPTA PHARMA GLAXOSMITHKLINE RENATA DRUG INTERNATIONAL CHEMIST TECHNO DRUGS ACME KEMIKO PHARMA LTD. Total (Cr) 73.27 16.34 11.06 10.73 8.34 8.23 4.63 2.50 2.42 2.25 1.28 Share 100 22.29 15.10 14.64 11.39 11.24 6.32 3.41 3.30 3.07 1.74 Gr % 34.78 35.23 28.29 52.44 33.68 30.28 44.64 7.31 61.29 4.57 627.97

Data source: Bangladesh Pharmaceutical Index 2Q11

Market Scenario: Thyroid Therapy

Rank Company THYROID THERAPY 1 2 3 4 5 6 7 8 9 RENATA SQUARE GLAXOSMITHKLINE NUVISTA PHARMA ROCHE POPULAR PHARMA INCEPTA PHARMA DRUG INTERNATIONAL JAYSON Total Share Gr % (Cr) 10.17 12.10 7.87 6.59 64.79 33.90 1.70 16.73 55.81 1.22 12.02 -58.12 0.47 4.65 51.45 0.12 1.18 -10.93 0.06 0.55 999.00 0.01 0.09 -70.63 0.00 0.00 0.00 0.00 0.00-100.00
Data source: Bangladesh Pharmaceutical Index 2Q11

General Hormone: Corticosteroid

GENERIC USE DOSAGE FORM
Tablet Tablet Tablet Tablet Solution Injection (Ampoule) Injection (Vial) Injection (Vial) Injection (Vial) Injection (Vial)

MARKET MAJOR BRAND (Local/Foreign) SIZE(Cr)

6.26 25.64 Betnelam(GSK) Cortan(IAP)

BETAMETHASONE 0.5 MG PREDNISOLONE 5 MG PREDNISOLONE 10 MG PREDNISOLONE 20 MG PREDNISOLONE 5 MG/ 5ML TRIAMCINOLONE ACETONIDE 10 MG

IMMUNOSUPPRESSANT

ALLERGIC DISORDER, CONNECTIVE TISSUE DISORDER TRIAMCINOLONE ACETONIDE INJ ALLERGIC DISORDER, IM. VIAL 40 MG CONNECTIVE TISSUE DISORDER DEXAMETHASONE INJ VIAL 5 MG INFLAMMATORY AND AUTOIMMUNE DISEASES HYDROCORTISONE INJ VIAL 100 BRONCHIAL ASTHMA, MG CONTACT DERMATITIS, ATOPIC DERMATITIS, SERUM HYDROCORTISONE VIAL SICKNESS, SEASONAL OR DRY+SOL 100 MG PERENNIAL ALLERGIC RHINITIS METHYLPREDNISOLONE INJ VIAL IMMUNOSUPPRESSANT 40 MG DEFLAZACORT 6

5.82 5.82 22.23 3.69 3.69

Cynocort(Techno) Cynocort(Techno) Oradexon(NUV) Cotson (OPI) Cotson (OPI)

Injection (Vial) Tablet

1.92 N/A

Medrol (Techno) Asteride (Dr.Reddy)

General Hormone: Thyroid Therapy

GENERIC USE DOSAGE FORM Tablet MARKET MAJOR BRAND SIZE(Cr) (Local/Foreig n) 1.77 Carbizol (SQA) 9.45 Thyrox(RTA)

CARBIMAZOLE 5 MG

HYPOTHYRODISM, RADIO IODIN ADJUNCT THERAPY HYPOTHYRODISM

LEVOTHYROXINE SODIUM

Tablet

General Hormone: Miscellaneous

GENERIC USE DOSAGE FORM Tablet Tablet Capsule Capsule Injection (Ampoule) MARKET MAJOR BRAND (Local/Foreign) SIZE(Cr) 0.22 Filfresh (SQA) 11.02 Gestrenol(RTA ) 6.93 Danamet (SKF) 6.93 2.51 Danamet (SKF) Linda-s (NUV)

MELATONIN 3 MG ALLYLESTRENOL 5 MG DANAZOL 100 MG DANAZOL 200 MG OXYTOCIN 5 I.U

SLEEP DISORDER THREATENED MISCARRIAGE FIBROCYSTIC BREAST DISEASE, ENDOMETRIOSIS FIBROCYSTIC BREAST DISEASE, ENDOMETRIOSIS POSTPARTUM HEMORRHAGE, UTERINE CONTRACTIONS DURING LABOR

Sex Hormone: Female & Male

GENERIC USE DOSAGE FORM MARKE MAJOR BRAND T (Local/Foreign ) SIZE(Cr)

NORETHISTERONE 5 MG ESTRIOL 1 MG

MENORRHAGIA, POSTPOND MENUSTRATION VAGINAL INFECTION

Tablet Tablet

15.8 2.85

Normens(RT A)

TESTOSTERONE 40REPLACEMENT THERAPY Capsule (TESTOSTERONE DIFFICIENCY) TESTOSTERONE REPLACEMENT THERAPY Injection 250MG/ML (TESTOSTERONE (Vial) DIFFICIENCY)

Ovestin (NUV) 5.91 Andriol(NUV) Andriol(NUV)

Sex Hormone: Growth Hormone& HRT

GENERIC USE DOSAGE FORM MARKE MAJOR BRAND T (Local/Foreign ) SIZE(Cr) N/A 7.5 1.6 Norditropin(N N) Ubilon(IAP) Estracon (RTA)

SOMATROPINE 5 MG/1.5 ML TIBOLONE 2.5 MG CONJUGATED ESTROGEN 1.25 MG

GROWTH PROMOTER MENOPAUSAL OSTEOPOROSIS OSTEOPOROSIS, AMENORRHOEA

Injection (Vial) Tablet Tablet

Hormone others:
Therapeutic Class
STERILITY PROMOTER

GENERIC
HUMAN CHORIONIC GONADOTROPHIN (HCG) 5000 IU CLOMIFENE 50 MG

USE
DRUGS FOR STERILITY

DOSAGE FORM
Injection (Ampoule)

MARKET SIZE(Cr)
1.01

MAJOR BRAND (Local/Foreign)

Pregnyl(NUV)

DRUGS FOR STERILITY

Tablet Injection (Vial) Tablet

3.08 11.1

Ovulet(RTA) Deca Durabolin(NUV)

ANABOLIC STEROID

NANDROLONE 50 OSTEOPOROSI MG S, APLASTIC ANEAMIA OXANDROLONE PROMOTE 2.5 MG WIGHT GAIN

N/A

Oxadrin (SAVIENT)

HORMONE MODULATOR

LETROZOLE 2.5

BREAST CANCER

Tablet

11.76

Letrol (RTA)

Contracepti ves

Market Scenario

Systemic Contraceptive

Market: Systemic Contraceptive

Company Total NUVISTA PHARMA SMC RENATA SOCIAL MARKETING GEDEON RICHTER POPULAR PHARMA WYETH PHARMACIA CILAG MEDIMPEX Total (Cr.) 39.104 21.236 11.248 4.764 0.558 0.465 0.461 0.247 0.113 0.010 0.003 Share 100.00 54.31 28.76 12.18 1.43 1.19 1.18 0.63 0.29 0.03 0.01 Gr % 30.23 46.77 -0.91 37.01 999.00 -15.15 315.44 999.00 330.88 -33.39 -86.93

Top 3 company leads 95 % of Market share

Data source: Bangladesh Pharmaceutical Index 2Q11

Hormone others:
Therapeutic Class
STERILITY PROMOTER

GENERIC
HUMAN CHORIONIC GONADOTROPHIN (HCG) 5000 IU CLOMIFENE 50 MG

USE
DRUGS FOR STERILITY

DOSAGE FORM
Injection (Ampoule)

MARKET SIZE(Cr)
1.01

MAJOR BRAND (Local/Foreign)

Pregnyl(NUV)

DRUGS FOR STERILITY

Tablet Injection (Vial) Tablet

3.08 11.1

Ovulet(RTA) Deca Durabolin(NUV)

ANABOLIC STEROID

NANDROLONE 50 OSTEOPOROSI MG S, APLASTIC ANEAMIA OXANDROLONE PROMOTE 2.5 MG WIGHT GAIN

N/A

Oxadrin (SAVIENT)

HORMONE MODULATOR

LETROZOLE 2.5

BREAST CANCER

Tablet

11.76

Letrol (RTA)