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Drug Generic Name Cloxacillin Trade Name

Mechanism of Action

Indication

Contraindicati ons

Adverse Reaction

Nursing Responsibilities

Avastoph
Classification Anti-infective, Antibiotic Dosage

150 mg every 6 hours


Routes of administration IVTT ANST (-)

Interferes with cell wall replication of susceptible organisms, the cell wall, rendered osmotically unstable, swell, bursts from osmotic pressure; resists the penicillinase action that inactivates penicillins.

Treatment of infections caused by pneumococci, Group A betahemolytic streptococci, and penicillin G sensitive staphylococci.

History of hypersensitivit y to penicillins and cephallosporin s. Sever pneumonia, emphysema, bacteremia, pericarditis, Prophylaxis: meningitis and Staphylococcal purulent and infection during septic arthritis major during the cardiovascular and acute the orthopedic stage. Subsurgery. conjunctival infections.

EENT: occasionally, laryngeal edema,

1.) Perform skin testing before giving the medication.

Skin: urticaria, skin RATIONALE: To prevent anaphylactic shock when rashes, exfoliative administered. dermatitis, rash
2.) Administer drug slowly to the IV line

GI: GI disturbances, nausea, vomiting, epigastric distress, diarrhea and flatulence, antibioticassociated pseudomembranous colitis GU: interstitial nephritis and vasculitis Hematologic: eosinophilia, agranulocytosis, anemia, thrombocytopenia, transient rise in transminases and alkaline phophatase Other: hypersensitivity reactions, serum sickness-like reactions, fever

RATIONALE: The drug is very irritating to the tissue and blood vessels. Injecting slowly the drug prevents phlebitis 3.) Explain to the patient that antibiotic therapy lasts for 7 days will take the drug without any miss. RATIONALE: Taking the drug for 7 days helps to kill the bacteria and growth. 4.) Make sure that the patient takes the drug at the same time of the day. And also to prevent them being drug resistant. RATIONALE: To prevent growth of bacteria and to continue the efficacy of the drug. 5.) Provide rest and comfort. RATIONALE: the drug may cause dizziness which is a normal side effect of the drug. 6.) Assess for any signs of hypersensitivity reaction such as purpura, rash, urticaria, exfoliative dermatitis, itching RATIONALE: to discontinue the therapy and immediately call the physician for an antidotE

Source: Karch, Amy: 2009 Lipincotts Nursing Drug Guide, pp. 930