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  • Furosemide Vs Thiazide

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    Taimoor Dogar
    36 vues1 page
    Both of these drugs cause METABOLIC ALKALOSIS. Which diuretic causes more METABOLIC ALKALOSIS depends on the diuretic that prevent more Na+ from being reabsorbed. Since Sodium is primarily reabsorbed in the Thick Acending Loop, inhibition of this pump by Furosemide will lead to increase Na+ in the tubule. This will eventually lead to more excretion of H+ ions resulting in a state of METABOLIC ALKALOSIS

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    Furosemide vs Thiazide

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    Both of these drugs cause METABOLIC ALKALOSIS. Which diuretic causes more METABOLIC ALKALOSIS depends on the diuretic that prevent more Na+ from being reabsorbed. Since Sodium is primarily reabsorbed in the Thick Acending Loop, inhibition of this pump by Furosemide will lead to increase Na+ in the tubule. This will eventually lead to more excretion of H+ ions resulting in a state of METABOLIC ALKALOSIS

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    36 vues1 page

    Furosemide Vs Thiazide

    Transféré par

    Taimoor Dogar
    Both of these drugs cause METABOLIC ALKALOSIS. Which diuretic causes more METABOLIC ALKALOSIS depends on the diuretic that prevent more Na+ from being reabsorbed. Since Sodium is primarily reabsorbed in the Thick Acending Loop, inhibition of this pump by Furosemide will lead to increase Na+ in the tubule. This will eventually lead to more excretion of H+ ions resulting in a state of METABOLIC ALKALOSIS

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 1

    THICK ASCENDING LOOP (TAL)

    Mech of H secretion in TAL and Early DCT

    IGNORE THE DOTTED LINE IT IS THE RECYCLING OF Carbon DIOXIDE TO HELP FORM HCO3Early Distal Convoluted Tubules (DCT)

    Both of these drugs cause METABOLIC ALKALOSIS. The mechanism is below: Dec reabsorption of Na+ and Cl- increase Na/Cl in Tubules increase delivery of K/Na/Cl to collecting duct when there is increase Na/Cl in collecting duct it stimulates the aldosteronesensitive sodium pump to increase sodium reabsorption in exchange for potassium and hydrogen ion excretion (as seen above)..meaning H+ will be excreted and metabolic alkalosis will occur Now which diuretic causes more Metabolic Alkalosis depends on the diuretic that prevent more Na+ from being reabsorbed and thus increasing its content in the Renal Tubule. Since Sodium is primarily reabsorbed in the Thick Acending Loop, inhibition of this pump by Furosemide will lead to increase Na+ in the tubule which will eventually lead to more excretion of H+ ions consequently resulting in a state of Metabolic Alkalosis

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