Abstract

Author: Walid Altayeb DDS, MSD, PhD

Dept. of Periodontology Faculty of Dentistry

Association between Periodontitis and Lipidemia Levels Related to

Cardiovascular Diseases
Background: Recent studies have proven that periodontal disease can produce
numerous changes in systemic health changing the blood chemistry with a rise in
proteins and lipids in the serum. These factors explain, at least in part, the probable
association between periodontitis and the susceptibility for certain systemic diseases,
such as the increased risk of cardiovascular disease. The aim of this study was to
evaluate the association between pathologic levels of lipidemia and periodontitis.
Materials & Methods: The levels of plasma lipids (Total cholesterol CHL
,triglycerides TG, high density lipoproteins HDL and low density lipoproteins LDL)
in 78 subjects without cardiovascular disease were divided into two groups, with and
without periodontitis (38 with periodontitis and 40 healthy control subjects) were
assayed in Alasad Hospital laboratory. The subjects was assessed using the
Community Periodontal Index of Treatment Needs (CPITN). The differences in the
lipids values between two group was examined by student t test and The associations
between periodontitis and lipidemia levels were examined by logistic regression
analysis. Results: statistical significant in lipids levels were observed in subjects
periodontitis, when compared to healthy. CHL, TG, and LDL were significantly
higher while HDL were lower in the case group (P=0.05). The frequency of persons
with pathologic values of lipidemia were significantly higher in cases compared with
controls. Strong correlation was observed between CPITN score 3 or 4 and pathologic
levels of lipidemia.
Discussion: These results showed that pathologic levels of lipidemia may be
associated with periodontitis. Periodontitis produce a variety of changes in
lipoproteins as a part of the APR through actions of cytokines. However, it is unclear
whether periodontitis causes an increase in levels of serum lipids or hyperlipidemia is
a risk factor for both periodontitis and cardiovascular disease.
Keywords: Periodontitis, Lipidemia, Cardiovascular disease.