Reactii de identificare a antibioticelor Identificarea antibioticelor -lactamice 1.Reactii pt.sistemul heterociclic -Identificarea sulfului -Reactii de degradare a nucleului A.

reactia de hidroliza acida

R CO NH O N S CH3 CH3 COOH
O OH + O OH O

HCl

C CHO C O OH
ACID PENALDIC

HS

+ H N C CH3 H 2 COOH
D-PENICILAMINA

CH3

HS

CH3 H2N C H COOH

CH3

O HS OH + NH3 + CO2 + C CH3 CH3 CHO

O OH +2NH3 + HO OH O
NINHIDRINA

O N O

-3 H2O O

ONH4

COLORANT INDAMINIC

B.reactia de hidroliza bazica

R CO NH O N S CH3 CH3 COOH HOR CO NH O HN OH
ACID PENICILOIC

CH3 CH3 COOH

H H2NOH

R CO NH O HN NHOH

CH3 CH3 COOH

FeCl3

R CO NH O Fe/3 O HN NH

CH3 CH3 COOH

ACID HIDROXAMIC

COMPLEX VIOLET

-Reactii de reducere
R CO NH O N S CH3 CH3 COOH HCl C CHO C O OH
ACID PENALDIC

HS

+ H N C CH3 H 2 COOH
D-PENICILAMINA

CH3

R CO NH R CO NH CH COOH CH CHO +2 Cu(OH)2 C O C O + Cu2O OH

ACID PENALDIC

OH