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Historical note
Tretiakoff (1919)
examined the brains of nine parkinsonian patients substantia nigra lesions were important in both Parkinsons disease and in postencephalitis patient
Friedrich Lewy (1912) They (intracellular inclusions) are simply nding which i up till now have found in all cases of paralysis agitans that i have examined, but which were absent in the other (control) cases
Lewy bodies
Lewy bodies are circular eosinophilic structures with a dense protein core surrounded by a peripheral halo located within the cytoplasm of neurons.
The ultrastructural appearance is like a sunower with a dense central core of circular shaped structures and a rim of radiating laments
Wednesday, July 18, 2012
Parkinsons disease
Microscopic Pathology:
Cell loss Substantia nigra (50% loss) Locus coeruleus Lewy bodies (8-30m, intracytoplasmic, neuronal inclusions) # Substantia nigra # locus coeruleus and raphe # IX & X cranial nerve nuclei # Mesocorticolimbic system # Meynert nucleus Cortex # Intermediolateral column of the cord # Sympathetic, parasympathetic neurons
Wednesday, July 18, 2012
Braak staging of PD
Etiology
Genetic Twin study, 1st degree relative Environmental factors rural area organophosphate Animal model: pyrethione pesticide
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Pathophysiology of PD
Wednesday, July 18, 2012
Discovery complex I deciency in PD Genetic encode mitochondrial protein mutation; PINK 1, DJ1= AR of PD
Wednesday, July 18, 2012
END