1) Deficiency complement component c5-c8 lead to a) Neisseria infection 2) Tumor correct except a) tyrosinase melanoma b) CEA & GI cancer

r c) Viral EBV Lymphoma d) BCR-Abl fusion protein multiple myeloma e) Alpha- feto protein hepatoma 3) The most common primary immuno deficiency a) X- linked agammagloblolinemia b) Selective deficiency IgG subclass c) IgA deficiency d) Transient hypogammagloblulinemia 4) all participate in PTK cascade, except a) Terminal TdT b) Ca+2 c) Phospholipase C gamma d) DAG e) Protein kinase C1 5) function similar to stem cell factor (SCF) a) Il-1 b) Il-7 c) Il-4 d) Il-2 e) Il-5 6) doesn't fix complement a) IgG2 b) IgG3 c) IgG4 d) IgG1 7) suppressor Th2 a) INF gamma b) TNF c) IL-1 d) IL-3 e) IL-5 8) HIV virus infects which cell? a) NK b) CD-8 c) B cell d) Glial cell e) Basophile

8) diagnostic of IgA pepsin , except a) (VH, CH1) X 2 b) (VH, CH1, VL, CL) X 2?? c) (VH, CH1, CH2, CH3) X 2 d) (VL, CL) X 2 9) Factor B a) Is the enzymatic part of the C3 convertase in the alternative pathway b) Only component of complement pathway that circulate active enzyme c) Bind covalently to pathogen through thioster bond d) Has no potential enzymatic activity e) Cleavage factor D 10) Cytokine important in control dissemination of M. leprosy a) TNF-alpha b) IL-4 c) IL 8 d) Th2 cytokines e) IL-5 11) mostly affected by INF type I (INF alpha and beta) a) Aspergellus b) Plasmodium c) Listeria bacteria d) Staphylococcus bacteria e) Influenza virus 12) immune system evasion except a) direct killing immuno competent cell b) MHC I inhibition c) Point mutation d) HLA-G Product e) Viral product inhibitory cytokines 13) The enzyme needed in liberation of HIV from infected cell a) Gp120 b) Protease c) Reverse transcriptase d) Integrase e) Collagenase 14) Preformed antibodies transplant a) Mixed lymphotype??? b) HLA typing c) HLA crossmatching??? d) Rh typing e) ABO typing???(khalil)

15) Blood group receptor for plasmodium vivax protozoa a) P system b) Lewis-secretor c) MNS system d) Kidd e) Duffy Fya- Fyb 16) Active immunity cancer except a) Vaccination by tumor antigen b) BCG local injections c) Anti-CD20 infusion d) Vaccination by whole cell e) IL-2 infusion 17) serum sickness except a) C-factor b) Monovalent antigen c) Persistence immune complex d) Nutrophils e) Equivalence of antigen and antibody 18) viruses and malignancy except a) Human papilloma virus- cervical cancer b) EBV lymphoma c) Human herpes virus 8 and lymphoma d) HTLV-1 acute T lymph-leukemia e) EBV nasopharyngeal 19) CD 4 molecules a) .Tyrosine kinase b) Cannot be expressed on surface of cytotoxic T cell c) Include cytoplasmic domain that has tyrosine kinase activity d) Can interact with MHC I on the B cell if CD 4 molecules is expressed on surface of cytotoxic T cell 20) elimination of bacteria by opsonization a) neutralization of bacterial toxin b) recognition of bacteria bound antibodies by Fc receptor on macrophage c) prevention of bacteria adhesion to endothelial cell d) binding antibodies Fc on bacteria e) class 1 MHC antigen 21) used by HIV for cell penetration beside CD4 a) CR2 b) Chemokine receptor c) Fc d) CD3 e) MHC I 22) factor other than CD4 T cell count vest to give prognosis of HIV infected patient

a) b) c) d) e)

CD8 T cell Anti HIV IgM level IgG level PPD skin test Viral protein count

23) Successful active immunotherapy by general immune system active locally except a) IL-2 in cancer b) Lymphokine activated killer cell for hypernephroma c) Cancer vaccine for lung cancer d) BCG for urinary bladder cancer e) Anti CD20 for B cell lymphoma 23) Difference between primary and secondary immune response except a) antig- C needed < primary response b) binding affinities much lower than primary response c) Lag phase is higher than primary response d) Concentration of IgG is much higher than primary e) Concentration of IgM is the same as in primary 24) recombination signal sequence best describes a) sequence that contain ITAM- signaling B cell b) sequence recognized by RAG1 RAG2 c) sequence responsible for type switching in B cell d) sequence encodes signal peptide responsible Ig e) sequence RNA splicing event IgM/IgD 25) best bronchial asthma allergic rhinitis as allergic a) food allergy b) atopic dermatitis c) drug allergy d) urticaria e) Conjunctivitis??? 26) NADPH oxidase lack which of the macrophages bactericidal mechanism a) H2O2 b) Acidification c) Defensin d) Lactoferrin 27) MHC I and MHC II a) Constituvely expressed by most cells in the b) expressed by Macrophage and dentritic cell c) Constituvely associated hapten d) Expressed INF gamma 28) Injecting Complement C killing antigen-Ab in patient lacks C3 a) Depress level of serum factor B b) Increased chemotactic C5a serum level c) Increased serum level of C8

d) Decreased level of C2 29) How does entamoeba evades the immune system a) By shedding 30) Trophoblast . Immunological phenomenon except a) antibody against paternal antigens b) Increased HLA- G antigens c) Decreased MHC I d) Blocking antibody e) Increased CD8- T recognition 31) All induces memory except a) IL-2 b) CD28 and B7 c) .on class II MHC to B cell d) CD40 / CD40L e) Crosslinking of B cell with polymeric antigen 32) Signal transduction of B cell involves all except a) Zeta b) Ig alpha c) Ig beta d) Syk e) Tyrosine kinase 33) Which one is false? a) Mast cell : IL 12 b) TH2 : IL6 c) TH1 : INF gamma d) Eosinophil : IL 5 34) Toll-like a) Recognizes gram bacteria cell 35) Anaphylacoid non IgE mediated a) Bee sting allergy b) Penicillin allergy c) Radio contrast allergy d) Food allergy e) House dust mite allergy 36) CD 19 marker is found on all of these except a) Hematopietic stem cell b) Mature B cell c) Pro B cell d) Pre B cell e) Immature B cell 37) C4, which one is true

a) C4 binds and cleaves C5 b) C4 cleaves C2 c) C4a fragment anaphylatoxin d) C4 binds only C1q e) Deletion of C4 allele is associated with SLE 38) Which one has J chain? a) IgD, IgA2 b) IgG2, IgE c) IgE, IgM d) IgG3, IgA1 e) IgA1, IgM 39) Not found on mature resting T cell a) CD5 b) MHC II c) MHC I d) CD2 e) CD3 40) Thymocyte is referred to double negative if: 41) 42) HLA-B35 and HLA-A2 refer to a) 2 alleles found on 1 locus??? b) 2 alleles found on 2 loci on chromosome 6??? 43) Regarding pregnancy, which is wrong? a) Androgen suppress T/B cells b) Estrogen suppress T cells c) Placenta TH1 suppress T cell d) NK cell suppressed by increased HLA-G 44) A 10 years old boy has recurrent skin and lung infections by staphylococcus aureus, what can be found at his diagnosis a) Low IgM, absence of B cell b) Low Ig low B cell c) Low terminal complement d) Abnormal NBT test 45) Which type of Ab is involved in SLE with recurrent mid trimester abortion and DVT and abnormal PTT test a) Anti Sm antibodies b) Anti Ds DNA antibodies c) Anti nuclear Ab d) Anti phospholipid Ab e) Rheumatic Ab 46) Recognition receptor functions as secreted receptor

a) Mannan binding lectin b) CD 14 c) Toll like receptor 47) Pulmonary edema that follows incompatible transfusion results in a) Donor WBC antibodies against recipient granulocytes 48) During B-cell development the rearrangement in Ig loci a) DH to JH, DJ to VH, VL to JL 49) Activation of mature B cell requires two signals a) An antigen and T cell help b) TCR occupancy and T cell help??? c) Antigen and cytokines??? d) TCR occupancy and cytokines 50) Immature response against human IgG in human, all of the following are true except a) 51) The BM transplantation is the most difficult .. a) Hyperacute b) Acute rejections c) GVHD d) Tolerance 52) Tumor, except a) Dysregulation of metabolism b) Dysregulation of respiration 53) Macrophages secretes all except a) IL- 6?? b) IL-8 c) INF gamma d) TNF alpha e) 54) Remission state in pregnancy happens in, except a) SLE b) Type I diabetes c) Contact dermatitis d) Arteritis 55) Causes tolerance rather the immunity a) Insoluble antigen b) Heterologous antigen c) Particulate antigen d) Antigen injected subcutaneously e) Injecting antigen to fetus in development

56) Autoimmune disease a) Shows HLA association b) Run a steady clinical course c) Affect both sexes equally d) are triggered by different antigen in different individuals 57) Candidate Immuno suppression by malnutrition of a) Thyroxin b) Insulin c) Leptin d) Glucagon 58) Cyclosporine A inhibits a) Calcinerium 59) Not used as an evading mechanism by viruses a) Mutation b) Production of cytotoxic Abs c) Downregulatin of MHC class I molecules d) Destroying the immune system 60) Regarding HIV vaccine candidates which one is wrong? a) Mucous and gp120 b) IM gp120 c) Recombinational vaccine was tried d) IM peptide e) DNA vaccine is practical 61) PALS a) T cells found in the spleen 62) Ab destruction by pepsin yields a) (F(ab'))2 fragments 63) Tolerance refers to 64) Regarding Parasitic infection, which one is false a) Complement is usually effective?? 65) M. tuberculosis is best eliminated by a) TNF alpha b) IL-4 c) IL-5 d) IL-8 66) Antibodies against sperms results in a) Idiopathic infertility 67) Which on is not involved in respiratory burst pathway of neutrophils killing a) Phospholipase C gamma

68) Pooled from normal human except a) Antivenom 69) Regarding Invariant chain all is true except a) It is responsible for TAP1 gene and TAP2 gene 70) Which one in the HIV genome is associated with Low Virulence? a) NEF gene b) POL gene c) GAG gene d) ENV gene 71) IgG in the surface of B cell???????? a) This Question is wrong: b) 72) Involved in stopping lymphocyte in HEV a) L-selectin b) LFA-1 73) Which is wrong concerning epitopes? a) Epitope is always immunogenic 74) T lymphocyte (wrong one) a) Somatic hypermutation 75) Allelic exclusion EXCEPT a) On one B lymphocyte you may find both a and b heavy chains 76) Which is wrong concerning the cytosolic pathway? a) It involves Invariant chain 77) About GVHD 78) All is true regarding atopy except a) Th1 79) Mast cell and basophiles have in common a) Heparin 80) Which one doesnt involve autoimmune disease? a) Osteomylitis b) Toxin epidermilosis syndrome 81) Immunogenic means a) Stimulates the immune system 82) (Was a pretty long Q)in a tumor of B cell that had mue heavy chain onlywe found that it is. a) Pre-cell

b) Pro-cell c) Immature cell 83) Restriction means a) The recognition of self MHC with antigen by T cells 84) Which of the following is wrong regarding the fetus? a) Reversed num of pmn and lymphocytes b) No IgM, IgA, IgG 85) Which one is wrong regarding bacteria? a) Bacteria is the same treatment in all bacteria 86) Complement activation a) Activate hapten b) Active C1q binds antigen-antibody complex c) C3 convertase C4bc2b d) C3 convertase C3bBb e) Regulate factor H