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Non-modifiable factors: -Sex(1.5-2:1 male to female ratio) -Age(common in children and young adults)
POTTS DISEASE
Progressive microcellular damage / injured cells release of chemicals (T9-T12) Circulating B-lymphocytes stimulated producing immunoglobulins (antibodies)
Disk tissue dies by caseation of disk tissue Cytokine interleukin-1 & 6 vasoconstrictive agents stimulate pyrogen release Inecrease metabolic function for body temperature w/ the aid of the hypothalamic thermo regulating system
Cytokine interleukin-2 (responsible for cell mediated response) Binds to interleukin-2 receptor site of TB specific lymphocytes
T lymphocites activated
TB specific lymphocytes identify the bacterial antigen & will perform phagocytosis Fragments of the bacillus triggers increase WBC production Diagnostic hematology WBC of 12,700mm3 Neutrophils: 87%
Fever
Microbial Killing
Leukocytosis
Increase capillary permeability of the surrounding area allowing plasma to leak from blood stream into the extravascular space Localize edema
Lymphocytes 7%
Back pain
Increase load on the spinal column Vertebral narrowing Vertebral collapse (T9-T12) Diagnostic -MRI -CT scan Urinary retention Kyphosis Decreased ability to feel the urge and to control defecation and micturation Constipation
Decreased Metabolism
Muscle atrophy