REAP 2 (10/19/11) Questions: mentoring@multicare.com.

ph Making a Data Collection Form Click Make View File New Name the view Multivent Save it to Documents Open Click OK See the Grid Right Click to open field definition in Question or Prompt, name it Multivent Trial in, arrow down to find Label/Trial font 18 Right click to open field definition in Question or Prompt, name it Treatment then click Legal Values then type Multivent then Enter then Salbutamol then click OK. Right click to open field definition in Question or Prompt, name it Name then click Right click to open field definition in Question or Prompt, name it Age then arrow down to find Number ## Right click to open field definition in Question or Prompt, name it Sex then click Legal Values then type Male then Female then check Do not sort then click OK. Then click Save Then click File then Exit then Yes. Entering Data in Data Collection Form Click Enter Data. Click File then click Open then click Open in My Documents then click OK. Enter your data. Then click File then click Save. Analyzing Data Click Analyze Data Screen: below is the program editor pane, left is the command pane Note: Epi Info can read Excel files Click Read (Import) Click Excel 8.0 (Note: the default is Epi 2000) Find the Excel file of Multivent vs Salbutamol then click Open. Highlight Sheet 1

Then click OK. Then click Yes when prompted with a question. What is the Mean Age: Mutivent vs Salbutamol? Look for Means at the left pane. Click means. ILL column (treatment) Height row (age) Means of click Age_in_Years Cross tabulate by value of click Treatment. Click OK. Then read the interpretation below the results pane. Look for Mean and Standard deviation. Look down the results pane fot the p-value: Less 30, look for Mann-Whitney U p-value. If more than 30, look for T-test p-value. (in this case, look for t-test) Click Tables. Exposure variable click Education. Outcome variable Treatment. Look for column% Then look down for p-value (chi square). Click means Means of Baseline Symptom score Cross tabulate by Treatment Click OK. Then look the results plane. Click means Means of After Treatment Score Cross tabulate by Treatment Click OK. Then look the results plane. Click means Means of Gain in Symptom Score Cross Tabulate by Treatment Click OK Then look the results plane. Graph Use Microsoft Word Graph using Table. (double click) Click Tables (RR risk or probability of having a good QoL) Exposure Treatment Outcome Good QoL Look at the results plane. Look at the row %.

Look below for OR or RR and 95% CI OR if cross sectional study or case-control study RR if RCT (in this case, RR) If OR/RR is greater than 1, the probability of having a good QoL is 1.35 times when taking multivent than salbutamol. (90/66.7) Click Tables Exposure Treatment Outcome variable Significant Clinical Improvement Click OK Then look at results plane Look at row %. Look for RR. Save the logged activity in the program editor plane. E-mail during Saturday and Sunday, the answers will be on Monday or Wednesday.

REAP 2 (09/21/12)

Dr Espallardo is now in Davao City due to projects for the European Union One on one mentoring: mentoring@multicare.com.ph Objectives of the workshop (REAP 2) Principles of data management Epi Info doesnt work in Apple Creating a project (data collection form) in Epi Info Example: hypothetical RCT of Pantoprazole+Domperidone (Prazole Plus) vs Domperidone alone Create a CRF: Use the MAKE VIEW function Click FILE menu Click NEW and save your project in My Documents and name it as Prazole Trial, Click Open Name VIEW: Data, Click OK the form has Grids (therefore ready to form CRF) Put cursor at center, then right click. Field Definition dialogue box: Prazole Trial (since this is a label: enlarge the font) Click Label or Title, then OK. Put cursor at the left corner, then right click. Field Definition dialogue box: Treatment Type: Text Right lower quadrant: click LEGAL VALUES, then put the Labels PRAZOLE and Domperidone, click DO NOT SORT Right Click at the Grid. Field Definition dialogue box: Patient Initials Type: Text Right Click at the Grid. Field Definition dialogue box: Age Type: Number (default 2 digits) Right Click at the Grid. Field Definition dialogue box: Sex Type: Text Click at right lower quadrant: Legal Values, Create New Value, Click Do Not Sort, then Click OK. Right Click at the Grid. Field Definition dialogue box: Education Type: Text Click at right lower quadrant: Legal Values, Create New Value, Click Do Not Sort, then Click OK. How to modify: double click your entry/item at the grid then make modifications.

If you are finished, then Click Exit, the dialogue will ask something, answer Yes.

Enter Data: Click File, then Click Open, then choose the name of the CRF Then enter data Analyze Data: Forget statistics first Look at your research objectives Establish what you want to communicate Develop dummy tables (see the Microsoft Document Tables) After Analyzing, put the Data one by one. Epi Info can read an Excel File Click ANALYZE DATA Read the Data first Click READ (Import) Data Format: Excel 8.0 Data Source: in CD Worksheet: Sheet1 Check: First Row contains Field Names Click OK. Click Statistics, then Click List (Variables), then Click OK. Click MEANS (if observation of numeric value) Means of: Age Cross-tabulate by: Treatment Click OK. Read the numbers below: Mean and Standard Deviation, P-values (tstatistics if pxs are 30 or more; if less than 30, use Kruskall-Wallis) Click TABLES (if frequency of nominal values) (Left: Exposure) Exposure: Rows: Sex Outcome: Columns: Treatment Click OK Read the numbers (how many males in Prazole group and column percent; how many females in Prazole group and column percent; etc.) p-values (chi-square; use uncorrected: observations more than 5 in all of them; if less than 5, use corrected) Click TABLES Exposure: Education

Outcome: Treatment Click OK Read the numbers (how many reached elementary in Prazole group and column percent; how many reached high school in Prazole group and column percent; etc.) p-values Click MEANS. Means of: Baseline Dyspepsia Score Cross-tabulate by: Treatment Click OK Read the numbers: Mean and Standard Deviation and P-values Click MEANS. Means of: After Treatment Cross-tabulate by: Treatment Click OK Read the numbers: Mean and Standard Deviation and P-values Click MEANS. Means of: Gain in Dyspepsia Score Cross-tabulate by: Treatment Click OK Read the numbers: Mean and Standard Deviation and P-values Click TABLES Exposure: Quality of Life Outcome: Treatment Click OK Read the numbers (mean QoL in Prazole group mean QoL in Domperidone group); risk ratio (the risk of developing the outcome using the treatment as compared to the risk of developing the outcome using the control treatment: QoL of Prazole divided by QoL of Domperidone; since this is an RCT, use RR), 95% CI (upper and lower limit) Click TABLES Exposure: Renal Side Effects Outcome: Treatment Click OK Read the numbers (mean Renal SE in Prazole group and mean Renal SE in Domperidone group) risk ratio (the risk of developing the outcome using the treatment as compared to the risk of developing the outcome using the control treatment: Renal SE of Prazole divided by Renal

SE of Domperidone; since this is an RCT, use RR), 95% CI (upper and lower limit) Click Program Editor. SAVE PROJECT in Program editor. Program: Analysis