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PCORI: Partnership & Funding Opportunities

Kara Odom Walker, MD, MPH, MSHS Partnership to Fight Chronic Disease Roundtable Discussion Washington, DC November 16, 2012


An independent, non-profit organization authorized by Congress. Committed to continuously seeking input from patients and a broad range of stakeholders to guide its work.


The Patient-Centered Outcomes Research Institute (PCORI) helps people make informed health care decisions, and improves health care delivery and outcomes, by producing and promoting high integrity, evidence-based information that comes from research guided by patients, caregivers and the broader health care community.

PCORIs Board of Governors Represents the Entire Health Care Community

PCORI Board of Governors, March 2012 in Baltimore, MD

PCORIs Core Duties

Establish national research priorities

Establish and carry out a research agenda Develop and update methodological standards
Disseminate research findings

Key 2012 Accomplishments

National Patient and Stakeholder Dialogue Definition of patient-centered outcomes

National Priorities and Research Agenda Funding applications for primary research Awarded 50 Pilot Projects Draft methodology report issued for public


Patient-Centered Outcomes Research Defined

Patient-Centered Outcomes Research (PCOR) helps people and their caregivers communicate and make informed health care decisions, allowing their voices to be heard in assessing the value of health care options.

Patient-Centered Outcomes Research Defined

This research answers patient-centered questions such as:
Given my personal characteristics, conditions and preferences, what should I expect will happen to me? What are my options and what are the potential benefits and harms of those options? What can I do to improve the outcomes that are most important to me? How can clinicians and the care delivery systems they work in help me make the best decisions about my health and healthcare?

PCORI Pilot Projects Program

PCORI Pilot Project Research Topics

Methods for engaging patients and stakeholders in: Informing PCORIs national priorities The research process, along with other stakeholders Developing evidence-based decision support tools that account for patient preferences Developing patient-centered outcomes instruments Researching behaviors, lifestyles, and choices Studying patient care team interactions in situations where multiple options exist Analytical methods for CER

Methodology Report

The mandate for PCORIs Methodology Committee is to define methodological standards and a translation table to guide health care stakeholders towards the best methods for patient-centered outcomes research (PCOR). Rigorous methods are essential to building trust in research findings. This report (which will continue to be revised and improved over time) is the necessary catalyst for scientifically rigorous, patient-centered outcomes research that can inform decision-making.

Methodology Report Timeline

May 10, 2012

Report delivered to PCORI Board of Governors

May 21, 201

Accepted by Board Staff instructed to prepare draft report for public comment

June 4, 2012
Preliminary draft posted on website

July 23, 2012

54-day Public Comment Period begins (ends Sept. 14)

September November 2012

Standards revised and adopted

From Priorities to Research Patients can Use

Future priorities and agendas will be informed by the development process, ongoing stakeholder engagement, and PCORIs research results.

Establishing PCORIs First National Priorities for Research and Initial Research Agenda

9 Criteria outlined by law

5 Draft priorities proposed

Corresponding agenda drafted

Public input received and evaluated

Priorities and agenda revised and approved

First primary funding announcements issued

Aug-Dec 2011

Jan-May 2012

May 2012

Criteria for Research Outlined by Law

Impact on Health of Individuals and Populations Addresses Current Gaps in Knowledge/ Variation in Care Impact on Health Care System Performance Potential to Influence Decision-Making


Improvability through Research

Rigorous Research Methods

Inclusiveness of Different Populations

Efficient Use of Research Resources

National Priorities for Research and Research Agenda

Assessment of Prevention, Diagnosis, and Treatment Options
Comparisons of alternative clinical options to support personalized decision-making and self-care Identifying patient differences in response to therapy Studies of patient preferences for various outcomes

Improving Healthcare Systems

Improving support of patient self-management Focusing on coordination of care for complex conditions and improving access to care Comparing alternative strategies for workforce deployment

Communication & Dissemination Research

Understanding and enhancing shared decision-making Alternative strategies for dissemination of evidence Exploring opportunities to improve patient health literacy

Addressing Disparities
Understanding differences in effectiveness across groups Understanding differences in preferences across groups Reducing disparities through use of findings from PCOR

Accelerating PCOR and Methodological Research

Improving study designs and analytic methods of PCOR Building and improving clinical data networks Methods for training researchers, patients to participate in PCOR Establishing methodology for the study of rare diseases

PCORIs Two Paths to Getting Specific in Research Funding

October 25, 2012


PCORIs Two Paths to Getting Specific in Research Funding

October 25, 2012


Suggest a Research Question

We want to know what health care question you may be facing. Your input can help us refine our research agenda.

Get Involved

Suggest a research question for PCORI to study.

Participate in an Engagement Workshop

Participate in PCORI sponsored Research/

Apply for Funding

Become a Reviewer of PCORI Research

Engagement Workshops

Transforming Patient-Centered Research: Building Partnerships and Promising Models

October 27-28, 2012 Washington, DC

What Should PCORI Study? A Call for Topics from Patients and Stakeholders
December 4, 2012 Washington, DC

PCORI Methodology Workshop for Prioritizing Specific Research Topics

December 5, 2012 Washington, DC

PCORI Funding Announcements (PFAs)

Point out interest in patients with rare diseases Emphasize outcomes that matter to patients Require patient partnerships in all aspects of research. www.pcori.org/funding-opportunities/fundingannouncements/

PCORI Funding Timeline

Funding Opportunities
PCORI will make a variety of external funding opportunities available throughout the course of its work. PCORI Funding Announcements (PFAs) PCORIs primary research awards will be issued in cycles to support our five established priority areas. Other Contract Research Requests for Proposals (RFPs) covering various fields of inquiry will be competitively awarded. Each RFP will contain a unique statement of work, requirements and evaluation criteria.
Track announcements of future funding opportunities by subscribing to the PCORI mailing list, or visiting http://www.pcori.org/funding-opportunities/

Cycle I
LOI Due Application Due Awards Announced Earliest Start Date 06/15/12 07/31/12

Cycle II
10/15/12 11/30/12

Cycle III
2/15/13 3/31/13







Available Funding Amounts

Funding Available for PCORI Funding Announcement Cycle I Assessment of Available Funds: Prevention, Expected Awards: Diagnosis, and Maximum Project Treatment Period Options Available Funds: Improving Healthcare Systems Expected Awards: Maximum Project Period $48 Million 54 Awards 3 Years $24 Million 27 Awards 3 Years $12 Million 14 Awards 3 Years $12 Million 14 Awards 3 Years Cycle II $48 Million 54 Awards 3 Years $24 Million 27 Awards 3 Years $12 Million 14 Awards 3 Years $12 Million 14 Awards 3 Years Cycle III TBD TBD TBD TBD TBD TBD TBD TBD TBD TBD TBD TBD

Communication Available Funds: and Expected Awards: Dissemination Maximum Project Research Period Available Funds: Addressing Disparities Expected Awards: Maximum Project Period

What Makes PCORI Funding Different?

User-friendly announcements to encourage broader
range of applicants

Patient & stakeholder engagement plan

Dissemination and implementation assessment

Reproducible and transparent research plan

PCORI criteria outlined by statute

Rigorous methodology standards

What roles should patients and stakeholders play in research teams?

The engagement of patients and stakeholders should include:
Participation in formulation of research questions; Defining essential characteristics of study participants, comparators, | and outcomes; Monitoring of study conduct and progress; and Dissemination of research results.

Become a Reviewer of PCORI Funding Applications


Next Steps for PCORI

Convene Patient and Stakeholder Workshops Establish advisory groups Issue targeted funding announcements Award first round of primary research contracts Training patients and stakeholders to serve as PCORI reviewers

Join Our Mailing List

Connect with PCORI

Visit us at www.pcori.org Follow @PCORI on Twitter Watch our YouTube channel PCORINews