Cell signalling 1.Cells in multicellular organisms need to communicate with one another to do the following except : A.

regulate their development into tissues B.control their growth C.inhibit their division D.co-ordinate their function 2.Gap junctions permit the movement of : A.large molecules B.ions C.small molecules D. b & c 3.The response for epinephrine signal is : A.hydrolysis of glycogen to release glucose for energy B. inhibition of glucose formation C.increase glucose uptake D.none of the above 4.All the following are examples of signal molecules except : A.hormones B.selective receiver C.cytokines D.neurotransmitters 5.signal transduction is involved in : A.intracellular homeostasis B.cell-cell communication C.cell's response to environment D.all the above 6.The increased glucose uptake is a response for a certain signal whose receptor is : A.beta-adrenergic receptor B.cargo receptor C.insulin receptor D.none of the above 7.All the following are mechanisms of signal transduction except : A.desensitization B.non destructive medium C.specifity D.Integration 8.The stimulus for release of the signal molecule can be : A.challenge to the organism B.threat to an organ C.threat / challenge to the integrity of a cell within the organism D.all the previous 9.All the following are different classes of transmembrane receptors except : A.integrins B.Cargo receptors C.receptor tryosine kinases D.G- protein coupled receptors 10.The following is/are examples for the integral transmembrane receptors: A.receptors for growth hormones B.receptors for epinephrine

C. a & b D.none of the above 11.All of the following are from factors account for the sensitivity of signal transductors except : A.high affinity of receptors for signal molecules B.amplification of the signal by enzyme cascade C.low affinity of receptors for signal molecules D. co-operativity in the ligand-receptor interaction 12.Specificity is promoted because : A.intracellular targets of a given signals pathway are present in all cells B.receptors of a given signal is present in certain types of cells C. a & b D.none of the above 13.In integration mechanism of cell signaling regulatory out come results: A. from one receptor B. from the integrated input from both receptors C. from none of them D.no correct True/False: 14.response given by integral transmembrane receptors is rapid as it occurs within seconds-minutes 15.In cell-surface receptors the second messengers concentration is higher before binding the ligand with the receptor 16.Cytoplasmic receptors can enter the cell nucleus and modulate gene expression 17.Estrogen and adrenal hormones are examples for intergral transmembrane receptors 18.During the transmembrane receptors the ligand pass through the plasma membrane 19.when the receptor activation triggers a feedback it approaches the receptor to the cell surface

General MCQ on histology 1-which of these responsible for cell membrane fluidity? a) Weak no covalent bonds between hydrophobic tails b) Unsaturated FA in hydrophobic tails c) Cholesterol d)all of above 2-perepheral pt exhibit a loose association with membrane surface due to a)electrostatic bonds with integral pt b)ionic inter action c)covalent bonds d)a&b 3-enzymes integral pt work mainly on supporting .. a)pumps pt b)channels c)linkers pt d)non of above 4-the PH of the early endosomes works on . a)containing the receptor-legand complexes b)uncoupling of receptor and the legand 3)activating lysosomal enzyme 4)protecting from bacteria invasion

5-while the PH of the late endosomes works on. a)containing the receptor-legand complexes b)uncoupling of receptor and the legand

3)activating lysosomal enzyme 4)protecting from bacteria invasion 6-if the rER allows some incorrectly modified protein to leave ; which organelle ll work? a)endosome b)ribosome c)proteasome d)the cell will die 7)the site of protein packaging is a)cis golgi network b)trans face golgi c)rER d)ribisomes 8)in case of extracellular small particles , the lysosome degradation forms a)multivesicular bodies b)autophagolysosomes c)phagolysosomes d)proteases 9-in case of large number excessive leakage of lysosomes, a)this provides protection against bacteria b)released enzymes would be inactivate due to neutral PH C)the cell would be destroyed d)non of above 10-cristea contain lollipop that works on . a)breaking bond in ATP and forming ADP b)forming ATP from ADP c)containing transport protein d)non of above 11-the pigmentation of skin and hair is .. a)hemoglobin b)lipofuscin c)keratin d)melanin 12-the pigment that presents the accumulated old worn-out cellular residues of lysosomal activity is a)lipofuscin b)keratin c)hemoglobin d)WBCs 13-polumerization in micro flaments is much rabid in . a)plus end b)minus end c)both ends d)according to the state 14-actine binds to in RBCs to .. a)myosin a)form their cytoskeleton b)pectin b)give them biconcave disk shape c)spectrin c)non of above d)keratin d) a&b 15- 13 units of .. bind together to form a microtubule

a)monomers b)protofilaments c)dimer d)motor protein

Questions on Nucleus (1-The nuclear envelope) 1.The following have more than one nucleus except: A.R.B.Cs B.osteoclasts C.liver cells D.skeletal muscle fibers 2.The following provide/s a channel through which the nucleus & cytoplasm communicate: A.nucleulos B.nuclear envelope C.nuclear pores D.nucleoplasm 3.All the following are functions of nuclear lamina except: A.influence chromosomes distribution B.anchor the glycoprotien components of the nuclear C.support inner membrane of nuclear envelope D.influences chromosomes functions with the cell 4.The following synthesize the transmembrane protiens of the nuclear membranes: A.mitochondria B.nucleus C.golgi body D.ribosomes 5.Nuclear pores increase to several thousands in the cells that are: A.metabolically inactive B.metabolically active C.large in size D.small in size 6.The following possesses cytoplasmic filaments: A.nuclear ring B.spoke ring C.cytoplasmic ring D.terminal ring 7.The number of similar units of which is formed the spoke ring is: A.5 B.6 C.7 D.8 8.In transport across NPC , the small molecules diffuse: A.passively B.actively C. a & b D.no correct answer 9.small molecules (according to transport across NPC) are : A. > 9 nanometer B. < 9 nanometer

C. = or > 9 nanometer D. = or < 9 nanometer

10.The following are examples of macromolecules : A.RNAs B.DNA & RNA polymerase C.histones D.All the previous True/False:11.The nucleus is the smallest organelle of the cell 12.The nucleus is usually laterally situated 13.R.B.Cs have no nucleus while W.B.Cs are mononuclear 14.The nuclear envelope consists of one perforated membrane 15.The nuclear pore is surounded by membranous structures embedded in it's rim Questions on vesicular transport of macromolecules 1] Exocytosis means : A.the uptake of material B.the destroy of material C.the release of material D.the synthesis of the material 2] When the ligand binds specifically to it's receptor : A.clathrin coated pits are formed B.uncoated endocytic vesicles containg ligand are formed C.clathrin coated pits invaginate and give rise to small spinous clathrin-coated vesicles D.LDL receptors are formed and uptake LDL from blood 3]Individuals who suffer from atherosclerosis leading to coronary disease inherit defective genes for synthesis of: A.LDL B.Ligands C.R.B.Cs D.LDL receptors 4](according to the previous question) this leads to : A.hypercholestrolemia B.hypolipidemia C.hypocholestrolemia D.anemia 5]Which from the following is cosidered as receptor-mediated endocytosis however it doesn't involve formation of coated pits or vesicles: A.pinocytosis B.exocytosis C.Phagocytosis D.endocytosis 6]From phagocytes: A. R.B.Cs B. W.B.C.s C. tissue macropahges D. b & c 7]The receptors on the surface of( phagocytes) are for:

A.binding with specific ligand B.protection of the cell C.Recognising and binding to the foregin bodies in extracellular space D.preventing binding to any bodies 8]while the cargo receptors are for : A.binding with specific ligand B.protection of the cell C.Recognising and binding to the foregin bodies in extracellular space D.preventing binding to any bodies 9]Binding of phagocytes receptor to foregin bodies results in : A.formation of pseudopedia by membrane exestension to engulf the particle B.formation of clathrin coated pits C.formation of vesicles D.All the previous 10]All of the following inculde formation of vesicles or presence of coated pits except : A.pinocytosis B.phagocytosis C.Receptor-mediated endocytosis D. A & B 11]All the following pass by passive transport except : A.electrolytes B.oxgyen C.carbon dioxide D.protiens 12]The excess membrane added to the cell membrane by : A.endocytosis B.active transport C.exocytosis D.passive transport 13]During exocytosis a vesicle moves from : A.mitochondria to cytoplasm B.plasma membrane to cytoplasm C.mitochondria to plasma membrane D.cytoplasm to plasma membrane 14]All of the following are applied on/ examples for the regulated secretion of exocytosis except : A.plasma cells secreting immunoglobulins B.stimulus-dependent exocytosis C.formation of membrane-bound secretory granules D.pancreatic acinar cell and recycled by :

True(T) or False(F) :
15] In constitutive secretion is concentrated forming secretory granules . 16]As a result of a hormone stimulus the cargo receptors move to the surface and fuse with cell membrane .

17] Recptor-mediated transport is a highly selective process while Pinocytosis in a non-selective process . 18]Endocytosis is an inactive process that involves invagation of the cell membrane to form membrane-bound vesicle .