PGS and PGD

PacGenomics provides you with the most art-of-the-state genetic testing technolgies. Our genetic laboratory provides both microarray-based Preimplantation Genetic Screening (PGS) and FISH-based Preimplantation Genetic Diagnosis (PGD) services.

Some reasons you may consider using PGS/PGD are:

Youre a woman over 35 years old Have experienced multiple miscarriages Have had multiple pregnancies with a chromosome abnormality Have had several unsuccessful IVF cycles You or your partner carry a unbalanced structural chromosome rearrangement You want to balance the gender in your family

PGS with Chromosomal Microarray Analysis (CMA) Technology

CMA testing is a new generation of genetic testing tools to detect small gains and losses of chromosomes. With CMA testing technologies, PacGenomics overcomes the limitations and combines the strengths of karyotyping and FISH, to offer you a wide range of high-resolution tests. The PGS services offered by PacGenomics have several unique features: One-stop shopping: including embryo biopsy, embryo cell loading, DNA amplication, array hybridization and interpretation to ensure a full quality control of all steps. Fast turn-around time: 95% of the PGS cases are reported within 16~24 hours after sample receipt. Super-clean environment: DNA amplication from a single cell is carried out in a class-100 cleanroom to eliminate possible DNA contaminations. Quality Assurance protocols: All critical technical steps are double-checked independently by a PacGenomics scientist. Data analysis and nal report are reviewed by two senior scientists before director reviews and signs off.

PGS Services available at PacGenomics:

Aneuploidy Screening for IVF

The aneuploidy screening is a comprehensive test that examines all 24 chromosomes including autosomes 1-22 and sex chromosomes (X, Y) using high-density Oligo and/or SNP array. An unbalanced translocation occurs when an embryo (or a child) inherits a chromosome with extra, or missing genetic material from a parent with a balanced translocation. Unbalanced translocation can cause cancer, birth defect and infertility. PGS with CMA is used to detect chromosomal deletion and duplication larger than 2Mb in size in our genetic laboratory.

Detecting Unbalanced Translocation for IVF

* PGS and PGD testings are for Research Use Only (RUO).

Village Medical Center 166 N. Moorpark Road, Suite 203 Thousand Oaks, CA 91360 www.PacGenomics.com (310) 956-4829

PGD with FISH Technology for Aneuploidy

Fluorescence in situ hybridization (FISH) is a technology used to identify a specic chromosomal region that contains a sequence complemented with a cloned segment of DNA. FISH is used to detect an abnormal number of chromosomes and a structural abnormality in one or more chromosomes. PGD with FISH for aneuploidy and unbalanced translocation is provided through our strategic partner PGD Science, Inc. Full PGD-FISH laboratory services include but not limited to: Embryo sex determination (2 chromosome panel) chromosomes X, Y Aneuploidy screening (5 chromosome panel) chromosomes 13, 18, 21, X, Y Aneuploidy screening (10 chromosome panel) chromosomes 8, 9, 13, 15, 16, 18, 21, 22, X, Y Translocation and Inversions study Translocation and Inversions study plus Aneuploidy screening (5 chromosome panel) Sperm sex determination, aneuploidy analysis, and translocation study

* PGS and PGD testings are for Research Use Only (RUO).

Village Medical Center 166 N. Moorpark Road, Suite 203 Thousand Oaks, CA 91360 www.PacGenomics.com (310) 956-4829