Biochemical Energetics and Metabolism Chemistry & Biochemistry 114B Winter 2013 (Peterson 108 MWF 10:00-10:50pm) Professor

Elizabeth Komives Email ekomives@ucsd.edu Phone 858-534-3058 Office Hours Website F, 2-5:00 PM, 4324 NSB http://ted.ucsd.edu

Required Text Biochemistry (7th Edition) 2011. Berg, Tymoczko, Stryer 6th Edition is reserved in the library Exams Mid-term 35% of final grade Final 35% of final grade Problem Sets 30% of final grade NO make up exams Will be discussed in sections, turned in, and graded. Work the following Problems Week 1 1 Mon 2 Wed 3 Fri Jan 7 Jan 9 Jan 11 Lecture Introduction to Metabolism Glycolysis Glycolysis continued Reading Ch. 15 Ch. 16, Sect. 1. Ch. 16, Sect. 2 and 3. PS1 Ch. 15: 10, 12, 13, 14, 17 (draw out answer), 19, 20, 21, 22, 23 (DUE in section week 2)

Problem Sets

Week 2 4 Mon 5 Wed 6 Fri

Jan 14 Jan 16 Jan 18

Gluconeogenesis Citric Acid Cycle I Citric Acid Cycle II

Ch. 16, Sect. 4. Ch. 17, Sect. 1 and 2. Ch. 17, Sect. 3, 4 and 5.

PS 2 Ch. 16: 3,6,10,14,16,18, 20,25,33, 36,42 (DUE in section week 3)

Week 3 Mon 7 Wed 8 Fri

Jan 21 Jan 23 Jan 25

Martin Luther King Holiday Oxidative Ch. 18, Sect. 1, 2 and 3. Phosphorylation I Oxidative Ch. 18, Sect. 4 and 5. Phosphorylation II

PS3 Ch. 17: 5,7,9,11,17 (include mechanisms), 18, 21, 26, 27, 28 Ch. 18: 5,6,9,10

Week 4 9 Mon 10 11 Wed Fri

Jan 28 Jan 30 Feb 1

Oxidative Phosphorylation III Photosynthesis I Photosynthesis II

Ch. 18, Sect. 6 Ch. 19, Sect. 1, 2 and 3. Ch. 19, Sect. 4, 5 and 6.

PS4 Ch. 18: 11,17a,c,f,28, 34, 37, 41,43 Ch. 19: 5,10,15,16,21

Week 5 12 Mon

Feb 4

Calvin Cycle I

Ch. 20, Sect. 1 and 2.

REVIEW FOR MIDTERM

13

Wed Fri

Feb 6 Feb 8

Calvin Cycle II Mid-term

Ch. 20, Sect. 3, 4 and 5.

Week 6 14 Mon 15 Wed 16 Fri

Feb 11 Feb 13 Feb 15

Glycogen Metabolism I Glycogen Metabolism II Fatty Acid Metabolism I

Ch. 21, Sect. 1 and 2. Ch. 21, Sect. 3, 4 and 5. Ch. 22, Sect. 1, 2 and 3.

PS5 TBA

Week 7 Mon 17 Wed 18 Fri Week 8 19 Mon 20 Wed 21 Fri Week 9 22 Mon 23 Wed 24 Fri Week 10 25 Mon 26 Wed 27 Fri

Feb 18 Feb 20 Feb 22

Presidents Day Holiday Fatty Acid Metabolism II Protein Turnover

Ch. 22, Sect. 4, 5 and 6. Ch. 23, Sect. 1, 2 and 3.

PS6 TBA

Feb 25 Feb 27 Mar 1

Amino Acid Catabolism Amino Acid Biosynthesis I Amino Acid Biosynthesis II

Ch. 23, Sect. 4 and 5. Ch. 24, Sect. 1 and 2. Ch. 24, Sect. 3 and 4.

PS7 TBA

Mar 4 Mar 6 Mar 8

Nucleotide Biosynthesis I Nucleotide Biosynthesis II Lipid Biosynthesis I

Ch. 25, Sect. 1 and 2. Ch. 25, Sect. 3 and 4. Ch. 26, Sect. 1 and 2.

PS8 TBA

Mar 11 Mar 13 Mar 15

Lipid Biosynthesis II Metabolism Integration and control I Metabolism Integration and control II

Ch. 26, Sect. 3 and 4. Ch. 27, Sect. 1 and 2. Ch. 27, Sect. 3, 4 and 5.

PS9 TBA

Fri

Mar 22

Final Exam 8:00am 11 am