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Kenalog; Oralone; Pediaderm TA; Trianex; Triderm; Zytopic Kenalog; Oracort; Triaderm Corticosteroid, Topical
Pharmacologic Category
Dermatoses (steroid-responsive, including contact/atopic dermatitis): Topical: Cream, Ointment: 0.025% or 0.05%: Apply thin film to affected areas 2-4 times/day 0.1% or 0.5%: Apply thin film to affected areas 2-3 times/day Spray: Apply to affected area 3-4 times/day Oral inflammatory lesions/ulcers: Oral topical: Press a small dab (about 1/4 inch) to the lesion until a thin film develops; a larger quantity may be required for coverage of some lesions. For optimal results, use only enough to coat the lesion with a thin film; do not rub in.
Dosing: Geriatric
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Aerosol, spray, topical, as acetonide: Kenalog: 0.2 mg/2-second spray (63 g, 100 g) [contains dehydrated ethanol 10.3%] Cream, topical, as acetonide: 0.025% (15 g, 80 g, 454 g); 0.1% (15 g, 30 g, 80 g, 454 g); 0.5% (15 g) Triderm: 0.1% (30 g, 85 g) Cream, topical, as acetonide [kit]: Pediaderm TA: 0.1% (30 g) [packaged with protective emollient] Zytopic: 0.1% (85 g) [packaged with cleanser and moisturizer] Lotion, topical, as acetonide: 0.025% (60 mL); 0.1% (60 mL); 0.1% Ointment, topical, as acetonide: 0.025% (15 g, 80 g, 454 g); 0.05% (430 g); 0.1% (15 g, 80 g, 454 g); 0.5% (15 g) Trianex: 0.05% (17 g, 85 g)
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Oral topical: Apply small dab to lesion until a thin film develops; do not rub in. Apply at bedtime or after meals if applications are needed throughout the day. Topical: Ointment: Apply a thin film sparingly. Do not use on open skin or wounds. Do not occlude area unless directed; if using occluding dressing, monitor for infection. Spray: Avoid eyes and do not inhale if spraying near face. Occlusive dressing may be used if instructed; monitor for infection.
Use
Oral topical: Adjunctive treatment and temporary relief of symptoms associated with oral inflammatory lesions and ulcerative lesions resulting from trauma Topical: Inflammatory dermatoses responsive to steroids
Dermatologic: Acneiform eruptions, allergic contact dermatitis, dryness, folliculitis, hypertrichosis, hypopigmentation, miliaria, perioral dermatitis, pruritus, skin atrophy, skin infection (secondary), skin maceration, striae Endocrine: HPA axis suppression; metabolic effects (hyperglycemia, hypokalemia) Local: Burning, irritation
Contraindications
Hypersensitivity to triamcinolone or any component of the formulation; fungal, viral, or bacterial infections of the mouth or throat (oral topical formulation)
Warnings/Precautions
Concerns related to adverse effects: Adrenal suppression: May cause hypercorticism or suppression of hypothalamic-pituitary-adrenal (HPA) axis, particularly in younger children or in patients receiving high doses for prolonged periods. HPA axis suppression may lead to adrenal crisis. Immunosuppression: Prolonged use may result in fungal or bacterial superinfection; discontinue if
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dermatological infection persists despite appropriate antimicrobial therapy. Sensitization: Topical use has been associated with local sensitization (redness, irritation); discontinue if sensitization is noted. Systemic effects: Topical corticosteroids may be absorbed percutaneously. Absorption may cause manifestations of Cushing's syndrome, hyperglycemia, or glycosuria. Absorption is increased by the use of occlusive dressings, application to denuded skin, or application to large surface areas. Special populations: Elderly: Because of the risk of adverse effects associated with systemic absorption, topical corticosteroids should be used cautiously in the elderly in the smallest possible effective dose for the shortest duration. Pediatrics: Children may absorb proportionally larger amounts after topical application and may be more prone to systemic effects. HPA axis suppression, intracranial hypertension, and Cushing's syndrome have been reported in children receiving topical corticosteroids. Prolonged use may affect growth velocity; growth should be routinely monitored in pediatric patients. Other warnings/precautions: Appropriate use: Do not use occlusive dressings on weeping or exudative lesions and general caution with occlusive dressings should be observed; discontinue if skin irritation or contact dermatitis should occur; do not use in patients with decreased skin circulation. High-potency products: Avoid the use of high-potency steroids on the face. Oral cavity application: When used as a topical agent in the oral cavity, if significant regeneration or repair of oral tissues has not occurred in seven days, re-evaluation of the etiology of the oral lesion is advised.
None known.
(For additional information: Launch Lexi-Interact Drug Interactions Program) Aldesleukin: Corticosteroids may diminish the antineoplastic effect of Aldesleukin. Risk X: Avoid combination Corticorelin: Corticosteroids may diminish the therapeutic effect of Corticorelin. Specifically, the plasma ACTH response to corticorelin may be blunted by recent or current corticosteroid therapy. Risk C: Monitor therapy Deferasirox: Corticosteroids may enhance the adverse/toxic effect of Deferasirox. Specifically, the risk for GI ulceration/irritation or GI bleeding may be increased. Risk C: Monitor therapy Hyaluronidase: Corticosteroids may diminish the therapeutic effect of Hyaluronidase. Management: Patients receiving corticosteroids (particularly at larger doses) may not experience the desired clinical response to standard doses of hyaluronidase. Larger doses of hyaluronidase may be required. Risk D: Consider therapy modification Telaprevir: Corticosteroids may decrease the serum concentration of Telaprevir. Telaprevir may increase the serum concentration of Corticosteroids. Management: Concurrent use of telaprevir and systemic corticosteroids is not recommended. When possible, consider alternatives. If used together, employ extra caution and monitor closely for excessive corticosteroid effects and diminished telaprevir effects. Risk D: Consider therapy modification
C (show table)
Corticosteroids were found to be teratogenic following topical application in animal reproduction studies. In general, the use of topical corticosteroids during pregnancy is not considered to
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have significant risk, however, intrauterine growth retardation in the infant has been reported (rare). The use of large amounts or for prolonged periods of time should be avoided.
Lactation
Breast-Feeding Considerations
Corticosteroids are excreted in human milk; information specific to triamcinolone has not been located. The amount of triamcinolone absorbed systemically following topical administration is variable. Hypertension in the nursing infant has been reported following corticosteroid ointment applied to the nipples. Use with caution.
Aftab (DE); Ahbina (KP); Aristo (HK); Aristocort A (MY, TH); Centocort (TH); Cortiflex (PE); Delphi Creme (BE, NL); Delphicort (AT, DE); Dermacort (HK, MY); Facort (TH); Ftoracort (EE); Gemicort (KP); Generlog (TH); Glytop (AR); Invert Plaster (KP); Kanolone (MY); Kena-Lite (TH); Kenacort (PH, VE); Kenacort A (NL); Kenacort A in Orabase (CH); Kenacort E (PE); Kenacort T (FI, SE); Kenacort-A (BH, EG, ID, KE, TW, TZ, UG); Kenacort-A in Orabase (NL); Kenalog (CL, DK, PK); Kenalog Gel (CL); Kenalog in Orabase (ID, ZA); Keno (SG); Ketricin (ID); Laver (TH); Ledercort (AR, IN, PK); Ledermix (NO); Manolone (TH); Metoral (MY, TH); Nincort (CL, TW); Oracort (NZ); Oramedy (HK, KP, SG); Orrepaste (MY, SG); Sinocort (ID); Tess (IN); Tramsone (SG); Tricin (PH); Tricort (FI, PH); Tricortone (AU); Volon A Antibiotikafrei (AT, DE)
Mechanism of Action
Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability; suppresses the immune system by reducing activity
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Pharmacodynamics/Kinetics
Absorption: Topical corticosteroids are absorbed percutaneously. The extent is dependent on several factors, including epidermal integrity (intact vs abraded skin), formulation, and the use of occlusive dressings. Half-life elimination: Biologic: 18-36 hours Excretion: Urine (~40%); feces (~60%) Use of UpToDate is subject to the Subscription and License Agreement. REFERENCES 1. American Academy of Pediatrics Committee on Drugs: Transfer of Drugs and Other Chemicals Into Human Milk,
Pediatrics, 2001, 108(3):776-89. [PubMed 11533352]
2. Pradat P, Robert-Gnansia E, Di Tanna GL, et al, First Trimester Exposure to Corticosteroids and Oral Clefts, Birth Defects
Res A Clin Mol Teratol, 2003, 67(12):968-70. [PubMed 14745915]
3. Reed, BR, Dermatologic Drugs, Pregnancy, and Lactation. A Conservative Guide, Arch Dermatol, 1997, 133(7):894-8.
[PubMed 9236528]
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