Evaluation: Pharmacology UY1/FMSB/PHCL200-L2S4 17mai2010 : 50mins Section A: Multiple Choice Questions (Choose the ONE best answer 1.

Which of the following properties of a drug encourage(s) their presence in breast milk? [a] High lipid solubility [b] Unionised state [c] Low molecular weight [d] Weak base [e] All of the above * 2. Sub-lingual route of drug administration could be useful for drugs with which of the following property [a] Renal elimination [b] Long half-life [c] Undergo entero-hepatic cycle [d] Extensive first pass metabolism * [e] Highly volatile 3. Which of the following pharmacokinetic models best describes the elimination of ethanol? [a] First order kinetics * [b] Second order kinetics [c] Zero order kinetics [d] Third order kinetics [e] None of the above 4. Which of the following drugs induces cytochrome P450 [a] Cimetidine [b] Quinine [c] Rifampin * [d] Isoniazid [e] ketoconazole 5. Individuals who are slow acetylators (ie have relatively low activities of hepatic N-acetyltransferase): [a] Are more likely to have higher renal clearance of isoniazid

Figure 01: Graphical representation of Concentartion-Effect curves of Drug A and various experimental substances (B,C & D) that are ligands to the same receptors For questions 6-9, refer to the figure above

6. Refer to the curves, which substance could be described as a full agonist?

[a] B [b] C * [c] D [d] All of the above [e] None of the Above 7. Refer to the curves, which substance could be described as an antagonist? [a] B [b] C [c] D [d] All of the above [e] None of the Above * 8. Refer to the curves, which substance could be described as a partial agonist with both reduced potency and reduced efficacy [a] B [b] C [c] D * [d] All of the above [e] None of the Above 9. Refer to the curves, which substance could be described as a partial agonist with maximum potency but reduced efficacy [a] B * [b] C [c] D [d] All of the above [e] None of the Above 10. The potency of a drug is determined by [a] The mechanism of action of the drug [b] The quantity of a drug required to elicit a particular response * [c] The capacity of a drug to elicit a particular response [d] The therapeutic index of the drug Page 1 sur 2

[b] Are more like to have adverse effects during isoniazid therapy * [c] Are more likely to have lower plasma concentration isoniazid during therapy [d] Are more likely to have lower rate of gastro-intestinal absorption of isoniazid [e] None of the above

[e] The biovailability of the drug

11. Indirect agonists of adrenergic receptors exert their effects by

[a] Inhibits the re-uptake of noradrenaline [b] Inhibits the degradation of Noradrenaline [c] Stimulates the release of Noradrenaline [d] All of the above * [e] None of the above 12. The drug metoclopramide (Primperan) has antagonistic effects on [a] Dopaminergic receptors * [b] Adrenergic receptors [c] GABAnergic receptors [d] Glutamate receptors [e] Gylcine Receptors 13. Histaminic H1 receptors are [a] G protein coupled receptors * [b] Linked to tyrosine kinase [c] Intracelluar receptors [d] DNA receptors [e] Ion channels Section B: OPEN Questions -

14. Cite 2 second messengers involved in signal transduction as concerns drug

action and describe the respective molecular mechanisms of signal transduction. (4pts) 15. Give a concise classification of cholinergic receptors and cite respectively a direct agonist and a direct antagonist. (4pts)

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