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The erythrocyte osmotic fragility tests has been used Figure 1. Osmotic fragility profile of erythrocytes. Each point is
the mean of at least four experiments.
as a measure of red cell tensile strength and is
related to cellular deformability which is a significant
aspect of red cell function.’ Indomethacin, a non- 100 -
steroidal anti-inflammatory drug, was found to in-
duce slight membrane changes in erythrocytes.²
80 -
We studied the effect of indomethacin on erythrocyte
osmotic fragility to ascertain its membrane stabilizing
‘;i
effect. & 60-
Young albino rats (Charles foster) weighing 200- .u,
2509 were maintained on commercial rat diet (Lip- E
ton Co., India) and water, They were divided into z
e 40 - o Control
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