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Keterangan mengenai tambahan antigen B yang positif palsu Antigen B yang positif palsu dapat disebabkan adanya proses

infeksi yang menyebabkan nekrosis, enzim yang berasal dari bakteri dapat mengubah antigen A1 menjadi B, dan menyebabkan B yang positif palsu. Apalagi pada neonates dibawah 6 bulan, hal ini juga ditemukan oleh berbagai metode, terutama untuk B yang positif palsu disebabkan infeksi bacterial. Disimpulkan oleh peneliti dibawah bahwa untuk infant lebih baik dikonfirmasikan dengan penentuan golongan darah memakai metode Gel. Kalau infeksi atau penyebabnya sudah diatasi, maka berangsur golongan darah akan kembali ke golongan darah semula, yaitu golongan darah A. Ada 2 literatur: Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Jun;11(3):301-4.

[ABO blood group typing for infants and its application for clinical transfusion].
[Article in Chinese]

Zhang YZ, Lan JC, Li W, Liu Z, Xia R, Zhou HY. Source

Department of Transfusion, The First Military Medical University, Guangzhou 510515, China. zyz200157@sohu.com

To study the correct method for determining ABO blood types in infants and its influencing factors, blood types of 33 infants under 6 months old were determined by routine serological method, micro-column gel typing system and PCR-SSP genotyping method. Of the 33 cases with discrepant results of ABO blood type by different methods, the blood types of 32 cases were discrepant between red cell and serological typings in the routine serological method, and a false coincidence in 1 case was caused by bacterial infection resulting in B-like antigen. Correct blood typing was obtained in 27 cases with a correct rate of 84.4% (27/32) by using micro-column gel typing system. PCR-SSP method gave correct results in all of 33 cases. There was a significant difference between the results of micro-column gel typing system and PCR-SSP. It is concluded that to determine ABO blood type for infants < 6 months old, it is recommended to adopt micro-column gel typing system method, and what must be taken into account is the possible false coincidence caused by bacterial infection resulting in B-like antigen. In micro-column gel typing system, if the results of red cell and serological typing are identical, the principle is that blood transfusion must be performed with same ABO blood type between recipient and donor. If not, washed O red blood cells should be used for infants, and then change to transfusion with identical blood group according to PCR-SSP typing results.

A number of illnesses may alter a person's ABO phenotype. Patients can "acquire" the B antigen during a necrotizing infection during which bacteria release an enzyme into the circulation that converts the A1 antigen into a B-like antigen (3). During this time, patients should not receive blood products that contain

the B antigen because their sera will still contain anti-B. Once the underlying infection is treated, the patients' blood groups return to normal.