Maximal oxygen uptake (V . O2max) is considered to be a fundamental biological index related to human health, fitness and performance.

A great portion of physiologists interest has focused on the factors that limit V . O2max. The prevailing theory holds that maximal value of oxygen uptake during exhaustive exercise is set primarily by maximal cardiac output (Qmax) [1-3] and oxygen delivery [4-6]. However, skeletal muscle has been also proposed as a limiting factor of V . O2max based on evidence that its value is affected by capillary-to-muscle fiber gradients, mitochondrial size and number, enzyme levels, oxidative potential and muscle capillary density [7, 8], but its functional role is considered more minor [9].

Maximal oxygen uptake (V . O2max) is considered to be a fundamental biological index related to human health, fitness and performance. A great portion of physiologists interest has focused on the factors that limit V . O2max. The prevailing theory holds that maximal value of oxygen uptake during exhaustive exercise is set primarily by maximal cardiac output (Qmax) [1-3] and oxygen delivery [4-6]. However, skeletal muscle has been also proposed as a limiting factor of V . O2max based on evidence that its value is affected by capillary-to-muscle fiber gradients, mitochondrial size and number, enzyme levels, oxidative potential and muscle capillary density [7, 8], but its functional role is considered more minor [9].

Maximal oxygen uptake (V . O2max) is considered to be a fundamental biological index related to human health, fitness and performance. A great portion of physiologists interest has focused on the factors that limit V . O2max. The prevailing theory holds that maximal value of oxygen uptake during exhaustive exercise is set primarily by maximal cardiac output (Qmax) [1-3] and oxygen delivery [4-6]. However, skeletal muscle has been also proposed as a limiting factor of V

. O2max based on evidence that its value is affected by capillary-to-muscle fiber gradients, mitochondrial size and number, enzyme levels, oxidative potential and muscle capillary density [7, 8], but its functional role is considered more minor [9].

Maximal oxygen uptake (V . O2max) is considered to be a fundamental biological index related to human health, fitness and performance. A great portion of physiologists interest has focused on the factors that limit V . O2max. The prevailing theory holds that maximal value of oxygen uptake during exhaustive exercise is set primarily by maximal cardiac output (Qmax) [1-3] and oxygen delivery [4-6]. However, skeletal muscle has been also proposed as a limiting factor of V . O2max based on evidence that its value is affected by capillary-to-muscle fiber gradients, mitochondrial size and number, enzyme levels, oxidative potential and muscle capillary density [7, 8], but its functional role is considered more minor [9].

Maximal oxygen uptake (V . O2max) is considered to be a fundamental biological index related to human health, fitness and performance. A great portion of physiologists interest has focused on the factors that limit V . O2max. The prevailing theory holds that maximal value of oxygen uptake during exhaustive exercise is set primarily by maximal cardiac output (Qmax) [1-3] and oxygen delivery [4-6]. However, skeletal muscle has been also proposed as a limiting factor of V . O2max based on evidence that its value is affected by capillary-to-muscle fiber gradients, mitochondrial size and number, enzyme levels, oxidative potential and muscle capillary density [7, 8], but its functional role is considered more minor [9].