Antiseptics and disinfectants 1. For the preparation of a patient`s burn skin surface a certain medication was used.

Its antiseptic action is provided by free oxygen that segregates in presence of organic substances. Choose the right answer: A. Potassium permanganate* B. Chlorhexidine C. Sodium bicarbonate D. Boric acid E. Furacilin. 2. Patient suffering from tonsillitis was recommended to gargle throat with preparation of nitrofurans. What drug was recommended? A. A solution of hydrogen peroxide, B. Solution of furacilinum,* C. Solution of silver nitrate, D. Chlorhexidine E. Alcoholic solution of iodine. 3. Burned skin surface was treated with antimicrobial preparation. Its antiseptic properties are provided by atomic oxygen that is formed in presence of organic substances. What preparation was applied? A. Potassium permanganate* B. Furacillin C. Chlorhexidine bigluconate D. Alcoholic iodine solution E. Boric acid . 4. Patient with abscess of the cut wound applied to the traumatological department. Doctor for the cleaning of the wound from the pus washed it with 3% hydrogen peroxide. Foam was absence. What is the cause of absence of the drug activity? A. Pus in the wound B. Low concentration of H2O2 C. Inherited insufficiency phosphatdehydrogenase of erythrocyte D. Shallow wound E. Inherited insufficiency of catalase*. 5. A group of students were traveling by countryside collecting medicinal plants. It was a hot day and the students spent the entire drinking water. The team leader offered the water of the pond, using the chlorine containing tablet for its disinfection. Point the drug. A. Chloramine-B B. Chlorhexidine C. Halozan* D. Brilliant Green E. Furacilinum.

6. A nurse washed the patients contaminated wound with 3% hydrogen peroxide solution that causes formation a lot of foam. What is the mechanism of antiseptic effect of this drug? A. The formation of molecular oxygen* B. The formation of atomic form of oxygen C. The interaction of hydrogen peroxide with fibrinolysine D. Aggressive action of hydrogen peroxide on tissues E. Formation of albuminates. 7. Patient with burns was treated by application of antiseptic containing halogen and polyvinyl pirrolidon. Point out this preparation. A. Iodovidon* B. Halozan C. Chlorhexidine D. Chloramine E. Pantocide. 8. The patient was admitted to the infectious disease clinic with complaints of vomiting, diarrhea, fever, after errors in diet. What antiseptic should be used for gastric lavage (washing out)? A. Ethanol B. Hydrogen peroxide C. Methylene blue D. Activated char coal E. Potassium permanganate*.

9. A patient has purulent wound with necrotic content. What medication should be used to cleanse the wound? A. Hydrogen peroxide* B. Furacilinum (Nitrofurazone) C. Sulfacyl sodium D. Alcohol solution of iodine E. Aetacridini lactas.

10. In the patient with syphilis treated by, bismuth preparations gray patches on the mucous membrane of the mouth and symptoms of kidney disturbances appeared. Which agent is advisable for the treatment of bismuth poisoning? A. Naloxone B. Unitiol* C. Methylene blue D. Nalorphine E. Bemegride.

11. Dentist handled herpetic lesions of 7 years old child with halogen antiseptic that has antimicrobial, antifungal and antiviral properties. Name the drug. A. Alcohol solution of iodine* B. Potassium permanganate C. Formaldehyde D. Silver nitrate E. Brilliant Green. 12. The patient with gingivitis after using applications was assigned to rinse oral cavity with antiseptic agent realizing its effect by atomic oxygen drug exerts deodorant and astringent effects. Identify the drug. A. Ethanol B. Chlorhexidine bigluconate C. Hydrogen peroxide D. Sodium bicarbonate E. Potassium permanganate* F. Hydrogen peroxide. 13. To prepare the operative field surgeon used a solution of iodine in alcohol. What is the chemical group of this antiseptic preparation? A. Heavy metals B. Halogen-containing compounds* C. Alcohols D. Detergents E. Aliphatic substance. 14. For disinfecting of metallic instruments in the surgical department the formaldehyde solution is used. What is the chemical group of this antiseptic preparation? A. Halogenated compounds B. Aromatic substance

C. D. E.

Detergents Aliphatic agent* Alcohols.

15. After extirpation of the tooth in the patient bleeding from the hole emerged. What drug from the group of antiseptics should be used in this case? A. A solution of hydrogen peroxide* B. Solution of epinephrine hydrochloride C. Solution of brilliant green D. Iodinol E. A solution of ethyl alcohol. 16. Patient suffering from tonsillitis was recommended to gargle throat with preparation of nitrofurans. What drug was recommended? A. A solution of hydrogen peroxide B. Solution of furacilinum* C. Solution of silver nitrate D. Chlorhexidine E. Alcoholic solution of iodine.

17. Burned skin surface was treated with antimicrobial preparation. Its antiseptic properties are provided by atomic oxygen that is formed in presence of organic substances. What preparation was applied? A. Potassium permanganate* B. Furacillin C. Chlorhexidine bigluconate D. Alcoholic iodine solution E. Boric acid . 18. Patient with abscess of the cut wound applied to the traumatological department. Doctor for the cleaning of the wound from the pus washed it with 3% hydrogen peroxide. Foam was absence. What is the cause of absence of the drug activity? A. Inherited insufficiency of catalase* B. Low concentration of H2O2 C. Inherited insufficiency phosphatdehydrogenase of erythrocyte D. Shallow wound E. Pus in the wound. 19. A group of students were traveling by countryside collecting medicinal plants. It was a hot day and the students spent the entire drinking water. The team leader offered the water of the pond, using the chlorine containing tablet for its disinfection. Point the drug. A. Chlorhexidine B. Chloramine-B C. Brilliant Green D. Halozan*

E.

Furacilinum.

20. A nurse washed the patients contaminated wound with 3% hydrogen peroxide solution that causes formation a lot of foam. What is the mechanism of antiseptic effect of this drug? A. The formation of atomic form of oxygen B. The formation of molecular oxygen* C. The interaction of hydrogen peroxide with fibrinolysine D. Aggressive action of hydrogen peroxide on tissues E. Formation of albuminates. 21. Patient with burns was treated by application of antiseptic containing halogen and polyvinyl pirrolidon. Point out this preparation. A. Halozan B. Chlorhexidine C. Iodovidon* D. Chloramine E. Pantocide. 22. Nitrofurane antiseptic was prescribed for mouth wash to patient with stomatitis. Point out this agent A. Hexamethylen tetraminum B. Aethonium C. Furacilinum* D. Boric acid E. Aethacridini lactates. 23. Teenager addressed dermatologist complaining of acne. Doctor prescribed him an antiseptic agent that gradually releases oxygen and is traditionally used locally for treatment of acne. Point out prescribed drug. A. Hydrogen peroxide B. Potassium permanganate C. Benzoyl peroxide* D. Boric acid E. Methylenum coeruleum. 24. To prevent pyodermia in 4-year-old girl with chickenpox mother was recommended to apply a preparation of a group of dyes. Point out this preparation. A. Chlorhexidine B. Alcoholic solution of iodine C. Furacilinum D. Alcoholic solution of of Brilliant Green* E. Chloramine. 25. Before the operation surgeon used degmicidum for disinfecting his hands. Point the group of this antimicrobial agent A. Group of detergent*

B. Group of dyes C. Halogen containing antiseptic D. Oxidizing agent E. Group of nitrofuranes . 26. A patient has purulent wound with necrotic content. What medication should be used to cleanse the wound? A. Furacilinum (Nitrofurazone) B. Hydrogen peroxide* C. Sulfacyl sodium D. Alcohol solution of iodine E. Aetacridini lactas. 27. Dentist handled herpetic lesions child 7 years old halogen antiseptic, has antimicrobial, antifungal and antiviral properties. Name the drug. A. Potassium permanganate B. Formaldehyde C. Silver nitrate D. Brilliant Green E. A solution of iodine in alcohol*. 28. After extirpation of the tooth bleeding from the hole occured in the patient. What drug from the group of antiseptics should be used to stop bleeding? A. Solution of epinephrine hydrochloride B. Solution of brilliant green C. Iodinol D. A solution of hydrogen peroxide* E. A solution of ethyl alcohol. 29. Doctor prescribed oral rinse for patient with stomatitis. Which antiseptic of oxidazinggroup is most suitable for this? A. Boric acid B. Potassium permanganate* C. Alcoholic solution of iodine D. Chloramine E. Ethanol. 30. Gastric lavage with a solution of potassium permanganate was performed in patient due to food poisoning. Which group of antiseptics does this drug belong to? A. Aromatic substances B. Halogens C. Acid D. Oxidizing agents* E. Detergents.

32. Solution of carbolic acid was used for disinfecting of instruments. To which group does this antiseptic belong? A. Oxidizing agents B. Phenols* C. Halogens D. Acid E. Detergents. 33. For disinfecting of hand before operation surgeon used chlorine containing antiseptic, that also widely used in dentistry. Point out this agent. A. Potassium permanganate B. Boric acid C. Alcoholic solution of iodine D. Chlorhexidine* E. Ethanol. 34. Surgeon was urgently summoned to the operating room. Choose the antiseptic used for surgeon hands in emergency. A. Boric acid B. Ethyl alcohol 96%* C. Ethacridine lactate D. Hydrogen peroxide E. Ethyl alcohol 70%.

Synthetic antimicrobial drugs. Fluoroquinolones. Sulfonamides.

35. A 7 vear old child is ill with bronchitis. It is necessary to administer him an antibacterial drug. What drug of fluoroquinolone group is CONTRA-INDICATED at this age? A. Cyprofloxacin* B. Sulfadimethoxine C. Ampiox D. Ampicillin E. Amoxicillin. 36. Patient with pneumonia has intolerance to antibiotics. Which of the combined sulfanilamide medicines should be prescribed to the patient? A. Sulfacyl sodium B. Aethazol C. Biseptol* D. Streptocid E. Sulfadimethoxine. 37. A 7 year old child is ill with bronchitis. It is necessary to prescribe him an antibacterial drug. What drug of fluoroquinolone group is contra-indicated at this age?

A. B. C. D. E. 38. What drug anaerobe? A. B. C. D. E.

Cyprofloxacin* Ampicillin Amoxicillin Sulfadimethoxine Ampiox . A patient consulted a stomatologist about purulent inflammation of his gums. will be the most effective if it is suspected that a causative agent is an Co-trimoxazole Gentamicin Oxacillin sodium Metronidazole* Nitroxoline .

39. A patient with pneumonia had a complex treatment that included sulfonamide preparation. What should doctor recommend to prevent cristaluria? A. Decrease the dose of sulfonamide* B. Drinking of alkaline solution C. Administration of drugs before meal D. Drinking of acidic solution E. Use of vitamins. 40. Gonorrhoea was revealed in the patient on bacterioscopy of the smear from urethra. Taking into account that medicines for gonorrhea are fluorquinolones, patient should be prescribed: A. Ciprofloxacin* B. Furazolidone C. Fluorouracil D. Urosulfan E. Cefazoline. 41. Patient with pneumonia has intolerance to antibiotics. Which of the combined sulfanilamide medicine should be prescribed to the patient? A. Trimethoprim B. Aethazol C. Natrium sulfacyl D. Streptocid E. Biseptol*. 42. A 30-year-old patient complains about having abdominal pain and diarrhea for 5 days body temperature rise up to 37,5o C along with chills. The day before patient had been in forest and drunk from open water reservoir. Laboratory analysis enabled to make the diagnosis of amebic dysentery. What is the drug of choice for its treatment? A. Phthalazol* B. Furazolidonum C. Emetine hydrochloride

D. E. 43. A. B. C. D. E.

Metronidazole Levomycetin. What is the mechanism of antimicrobial effect of sulfonamide? Inhibition of protein synthesis Inhibition of bacterial cell wall synthesis Competitive antagonism with para-aminobensoic acid* Inhibition of cell membrane synthesis Inhibition of nucleic acid synthesis.

44. Combined sulfonamide preparation with bactericidal effect was prescribed for treatment of sore throat in 13 years old child. Point out this drug. A. Biseptol* B. Eneroceptol C. Sulfalen D. Aethasolum E. Urosulfanum. 45. A HIV patient has bacterial dysentery. On the result of antimicrobial sensitivity test doctor prescribed him cotrimoxazol (bactrim,biseptol). What type of antibacterial action has this drug? A. Virostatic B. Bacteriostatic C. Fungicidal D. Fungistatic E. Bactericidal*. 46. A Bactrim was prescribed for 35-years old patient with bronchitis. What is the mechanism of action of this drug? A. Sequential block of two stages of bacterial folate metabolism* B. Inhibition of bacterial cell wall synthesis C. Inhibition of protein synthesis D. Inhibition of cell membrane synthesis E. Inhibition of nucleic acid synthesis. 47. For treatment of typhoid fever ciprofloxacin was prescribed. What is mechanism of this drug action? A. Inhibition of bacterial cell wall synthesis B. Inhibition of DNA gyrase* C. Inhibition of protein synthesis D. Competitive antagonism with paraaminobenzoic acid E. Inhibition of nucleic acid synthesis. 48. A. B. C. Due to which side effect ciprofloxacin is contraindicated in children? Hepatotoxicity Glucosuria Cartilage damage*

D. E.

Nausea Insomnia.

49. A doctor prescribed sulfonamide drug to patient with acute bronchitis. After urinalyses he changed it for antibiotic of penicillin group. The possibility of which side effect of sulfonamide was the base for changing it by other drug? A. Mental confusion B. Hyperglycemia C. Allergic reaction D. Crystalurea* E. Glucosurea . 50. Urinalyses revealed crystaluria in patient who used synthetic antimicrobial drug for treatment of bronchitis. Which group of antimicrobial drug can cause such side effect? A. Sulfonamides* B. Fluorochinolons C. Tetracyclines D. Penicillins E. Macrolydes. 51. Sulfonamides are the drugs of broad antimicrobial spectrum that includes some protozoa. For complex treatment of which protozoal infection is it used? A. Tuberculosis B. Malaria* C. Amebiasis D. Otitis E. Bronchitis. 52. A. B. C. D. E. Why procaine is not compatible with sulfonamides? It binds with sulfonamide It forms paraaminobenzoic acid when metabolized.* It inhibits bacterial cell wall synthesis It interferes with sulfonamide absorption It interfere with sulfonamide distribution.

53. Synthetic antimicrobial drug of quinolones with moderate activity against mycobacteria tuberculosis was recently included in second-line antitubercular drugs. Point this drug. A. Furozalidone B. Sulfadimetoxine C. Biseptol D. Isoniazid E. Ciprofloxacin*.

Antibiotics I

54. A 60-year-old patient was admitted to the surgical department because of infection caused by blue pus bacillus (Pseudomonas aeruginosa) which is sensitive to penicillin antibiotics. Indicate which of the given penicillins has marked activity to the Pseudomonas aeruginosa? A. Methicillin B. Phenoxymethylpenicillin C. Carbenicillin disodium* D. Oxacillin E. Benzylpeniciilin. 55. A 50-year-old patient with typhoid fever was treated with Levomycetin, next day his condition became worse, temperature rose to 39,6C. What caused the complication? A. The effect of endotoxin agent* B. Reinfection C. Secondary infection addition D. Irresponsiveness of an agent to the levomycetin E. Allergic reaction. 56. A patient suffers from severe postoperative pseudomonadous infection. What of the following antibiotics should be administered in this case? A. Erythromycin B. Doxycycline C. Cephazolin D. Benzylpenicillin E. Amicacin sulfate*. 57. Car driver has got into accident and was admited to emergancy department. Surgical invasion in abdominal cavity was successfuly performed, but postoperative period was complicated by peritonitis. Bacterial analysis revealed Pseudomonas aeruginosa. For treatment of patient you may propose any antibiotic leasted below with axception A. Azlocillin B. Genamycine C. Cefotaxim D. Imipenem (Tienam) E. Tetracycline*. 58. A 6-year boy was admitted to hospital with pneumonia. Treatment with amoxycycline was not effective. Bacterial analysis revealed Micoplasma pneumoniae. Choose the most suitable drug for treatment of this child. A. Tetracycline B. Azithromycine* C. Bicillin 5 D. Nystatin

E.

Oxacillin.

59. A 20 years old man with gonorrhea was treated with penicillin G in combination with probenecid. His state was improved, but 1 week later the patient was still complaining of a persistent urethral discharge and pain on urination. Laboratory test reveals chlamidia in discharge. Which of the listed drugs effective both in gonorrhea and chlamidial infection must be used for further treatment A. Amoxicillin B. Doxycycline* C. Oxacillincin D. Gentamycin E. Streptomycin. 60. Patient with tuberculosis was on the complex treatment including antibiotics. At the end of first course doctor noticed significant decrease in patient hearing. Which of the following drugs can cause such side effect? A. Isoniazid B. Rifampicin C. Streptomycin* D. Paraaminosalicylic acid E. Pirazinamide . 61. Patient, with severe pneumonia was treated with the III generation cephalosporin. Doctor warned him about the danger of alcohol usage while treatment. What the drug was used for treatment of patient? A. Carbenicilin B. Cefotaxim* C. Cefalexin D. Gentamycin E. Doxycycline. 62. Patient was admitted to the infection unit with diagnosis of bacterial dysentery. On laboratory studies it was revealed that causative element is sensitive to the many antimicrobial medicines, but patient has anemia. What medicine is contra-indicated to the patient? A. Levomycetin* B. Phthalazol C. Enteroseptol D. Furazolidone E. Ampicillin. 63. Patient with pneumonia, prone to use alcohol, was treated with antibiotic of wide spectrum. On the third day of treatment after alcohol usage severe antabus-like reaction occurs. What was the group of antibiotic used for treatment of patient? A. Biosynthetic penicillin B. Aminoglycoside C. 3rd generation cephalosporin*

D. E.

Penicilinse resistant penicillin Tetracycline.

64. Patient condition after long term atimicrobial treatment was complicated by pseudomembranous enterocolitis. For it treatment vancomycin was prescribed. What is the mechanism of its antimicrobial effect? A. Disturbances of structure and function of cell membrane B. Inhibition of cell wall synthesis* C. Inhibition of protein synthesis D. Inhibition of nucleic acid synthesis E. Inhibition of folic acid metabolism. 65. Patient was admitted to the infection unit with diagnosis of bacterial dysentery. On laboratory studies it was revealed that causative element is sensitive to the many antimicrobial medicines, but patient has anemia. What antibiotic can be recommended for this patient? A. Levomycetin B. Amoxicillin* C. Erythromycin D. Cotrimoxazol E. Oxacillin. 66. A 5-year-old child has been diagnosed with acute right distal pneumonia. Sputum inoculation revealed that the causative agent is resistant to penicillin, but it is senstive to macrolides. What drug should be prescribed? A. Azithromycin* B. Tetracycline C. Gentamycin D. Streptomycin 67. E. Ampicillin . 68. A 19 year old woman suffers from primary syphilis. Doctor administered her complex therapy that includes benzylpenicillin sodium salt. What is the mechanism of action of this drug? A. It blocks RNA synthesis B. It blocks synthesis of cytoplasm proteins C. It blocks thiol enzymes D. It blocks synthesis of peptidoglycan of microbal wall* 69. E. It blocks DNA synthesis . 70. A patient suffers from severe postoperative pseudomonadous infection. What of the following antibiotics should be administered in this case? A. Amikacin sulfate* B. Benzylpenicillin C. Cephazolin D. Erythromycin E. Doxycycline .

71. A patient underwent appendectomy. In the postoperative period he has been taking an antibiotic. The patient complains about hearing impairment and vestibular disorders. What group of antibiotics has such side-effects? A. Cephalosporins B. Penicillins C. Tetracyclines D. Macrolides E. Aminoglycosides*. 72. A patient with bacterial pneumonia was prescribed benzylpenicillin. What is the mechanism of its antibacterial effect? A. Abnormal permeability of cytoplasmic membrane B. Inhibition of intracellular protein synthesis C. Inhibition of synthesis of microbial cell wall* D. Inhibition of SH-groups of microorganism enzymes E. Antagonism with p-amino-benzoic acid . 73. A patient with gastric peptic ulcer was on complex treatment that includes antibiotic of macrolide group. Point out this antibiotic. A. Clarithromycin* B. Tetracycline C. Gentamycin D. Streptomycin 74. E. Ampicillin . 75. A. B. C. D. E. 76. A. B. C. D. E. 77. A. B. C. D. E. Antibiotic used for the treatment of typhoid fever is: Oxacillin Erythromycin Cephalexin Benzylpenicillin Levomicetin*. Patient has primary syphilis. What is the most effective antibiotic in this case? Penicillin* Nystatin Amphotericin Streptomycin Kanamycin. Why tetracycline is not recommended in pregnant women? Due to ototoxicity Due to the depressing effect on the respiration of the fruit Due to the ability of the drug to increase uterine tone Due to the teratogenic effect of the drug* Due to the ability to cause anemia in pregnant.

78. The patient, who has long used tetracycline, there was mucosal candidiasis. What medication should be appointed to treat it? A. Nystatin* B. Nizoral C. Griseofulvin D. Furadonin E. Nitrofungin. 79. Mother of 2 years old child addressed dentist with tooth abnormality in her child. On child examination the destruction of the incisors, yellow enamel, the brown rim on the necks of the teeth ware revealed. Mother informed doctor that she had infection and used antibiotics. Which of the drugs has a strong teratogenic effect, disrupting the development of teeth? A. Polymyxin B. Erythromycin C. Tetracycline* D. Cefrenol E. Ampiox. 80. The patient of 42 years old for the treatment of bacterial pneumonia was appointed ampicillin. Specify the mechanism of bactericidal action of the drug A. Inhibition of intracellular protein synthesis B. Inhibition of the synthesis of the cell wall of the microorganism* C. Violation of the permeability of the cytoplasmic membrane D. Inhibition of SH - groups of enzymes of microorganisms E. Antagonism with paraaminobenzoic acid. 81. Infectious patient is sensitized to benzylpenicillin. Which of the following antibiotics would be the safest in this case? A. Amoxicillin B. Ampicillin C. Erythromycin* D. Oxacillin E. Bicillin 1. 82. A 6 year child was admitted to the hospital with diagnosis of candidiasis mycosis caused by Candida albicans, the mucous membrane of cheeks, palate and tongue was cowered by fur of white and yellow color. Which of the drugs can be used to treat the child? A. Gentamicin B. Ketoconazole* C. Tetracycline D. Cefran E. Penicillin. 83. A patient with impaired hearing has severe bacillary infection. Which group of antibiotics is contraindicated in this case?

A. B. C. D. E.

Aminoglycosides* Penicillins Cephalosporins Tetracyclines Rifamycins.

84. A patient diagnosed with purulent pleurisy caused by penicillin resistant staphylococcus. What preparation of penicillin resistant to beta-lactamase may be used for the treatment of this patient? A. Ampicillin B. Benzylpenicillin C. Phenoxymethylpenicillin D. Augmentin* E. Carbenicillin. 85. A. B. C. D. E. Use of which broad-spectrum antibiotic is contraindicated in liver disease? Polymyxin Lincomycin Tetracycline* Oxacillin Penicillin G.

86. Patient with staphylococcal sepsis was treated with benzylpenicillin. Therapy was ineffective. What preparation of penicillin group should be prescribed for the patient to continue treatment? A. Oxacillin* B. Polymyxin C. Erythromycin D. Phtalazol E. Aztreonam. 87. Child of 5 years with a staphylococcus infection was assigned penicillin antibiotic without testing pathogen susceptibility to drugs of this group. Which drug of penicillin group is resistant to beta-lactamase and effectively influences on the penicillinresistant staphylococci? A. Carbenicillin B. Ampicillin C. Bicillin-5 D. Phenoxymethylpenicillin E. Oxacillin*.

Antituberculous drugs, antiviral, antispirochetous drugs. Antimycotic agents

88. A 35-year-old man under the treatment for pulmonary tuberculosis has acuteonset of right big toe pain, swelling, and low-grade fever. The gouty arthritis was

diagnosed and high serum uric acid level was found. Which of the following antituberculosis drugs are known for causing high uric acid levels? A. Rifampicin B. Aminosalicylic acid C. Thiacetazone D. Pyrazinamide* E. Cycloserine. 89. A 35-year-old man under the treatment for pulmonary tuberculosis has acute pain onset of right big toe, swelling and lowgrade fever. The gouty arthritis was diagnosed and high serum uric acid level was found. Which of the following antituberculous drugs are known for causing high uric acid levels? A. Pyrazinamide* B. Thiacetazone C. Aminosalicylic acid D. Cycloserine E. Rifampicin. 90. Tuberculosis can be treated by means of combined chemotherapy that includes substances with different mechanisms of action. What antituberculous medication inhibits transcription of RNA into DNA in mycobacteria? A. Isoniazid B. Para-aminosalicylic acid C. Rifampicin* D. Ethionamide E. Streptomycin. 91. A patient was diagnosed with active focal pulmonary tuberculosis. What drug should be prescribed in the first place? A. Ethionamide B. Isoniazid* C. Ethoxide D. Sulfalen E. Cyclocerine. 92. A patient was diagnosed with active focal pulmonary tuberculosis. What drug should be prescribed in the first place? A. Isoniazid* B. Sulfalen C. Cyclocerine D. Ethionamide E. Etoposide . 93. A patient suffers from pulmonary tuberculosis. During treatment neuritis of visual nerve occurred. What drug has caused this side effect? A. Isoniazid B. Ethambutol*

C. Kanamycin D. Rifampicin E. Streptomycin . 94. Patient suffering from tuberculosis was treated with isoniazid. In the course of treatment peripheral neuritis was developed. What is the mechanism of this side effect? A. Direct toxic effect of drug on peripheral nerves B. Inhibition of myoneural junctions C. Interference with pyridoxine metabolism* D. Interference with folic acid synthesis E. Inhibition of sodium channels. 95. Patient with tuberculosis was on the complex treatment including antibiotics. At the end of first course doctor noticed significant decrease in patient hearing. Which of the following drugs can cause such side effect? A. Isoniazid B. Rifampicin C. Streptomycin* D. Paraaminosalicylic acid E. Pirazinamide . 96. One of the problems in the treatment of tuberculosis is caused by existence of metabolically dormant forms of mycobacterium (persister). Which of the drugs is effective against all subpopulations of Mycobacteria tuberculosis and causes sterilizing effect? A. Streptomycin B. Isoniazid C. Kanamycin D. Rifampicin* E. Paraaminosalicylic acid. 97. The patient suffering from tuberculosis was treated with combination of antituberculous drugs, including isoniazid. Which drug should be added to prevent neurological side effects of isoniazid? A. Streptomycin B. PASA C. Rifampicin D. Pyridoxine* E. Ascorbic acid. 98. A patient has herpetic rash. What medication should be administered? A. Acyclovir* B. Gentamycin C. Clotrimazole D. Benzylpenicillin sodium salt E. Biseptol . 99. Point out the antiviral agent used in influenza.

A. B. C. D. E.

Oseltamivir.* Streptomycine Gentamycin Clotrimazole Pyridoxine.

100. A patient with lung tuberculosis is treated with a drug that has a wide antimicrobial spectrum; mycobacteria of tuberculosis are highly sensitive to it. Its effect is realized by depression of bacterial RNA synthesis. Drug is staining body liquids (urine, sputum, tears) in red color. What the drug is used? A. Streptomycin B. Isoniazid C. Ethambutol D. Rifampicin* E. Paraaminosalicylic acid. 101. Treatment of tuberculosis is realized by means of combination chemotherapy, including agents with different mechanisms of action. Which of the antituberculosis drugs inhibit the transcription of DNA into RNA of mycobacteria? A. Rifampicin* B. Isoniazid C. Streptomycin D. Ethionamide E. PAS. 102. The patient went to a doctor complaining of red staining of urine and tear. From his case history it is known that he is treated on pulmonary tuberculosis. Which of anti-TB drugs is responsible for this phenomenon? A. Isoniazid B. Ethionamide C. Ethambutol D. Rifampicin* E. Streptomycin . 103. How do you explain the fact that the in treatment of tuberculosis with isoniazid dose is adjusted individually, with mandatory measurement of its concentration in the urine after the first drug? A. Genetically determined differences in rate of drug acetylating* B. Occurrence of hyperglycemia as a side effect C. The development of renal failure D. Irritant action of the drug E. Development of hemolytic anemia. 104. TB patient after prolonged treatment with effective anti-TB drug called attention to breast enlargement. On this occasion he went to a doctor, who confirmed gynecomastia. Identify the drug, which he used. A. Cycloserine

B. C. D. E.

Ethambutol Isoniazid* Rifampicin Streptomycin sulfate .

105. As a result of prolonged use of broad spectrum antibiotics intestinal candidamycosis was developed. What should be prescribed to treat it? A. Interferon B. Remantadin C. Itraconazole* D. Rifampicin E. Gramicidin. 106. A patient with a diagnosis of AIDS was admitted to the infectious disease hospital. To improve the immune status of patient, stabilizing body weight and improwement of his condition, antiviral agent - an antagonist of thymidine, which blocks the DNA polymerase of HIV was prescribed. Select the designated agent. A. Azidothymidine* B. Acyclovir C. Interferon D. Rimantadine E. Midantan. 107. Patients with herpes doctor prescribed an antiviral drug, which the main mechanism of action is inhibition of viral DNA polymerase, and the ability to be integrated instead of deoxyguanosine into viral DNA. Name the drug. A. Interferon B. Azidothymidine C. Acyclovir* D. Midantan E. Ethambutol. 108. A 20 years old patient with primary syphilis is receiving combined therapy, which includes the sodium salt of benzylpenicillin. What is the mechanism of action of this drug? A. Blockade of DNA synthesis B. RNA synthesis blockade C. Blockade of the SH- groups of enzymes D. Blockade of the synthesis murein of cell wall of microorganisms* E. Blockade of protein synthesis in cytoplasm. 109. A patient addressed doctor with complaints on the damage of skin between the fingers of foot, exudation and itching. Doctor prescribed paste containing antifungal agent of wide spectrum. Point out this drug A. Nystatin B. Clotrimazole* C. Streptomycin

D. E.

Co-trimoxazol Levorin.

110. This drug is used for treatment of tuberculosis, rate of its inactivation in the liver is genetically determined and is different in different persons. Point out this drug A. Acyclovir B. Azidothymidine C. Ciprofloxacin D. Isoniazid* E. Rifampicin.

Antiprotozoal drugs

111. To prevent long-term effects of 4-day malaria a 42-year-old patient was prescribed primaquine. On the 3-rd day from the begin of treatment there appeared stomach and heart pains, dyspepsia, general cyanosis, hemoglobinuria. What caused side effects of the preparation? A. Drug potentiation by other preparations B. Cumulation of the preparation C. Delayed urinary excretion of the preparation D. Decreased activity of microsomal liver enzymes E. Genetic insufficiency of glucose 6-phosphate dehydrogenase*. 112. A 52-year-old patient has the following diagnosis: systemic amebiasis with involvement of intestines, liver, lungs. What drug should be prescribed? A. Enteroseptol B. Tetracycline C. Quiniofone D. Quingamine E. Metronidasol*. 113. A patient consulted a doctor about bowels disfunction. The doctor established symptoms of duodenitis and enteritis. Laboratory examination helped to make the following diagnosis: lambliosis. What medication should be administered? A. Tetracycline B. Monomycin C. Metronidazole* D. Erythromycin E. Chingamin. 114. What drug anaerobe? A. B. A patient consulted a stomatologist about purulent inflammation of his gums. will be the most effective if it is suspected that a causative agent is an Oxacillin sodium Gentamicin

C. D. E.

Nitroxoline Co-trimoxazole Metronidazole*.

115. A patient ill with amebiasis was prescribed a certain drug. The use of alcohol together with this drug is contra-indicated because the drug inhibits metabolism of ethyl alcohol. What drug is it? A. Clonidine B. Metronidazole* C. Reserpine D. Diazepam E. Aminazine. 116. Before the doctors business trip to foreign country he was proposed histoschizontocidal antimalarial drug for the personal prevention of malaria. Which drug has got a specialist? A. Mefloquine B. Chloroquine C. Quinine D. Doxycycline E. Primaquine*. 117. The patient with lovered immunity was examined concerning helminthiasis. Laboratory studies have found ascariasis. Which drug should be prescribed? A. Niclosamide B. Piperazine C. Furazolidone D. Gentamicin E. Levamisole*. 118. The patient addresed her gynecologist complaining of heavy vaginal discharge with an unpleasant odor. After the smears bacterioscopy trichomoniasis was diagnosed. What the drug is indicated in this case? A. Sulfadimezin B. Chloroquine C. Pyrimethamine D. Metronidazole* E. Monomecinum. 119. The patient has a mixed helminthic invasion: intestinal ascariasis and liver trematodes. What anthelminthic drugis the most advisable for the treatment of this patient? A. Mebendazole* B. Pyrantel B. C. Chloxylum D. Piperazine adipate E. Levamisole.

120. The drug has a devastating effect on the erythrocytic forms of malaria parasites, dysenteric amoeba. It is used to treat and prevent malaria, the treatment of amoebiasis and connective tissue diseases. Identify the drug. A. Emetine hydrochloride B. Chloroquine* C. Tetracycline D. Erythromycin E. Quinine. 121. The patient addressed doctor complaining of epigastric discomfort, nausea, loss of appetite. The study of duodenal content revealed Giardia resistant to metronidazole. Which drug should be appointed? A. Rifampicin B. Chloroquine* C. Metronidazole D. Isoniazid E. Acyclovir . 122. Antiprotozoal agent of wide spectrum was included in complex treatment of patient with gastric peptic ulcer. Doctor warned patient about prohibition of alcohol usage during treatment with this drug. What the drug was used? A. Chloramphenicol B. Metronidazole* C. Cotrimoxazole D. Chloroquine E. Praziquantel. 123. Patient suffering from severe malaria caused by plasmodium falciparum resistant to chloroquine was treated with the oldest antimalarial drug, obtained from the bark of cinchona tree. Point out this drug. A. Primaquine B. Proguanil C. Pyrimethamine D. Quinine* E. Emetine. 124. Point out the drug of first choice for treatment of patient suffering from kalaazar (visceral leishmaniasis) A. Metronidazole B. Sodium stibogluconate* C. Tetracycline D. Pyrimethamine E. Nystatin. 125. For treatment of neck phlegmon caused by anaerobic infection antimicrobial drug of imidasole group was included. Point out this drug A. Norfloxacin

B. C. D. E.

Clindamycin Metronidasole* Tetracycline Ampicillin.

126. A 30-year-old patient complains about having abdominal pain and diarrhea for five days body temperature rise up to 37,5oC along with chills. The day before a patient had been in a forest and drunk from an open water reservoir. Laboratory analyses enabled to make the following diagnosis: amebic dysentery. What is the drug of choice for its treatment? A. Metronidazole* B. Furazolidonum C. Levomycetin D. Phthalazol E. Emetine hydrochloride . 127. A patient ill with amebiasis was prescribed a certain drug. The use of alcohol together with this drug is contra-indicated because it inhibits metabolism of ethyl alcohol. What drug is it? A. Metronidazole* B. Reserpine C. Clonidine D. Diazepam E. Aminazine . 128. Amebiasis of hepatic localization was diagnosed in patient. Choose the drug for treatment of patient. A. Norfloxacin B. Clindamycin C. Chloroquine* D. Tetracycline E. Ampicillin. 129. The drug with histoschizontocydal and gametocydal action was used for causal prophylaxis of malaria. Point out this drug. A. Metronidasole B. Primaquine* C. Chloroquine D. Tetracycline E. Emetine hydrochloride . 130. Point out the antimalarial drug that exert erythrocytic schizontocidal effect by changing pH in parasitic vesicles and prevention of haeme transformation to hemozoin. A. Primaquine B. Chloroquine* C. Metronidasole D. Sulfadoxine

E.

Pyrimethamine.

Anticancer drugs. Preparations of acids, bases and salts. Basic principles of acute poisoning treatment

131. The preventive radio protector was given to worker of a nuclear power station. What mechanism from the below mentioned is considered to be the male mechanism of radioprotection? A. Prevention of tissue's hypoxia B. Inhibition of free radicals formation* C. Activation of oxidation reactions D. Increasing of tissue blood supply E. Increasing of respiration. 132. A patient who was previously ill with mastectomy as a result of breast cancer was prescribed radiation therapy. What vitamin preparation has marked radioprotective action caused by antioxidant activity? A. Ergocalciferol B. Tocopherol acetate* C. Thiamine chloride D. Ribof1avin E. Folic acid. 133. In order to accelerate healing of a radiation ulcer a vitamin drug was administered. What drug is it? A. Methyluracil B. Retinol acetate* C. Levamisole D. Prednisolone E. Retabolil. 134. An oncological patient was prescribed methotrexate. With the lapse of time target cells of the tumour lost susceptibility to this drug. There is change of gene expression of the folowing enzyme: A. Thiaminase B. Deaminase C. Dehydrofolate reductase* D. Folate decarboxylase E. Folate oxidase. 135. Patient after surgery for breast cancer chemotherapy with antiestrogen agent was prescribed. Which of the following drugs belongs to antiestrogen with anticancer activity? A. Tamoxifen* B. Cyclophosphamide

C. D. E. 136. derivative? A. B. C. D. E.

Chlorbutin Cisplatin Fosfestrol. What is the basic mechanism of anticancer action of ethyleneimine Alkylation of RNA and DNA of tumor cells* Inhibition of cell division in metaphase Formation of stable complexes with DNA of tumor cells Competitive inhibition of nucleic acid metabolism in tumors Cytorecptors blockade on the cell membrane.

137. In the intensive care unit a child was enrolled with pronounced signs of acidosis, to relieve his condition immediat drip of infusion was started. Which of the following drugs should be used in acidosis? A. Potassium Chloride B. Sodium Chloride C. Sodium bicarbonate* D. Glucose E. Magnesium sulfate. 138. Patients with chronic heart failure was using digoxin. To increase the result of treatment additional drug was included in patient therapy. It resulted in the development of symptoms of intoxication. Which drug can cause increase in cardiac glycoside toxycity? A. Potassium chloride B. Magnesium chloride C. Asparkam D. Glucose E. Calcium chloride*. 139. A patient with acute poisoning was admitted to emergency department. It was established that poisonous substance was excreted by kidney. Choose the best diuretic for forced diuresis. A. Acetazolamide B. Amiloride C. Spironolactone D. Furosemide* E. Hydrochlorothiazide. 140. alkaloid A. B. C. D. E. Choose the most beneficial agent for stomach wash in patient poisoned with Physiological solution Chlorhexidine Sodium bicarbonate Potassium permanganate* 5% solution of glucose.

141. A. B. C. D. E.

Point out the antidote used in poisoning with salts of heavy metals Penicillamine Unithiolum* Acetylcysteine Magnesium sulfate Atropine.

142. A patient in comatose state was admitted to emergency department. His respiration was abnormal (Cheyn-Stokes respiration). Poisoning with opioid analgesic was diagnosed. After intravenous administration of antidote respiration was restored. What agent was used as antidote? A. Pralidoxime B. Naloxone* C. Ethanol D. Acetazolamide E. Unithiolum. 143. A patient with myocardium infarction was treated with heparin. On 6th day of treatment nasal bleeding occurred. Overdose of heparin was diagnosed. Point out the antidote of heparin A. Acetylcysteine B. Protamine sulfate* C. Magnesium sulfate D. Unithiolum E. Deferoxamine. 144. Patient suffering from cancer of skin is treated with anticancer antibiotic. Point out this drug A. Neomycin B. Danazol C. Mercaptopurine D. Phtoruracil E. Bleomycin*. 145. Radio protector was given to a worker of a nuclear power station. What mechanism is considered to be responsible for radioprotection? A. Increasing of respiration B. Inhibiton of free radicals formation* C. Activation of oxidation reactions D. Prevention of tissue's hypoxia E. Increasing of tissue blood supply. 146. Patient suffering from acute leucosis was treated with agent that is competitive antagonist of folic acid. Point out this agent A. Phtoruracil B. Methotrexate* C. Mercaptopurine

D. E.

Phtorafur Cytarabine.

147. Patient with gastric cancer is treated with drug that interferes with synthesis of nucleic acids due to its resemblance with pirimidine. Point out this drug A. Mercaptopurine B. Methotrexate C. Phluorouracil (Phtoruracil)* D. Neomycin E. Bleomycin. 148. Highly dehydrated patient with cholera was admitted to specialized department. Which agent is necessary to use to normalize the volume of circulating blood? A. Solution KCl 4% B. Solution of calcium chloride 10% C. Solution of glucose 40% D. Solution calcium gluconate E. Solution of NaCl 0,9%*. 149. A 38-year-old man who poisoned himself with mercury dichloride was taken to the admission room in grave condition. What antidote should be immediately introduced? A. Isonitrosine B. Dipiroxim C. Unithiol* D. Nalorphine E. Atropine. 150. department A. B. C. D. E. A patient working at a chemical plant was admitted to the toxicological with mercury poisoning. What medicine should be used? Isonitrozin Naloxone Enterosorbent Unithiol* Activated carbon.