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Subject Biotechnology
Holidays Home Work
1. What is a cotig?
BLAST, EST, NCBI, FISH, EMBL, PDB, PIR
2. Write the full form of the following
3 What is a database?
4. When was the Human Genome finally deciphered?
5. Define Genomics
6. List four reasons for screening a genome.
7. Explain the necessity of creating Bio information database.
8. What is the needed of IUPAC system in Bioinformatics.
9 Describe the contribution made by ‘Margaret Dayhoff; towards the development of
Bioinformatics.
10 What is BLAST? How is it used in Bioinfo analysis.
11. Name the database having mRNA and proteins of Human, Mouse & Rat.
12. Who is an annotator?
13. What is the importance of Bioinformatics?
14. What is the significance of Random Shotgun sequencing.
15. You are given a DNA sequence. Describe how will you use the Bioinformatics tools to
analyse the sequence to find out a gene & its possible protein.
16. List the important database used in routine bioinformatics.
17. How can you search for genes using computers?
18. What do you understand by the term ‘Gemomics’?
19. What are SNPs and what are their applications?
20 What are the different types of molecules on which sequence data is obtained are
deposited in database?
21. Explain different types of sequencing methods using in Genome sequencing projects.
22. Differentiate between structural and functional Genomics.
23. What does ‘Entrez’ information include?
24. Which database contains the information about “annotated protein sequence”?
25. List any six resources available form NCBI and their uses.
26.Genome size of Humans ______________________& Drosphila melanogaster
_______________________.
27.Term ‘Genome’ was coined by___________________ and “Genomics”
by_________________.
28 What is number of predicted genes in E-coli & Humans & worm (coenorhabdits
elegans).
29. What is the “physical Map” of an organism mean?
30 Define genome annotation.
31. How can DNA micro array technique be used to study cellular response to the
environment?
32. Describe the ‘FISH’ technique & briefly explain any one of its applications.
33. What are database retrieval tools? Name & explain the use of a tool to classify a newly
discovered species.
34. youu have the gene sequence of a protein which has protein which has proteolytic
activity. How will you establish the tools of Bioinformatics that this protein.
i. Has homologus in other organisms.
ii. Belongs to the chymotrypsin family.
35. Explain BLAST. How can this bioinfo search tool be employed for finding homology
between genes? Does similarity between two sequences always indicate their
homology?
36 What is the IUPAC code for G and A? write the complementary sequence of the
following sequence.
5’ – ATGAYCGBT _________ 3’
37 Bioinfo database provide many different types of sequences, such as c D N A,
Genome, EST & peptide etc. which of these would you use as the most suitable point
for identifying.
a. Promoter
b ORF (open reading frame)
c Intron.