Manuscript Submission. All papers must be submitted via the online system.

Biopharmaceutics & Drug Disposition operates an online submission and peer review system that allows authors to submit articles online and track their progress via a web interface, http://mc.manuscriptcentral.com/bdd. If Authors are using the system for the first time, Authors must create an account before Authors can submit online. Organization of the Manuscript The journal accepts short communications, original research papers, and review articles. The language of the journal is English. All submissions must have a margin of 2.2 cm all round, and be double-spaced. Illustrations must be on separate sheets, and not be incorporated into the text. All of the article types should follow the instructions described hereafter. Submissions that do not follow the proposed format will not be reviewed. Each manuscript should contain the following text sections: Title page, Running title page, Abstract, Introduction, Material and Methods, Results, Discussion and Conclusion in the order listed. Each section should be titled and begin on a new page. All pages, excluding figure pages, should be numbered consecutively. Title page. The title should be pertinent and descriptive, and the page must list the full title and names and affiliations of all authors. At the bottom of the tile page, include the name(s) of any sponsor(s) of the research contained in the paper, along with grant number(s). Running page title. Provide a short title no more than 60 characters. Give the full address, including e-mail, telephone and fax, of the corresponding author. Abstract page. Supply an abstract of no more than 250 wordsfor all article types. An abstract is a concise summary of the whole paper not just the conclusions, and is understandable without reference to the rest of the paper. It should contain no citation to other published work. Include 3-5 keywords that describe Authors' paper for indexing purposes. Text. The text includes Introduction, Material and Methods, Results, Discussion, and Conclusion. Appendix. Appendices, if present, should come immediately after the main text and before the references. Acknowledgments. The Acknowledgments section is placed at the end of the text. Grant support and personal assistance are noted here. References. References should not exceed 50, and cited by numbers in square brackets and listed at the end of the paper in the order in which they appear in the text. All references must be complete and accurate. Where possible the DOI for the reference should be included at the end of the reference. Online citations should include date of access. Use Index Medicus abbreviations for journal names. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=journals . If necessary, cite unpublished or personal work in the text but do not include it in the reference list. References should be listed in the following style: 1. Aungst BJ, Blake JA, Hussain MA. An in vitro evaluation of metabolism and poor membrane permeation impeding intestinal absorption of leucine enkephalin, and

methods to increase adsorption. Biopharm Drug Dispos 2003; 24 : 1-16. DOI:10.1002/bdd.258 2. Altman DG. Practical Statistics for Medical Research . Chapman & Hall: London, 1991; 36-38. 3. Smith QR. Quantitation of blood-brain barrier permeability. In Implication of the Blood-Brain Barrier and Its Manipulation , Neuwelt EA (ed). Plenum Medical Book Company: New York, 1989; 85-117. 4. The Oncology Website. http://www.mit.com/oncology/[24 April 1999]. Figure legends. The legend page follows immediately after reference pages in the main document. Tables. Tables should be part of the main document and should be placed after the figure legend pages. Do not use excel files for tables for submission. Group all of the above sections into one, main document for submission. Illustrations Do not include figures in the main document. Upload each figure as a separate file in either .tiff or .eps format, with the lead author's name, the figure number at the top of the figure indicated. Compound figures e.g. 1a, b, c should be uploaded as one figure. Tints are not acceptable. Lettering must be of reasonable size that would still be clearly legible upon reduction and consistent within each figure and set of figures. Where a key to symbols is required, please include this in the artwork itself, not in the figure legend. All instructions must be supplied at the correct resolution: o o o Black and white and colour photos - 300 dpi minimum Graphs, drawings, etc - 800 dpi preferred; 600 dpi minimum Combinations of photos and drawings (black and white and colour) - 500 dpi minimum

Others. Structural formulae of parent compounds and metabolites should be given; where possible, these should be general formulae with variable groups identified in a legend. Short Communications Short communications are intended for the dissemination of the results of studies that are slightly more limited in scope than those warranting a full paper, and should not exceed 1000 words (excluding references) plus a maximum of one figure and/or one table. Short Communications are subject to the same review process as full papers. Short Communications should contain the same sections as full papers. The Results and Discussion sections may be combined. Reviews Contemporary reviews on topics of interest covering more recent aspects of a topic will be published. These may be critical reviews that present the authors' view of the current state of the subject or prospective articles intended to stimulate discussion and research. Manuscripts submitted under this category may be unsolicited or may be invited by the editor. Post Acceptance Further Information

Proofs will be sent to the author for checking. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, preferably within two days of receipt, will minimize the risk of the paper being held over to a later issue. Free access of the final PDF offprint of your article will be available via Author Services only. Please therefore sign up for Author Services if you would like to access your PDF offprint and enjoy the many other benefits the service offers. Further offprints and copies of the journal may be ordered. There is no page charge to authors. Authors Resources: Manuscript accepted for publication If so, check out our suite of tools and services for Authors and sign up for: Article Tracking E-mail Publication Alerts Personalization Tools Accepted Articles Accepted Articles have been accepted for publication and undergone full peer review but have not been through the copyediting, typesetting, pagination and proofreading process. Accepted Articles are published online a few days after final acceptance, appear in PDF format only, are given a Digital Object Identifier (DOI), which allows them to be cited and tracked, and are indexed by PubMed. A completed copyright form is required before a manuscript can be processed as an Accepted Article. EarlyView EarlyView is Wiley's exclusive service presenting individual, complete, peer-reviewed articles as soon as they are ready before the release of the compiled print issue. Cite EarlyView Articles To link to an article, take the DOI (digital object identifier) and append it to "http://dx.doi.org/" as per the following example: DOI 10.1002/hep.20941, becomes http://dx.doi.org/10.1002/hep.20941. To include the DOI in a citation to an article, simply append it to the reference as in the following example: Oestreicher, N., The cost of adjuvant chemotherapy in patients with early-stage breast carcinoma, Cancer 10(1) , pp. 2054 - 2062, DOI: 10.1002/cncr.21464. OnlineOpen OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to nonsubscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms. Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website at: https://onlinelibrary.wiley.com/onlineOpenOrder

Prior to acceptance there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit. For Authors For additional tools visit Author Resources - an enhanced suite of online tools for Wiley InterScience journal authors, featuring Article Tracking, E-mail Publication Alerts and Customized Research Tools. Copyright Transfer Agreement Permission Request Form The National Institute of Health Public Access Initiative File types. Preferred formats for the text and tables of Authors manuscript are .doc, .docx, .rtf, .ppt, .xls. LaTeX files may be submitted provided that an .eps or .pdf file is provided in addition to the source files. Figures may be provided in .tiff or .eps format. Pre-submission English language editing. Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. A list of independent suppliers of editing services can be found at www.blackwellpublishing.com/bauthor/english_language.asp. Japanese authors can also find a list of local English improvement services at http://www.wiley.co.jp/journals/editcontribute/editservlist.html. All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication. Initial Submission Non-LaTeX Users: Upload Authors manuscript files and any supplementary material files. At this stage, further source files do not need to be uploaded. LaTeX Users: For reviewing purposes Author should upload a single .pdf (including any supplementary material) that Author have generated from Authors source files. Authors must use the File Designation "Main Document" from the dropdown box. Revision Submission Non-LaTeX Users: Editable source files must be uploaded at this stage. Tables must appear after the reference list, and be incorporated into the main text. Figures should be uploaded as separate figure files. LaTeX Users: When submitting the revision, Authors must still upload a single .pdf that Authors have generated from the now revised source files. Authors must use the File Designation "Main Document" from the dropdown box. In addition Authors must upload the TeX source files. For all Authors source files Authors must use the File Designation "Supplemental Material not for review". Previous versions of uploaded documents must be deleted. For the accepted manuscript, Wiley will use the files which Authors have uploaded to typeset the article within a totally digital workflow.

 Authors are advised to highlight the changes made according to the suggestions of the reviewers in the revised manuscript show with different color fonts. Authors can load this version after the unmarked or clean revised version. The rebuttal should be uploaded as a supplemental file. The ID# and the revision version should be centered in the header (e.g. BDD-00189-R2). No Colour Charges Biopharmaceutical & Drug Disposition offers authors the opportunity to reproduce colour figures in colour for free in both online and printed version of the article. Extensions Unless indicated, authors are given 3 months to resubmit revisions. An extension to deadline must be communicated by the corresponding author for approval to the Editor who is handling the manuscript. If the Author has created the revision or resubmission and the work is in progress but expires prior to the Author submitting the revised paper, s/he must seek extension in writing. There is no mechanism to accept delayed submissions. A lapsed manuscript may be re-submitted to the journal as a new submission. However, the new submission will be subject to a new process of review and cause delay in the review process. Copyright and Permissions Authors must sign, scan and upload to the online system: a Copyright Transfer Agreement with original signature(s) - without this we are unable to accept the submission, and permission grants - if the manuscript contains extracts, including illustrations, from other copyright works (including material from on-line or intranet sources) it is the author's responsibility to obtain written permission from the owners of the publishing rights to reproduce such extracts using the Wiley Permission Request Form. The Copyright Transfer Form and the Permissions Form should be uploaded as Supplementary files not for review with the online submission of Authors article. If Authors do not have access to a scanner, further instructions will be given to authors after acceptance of the manuscript. To enable the publisher to disseminate the author's work to the fullest extent, the author must sign a Copyright Transfer Agreement, transferring copyright in the article from the author to the publisher, and submit the original signed agreement with the article presented for publication. A copy of the agreement to be used (which may be photocopied) can be found in the first issue of the year, on the Wiley Online Library website and through links in the online submission system. Copies may also be obtained from the publisher. Submission of a manuscript will be held to imply that it contains original unpublished work and is not being submitted for publication elsewhere at the same time. Submitted material will not be returned to the author, unless specifically requested. Conflict of Interest All authors must declare financial/commercial conflicts of interest. Even if there is none, this should be stated in a separate paragraph following on from the acknowledgements section. This is a mandatory requirement for all articles.

Plagiarism and COPE Membership Biopharmaceutics and Drug Disposition endorses the COPE (Committee on Publication Ethics) guidelines and will pursue cases of suspected research and publication misconduct (e.g. falsification, fabrication, plagiarism, inappropriate image manipulation, redundant publication). In such cases, the journal will follow the processes set out in by COPE. For more information about COPE please visit the COPE website at http://www.publicationethics.org.uk.

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