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The development and manipulation of laboratory-grown molecules, cells, tissues, and organs to replace or support the function of defective or injured body parts

Represent applications that repair or replace structural tissues (i.e. bone, cartilage, blood vessels, bladder, etc.), tissues that function by virtue of their mechanical properties

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Also applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bioartificial liver)

Where cells are implanted or seeded into an artificial structure capable of supporting threedimensional tissue formation

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Allow cell attachment and migration Deliver and retain cells and biochemical factors Enable diffusion of vital cell nutrients and expressed products Exert certain mechanical and biological influences to modify the behaviour of the cell phase

Providing cellular replacement parts

The living skin equivalent that consisted of a dermal component with a fully developed epidermis

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Providing formed acellular replacement parts capable of inducing regeneration

Demineralized bones can induce regeneration of cartilage and bone tissue

Providing tissue or organ-like model systems populated with cells for basic research and for many applied uses such as toxicity testing with normal cells and the study of disease states using aberrant cells

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Providing vehicles for delivering engineered cells to the organism

Bioartificial liver device Artificial pancreas Artificial bladders Cartilage Doris Taylor's heart in a jar Tissue-engineered airway Artificial skin Artificial bone marrow

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The ultimate goal is to develop powerful new therapies biological substitutes for structural and functional disorders of the human health that have proven difficult or impossible to address successfully with the existing tools of medicine.

Bi-layered skin substitute from human neonatal foreskin tissue

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A two-layer wound dressing that contains live human skin cells combined with bovine collagen 1998 approved for treatment of leg ulcers

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Time Immunogenicity Preservation Tissue culture Vascularization Organogenesis Ethics

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Chimeric Immune System

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What can it offer?

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