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Effect of landiolol on bispectral index and spectral entropy responses to tracheal intubatio...

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Effect of landiolol on bispectral index and spectral entropy responses to tracheal intubation during propofol anaesthesia
M. Kawaguchi, I. Takamatsu , K. Masui and T. Kazama

+ Author Affiliations

Corresponding author. E-mail: tisao@ndmc.ac.jp Accepted May 8, 2008.

Abstract Background 1-Adrenoceptor antagonists suppress the haemodynamic two spectral entropy-based indices, response entropy (RE) and state entropy (SE). The difference between RE and SE (RESE) may reflect nociception during general anaesthesia. In the present study, we tracheal intubation.

and arousal responses to tracheal intubation. The Entropy Module shows

investigated the effect of landiolol on entropy indices in response to Methods A total of 60 patients were randomly assigned to receive saline induced by propofol target-controlled infusion. Two minutes after the induction of anaesthesia, infusion with vecuronium bromide and

(Group S), remifentanil (Group R), or landiolol (Group L). Anaesthesia was

remifentanil, landiolol, or saline was initiated. Tracheal intubation was

performed 7 min after anaesthesia induction. Arterial pressure, heart rate (HR), bispectral index (BIS), and entropy indices were recorded. Results In Group S, RE increased significantly after tracheal intubation, but there was no significant increase in BIS or SE. These increases in RE were abolished in Groups R and L. RESE increased significantly after tracheal intubation in Group S, whereas no increase in RESE was observed in

Groups R and L. Increases in mean arterial pressure and HR after tracheal intubation were suppressed in Groups R and L compared with Group S. Conclusions RE increased in response to tracheal intubation, whereas BIS and SE did not. Landiolol and remifentanil suppressed the increase in RE after tracheal intubation with significant inhibition of RESE difference.
Key words

anaesthetics i.v., propofol analgesics opioid, remifentanil monitoring, bispectral index monitoring, electroencephalography sympathetic nervous system, adrenergic block

The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

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