Biotechnology

Biotechnology, the manipulation of biological organisms to make products that benefit human beings. Biotechnology contributes to such diverse areas as food production, waste disposal, mining, and medicine. Although biotechnology has existed since ancient times, some of its most dramatic advances have come in more recent years. Modern achievements include the transferal of a specific gene from one organism to another (by means of a set of genetic engineering techniques known as transgenics); the maintenance and growth of genetically uniform plant- and animal-cell cultures, called clones; and the fusing of different types of cells to produce beneficial medical products such as monoclonal antibodies, which are designed to attack a specific type of foreign substance.

Significance of Biotechnology
Today biotechnology is applied in various fields. In waste management, for example, biotechnology is used to create new biodegradable materials. One such material is made from the lactic acid produced during the bacterial fermentation of discarded corn stalks. When individual lactic acid molecules are joined chemically, they form a material that has the properties of plastics but is biodegradable. Widespread production of plastic from this material is expected to become more economically viable in the future.

Biotechnology also has applications in the mining industry. In its natural state, copper is found combined with other elements in the mineral chalcopyrite. The bacterium Thiobacillus ferrooxidans can use the molecules of copper found in chalcopyrite to form the compound copper sulfate (CuSO4), which, in turn, can be treated chemically to obtain pure copper.

Genetic Engineering
Genetic Engineering, alteration of an organism's genetic, or hereditary, material to eliminate undesirable characteristics or to produce desirable new ones. Genetic engineering is used to increase plant and animal food production; to help dispose of industrial wastes; and to diagnose disease, improve medical treatment, and produce vaccines and other useful drugs. Included in genetic engineering techniques are the selective breeding of plants and animals, hybridization (reproduction between different strains or species), and recombinant deoxyribonucleic acid (DNA).

Significance of Genetic Engineering

The first-known genetic engineering technique, still used today, was the selective breeding of plants and animals, usually for increased food production. In selective breeding, only those plants or animals with desirable characteristics are chosen for further breeding. Corn has been selectively bred for increased kernel size and number and for nutritional content for about 7,000 years. More recently, selective breeding of wheat and rice to produce higher yields has helped supply the world's ever-increasing need for food. Cattle and pigs were first domesticated about 8,500 to 9,000 years ago and through selective breeding have become main sources of animal food for humans. Dogs and horses have been selectively bred for thousands of years for work and recreational purposes, resulting in more than 150 dog breeds and 100 horse breeds.

Deoxyribonucleic Acid (DNA)

Deoxyribonucleic Acid (DNA), genetic material of all cellular organisms and most viruses. DNA carries the information needed to direct protein synthesis and replication. Protein synthesis is the production of the proteins needed by the cell or virus for its activities and development. Replication is the process by which DNA copies itself for each descendant cell or virus, passing on the information needed for protein synthesis. In most cellular organisms, DNA is organized on chromosomes located in the nucleus of the cell.

Significance of DNA
Research into DNA has had a significant impact on medicine. Through recombinant DNA technology, scientists can modify microorganisms so that they become so-called factories that produce large quantities of medically useful drugs. This technology is used to produce insulin, which is a drug used by diabetics, and interferon, which is used by some cancer patients. Studies of human DNA are revealing genes that are associated with specific diseases, such as cystic fibrosis and breast cancer. This information is helping physicians to diagnose various diseases, and it may lead to new treatments. For example, physicians are using a technology called chimeraplasty, which involves a synthetic molecule containing both DNA and RNA strands, in an effort to develop a treatment for a form of hemophilia.

Forensic science uses techniques developed in DNA research to identify individuals who have committed crimes. DNA from semen, skin, or blood taken from the crime scene can be compared with the DNA of a suspect, and the results can be used in court as evidence. Techniques of DNA manipulation are used in farming, in the form of genetic engineering and biotechnology. Strains of crop plants to which genes have been transferred may produce higher yields and may be more resistant to insects. Cattle have been similarly treated to increase milk and beef production, as have hogs, to yield more meat with less fat.