3. DRY GRANULATION METHOD a. weighing of raw material b. screening c. mixing d. compression to slugs e. milling f. mixing g.

compression to finished tablets WET GRANULATION METHOD a. Mixing of the drug(s) and excipients b. Preparation of binder solution c. Mixing of binder solution with powder mixture to form wet mass. d. Drying of moist granules e. Mixing of screened granules with disintegrant, glidant, and lubricant. DIRECT COMPRESSION a. Milling of drug and excipients b. Mixing of drug and excipients c. Tablet compression 4. acetaminophen and ampicillin/probenecid Probenecid may slightly increase the therapeutic effects of acetaminophen. At usual doses, however, no intervention appears to be necessary. acetaminophen and atropine Anticholinergic agents may delay and/or decrease the gastrointestinal absorption of acetaminophen by reducing gastric motility and delaying gastric emptying. However, the clinical relevance is probably minimal. acetaminophen and cimetidine Animal studies and some limited human studies have suggested that cimetidine may decrease the potential hepatotoxic effects of acetaminophen. The mechanism may be related to reductions in the rate at which reactive intermediate metabolites are formed. Not all studies have confirmed the occurrence of this interaction. No alterations in dosage are necessary.

acetaminophen and isoniazid Some reports have suggested that isoniazid may increase the potential hepatotoxicity of acetaminophen. The mechanism may be related to induction of CYP450 2E1 metabolism of acetaminophen to toxic metabolites during concurrent administration, or transient increased metabolism of acetaminophen after discontinuation of isoniazid. Study data have been conflicting and causality is unclear due to the presence of other drugs in some cases. Both isoniazid and acetaminophen have individually been associated with hepatotoxicity.

5. Lubricants prevent ingredients from clumping together and from sticking to the tablet punches or capsule filling machine.
Lubricants also ensure that tablet formation and ejection can occur with low friction between the solid and die wall, as well as between granules, which helps in uniform filling of the die. WHAT ARE LUBRICANTS? Lubricants are agents added in small quantities to tablet and capsule formulations to improve certain processing characteristics. . There are three roles identified with lubricants as follows: 1. True Lubricant Role: To decrease friction at the interface between a tablets surface and the die wall during ejection and reduce wear on punches & dies. 2. Anti-adherent Role: Prevent sticking to punch faces or in the case of encapsulation, lubricants prevent sticking to machine dosators, tamping pins, etc 3. Glidant Role: Enhance product flow by reducing interparticulate friction.