Quizlet Osteoblasts become surrounded by newly deposited organic matrix they become what? What cells are responsible for bone resorption? ‘Where woven bone normally DYSOSTOSES Most common disease of the growth plateand of dwarfism? BONE DYSPLASIAS. 4. What is the most common lethal form of dwarfism? 2. What usually causes death in these patients? Which type of osteogenesis imperfecta is, uniformly fatal? ‘What do you see intypes ‘osteogenesis imperfecta? Robbins Ch. 26 Bones, Joints, and Soft-Tissue Tumors Review Study online at quizlet.cony_er136 ‘osteocytes osteoclasts sites of rapid bone formation (fetal skeleton and base of growth plates) development anomalies resulting from localized problems in migration of mesenchymal eds and formation of condensations achondroplasia ‘mutations in the regulators of skeletal “organogenesis, such as signaling molecules (eg., growth factors and their receptors) and matrix components (€.., types 1 and 2 collagen) affect cartilage and ‘bone tissues globally 1. Thanatophorie ‘2, respiratory insufficiency becuase chest cavity is too small fractures lessen after puberty > Table 26-3 (Highlighted) What are the ‘osteogenesis imperfectas based off of? What is another name for ‘osteopetrosis? What happens in ‘osteopetrosis? What happens in medullary canalina patient with ‘osteopetrosis? Characterize ‘osteoporosis What populations do you see ‘osteoporosis most often? Marble bone disease or Albers-Schonberg disease reduced bone resorption, skeletal sclerosis due to impaired function of osteoclasts lacking; ends of ong bones are bulbous and misshapen + extra-medullary hematopoiesis porous bones and reduced bone mass ‘women (post-menopausal)Whatare thes. phases of Pagets disease? Deseribe thes. Phases of Paget Disease Long term, what is a really bad possibility with, Pagets? 4.Whatis Rickets? 2. Whatis itealled in adults? osteolytie phase, mixed phase, asteasclerotie phase 1) Osteolytie stage (waves of osteoclastic activity ‘and numerous resorption pits) + 2) osteoelastic- osteoblastie stage (bone surfaces are lined by osteoblasts; adjacent marrow is replaced byloose connective tissue) + 3) bumt-out quieseent osteosclerotie stage (cll activity decreases, the periosseous fibrovascular tissue recedes and is replaced by normal marrow) = gain in bone mass (bone is larger than normal, soft and porous, and lacks structural stability) development of osteosarcoma 1. disorder in children in which deranged bone growth produces distinctive skeletal deformities; Vitamin D deficiency 2. osteomalacia Pathogenesis of Renal Osteodystrophy Breakin a bone thatis altered by disease process? ‘What bone specimen do you See most often with pathologie fracture? How does one typically acquired osteomyelitis? Whatis osteomyelitis? ‘This is the most primary malignant tumor of bone? What will you radiographically for an osteosarcoma? Chronic renal failure + phosphate retention & hyperphosphatemia Induces secondary hyperparathyrotdism. ~ Hypocaleemia due to decreased vitamin D+ PTH secretion increases serum calcium + secondary hyperparathyroidism + increased osteoclast activity > Metabolic acidosis (rom Renal failure) stimulates bone resorption and release ofealeium hydroxyapatite = Other factors important in the genesis of dynamic renal osteodystrophy include DM, high Ca2+ ingestion, inereasing age, and Fe accumulation in bone and AL deposition atthe site of mineralization; = Acomplication associated with hemodialysis is the deposition of amyloid in bone and periarticular structures pathologic fracture vertebral bodies, femur infection by hematogenous spread inflammation of bone and marrow osteosarcoma Codman tiangleWhatis the Codman Triangle? Whatis the most common benign bone tumor? Whatis an osteochondroma? Chondromas are benign tumors of hyaline cartilage. What are they called in the ‘medullary cavity? Second most malignant matrix producing tumor of bone? Wheredoyou generally see osteosarcomas most frequently? Where do you see chondrosarcomas most frequently? 4.Whatis difference between Ewing sarcoma and PNET sarcomas? 2, What types of cells are they? Giant-Cell Tumor atiangularshadow b/ttheeortex and = raised ends of periosteum. ‘osteochondroma benign cartilage eapped tumor attached to underlying skeleton by bony stalk enchondromas chondrosareoma about the knee pelvis, shoulder, ribs 1. PNET = neural differentiation; Ewing = NO neutal differentiation 2, Small round blue eell tumors contains a mixture of mononuclear cells and a profusion of multinucleated ‘osteoclast-type giant ells, giving rise to the synonym osteoclastoma. This tumor isa relatively uncommon benign but locally aggressive neoplasm, Itusually arises in individuals in their 208 to 40s. Gross and histologic characteristics of Giant-Cell ‘Tumors Whatis the most common formof skeletal malignaney? Whatis another name for osteoarthritis? What do you see on bone surface with psp? Whatis pannus in RA? 7 FEATURES ‘NEEDED TO DIAGNOSERA Gotzare required for the Dx) red-brown tumors that frequently undergo cystic degeneration. They are mostly ‘composed of uniform oval mononuclear cells that constitute the proliferating component ofthe tumor. Seattered within this background are numerous osteoclast type giant cells having 100 or more nuclei that resemble those of the mononuclear cells (Fig. 26-36). Necrosis, hemorshage, ‘hemosiderin deposition, and reactive bone formation are common secondary features. metastasis degenerative joint disease (DJD), wear- aand:-tear disease ‘ebumation ‘mass of synovium and synovial stroma consisting of inflammatory cells, granulation tissue, and fibroblasts - Morning stiffness Arthritis in three or more joint areas + Arthritis of hand joints = Symmetric arthritis = Rheumatoid nodules Serum rheumatoid factor = Radiographie changes