The fastest way to see cancer

Can you aord to wait?

Friday, September 28, 12

What is Cellvizio ?
The optical biopsy system ...
Cellvizio images in the esophagus*

Squamous (Healthy)

Intestinal Metaplasia

Dysplasia

Adenocarcinoma
*Images extracted from DONT BIOPCE trial

... providing the Fastest Way to See Cancer

Cellvizio Pitch - Sept 2012 - V1.00

Friday, September 28, 12

What is Cellvizio ?

Cellvizio is a considerable progress for patients who must undergo a biopsy today. It enables physicians to know instantly what their patient has, without taking biopsies, so they can reassure their patient in most cases, or treat them immediately, if needed. Cellvizio enables accelerated patient management and peace of mind for the patient and for the physician in a usually stressful context.

Cellvizio Pitch - Sept 2012 - V1.00

Friday, September 28, 12

Cellvizio video
displayed in realtime

1 2
Probe appears on
endoscopic image

Probe positioned in
contact with mucosa

Area of interest
identied during endoscopic procedure

Cellvizio Probe
introduced into working channel of any endoscope

How does it work ?

Friday, September 28, 12

6 Main Targeted Indications in the Gastrointestinal Tract (1/2)

Clinical studies have demonstrated that Cellvizio can facilitate:

Barretts Esophagus surveillance and treatment

Bilio-Pancreatic Strictures

Pancreatic Cysts leare c t No

W NE t d ye

Comprehensive disease

The detection of more malignant

The dierentiation between

characterization1,2
Smarter, more ecient

strictures during ERCP procedures3,4

Telling patients on the spot that

surveillance1,2
Immediate response and real-

mucinous and non-mucinous pancreatic cysts during EUSFNA procedures5, 6

The quick identication of

time treatment1,2
Decision-making in ruling out

the stricture appears nonmalignant3

An improved patient quality of care

patients who need surgery5, 6

The reduction of unnecessary

on the

spot1,2

through a more informed therapeutic choice3,4

diagnostic procedures5, 6

References 1. Sharma P. et al., Real-time Increased Detection of NeoplasticTissue in Barrett's Esophagus with probe-based Confocal Laser Endomicroscopy: Final Results of a Multi-center Prospective International Randomized Controlled Trial. GIE, 2011. 2 Pohl H et al., Miniprobe Confocal Lase Microscopy for the Detection of Invisible Neoplasia in Patients with Barrett's Esophagus. Gut, 2008. 3 Meining A. et al., Classication of probe based Confocal Laser Endomicroscopy ndings in pancreaticobiliary strictures. Endoscopy, 2012 4. Meining A, Chen YK. et al., Direct visualization of indeterminate pancreaticobiliary strictures using probe based Confocal Laser Endomicroscopy - A multi-center experience. Gastrointestinal Endoscopy. GIE 2011. 5. Konda V, An International, Multi-Center Trial on Needle-Based Confocal Laser Endomicroscopy (nCLE): Results From the In Vivo CLE Study in the Pancreas With Endosonography of Cystic Tumors (INSPECT), poster at DDW 2012 6. Nakai Y, Chang K, Diagnosis of Pancreatic Cysts: Endoscopic Ultrasound, Through-the-Needle Confocal Laser-Induced Endomicroscopy and Cystoscopy Trial (DETECT Study), oral presentation at DDW 2012

Cellvizio Pitch - Sept 2012 - V1.00

Friday, September 28, 12

6 Main Targeted Indications in the Gastrointestinal Tract (2/2)

Clinical studies have demonstrated that Cellvizio can facilitate:

Colorectal lesions surveillance

Colorectal mucosal resection follow-up

Inammatory Bowel Disease surveillance

A comprehensive disease

characterization with dierentiation between non-neoplastic and neoplastic polyps1,2,3 with a short learning curve and high interobserver agreement4,5
Real-time and oine image

In-vivo characterization at the

A comprehensive disease

resection site and reliable detection of residual neoplasia7

Completeness of treatment with

characterization8,9 with a short learning curve and high agreement between pCLE and histopathological ndings.11
In-vivo dierentiation between

condence 4,7

interpretation with a statistically equivalent accuracy6

DALM and ALM can be achieved with an accuracy up to 97%10,12

References 1 Vivian M. Ussui and Michael B. Wallace, Confocal endomicroscopy of colorectal polyps, Gastroenterology Research and Practice Volume 2012, Article ID 545679, 6 pages 2. A.M. Buchner, M.W. Shahid, M.G. Heckman, et al., Comparison of Probe-Based Confocal Laser Endomicroscopy With Virtual Chromoendoscopy for Classication of Colon Polyps. Gastroenterology. 2010 Mar;138(3):834-42 3. M.W. Shahid, A.M. Buchner, M.G. Heckman, et al. Diagnostic Accuracy of Probe-Based Confocal Laser Endomicroscopy and Narrow Band Imaging for Small Colorectal Polyps: A Feasibility Study, Am J Gastroenterol, 2012 Feb;107(2):231-9 4.. V. Gmez, A.M. Buchner, E. Dekker, et al., Interobserver agreement and accuracy among inter- national experts with probe-based confocal laser endomicroscopy in predicting colorectal neoplasia, Endoscopy2010;42:286291 5. Buchner AM, Gomez V, Heckman MG, et al. The learning curve of in vivo probe-based confocal laser endomicroscopy for prediction of colorectal neoplasia. Gastrointestinal Endoscopy. 2011;73(3):556-60 6. M.W. Shahid, A.M. Buchner, M. Raimondo, et.al. Accuracy of real-time vs. blinded oine diagnosis of neoplastic colorectal polyps using probe-based confocal laser endomicroscopy: a pilot study. Endoscopy, 2012 Apr;44(4):343-8 7. Shahid M. et al.,Diagnosis accuracy of probe-based Confocal Laser Endomicroscopy (pCLE) in detecting recurrence of colorectal neoplasia after endoscopic mucosal resection. GIE 2011 8. R. Kiesslich, M. Goetz, K. Lammersdorf, et al., Chromoscopy-Guided Endomicroscopy Increases the Diagnostic Yield of Intraepithelial Neoplasia in Ulcerative Colitis, Gastroenterology 2007;132:874882 9. F.J.C. van den Broek, J.A.van Es, S.van Eeden, et al., Pilot study of probe-based confocal laser endomicroscopy during colonoscopic surveillance of patients with longstanding ulcerative colitis, Published ahead of print Endoscopy 10. G.D.De Palma, S.Staibano, S.Siciliano, et al., In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy, World J Gastroenterol 2011 February 7; 17(5): 1-0000 11 H. Neumann, M.Vieth, R. Atreya, et al., Prospective evaluation of the learning curve of confocal laser endomicroscopy in patients with IBD, Histol Histopathol (2011) 26:867-872 12. H. Neumann, M. Vieth, C. Langer et al., Cancer risk in IBD: How to diagnose and how to manage DALM and ALM. World J Gastroenterol 2011 July 21; 17(27):3184-3191

Cellvizio Pitch - Sept 2012 - V1.00

Friday, September 28, 12

Easy to Learn and to Integrate in your Practice

Almost immediate prociency
Published short learning curve Established training tools and

programs
Standardized workshops Dedicated educational website: cellvizio.net International Conference of Cellvizio Users

An immediate benet for your patients

Denitive diagnosis rather than

... and for your hospital

Advanced endoscopy program Position as technology leader Attract more patients Breach into other specialties

indetermination (less stress)

Increased chance of getting treated on time Increased condence in physician & hospital

Cellvizio Pitch - Sept 2012 - V1.00

Friday, September 28, 12

Over 300 users worldwide

Cellvizio Pitch - Sept 2012 - V1.00

Friday, September 28, 12