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  • Acute Glomerulonephritis Pathophysiology

    Transféré par

    Chester Nicole
    544 vues4 pages
    The document outlines the pathophysiological process of glomerulonephritis, which is an inflammation of the glomeruli in the kidney. It begins with an antigen-antibody reaction in the bloodstream that traps in the glomerulus and causes swelling and inflammation. This narrows the capillary lumen, decreases blood flow and GFR, and can damage the glomerular basement membrane. Over time, this can lead to scarring, decreased kidney function, proteinuria, edema, hypertension, and a buildup of waste products in the blood if left untreated.

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    Titre original

    50790873 Acute Glomerulonephritis Pathophysiology

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    The document outlines the pathophysiological process of glomerulonephritis, which is an inflammation of the glomeruli in the kidney. It begins with an antigen-antibody reaction in the bloodstream that traps in the glomerulus and causes swelling and inflammation. This narrows the capillary lumen, decreases blood flow and GFR, and can damage the glomerular basement membrane. Over time, this can lead to scarring, decreased kidney function, proteinuria, edema, hypertension, and a buildup of waste products in the blood if left untreated.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    544 vues4 pages

    Acute Glomerulonephritis Pathophysiology

    Transféré par

    Chester Nicole
    The document outlines the pathophysiological process of glomerulonephritis, which is an inflammation of the glomeruli in the kidney. It begins with an antigen-antibody reaction in the bloodstream that traps in the glomerulus and causes swelling and inflammation. This narrows the capillary lumen, decreases blood flow and GFR, and can damage the glomerular basement membrane. Over time, this can lead to scarring, decreased kidney function, proteinuria, edema, hypertension, and a buildup of waste products in the blood if left untreated.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 4

    Non Modifiable: - Male, 24 yrs old - -

    Modifiable: - Diet, Nephrotoxins and

    Sedentary lifestyle

    Antigen-antibody reactions Goes in the circulation Traps in glomerulus Produce swelling of cells Inflammation process occurs Activates complement pathways Stimulation of hypothalamus (heat regulating system)

    Narrowing of capillary lumen Decrease blood flow Decrease GFR

    fever

    Oliguria and increase waste product in the blood

    Attack glomerular basement membrane

    Activation of RAAS

    Glomerular proliferation

    Impedes function of kidney

    Damage Glomeruli

    Irritation on the tissue hematuria

    Scarring occurs

    Increase capillary permeability Excretion of protein and albumin Proteinuria and albuminuria Decrease protein and albumin in the body

    Decrease GFR

    Oliguria and increase waste product in the blood

    Decrease protein and albumin in the body

    Muscle weakness, fatigue and poor appetite

    Synthesis of lipoprotein

    Decrease oncotic pressure

    hyperlipidemia

    Fluid shifting Decrease fluid in the circulation

    RAAS activation

    B
    Decrease concentration of urine Decrease erythropoiesis

    Impedes function of kidney Increase creatinine and potassium Accumulates in the brain seizure

    Unable to excrete wastes products

    Decrease specific gravity and pH

    Diminished blood flow

    Hypoxemia to different tissue Acidosis kidney stomach Anaerobic metabolism constipation Increase amount of acid

    Decrease GFR

    RAAS activation

    Hyperventilate

    Oliguria and increase waste product in the blood

    RAAS activation Sodium and Water Retention Fluid shifting Increase blood volume

    ascites

    accumulation of fluid in the lung capillaries

    Compression of diaphragm Pulmonary hypertension Difficulty of breathing Increase pulmonary arterial pressure

    Generalized edema (ANASARCA) Periorbital edema Facial edema Ascites Edema on both upper and lower extremities

    Hypertension

    Rupture of microvascular aneurysm

    Hemoptysis

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